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Items: 1 to 50 of 472

1.

The Role of Iron and Nerve Inflammation in Diabetes Mellitus Type 2-Induced Peripheral Neuropathy.

Paeschke S, Baum P, Toyka KV, Blüher M, Koj S, Klöting N, Bechmann I, Thiery J, Kosacka J, Nowicki M.

Neuroscience. 2019 May 15;406:496-509. doi: 10.1016/j.neuroscience.2019.03.005. Epub 2019 Mar 10.

PMID:
30867132
2.

Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.

Gerber D, Ghidinelli M, Tinelli E, Somandin C, Gerber J, Pereira JA, Ommer A, Figlia G, Miehe M, Nägeli LG, Suter V, Tadini V, Sidiropoulos PN, Wessig C, Toyka KV, Suter U.

Elife. 2019 Jan 16;8. pii: e42404. doi: 10.7554/eLife.42404.

3.

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Kosacka J, Woidt K, Toyka KV, Paeschke S, Klöting N, Bechmann I, Blüher M, Thiery J, Ossmann S, Baum P, Nowicki M.

Neurol Res. 2019 Apr;41(4):341-353. doi: 10.1080/01616412.2018.1564191. Epub 2019 Jan 13.

PMID:
30638160
4.

Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Grünewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C.

Elife. 2017 Nov 14;6. pii: e28685. doi: 10.7554/eLife.28685.

5.

Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.

Ip CW, Isaias IU, Kusche-Tekin BB, Klein D, Groh J, O'Leary A, Knorr S, Higuchi T, Koprich JB, Brotchie JM, Toyka KV, Reif A, Volkmann J.

Acta Neuropathol Commun. 2016 Oct 3;4(1):108.

6.

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies.

Grünewald B, Bennett JL, Toyka KV, Sommer C, Geis C.

Int J Mol Sci. 2016 Aug 26;17(9). pii: E1407. doi: 10.3390/ijms17091407.

7.

Cellular infiltrates in skin and sural nerve of patients with polyneuropathies.

Üçeyler N, Braunsdorf S, Kunze E, Riediger N, Scheytt S, Divisova Š, Bekircan-Kurt CE, Toyka KV, Sommer C.

Muscle Nerve. 2017 Jun;55(6):884-893. doi: 10.1002/mus.25240. Epub 2017 Mar 28.

PMID:
27387067
8.

Immunoadsorption versus plasma exchange versus combination for treatment of myasthenic deterioration.

Schneider-Gold C, Krenzer M, Klinker E, Mansouri-Thalegani B, Müllges W, Toyka KV, Gold R.

Ther Adv Neurol Disord. 2016 Jul;9(4):297-303. doi: 10.1177/1756285616637046. Epub 2016 Mar 10.

9.

Malignancies after mitoxantrone for multiple sclerosis: A retrospective cohort study.

Buttmann M, Seuffert L, Mäder U, Toyka KV.

Neurology. 2016 Jun 7;86(23):2203-7. doi: 10.1212/WNL.0000000000002745. Epub 2016 May 11.

10.

The role of nerve inflammation and exogenous iron load in experimental peripheral diabetic neuropathy (PDN).

Baum P, Kosacka J, Estrela-Lopis I, Woidt K, Serke H, Paeschke S, Stockinger M, Klöting N, Blüher M, Dorn M, Classen J, Thiery J, Bechmann I, Toyka KV, Nowicki M.

Metabolism. 2016 Apr;65(4):391-405. doi: 10.1016/j.metabol.2015.11.002. Epub 2015 Nov 6.

PMID:
26975531
11.

Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition.

Werner C, Pauli M, Doose S, Weishaupt A, Haselmann H, Grünewald B, Sauer M, Heckmann M, Toyka KV, Asan E, Sommer C, Geis C.

Brain. 2016 Feb;139(Pt 2):365-79. doi: 10.1093/brain/awv324. Epub 2015 Nov 18.

PMID:
26582558
12.

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.

Steinbeck JA, Jaiswal MK, Calder EL, Kishinevsky S, Weishaupt A, Toyka KV, Goldstein PA, Studer L.

Cell Stem Cell. 2016 Jan 7;18(1):134-43. doi: 10.1016/j.stem.2015.10.002. Epub 2015 Nov 5.

13.

Endoneurial edema in sural nerve may indicate recent onset inflammatory neuropathy.

Üçeyler N, Necula G, Wagemann E, Toyka KV, Sommer C.

Muscle Nerve. 2016 May;53(5):705-10. doi: 10.1002/mus.24930. Epub 2016 Jan 27.

PMID:
26439587
14.

Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis.

Nagel MA, White T, Khmeleva N, Rempel A, Boyer PJ, Bennett JL, Haller A, Lear-Kaul K, Kandasmy B, Amato M, Wood E, Durairaj V, Fogt F, Tamhankar MA, Grossniklaus HE, Poppiti RJ, Bockelman B, Keyvani K, Pollak L, Mendlovic S, Fowkes M, Eberhart CG, Buttmann M, Toyka KV, Meyer-ter-Vehn T, Petursdottir V, Gilden D.

JAMA Neurol. 2015 Nov;72(11):1281-7. doi: 10.1001/jamaneurol.2015.2101.

15.

Non-systemic vasculitic neuropathy: single-center follow-up of 60 patients.

Üçeyler N, Geng A, Reiners K, Toyka KV, Sommer C.

J Neurol. 2015 Sep;262(9):2092-100. doi: 10.1007/s00415-015-7813-5. Epub 2015 Jun 20.

PMID:
26092519
16.

Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.

Simon CM, Rauskolb S, Gunnersen JM, Holtmann B, Drepper C, Dombert B, Braga M, Wiese S, Jablonka S, Pühringer D, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka KV, Sendtner M.

Acta Neuropathol. 2015 Sep;130(3):373-87. doi: 10.1007/s00401-015-1446-8. Epub 2015 May 30.

17.

The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model.

Geis C, Ritter C, Ruschil C, Weishaupt A, Grünewald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B, Stadelmann C, Bennett JL, Sommer C, Toyka KV.

Exp Neurol. 2015 Mar;265:8-21. doi: 10.1016/j.expneurol.2014.12.015. Epub 2014 Dec 24.

18.

Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms.

Werner C, Haselmann H, Weishaupt A, Toyka KV, Sommer C, Geis C.

J Neural Transm (Vienna). 2015 Mar;122(3):357-62. doi: 10.1007/s00702-014-1268-1. Epub 2014 Jul 3.

PMID:
24990310
19.

Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1.

Krieger F, Elflein N, Saenger S, Wirthgen E, Rak K, Frantz S, Hoeflich A, Toyka KV, Metzger F, Jablonka S.

Brain. 2014 May;137(Pt 5):1374-93. doi: 10.1093/brain/awu059. Epub 2014 Mar 27.

PMID:
24681663
20.

The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.

Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U.

Brain. 2014 Mar;137(Pt 3):668-82. doi: 10.1093/brain/awt371. Epub 2014 Jan 29.

21.

Effects of isoflurane anesthesia on F-waves in the sciatic nerve of the adult rat.

Nowicki M, Baum P, Kosacka J, Stockinger M, Klöting N, Blüher M, Bechmann I, Toyka KV.

Muscle Nerve. 2014 Aug;50(2):257-61. doi: 10.1002/mus.24150. Epub 2014 May 5.

PMID:
24347162
22.

Increased autophagy in peripheral nerves may protect Wistar Ottawa Karlsburg W rats against neuropathy.

Kosacka J, Nowicki M, Blüher M, Baum P, Stockinger M, Toyka KV, Klöting I, Stumvoll M, Serke H, Bechmann I, Klöting N.

Exp Neurol. 2013 Dec;250:125-35. doi: 10.1016/j.expneurol.2013.09.017. Epub 2013 Oct 3.

PMID:
24095727
23.

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

Camara M, Beyersdorf N, Fischer HJ, Herold MJ, Ip CW, van den Brandt J, Toyka KV, Taurog JD, Hünig T, Herrmann T, Reichardt HM, Weishaupt A, Kerkau T.

J Neuroimmunol. 2013 Jul 15;260(1-2):17-27. doi: 10.1016/j.jneuroim.2013.04.014. Epub 2013 May 7.

PMID:
23664330
24.

Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle-specific kinase autoantibody.

Morsch M, Reddel SW, Ghazanfari N, Toyka KV, Phillips WD.

J Physiol. 2013 May 15;591(10):2747-62. doi: 10.1113/jphysiol.2013.251827. Epub 2013 Feb 25.

25.

Intravenous immunoglobulin for myasthenia gravis.

Gajdos P, Chevret S, Toyka KV.

Cochrane Database Syst Rev. 2012 Dec 12;12:CD002277. doi: 10.1002/14651858.CD002277.pub4. Review.

PMID:
23235588
26.

Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.

Horn M, Baumann R, Pereira JA, Sidiropoulos PN, Somandin C, Welzl H, Stendel C, Lühmann T, Wessig C, Toyka KV, Relvas JB, Senderek J, Suter U.

Brain. 2012 Dec;135(Pt 12):3567-83. doi: 10.1093/brain/aws275. Epub 2012 Nov 20.

27.

Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats.

Hansen N, Grünewald B, Weishaupt A, Colaço MN, Toyka KV, Sommer C, Geis C.

Exp Neurol. 2013 Jan;239:202-9. doi: 10.1016/j.expneurol.2012.10.013. Epub 2012 Oct 23.

PMID:
23099416
28.

Excitability decreasing central motor plasticity is retained in multiple sclerosis patients.

Zeller D, Dang SY, Weise D, Rieckmann P, Toyka KV, Classen J.

BMC Neurol. 2012 Sep 13;12:92. doi: 10.1186/1471-2377-12-92.

29.

Intrathecal, polyspecific antiviral immune response in oligoclonal band negative multiple sclerosis.

Brecht I, Weissbrich B, Braun J, Toyka KV, Weishaupt A, Buttmann M.

PLoS One. 2012;7(7):e40431. doi: 10.1371/journal.pone.0040431. Epub 2012 Jul 9.

30.

Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors.

Morsch M, Reddel SW, Ghazanfari N, Toyka KV, Phillips WD.

Exp Neurol. 2012 Oct;237(2):286-95. doi: 10.1016/j.expneurol.2012.06.034. Epub 2012 Jul 10.

PMID:
22789393
31.

The lateral thoracic nerve and the cutaneous maximus muscle--a novel in vivo model system for nerve degeneration and regeneration studies.

Pan B, Grünewald B, Nguyen T, Farah M, Polydefkis M, McDonald J, Schramm LP, Toyka KV, Höke A, Griffin JW.

Exp Neurol. 2012 Jul;236(1):6-18. doi: 10.1016/j.expneurol.2012.02.006. Epub 2012 Feb 14.

32.

Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer.

Geis C, Grünewald B, Weishaupt A, Wultsch T, Toyka KV, Reif A, Sommer C.

J Neural Transm (Vienna). 2012 Aug;119(8):981-5. doi: 10.1007/s00702-012-0773-3. Epub 2012 Feb 14.

PMID:
22331304
33.

Fatal PML associated with efalizumab therapy: insights into integrin αLβ2 in JC virus control.

Schwab N, Ulzheimer JC, Fox RJ, Schneider-Hohendorf T, Kieseier BC, Monoranu CM, Staugaitis SM, Welch W, Jilek S, Du Pasquier RA, Brück W, Toyka KV, Ransohoff RM, Wiendl H.

Neurology. 2012 Feb 14;78(7):458-67; discussion 465. doi: 10.1212/WNL.0b013e3182478d4b. Epub 2012 Feb 1.

34.

Biomarkers in the diagnosis and therapy of CIDP: Proceedings of the Biomarkers Faculty Meeting; June 8-9, 2010, Athens, Greece.

Latov N, Dalakas M, Vallat JM, Donofrio P, Hartung HP, Toyka KV.

J Peripher Nerv Syst. 2011 Jun;16 Suppl 1:1-2. doi: 10.1111/j.1529-8027.2011.00297.x. No abstract available.

PMID:
21696489
35.

Vasculitis-like neuropathy in amyotrophic lateral sclerosis unresponsive to treatment.

Devigili G, Uçeyler N, Beck M, Reiners K, Stoll G, Toyka KV, Sommer C.

Acta Neuropathol. 2011 Sep;122(3):343-52. doi: 10.1007/s00401-011-0837-8. Epub 2011 May 28.

PMID:
21626035
36.

[Multiple sclerosis: updates on pathogenesis and treatment: report from the 9th MS Symposium held by the German Multiple Sclerosis Society].

Hohlfeld R, Toyka KV.

Nervenarzt. 2011 Aug;82(8):1026-35. doi: 10.1007/s00115-011-3264-0. German. No abstract available.

PMID:
21424411
37.

Human stiff-person syndrome IgG induces anxious behavior in rats.

Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C.

PLoS One. 2011 Feb 8;6(2):e16775. doi: 10.1371/journal.pone.0016775.

38.

Functional role of ipsilateral motor areas in multiple sclerosis.

Zeller D, Dang SY, Stefan K, Biller A, Bartsch A, Saur D, Bendszus M, Rieckmann P, Toyka KV, Classen J.

J Neurol Neurosurg Psychiatry. 2011 May;82(5):578-83. doi: 10.1136/jnnp.2010.219964. Epub 2010 Oct 27.

PMID:
20980484
39.

Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.

Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C.

Brain. 2010 Nov;133(11):3166-80. doi: 10.1093/brain/awq253. Epub 2010 Sep 30.

PMID:
20884644
40.

Serum antibodies to conformational and linear epitopes of myelin oligodendrocyte glycoprotein are not elevated in the preclinical phase of multiple sclerosis.

Chan A, Decard BF, Franke C, Grummel V, Zhou D, Schottstedt V, Toyka KV, Hemmer B, Gold R.

Mult Scler. 2010 Oct;16(10):1189-92. doi: 10.1177/1352458510376406. Epub 2010 Aug 4.

PMID:
20685767
41.

Auto-SCT in severe paraproteinemic neuropathy.

Hummel HD, Rath JC, Wiendl H, Hetzel W, Bargou RC, Toyka KV, Sommer C, Einsele H, Topp MS.

Bone Marrow Transplant. 2011 Mar;46(3):457-9. doi: 10.1038/bmt.2010.124. Epub 2010 May 31. No abstract available.

PMID:
20577220
42.

Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy.

Uçeyler N, Kafke W, Riediger N, He L, Necula G, Toyka KV, Sommer C.

Neurology. 2010 Jun 1;74(22):1806-13. doi: 10.1212/WNL.0b013e3181e0f7b3.

PMID:
20513817
43.

[Amyotrophic lateral sclerosis: management of bulbar symptoms].

Kraft P, Beck M, Grimm A, Wessig C, Reiners K, Toyka KV.

Nervenarzt. 2010 Oct;81(10):1218-25. doi: 10.1007/s00115-010-3008-6. German.

PMID:
20401600
44.

An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis.

Schwab N, Zozulya AL, Kieseier BC, Toyka KV, Wiendl H.

J Immunol. 2010 May 1;184(9):5368-74. doi: 10.4049/jimmunol.0903662. Epub 2010 Mar 31.

45.

Skin biopsy as an additional diagnostic tool in non-systemic vasculitic neuropathy.

Uçeyler N, Devigili G, Toyka KV, Sommer C.

Acta Neuropathol. 2010 Jul;120(1):109-16. doi: 10.1007/s00401-010-0662-5. Epub 2010 Mar 5.

PMID:
20204385
46.

Rapid-onset central motor plasticity in multiple sclerosis.

Zeller D, aufm Kampe K, Biller A, Stefan K, Gentner R, Schütz A, Bartsch A, Bendszus M, Toyka KV, Rieckmann P, Classen J.

Neurology. 2010 Mar 2;74(9):728-35. doi: 10.1212/WNL.0b013e3181d31dcf.

PMID:
20194911
47.

Axonal prion protein is required for peripheral myelin maintenance.

Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A.

Nat Neurosci. 2010 Mar;13(3):310-8. doi: 10.1038/nn.2483. Epub 2010 Jan 24.

PMID:
20098419
48.

Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction.

Boettger MK, Weishaupt A, Geis C, Toyka KV, Sommer C.

J Neural Transm (Vienna). 2010 Feb;117(2):165-9. doi: 10.1007/s00702-009-0342-6. Epub 2009 Nov 28.

PMID:
19946712
49.

Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

Huang YH, Zozulya AL, Weidenfeller C, Metz I, Buck D, Toyka KV, Brück W, Wiendl H.

Ann Neurol. 2009 Aug;66(2):171-83. doi: 10.1002/ana.21705.

PMID:
19705413
50.

The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.

Chuang WY, Ströbel P, Belharazem D, Rieckmann P, Toyka KV, Nix W, Schalke B, Gold R, Kiefer R, Klinker E, Opitz A, Inoue M, Kuo TT, Müller-Hermelink HK, Marx A.

Genes Immun. 2009 Dec;10(8):667-72. doi: 10.1038/gene.2009.64. Epub 2009 Aug 20.

PMID:
19693092

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