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Items: 45

1.

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway.

Li Z, Razavi P, Li Q, Toy W, Liu B, Ping C, Hsieh W, Sanchez-Vega F, Brown DN, Da Cruz Paula AF, Morris L, Selenica P, Eichenberger E, Shen R, Schultz N, Rosen N, Scaltriti M, Brogi E, Baselga J, Reis-Filho JS, Chandarlapaty S.

Cancer Cell. 2018 Dec 10;34(6):893-905.e8. doi: 10.1016/j.ccell.2018.11.006.

2.

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL.

Elife. 2018 Nov 29;7. pii: e37161. doi: 10.7554/eLife.37161.

3.

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.

Sharma A, Toy W, Guillen VS, Sharma N, Min J, Carlson KE, Mayne CG, Lin S, Sabio M, Greene G, Katzenellenbogen BS, Chandarlapaty S, Katzenellenbogen JA.

ACS Chem Biol. 2018 Dec 21;13(12):3374-3384. doi: 10.1021/acschembio.8b00877. Epub 2018 Nov 26.

PMID:
30404440
4.

Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing.

Ross DS, Zehir A, Brogi E, Konno F, Krystel-Whittemore M, Edelweiss M, Berger MF, Toy W, Chandarlapaty S, Razavi P, Baselga J, Wen HY.

Mod Pathol. 2019 Jan;32(1):81-87. doi: 10.1038/s41379-018-0116-5. Epub 2018 Aug 29.

PMID:
30158597
5.

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons.

Wang L, Guillen VS, Sharma N, Flessa K, Min J, Carlson KE, Toy W, Braqi S, Katzenellenbogen BS, Katzenellenbogen JA, Chandarlapaty S, Sharma A.

ACS Med Chem Lett. 2018 Jul 5;9(8):803-808. doi: 10.1021/acsmedchemlett.8b00106. eCollection 2018 Aug 9.

6.

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

Giltnane JM, Hutchinson KE, Stricker TP, Formisano L, Young CD, Estrada MV, Nixon MJ, Du L, Sanchez V, Ericsson PG, Kuba MG, Sanders ME, Mu XJ, Van Allen EM, Wagle N, Mayer IA, Abramson V, Gόmez H, Rizzo M, Toy W, Chandarlapaty S, Mayer EL, Christiansen J, Murphy D, Fitzgerald K, Wang K, Ross JS, Miller VA, Stephens PJ, Yelensky R, Garraway L, Shyr Y, Meszoely I, Balko JM, Arteaga CL.

Sci Transl Med. 2017 Aug 9;9(402). pii: eaai7993. doi: 10.1126/scitranslmed.aai7993. Erratum in: Sci Transl Med. 2019 Feb 13;11(479):.

7.

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.

Toy W, Weir H, Razavi P, Lawson M, Goeppert AU, Mazzola AM, Smith A, Wilson J, Morrow C, Wong WL, De Stanchina E, Carlson KE, Martin TS, Uddin S, Li Z, Fanning S, Katzenellenbogen JA, Greene G, Baselga J, Chandarlapaty S.

Cancer Discov. 2017 Mar;7(3):277-287. doi: 10.1158/2159-8290.CD-15-1523. Epub 2016 Dec 16.

8.

Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease.

Wang Z, Stefanko DP, Guo Y, Toy WA, Petzinger GM, Jakowec MW, Holschneider DP.

Neuroreport. 2016 Jun 15;27(9):632-9. doi: 10.1097/WNR.0000000000000587.

PMID:
27082842
9.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

10.

The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry.

Petzinger GM, Holschneider DP, Fisher BE, McEwen S, Kintz N, Halliday M, Toy W, Walsh JW, Beeler J, Jakowec MW.

Brain Plast. 2015;1(1):29-39.

11.

Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling.

Will M, Qin AC, Toy W, Yao Z, Rodrik-Outmezguine V, Schneider C, Huang X, Monian P, Jiang X, de Stanchina E, Baselga J, Liu N, Chandarlapaty S, Rosen N.

Cancer Discov. 2014 Mar;4(3):334-47. doi: 10.1158/2159-8290.CD-13-0611. Epub 2014 Jan 16.

12.

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

Toy WA, Petzinger GM, Leyshon BJ, Akopian GK, Walsh JP, Hoffman MV, Vučković MG, Jakowec MW.

Neurobiol Dis. 2014 Mar;63:201-9. doi: 10.1016/j.nbd.2013.11.017. Epub 2013 Dec 5.

13.

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.

Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S.

Nat Genet. 2013 Dec;45(12):1439-45. doi: 10.1038/ng.2822. Epub 2013 Nov 3.

14.

Lower circulating irisin is associated with type 2 diabetes mellitus.

Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, Tavintharan S, Sum CF, Lim SC.

J Diabetes Complications. 2013 Jul-Aug;27(4):365-9. doi: 10.1016/j.jdiacomp.2013.03.002. Epub 2013 Apr 22.

PMID:
23619195
15.

Elevated undercarboxylated and reduced carboxylated osteocalcin are associated with metabolic syndrome in middle age Asian females.

Liu JJ, Toy WC, Wong MD, Tan CS, Tavintharan S, Wong MS, Sum CF, Lim SC.

Exp Clin Endocrinol Diabetes. 2013 Jun;121(6):329-33. doi: 10.1055/s-0033-1334883. Epub 2013 Mar 19.

PMID:
23512417
16.

Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes.

Liu JJ, Toy WC, Liu S, Cheng A, Lim BK, Subramaniam T, Sum CF, Lim SC.

Biochem Biophys Res Commun. 2013 Feb 8;431(2):192-6. doi: 10.1016/j.bbrc.2012.12.136. Epub 2013 Jan 9.

PMID:
23313487
17.

Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.

Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.

J Proteome Res. 2012 Dec 7;11(12):5736-47. doi: 10.1021/pr300555y. Epub 2012 Nov 26.

18.

EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.

Assiddiq BF, Tan KY, Toy W, Chan SP, Chong PK, Lim YP.

J Proteome Res. 2012 Aug 3;11(8):4110-9. doi: 10.1021/pr3002029. Epub 2012 Jul 10.

PMID:
22703031
19.

Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors.

Pentkowski NS, Cheung TH, Toy WA, Adams MD, Neumaier JF, Neisewander JL.

Biol Psychiatry. 2012 Sep 1;72(5):396-404. doi: 10.1016/j.biopsych.2012.03.024. Epub 2012 Apr 27.

20.

Adipocytokine zinc α2 glycoprotein (ZAG) as a novel urinary biomarker for normo-albuminuric diabetic nephropathy.

Lim SC, Liying DQ, Toy WC, Wong M, Yeoh LY, Tan C, Lau D, Tan C, Subramaniam T, Sum CF.

Diabet Med. 2012 Jul;29(7):945-9. doi: 10.1111/j.1464-5491.2011.03564.x.

PMID:
22211921
21.

Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation.

Choong LY, Lim SK, Chen Y, Loh MC, Toy W, Wong CY, Salto-Tellez M, Shah N, Lim YP.

Genes Chromosomes Cancer. 2011 Oct;50(10):837-47. doi: 10.1002/gcc.20905. Epub 2011 Jul 18.

PMID:
21769958
22.

Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.

Lim SK, Orhant-Prioux M, Toy W, Tan KY, Lim YP.

FASEB J. 2011 Sep;25(9):3004-18. doi: 10.1096/fj.10-169136. Epub 2011 Jun 3.

PMID:
21642474
23.

EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.

Toy W, Lim SK, Loh MC, Lim YP.

Cell Signal. 2010 Mar;22(3):437-46. doi: 10.1016/j.cellsig.2009.10.015.

PMID:
19887107
24.

Novel breast cancer metastasis-associated proteins.

Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP.

J Proteome Res. 2009 Feb;8(2):583-94. doi: 10.1021/pr8007368.

PMID:
19086899
25.

An unusual case of hypokalemic paralysis associated with primary Sjogren's syndrome.

Toy WC, Jasin HE.

J Ark Med Soc. 2008 Jun;104(12):286-7.

PMID:
18564466
26.

Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics.

Choong LY, Lim S, Loh MC, Man X, Chen Y, Toy W, Pan M, Chen CS, Poonepalli A, Hande MP, Tan PH, Salto-Tellez M, Wong CY, Shah N, Druker BJ, Lim YP.

Mol Cancer Ther. 2007 Nov;6(11):2828-42. Epub 2007 Nov 7.

27.

Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.

Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP.

Proteomics. 2007 Jul;7(14):2384-97.

PMID:
17570516
28.

Influenza immunization of medical residents: knowledge, attitudes, and behaviors.

Toy WC, Janosky JE, Laird SB.

Am J Infect Control. 2005 Oct;33(8):473-5.

PMID:
16216662
29.

Prospective evaluation of an outpatient heart failure disease management program designed for primary care: the Oregon model.

Hershberger RE, Nauman DJ, Byrkit J, Gillespie G, Lackides G, Toy W, Burgess D, Dutton D.

J Card Fail. 2005 May;11(4):293-8.

PMID:
15880339
30.

Pre-operative renal function predicts development of chronic renal insufficiency after orthotopic heart transplantation.

Vossler MR, Ni H, Toy W, Hershberger RE.

J Heart Lung Transplant. 2002 Aug;21(8):874-81.

PMID:
12163087
31.

Periodic rescreening is indicated for family members at risk of developing familial dilated cardiomyopathy.

Crispell KA, Hanson EL, Coates K, Toy W, Hershberger RE.

J Am Coll Cardiol. 2002 May 1;39(9):1503-7.

32.

Novel lamin A/C mutations in two families with dilated cardiomyopathy and conduction system disease.

Jakobs PM, Hanson EL, Crispell KA, Toy W, Keegan H, Schilling K, Icenogle TB, Litt M, Hershberger RE.

J Card Fail. 2001 Sep;7(3):249-56.

PMID:
11561226
33.

Distribution and declines in cardiac allograft radionuclide left ventricular ejection fractions in relation to late mortality.

Hershberger RE, Ni H, Toy W, Wilson RA.

J Heart Lung Transplant. 2001 Apr;20(4):417-24.

PMID:
11295579
34.

Prospective evaluation of an outpatient heart failure management program.

Hershberger RE, Ni H, Nauman DJ, Burgess D, Toy W, Wise K, Dutton D, Crispell K, Vossler M, Everett J.

J Card Fail. 2001 Mar;7(1):64-74.

PMID:
11264552
35.

Comparative responsiveness of Short-Form 12 and Minnesota Living With Heart Failure Questionnaire in patients with heart failure.

Ni H, Toy W, Burgess D, Wise K, Nauman DJ, Crispell K, Hershberger RE.

J Card Fail. 2000 Jun;6(2):83-91.

PMID:
10908081
36.

Medication misadventures resulting in emergency department visits at and HMO medical center.

Schneitman-McIntire O, Farnen TA, Gordon N, Chan J, Toy WA.

Am J Health Syst Pharm. 1996 Jun 15;53(12):1416-22.

PMID:
8781687
37.

Designing an advanced laparoscopic surgery training center.

Szabó Z, Biggerstaff ED, Kelly NJ, Toy W.

Surg Technol Int. 1995;IV:49-54.

PMID:
21400410
39.

Recent advances in understanding the mechanisms of drug-induced torsades de pointes arrhythmias.

Sasyniuk BI, Valois M, Toy W.

Am J Cardiol. 1989 Dec 5;64(20):29J-32J.

PMID:
2596410
40.

Hazardous waste minimization: Part IX. Waste minimization in the automotive repair industry.

Toy WM.

JAPCA. 1988 Nov;38(11):1422-6. No abstract available.

PMID:
3236044
41.

Equal pay: now legally it exists--or does it?

Toy WJ.

UNA Nurs J. 1969 Jun;67:8-9. No abstract available.

PMID:
5195631
42.

Viewpoint (social security for nurses).

Toy WJ.

UNA Nurs J. 1968 Oct-Nov;66:306-9. No abstract available.

PMID:
4236706
43.

Viewpoint: on the desirability of nurses being involved in the field of industrial relations.

Toy WJ.

UNA Nurs J. 1968 Apr;66:108-9. No abstract available.

PMID:
5187061
44.

Viewpoint on economic welfare.

Toy WJ.

UNA Nurs J. 1968 Jan;66:10-2. No abstract available.

PMID:
5184490
45.

Viewpoint.

Toy WJ.

UNA Nurs J. 1967 Feb;65:38. No abstract available.

PMID:
5181508

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