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TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
Wang L, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D. Wang L, et al. Cell Metab. 2022 Jan 4;34(1):158-170.e5. doi: 10.1016/j.cmet.2021.11.013. Epub 2021 Dec 15. Cell Metab. 2022. PMID: 34914893 Free PMC article.
Moreover, TOX4 ablation fails to reverse the metabolic derangement brought by insulin receptor knockout. ...In the latter two murine models, knockdown Tox4 decreases glycemia and improves glucose tolerance. We conclude that TOX4 is an insulin receptor-indepen …
Moreover, TOX4 ablation fails to reverse the metabolic derangement brought by insulin receptor knockout. ...In the latter two murine …
Tox4 modulates cell fate reprogramming.
Vanheer L, Song J, De Geest N, Janiszewski A, Talon I, Provenzano C, Oh T, Chappell J, Pasque V. Vanheer L, et al. J Cell Sci. 2019 Oct 22;132(20):jcs232223. doi: 10.1242/jcs.232223. J Cell Sci. 2019. PMID: 31519808 Free PMC article.
We found that Tox4 is needed early in reprogramming to efficiently generate early reprogramming intermediates, irrespective of the reprogramming conditions used. ...We show that the TOX4 protein assembles into a high molecular form. Moreover, Tox4 is also req …
We found that Tox4 is needed early in reprogramming to efficiently generate early reprogramming intermediates, irrespective of the re …
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis.
Chen YL, Liu YN, Lin YT, Tsai MF, Wu SG, Chang TH, Hsu CL, Wu HD, Shih JY. Chen YL, et al. J Biomed Sci. 2023 Sep 19;30(1):80. doi: 10.1186/s12929-023-00973-9. J Biomed Sci. 2023. PMID: 37726723 Free PMC article.
SLCO4A1-AS1 directly interacted with the DNA-binding protein, TOX High Mobility Group Box Family Member 4 (TOX4), to inhibit TOX4-induced migration and invasion. Furthermore, RNA-seq revealed that neurotensin receptor 1 (NTSR1) is a novel and convergent downstream t …
SLCO4A1-AS1 directly interacted with the DNA-binding protein, TOX High Mobility Group Box Family Member 4 (TOX4), to inhibit TOX4 …
Tox4 regulates transcriptional elongation and reinitiation during murine T cell development.
Wang T, Zhao R, Zhi J, Liu Z, Wu A, Yang Z, Wang W, Ni T, Jing L, Yu M. Wang T, et al. Commun Biol. 2023 Jun 7;6(1):613. doi: 10.1038/s42003-023-04992-y. Commun Biol. 2023. PMID: 37286708 Free PMC article.
HMG protein Tox4 is a regulator of PP1 phosphatases with unknown function in development. ...Moreover, genes with high and low expression level are more dependent on Tox4 than genes with medium expression level. Mechanistically, Tox4 may facilitate transcript …
HMG protein Tox4 is a regulator of PP1 phosphatases with unknown function in development. ...Moreover, genes with high and low expres …
TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells.
Liu Z, Wu A, Wu Z, Wang T, Pan Y, Li B, Zhang X, Yu M. Liu Z, et al. Commun Biol. 2022 Apr 1;5(1):300. doi: 10.1038/s42003-022-03214-1. Commun Biol. 2022. PMID: 35365735 Free PMC article.
TOX4 is one of the regulatory factors of PP1 phosphatases with poorly understood functions. ...These results lay the foundation for a better understanding of the role of TOX4 in transcriptional regulation....
TOX4 is one of the regulatory factors of PP1 phosphatases with poorly understood functions. ...These results lay the foundation for a …
MBD2 mediates renal cell apoptosis via activation of Tox4 during rhabdomyolysis-induced acute kidney injury.
Sun T, Liu Q, Wang Y, Deng Y, Zhang D. Sun T, et al. J Cell Mol Med. 2021 May;25(10):4562-4571. doi: 10.1111/jcmm.16207. Epub 2021 Mar 25. J Cell Mol Med. 2021. PMID: 33764669 Free PMC article.
Chromatin immunoprecipitation analysis indicated that MBD2 directly bound to CpG islands in the Tox4 promoter region, thus preventing promoter methylation. Furthermore, siRNA inhibition of Tox4 attenuated myoglobin-induced apoptosis in BUMPT cells. Finally, MBD2-KO …
Chromatin immunoprecipitation analysis indicated that MBD2 directly bound to CpG islands in the Tox4 promoter region, thus preventing …
E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis.
Huang Y, Chen T, Jiang M, Xiong C, Mei C, Nie J, Zhang Q, Zhu Q, Huang X, Zhang X, Li Y. Huang Y, et al. Cell Death Dis. 2024 Jan 11;15(1):29. doi: 10.1038/s41419-023-06410-x. Cell Death Dis. 2024. PMID: 38212319 Free PMC article.
TRIM65 binds directly to the N-terminal of TOX4 through its coiled-coil and SPRY structural domains. Immunofluorescence confocal microscopy showed that they can co-localize both in the cytoplasm and nucleus. Furthermore, TRIM65 mediated the K48 ubiquitination and degradati …
TRIM65 binds directly to the N-terminal of TOX4 through its coiled-coil and SPRY structural domains. Immunofluorescence confocal micr …
TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs.
Bounaix Morand du Puch C, Barbier E, Kraut A, Couté Y, Fuchs J, Buhot A, Livache T, Sève M, Favier A, Douki T, Gasparutto D, Sauvaigo S, Breton J. Bounaix Morand du Puch C, et al. Arch Biochem Biophys. 2011 Mar 15;507(2):296-303. doi: 10.1016/j.abb.2010.12.021. Epub 2010 Dec 22. Arch Biochem Biophys. 2011. PMID: 21184731
Some of them were already known interactome members like high mobility group protein 1 (HMGB1) or the human upstream binding factor (hUBF), but we also succeeded in identifying unexpected proteins such as TOX HMG box family member 4 (TOX4), phosphatase 1 nuclear targeting …
Some of them were already known interactome members like high mobility group protein 1 (HMGB1) or the human upstream binding factor (hUBF), …
TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.
Morchikh M, Naughtin M, Di Nunzio F, Xavier J, Charneau P, Jacob Y, Lavigne M. Morchikh M, et al. PLoS One. 2013 Nov 27;8(11):e81217. doi: 10.1371/journal.pone.0081217. eCollection 2013. PLoS One. 2013. PMID: 24312278 Free PMC article.
Three of these partners interact with full length LEDGF/p75, they are specific for PWWP domains of the HDGF family and they require PWWP amino acids essential for the interaction with chromatin. Among them, the transcription activator TOX4 and the splicing cofactor NOVA1 w …
Three of these partners interact with full length LEDGF/p75, they are specific for PWWP domains of the HDGF family and they require PWWP ami …
Higher TOX Genes Expression Is Associated With Poor Overall Survival for Patients With Acute Myeloid Leukemia.
Liang C, Zhao Y, Chen C, Huang S, Deng T, Zeng X, Tan J, Zha X, Chen S, Li Y. Liang C, et al. Front Oncol. 2021 Oct 8;11:740642. doi: 10.3389/fonc.2021.740642. eCollection 2021. Front Oncol. 2021. PMID: 34692519 Free PMC article.
Thymocyte selection-associated HMG box (TOX) is a transcription factor that belongs to the high mobility group box (HMG-box) superfamily, which includes four subfamily members: TOX, TOX2, TOX3, and TOX4. TOX is related to the formation of multiple malignancies and contribu …
Thymocyte selection-associated HMG box (TOX) is a transcription factor that belongs to the high mobility group box (HMG-box) superfamily, wh …
53 results