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Items: 40

1.

Computational prediction of GPCR oligomerization.

Townsend-Nicholson A, Altwaijry N, Potterton A, Morao I, Heifetz A.

Curr Opin Struct Biol. 2019 Apr;55:178-184. doi: 10.1016/j.sbi.2019.04.005. Epub 2019 Jun 4. Review.

PMID:
31170578
2.

Characterising GPCR-ligand interactions using a fragment molecular orbital-based approach.

Heifetz A, James T, Southey M, Morao I, Aldeghi M, Sarrat L, Fedorov DG, Bodkin MJ, Townsend-Nicholson A.

Curr Opin Struct Biol. 2019 Apr;55:85-92. doi: 10.1016/j.sbi.2019.03.021. Epub 2019 Apr 22. Review.

PMID:
31022570
3.

Ensemble-Based Steered Molecular Dynamics Predicts Relative Residence Time of A2A Receptor Binders.

Potterton A, Husseini FS, Southey MWY, Bodkin MJ, Heifetz A, Coveney PV, Townsend-Nicholson A.

J Chem Theory Comput. 2019 May 14;15(5):3316-3330. doi: 10.1021/acs.jctc.8b01270. Epub 2019 Apr 26.

PMID:
30893556
4.

Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery.

Heifetz A, Southey M, Morao I, Townsend-Nicholson A, Bodkin MJ.

Methods Mol Biol. 2018;1705:375-394. doi: 10.1007/978-1-4939-7465-8_19.

PMID:
29188574
5.

Synergistic Use of GPCR Modeling and SDM Experiments to Understand Ligand Binding.

Potterton A, Heifetz A, Townsend-Nicholson A.

Methods Mol Biol. 2018;1705:335-343. doi: 10.1007/978-1-4939-7465-8_15.

PMID:
29188570
6.

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S, Caulfield MJ.

Hum Mol Genet. 2018 Jan 1;27(1):199-210. doi: 10.1093/hmg/ddx375.

7.

Rapid and accurate assessment of GPCR-ligand interactions Using the fragment molecular orbital-based density-functional tight-binding method.

Morao I, Fedorov DG, Robinson R, Southey M, Townsend-Nicholson A, Bodkin MJ, Heifetz A.

J Comput Chem. 2017 Sep 5;38(23):1987-1990. doi: 10.1002/jcc.24850. Epub 2017 Jul 4.

8.

An Ensemble-Based Protocol for the Computational Prediction of Helix-Helix Interactions in G Protein-Coupled Receptors using Coarse-Grained Molecular Dynamics.

Altwaijry NA, Baron M, Wright DW, Coveney PV, Townsend-Nicholson A.

J Chem Theory Comput. 2017 May 9;13(5):2254-2270. doi: 10.1021/acs.jctc.6b01246. Epub 2017 Apr 25.

9.

An Immunological Approach to Increase the Brain's Resilience to Insults.

Lin EJ, Symes CW, Townsend-Nicholson A, Klugmann M, Klugmann CB, Lehnert K, Fong D, Young D, During MJ.

ISRN Neurosci. 2014 Apr 24;2014:103213. doi: 10.1155/2014/103213. eCollection 2014.

10.

Molecular characterisation of post-bio-electrosprayed human brain astrocytoma cells.

Eddaoudi A, Townsend-Nicholson A, Timms JF, Schorge S, Jayasinghe SN.

Analyst. 2010 Oct;135(10):2600-12. doi: 10.1039/c0an00213e. Epub 2010 Aug 6.

PMID:
20694206
11.

Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle.

King BF, Townsend-Nicholson A.

J Pharmacol Exp Ther. 2008 Mar;324(3):1055-63. Epub 2007 Nov 29.

PMID:
18048695
12.

A novel nucleotide receptor in Xenopus activates the cAMP second messenger pathway.

Devader C, Drew CM, Geach TJ, Tabler J, Townsend-Nicholson A, Dale L.

FEBS Lett. 2007 Nov 13;581(27):5332-6. Epub 2007 Oct 23.

13.
14.

Bio-electrosprays: the next generation of electrified jets.

Jayasinghe SN, Townsend-Nicholson A.

Biotechnol J. 2006 Sep;1(9):1018-22.

PMID:
16941448
15.

Stable electric-field driven cone-jetting of concentrated biosuspensions.

Jayasinghe SN, Townsend-Nicholson A.

Lab Chip. 2006 Aug;6(8):1086-90. Epub 2006 Jun 9.

PMID:
16874383
16.

Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red.

King BF, Liu M, Townsend-Nicholson A, Pfister J, Padilla F, Ford AP, Gever JR, Oglesby IB, Schorge S, Burnstock G.

Br J Pharmacol. 2005 Jun;145(3):313-22.

17.

Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: a system suitable for the study of purine receptor-mediated cell death.

Hillman KA, Harada H, Chan CM, Townsend-Nicholson A, Moss SE, Miyamoto K, Suketa Y, Burnstock G, Unwin RJ, Dunn PM.

Biochem Pharmacol. 2003 Aug 1;66(3):415-24.

PMID:
12907240
18.

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.

Brown SG, Townsend-Nicholson A, Jacobson KA, Burnstock G, King BF.

J Pharmacol Exp Ther. 2002 Feb;300(2):673-80.

19.
20.

Expression of P2 receptors in bone and cultured bone cells.

Hoebertz A, Townsend-Nicholson A, Glass R, Burnstock G, Arnett TR.

Bone. 2000 Oct;27(4):503-10.

PMID:
11033445
21.

Recombinant P2Y receptors: the UCL experience.

King BF, Townsend-Nicholson A.

J Auton Nerv Syst. 2000 Jul 3;81(1-3):164-70. Review.

PMID:
10869716
22.

P2 receptors in the thymus: expression of P2X and P2Y receptors in adult rats, an immunohistochemical and in situ hybridisation study.

Glass R, Townsend-Nicholson A, Burnstock G.

Cell Tissue Res. 2000 May;300(2):295-306.

PMID:
10867824
23.

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes.

King BF, Townsend-Nicholson A, Wildman SS, Thomas T, Spyer KM, Burnstock G.

J Neurosci. 2000 Jul 1;20(13):4871-7.

24.

Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo.

Meyer MP, Clarke JD, Patel K, Townsend-Nicholson A, Burnstock G.

Dev Dyn. 1999 Feb;214(2):152-8.

25.

Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors.

Townsend-Nicholson A, King BF, Wildman SS, Burnstock G.

Brain Res Mol Brain Res. 1999 Feb 5;64(2):246-54.

PMID:
9931497
26.

Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.

Camp D, Green JM, Kaiser SM, Moni RW, Townsend-Nicholson A, Schofield PR, Quinn RJ.

Bioorg Med Chem Lett. 1998 Mar 17;8(6):691-4.

PMID:
9871584
27.

Metabotropic receptors for ATP and UTP: exploring the correspondence between native and recombinant nucleotide receptors.

King BF, Townsend-Nicholson A, Burnstock G.

Trends Pharmacol Sci. 1998 Dec;19(12):506-14. Review.

PMID:
9871413
28.

Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors.

Dalpiaz A, Townsend-Nicholson A, Beukers MW, Schofield PR, IJzerman AP.

Biochem Pharmacol. 1998 Dec 1;56(11):1437-45.

PMID:
9827575
29.

A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonists.

de Zwart M, Link R, von Frijtag Drabbe K├╝nzel JK, Cristalli G, Jacobson KA, Townsend-Nicholson A, IJzerman AP.

Nucleosides Nucleotides. 1998 Jun;17(6):969-85.

30.

Antagonism of an adenosine/ATP receptor in follicular Xenopus oocytes.

King BF, Wildman SS, Townsend-Nicholson A, Burnstock G.

J Pharmacol Exp Ther. 1998 Jun;285(3):1005-11.

PMID:
9618401
31.

Localization of P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys.

Chan CM, Unwin RJ, Bardini M, Oglesby IB, Ford AP, Townsend-Nicholson A, Burnstock G.

Am J Physiol. 1998 Apr;274(4):F799-804. doi: 10.1152/ajprenal.1998.274.4.F799.

PMID:
9575906
32.

Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene.

Atkinson MR, Townsend-Nicholson A, Nicholl JK, Sutherland GR, Schofield PR.

Neurosci Res. 1997 Sep;29(1):73-9.

PMID:
9293494
33.

Approaches to the stable transfection of G protein-coupled receptors.

Townsend-Nicholson A.

Methods Mol Biol. 1997;83:45-54. Review. No abstract available.

PMID:
9210135
34.

Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A.

Le F, Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR.

Biochem Biophys Res Commun. 1996 Jun 14;223(2):461-7.

PMID:
8670304
35.
36.

Localization of the adenosine A1 receptor subtype gene (ADORA1) to chromosome 1q32.1.

Townsend-Nicholson A, Baker E, Schofield PR, Sutherland GR.

Genomics. 1995 Mar 20;26(2):423-5. No abstract available.

PMID:
7601478
37.

Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids.

Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR.

Genomics. 1995 Jan 20;25(2):605-7. No abstract available.

PMID:
7790006
38.
39.

Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA.

Townsend-Nicholson A, Shine J.

Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70.

PMID:
1339301
40.

Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences.

Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J.

Brain Res Mol Brain Res. 1992 Mar;13(1-2):159-63.

PMID:
1315913

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