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Items: 1 to 50 of 86

1.

Permeability and calcium signaling in lung endothelium: unpack the box….

Townsley MI.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217738218. doi: 10.1177/2045893217738218. Epub 2017 Oct 17.

2.

Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry.

Zhou C, Townsley MI, Alexeyev M, Voelkel NF, Stevens T.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L560-9. doi: 10.1152/ajplung.00057.2016. Epub 2016 Jul 15.

3.

In Memoriam: Aubrey E. Taylor (1933-2015).

Granger DN, Townsley MI.

Physiologist. 2016 Mar;59(2):117-8. No abstract available.

PMID:
27120867
4.

Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.

Yap FC, Weber DS, Taylor MS, Townsley MI, Comer BS, Maylie J, Adelman JP, Lin MT.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1151-63. doi: 10.1152/ajpheart.00787.2015. Epub 2016 Mar 4.

5.

Functional coupling of TRPV4, IK, and SK channels contributes to Ca(2+)-dependent endothelial injury in rodent lung.

Lin MT, Jian MY, Taylor MS, Cioffi DL, Yap FC, Liedtke W, Townsley MI.

Pulm Circ. 2015 Jun;5(2):279-90. doi: 10.1086/680166.

6.

The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1).

Bongard RD, Townsley MI, Merker MP.

Free Radic Biol Med. 2015 Feb;79:69-77. doi: 10.1016/j.freeradbiomed.2014.09.030. Epub 2014 Oct 15.

PMID:
25452141
7.

Role of MMP2 and MMP9 in TRPV4-induced lung injury.

Villalta PC, Rocic P, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L652-9. doi: 10.1152/ajplung.00113.2014. Epub 2014 Aug 22.

8.

Transient receptor potential channels and regulation of lung endothelial permeability.

Villalta PC, Townsley MI.

Pulm Circ. 2013 Dec;3(4):802-15. doi: 10.1086/674765. Review.

9.

TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells.

Parker JC, Hashizumi M, Kelly SV, Francis M, Mouner M, Meyer AL, Townsley MI, Wu S, Cioffi DL, Taylor MS.

Physiol Rep. 2013 Oct;1(5):e00121. doi: 10.1002/phy2.121. Epub 2013 Oct 27.

10.

Depleted energy charge and increased pulmonary endothelial permeability induced by mitochondrial complex I inhibition are mitigated by coenzyme Q1 in the isolated perfused rat lung.

Bongard RD, Yan K, Hoffmann RG, Audi SH, Zhang X, Lindemer BJ, Townsley MI, Merker MP.

Free Radic Biol Med. 2013 Dec;65:1455-1463. doi: 10.1016/j.freeradbiomed.2013.07.040. Epub 2013 Aug 1.

11.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

12.

Structure and composition of pulmonary arteries, capillaries, and veins.

Townsley MI.

Compr Physiol. 2012 Jan;2(1):675-709. Review.

13.

TRPV4 channels augment macrophage activation and ventilator-induced lung injury.

Hamanaka K, Jian MY, Townsley MI, King JA, Liedtke W, Weber DS, Eyal FG, Clapp MM, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L353-62. doi: 10.1152/ajplung.00315.2009. Epub 2010 Jun 18.

14.

Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.

Zhou C, Chen H, King JA, Sellak H, Kuebler WM, Yin J, Townsley MI, Shin HS, Wu S.

Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L86-97. doi: 10.1152/ajplung.00331.2009. Epub 2010 Apr 30.

15.

Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.

Townsley MI, Morisseau C, Hammock B, King JA.

Microcirculation. 2010 Feb;17(2):137-46. doi: 10.1111/j.1549-8719.2009.00013.x.

16.

Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.

Wu S, Jian MY, Xu YC, Zhou C, Al-Mehdi AB, Liedtke W, Shin HS, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L650-7. doi: 10.1152/ajplung.00015.2009. Epub 2009 Jul 17.

17.

Physiological determinants of the pulmonary filtration coefficient.

Parker JC, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L235-7. doi: 10.1152/ajplung.00064.2008. Epub 2008 May 23. Review.

18.

High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.

Jian MY, King JA, Al-Mehdi AB, Liedtke W, Townsley MI.

Am J Respir Cell Mol Biol. 2008 Apr;38(4):386-92. Epub 2007 Oct 25.

19.

TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.

Hamanaka K, Jian MY, Weber DS, Alvarez DF, Townsley MI, Al-Mehdi AB, King JA, Liedtke W, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L923-32. Epub 2007 Jul 27.

20.

Ca2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension.

Townsley MI, King JA, Alvarez DF.

Microcirculation. 2006 Dec;13(8):725-39. Review.

PMID:
17085430
21.

Special topics issue of microcirculation: ion channels and pulmonary vascular function.

Townsley MI.

Microcirculation. 2006 Dec;13(8):611-3. Review.

PMID:
17085422
22.

Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.

Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI.

Circ Res. 2006 Oct 27;99(9):988-95. Epub 2006 Sep 28.

23.

Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure.

Alvarez DF, King JA, Townsley MI.

Am J Respir Crit Care Med. 2005 Nov 1;172(9):1153-60. Epub 2005 Jul 28.

24.

Harmonic analysis of perfusion pumps.

Dougherty FC, Donovan FM Jr, Townsley MI.

J Biomech Eng. 2003 Dec;125(6):814-22.

PMID:
14986406
25.

Evaluation of lung injury in rats and mice.

Parker JC, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L231-46. Review.

26.

Role of EETs in regulation of endothelial permeability in rat lung.

Alvarez DF, Gjerde EA, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L445-51. Epub 2003 Oct 24.

27.

Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lung.

Trout L, Townsley MI, Bowden AL, Ballard ST.

J Physiol. 2003 Jun 15;549(Pt 3):845-53. Epub 2003 Apr 17.

28.

Phosphodiesterase 3 activity is reduced in dog lung following pacing-induced heart failure.

Tarpey SB, Sawmiller DR, Kelly C, Thompson WJ, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L766-73. Epub 2003 Jan 10.

29.

Attenuation of histamine-induced endothelial permeability responses after pacing-induced heart failure: role for endogenous catecholamines.

Dyess DL, Hunter JL, Lakey JR, Moyer D, Dougherty FC, Townsley MI.

Microcirculation. 2000 Oct;7(5):307-15.

PMID:
11079249
30.

Modulation of microvascular permeability by 21-aminosteroids after burn injuries.

Dyess DL, Collins JN, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ.

J Burn Care Rehabil. 2000 Sep-Oct;21(5):406-13.

PMID:
11020047
31.

Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure.

Townsley MI, Snell KS, Ivey CL, Culberson DE, Liu DC, Reed RK, Mathieu-Costello O.

J Appl Physiol (1985). 1999 Nov;87(5):1823-30.

32.

Alpha-adrenergic vasoreactivity of canine intrapulmonary bronchial arteries in pacing-induced heart failure.

McMillon RK, Townsley MI.

Am J Physiol. 1999 Oct;277(4):H1392-402. doi: 10.1152/ajpheart.1999.277.4.H1392.

PMID:
10516174
33.

Ca2+ dependence of mechanical injury to lung capillaries.

Parker JC, Townsley MI, Stevens T.

J Appl Physiol (1985). 1999 Feb;86(2):775-6. No abstract available.

34.

Involvement of cytochrome P-450 enzyme activity in the control of microvascular permeability in canine lung.

Ivey CL, Stephenson AH, Townsley MI.

Am J Physiol. 1998 Oct;275(4 Pt 1):L756-63. doi: 10.1152/ajplung.1998.275.4.L756.

PMID:
9755108
35.

Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+ signaling.

Ivey CL, Roy BJ, Townsley MI.

Am J Physiol. 1998 Sep;275(3):H844-51. doi: 10.1152/ajpheart.1998.275.3.H844.

PMID:
9724288
36.

Enterostatin efflux in cat intestinal lymph: relation to lymph flow, hyaluronan, and fat absorption.

Townsley MI, Erlanson-Albertsson C, Ohlsson A, Rippe C, Reed RK.

Am J Physiol. 1996 Oct;271(4 Pt 1):G714-21.

PMID:
8897893
37.

Pulmonary vascular response to angiotensin II in canine pacing-induced heart failure.

Roy BJ, Pitts VH, Townsley MI.

Am J Physiol. 1996 Jul;271(1 Pt 2):H222-7.

PMID:
8760178
38.
39.

Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2.

Rizzo A, Taylor AE, Townsley MI, Logsdon P, Khimenko PL, Fletcher JR.

Am J Physiol. 1995 May;268(5 Pt 2):H1954-8.

PMID:
7771545
40.

Hyaluronan efflux from canine lung with increased hydrostatic pressure and saline loading.

Townsley MI, Reed RK, Ishibashi M, Parker JC, Laurent TC, Taylor AE.

Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1605-11.

PMID:
7952622
41.

Effects of graded thermal injury on microvascular permeability at the site of injury.

Ferrara JJ, Dyess DL, Collins JN, Fish JM, Markert AJ, Ardell JL, Townsley MI, Flint LM, Taylor AE.

J Surg Res. 1994 Sep;57(3):420-6.

PMID:
8072291
42.

Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure.

Townsley MI, Pitts VH, Ardell JL, Zhao Z, Johnson WH Jr.

Circ Res. 1994 Aug;75(2):347-56.

PMID:
7518365
43.

Increased hyaluronan flux in canine paw lymph is induced by histamine and the histamine-releasing agent compound 48/80.

Rodt SA, Reed RK, Townsley MI.

Int J Microcirc Clin Exp. 1994 Jul-Aug;14(4):212-7.

PMID:
7852029
44.

Permeability of parietal pleura to liquid and proteins.

Negrini D, Venturoli D, Townsley MI, Reed RK.

J Appl Physiol (1985). 1994 Feb;76(2):627-33.

PMID:
7513686
45.

Effects of pentafraction administration on microvascular permeability alterations induced by graded thermal injury.

Ferrara JJ, Dyess DL, Collins JN, Fish JM, Ardell JL, Townsley MI, Taylor AE, Flint LM.

Surgery. 1994 Feb;115(2):182-9.

PMID:
7508639
46.

The effects of albumin administration on microvascular permeability at the site of burn injury.

Collins JN, Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ.

J Trauma. 1994 Jan;36(1):27-33.

PMID:
8295246
47.

Lymphatic hyaluronan flux from skin increases during increased lymph flow induced by intravenous saline loading.

Reed RK, Townsley MI, Zhao Z, Ishibashi M, Laurent TC, Taylor AE.

Int J Microcirc Clin Exp. 1994 Jan-Apr;14(1-2):56-61.

PMID:
7960445
48.

Blood-to-tissue clearance vs. lymph analysis in determining capillary transport characteristics for albumin in skin.

Reed RK, Ishibashi M, Townsley MI, Parker JC, Taylor AE.

Am J Physiol. 1993 May;264(5 Pt 2):H1394-401.

PMID:
8498553
49.

PS products and capillary reflection coefficients from analysis of lymphatic protein flux data.

Reed RK, Townsley MI, Korthius R, Taylor AE.

Am J Physiol. 1992 Dec;263(6 Pt 2):H1972-3. No abstract available.

PMID:
1481921
50.

Increased lymphatic flux of hyaluronan from cat intestine during fat absorption.

Reed RK, Townsley MI, Pitts VH, Laurent TC, Taylor AE.

Am J Physiol. 1992 Jul;263(1 Pt 1):G6-11.

PMID:
1636716

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