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Items: 1 to 50 of 200

1.

Genotype- and sex-dependent effects of altered Cntnap2 expression on the function of visual cortical areas.

Townsend LB, Smith SL.

J Neurodev Disord. 2017 Jan 19;9:2. doi: 10.1186/s11689-016-9182-5. eCollection 2017.

2.

Stream-dependent development of higher visual cortical areas.

Smith IT, Townsend LB, Huh R, Zhu H, Smith SL.

Nat Neurosci. 2017 Feb;20(2):200-208. doi: 10.1038/nn.4469. Epub 2017 Jan 9.

3.

Tetrahalogenated benzimidazole D-ribonucleosides are active against rat cytomegalovirus.

Dittmer A, Woskobojnik I, Adfeldt R, Drach JC, Townsend LB, Voigt S, Bogner E.

Antiviral Res. 2017 Jan;137:102-107. doi: 10.1016/j.antiviral.2016.11.012. Epub 2016 Nov 18.

PMID:
27871886
4.

A touchscreen based global motion perception task for mice.

Stirman J, Townsend LB, Smith S.

Vision Res. 2016 Oct;127:74-83. doi: 10.1016/j.visres.2016.07.006. Epub 2016 Aug 9.

5.

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Gentry BG, Phan Q, Hall ED, Breitenbach JM, Borysko KZ, Kamil JP, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2015 Jan;59(1):226-32. doi: 10.1128/AAC.03686-14. Epub 2014 Oct 27.

6.

Chronic cocaine exposure during pregnancy increases postpartum neuroendocrine stress responses.

Williams SK, Barber JS, Jamieson-Drake AW, Enns JA, Townsend LB, Walker CH, Johns JM.

J Neuroendocrinol. 2012 Apr;24(4):701-11. doi: 10.1111/j.1365-2826.2012.02291.x.

7.

Benzimidazole analogs inhibit human herpesvirus 6.

Prichard MN, Frederick SL, Daily S, Borysko KZ, Townsend LB, Drach JC, Kern ER.

Antimicrob Agents Chemother. 2011 May;55(5):2442-5. doi: 10.1128/AAC.01523-10. Epub 2011 Feb 7.

8.

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.

Ptak RG, Gentry BG, Hartman TL, Watson KM, Osterling MC, Buckheit RW Jr, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2010 Apr;54(4):1512-9. doi: 10.1128/AAC.01443-09. Epub 2010 Jan 19.

9.

Susceptibilities of human cytomegalovirus clinical isolates and other herpesviruses to new acetylated, tetrahalogenated benzimidazole D-ribonucleosides.

Hwang JS, Schilf R, Drach JC, Townsend LB, Bogner E.

Antimicrob Agents Chemother. 2009 Dec;53(12):5095-101. doi: 10.1128/AAC.00809-09. Epub 2009 Sep 28.

10.

Toyocamycin specifically inhibits auxin signaling mediated by SCFTIR1 pathway.

Hayashi K, Kamio S, Oono Y, Townsend LB, Nozaki H.

Phytochemistry. 2009 Jan;70(2):190-7. doi: 10.1016/j.phytochem.2008.12.020. Epub 2009 Jan 24.

PMID:
19171357
11.

Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.

Chien TC, Drach JC, Townsend LB.

Nucleic Acids Symp Ser (Oxf). 2008;(52):593-4. doi: 10.1093/nass/nrn300.

PMID:
18776519
12.

Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus.

Hwang JS, Kregler O, Schilf R, Bannert N, Drach JC, Townsend LB, Bogner E.

J Virol. 2007 Nov;81(21):11604-11. Epub 2007 Aug 29.

13.

N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL.

Drug Metab Dispos. 2006 Jun;34(6):1070-7. Epub 2006 Mar 24.

PMID:
16565170
14.

Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine.

Chien TC, Berry DA, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1971-96.

PMID:
16438060
15.

Synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides.

Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1613-26.

PMID:
16438038
16.

Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides.

Chen JJ, Wei Y, Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1417-37.

PMID:
16438026
19.

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL.

J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. Epub 2005 May 18.

PMID:
15901797
20.

Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.

Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL.

J Med Chem. 2005 Feb 24;48(4):1274-7.

PMID:
15715497
21.

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

Williams JD, Ptak RG, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5773-82.

PMID:
15509176
22.

Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5766-72.

PMID:
15509175
23.

Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5753-65.

PMID:
15509174
24.
25.

Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.

Evers DL, Komazin G, Ptak RG, Shin D, Emmer BT, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2004 Oct;48(10):3918-27.

26.
27.

Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.

Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):805-12.

PMID:
15281368
28.

Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.

North TW, Sequar G, Townsend LB, Drach JC, Barry PA.

Antimicrob Agents Chemother. 2004 Jul;48(7):2760-5.

29.

Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.

Kern ER, Hartline CB, Rybak RJ, Drach JC, Townsend LB, Biron KK, Bidanset DJ.

Antimicrob Agents Chemother. 2004 May;48(5):1749-55.

30.

Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.

Underwood MR, Ferris RG, Selleseth DW, Davis MG, Drach JC, Townsend LB, Biron KK, Boyd FL.

Antimicrob Agents Chemother. 2004 May;48(5):1647-51.

31.

An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties.

Porcari AR, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):31-9.

PMID:
15043134
32.

Synthesis and antiviral activity of 2-substituted analogs of triciribine.

Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2003 Dec;22(12):2171-93.

PMID:
14714765
33.
34.

Design and synthesis of acyclic nucleoside analogs with chlorinated imidazo[1,2-a]pyridine bases.

Williams JD, Mourad AE, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2003 Oct;22(10):1907-17.

PMID:
14609230
35.

Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs.

Komazin G, Ptak RG, Emmer BT, Townsend LB, Drach JC.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1725-7. No abstract available.

PMID:
14565505
36.

Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27.

Komazin G, Ptak RG, Emmer BT, Townsend LB, Drach JC.

J Virol. 2003 Nov;77(21):11499-506.

37.

The synthesis of 4-deazaformycin A.

Kourafalos VN, Marakos P, Pouli N, Townsend LB.

J Org Chem. 2003 Aug 8;68(16):6466-9.

PMID:
12895092
38.

In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

Williams SL, Hartline CB, Kushner NL, Harden EA, Bidanset DJ, Drach JC, Townsend LB, Underwood MR, Biron KK, Kern ER.

Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92.

39.
40.

Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents.

Chen JJ, Drach JC, Townsend LB.

J Org Chem. 2003 May 30;68(11):4170-8.

PMID:
12762715
42.

Identification of the ATP-binding site in the terminase subunit pUL56 of human cytomegalovirus.

Scholz B, Rechter S, Drach JC, Townsend LB, Bogner E.

Nucleic Acids Res. 2003 Mar 1;31(5):1426-33.

43.

Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus.

Evers DL, Komazin G, Shin D, Hwang DD, Townsend LB, Drach JC.

Antiviral Res. 2002 Oct;56(1):61-72.

PMID:
12323400
44.

Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.

Evers DL, Breitenbach JM, Borysko KZ, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2002 Aug;46(8):2470-6.

45.

Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.

Koszalka GW, Johnson NW, Good SS, Boyd L, Chamberlain SC, Townsend LB, Drach JC, Biron KK.

Antimicrob Agents Chemother. 2002 Aug;46(8):2373-80.

46.

Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.

Biron KK, Harvey RJ, Chamberlain SC, Good SS, Smith AA 3rd, Davis MG, Talarico CL, Miller WH, Ferris R, Dornsife RE, Stanat SC, Drach JC, Townsend LB, Koszalka GW.

Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72.

47.

Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.

Krosky PM, Borysko KZ, Nassiri MR, Devivar RV, Ptak RG, Davis MG, Biron KK, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2002 Feb;46(2):478-86.

48.

Dimetalation of pyrazines. a one-pot synthesis of multisubstituted pyrazine C-nucleosides.

Liu W, Wise DS, Townsend LB.

J Org Chem. 2001 Jul 13;66(14):4783-6.

PMID:
11442404
49.

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