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Items: 11


Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells.

Toyama BH, Arrojo E Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer MW.

J Cell Biol. 2019 Feb 4;218(2):433-444. doi: 10.1083/jcb.201809123. Epub 2018 Dec 14.


Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.

Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M.

Cell Syst. 2015 Sep 23;1(3):224-37. doi: 10.1016/j.cels.2015.08.012. Epub 2015 Sep 17.


Identification of long-lived proteins reveals exceptional stability of essential cellular structures.

Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR 3rd, Hetzer MW.

Cell. 2013 Aug 29;154(5):971-982. doi: 10.1016/j.cell.2013.07.037.


Protein homeostasis: live long, won't prosper.

Toyama BH, Hetzer MW.

Nat Rev Mol Cell Biol. 2013 Jan;14(1):55-61. doi: 10.1038/nrm3496. Review.


Extremely long-lived nuclear pore proteins in the rat brain.

Savas JN, Toyama BH, Xu T, Yates JR 3rd, Hetzer MW.

Science. 2012 Feb 24;335(6071):942. doi: 10.1126/science.1217421. Epub 2012 Feb 2.


Amyloid structure: conformational diversity and consequences.

Toyama BH, Weissman JS.

Annu Rev Biochem. 2011;80:557-85. doi: 10.1146/annurev-biochem-090908-120656. Review.


Strain conformation, primary structure and the propagation of the yeast prion [PSI+].

Verges KJ, Smith MH, Toyama BH, Weissman JS.

Nat Struct Mol Biol. 2011 Apr;18(4):493-9. doi: 10.1038/nsmb.2030. Epub 2011 Mar 20.


Differences in prion strain conformations result from non-native interactions in a nucleus.

Ohhashi Y, Ito K, Toyama BH, Weissman JS, Tanaka M.

Nat Chem Biol. 2010 Mar;6(3):225-230. Epub 2010 Jan 17.


Small-molecule aggregates inhibit amyloid polymerization.

Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK.

Nat Chem Biol. 2008 Mar;4(3):197-9. doi: 10.1038/nchembio.65. Epub 2008 Jan 27.


The structural basis of yeast prion strain variants.

Toyama BH, Kelly MJ, Gross JD, Weissman JS.

Nature. 2007 Sep 13;449(7159):233-7. Epub 2007 Sep 2.


The physical basis of how prion conformations determine strain phenotypes.

Tanaka M, Collins SR, Toyama BH, Weissman JS.

Nature. 2006 Aug 3;442(7102):585-9. Epub 2006 Jun 28.


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