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Preclinical Evaluation of Vaccines to Treat Opioid Use Disorders: How Close are We to a Clinically Viable Therapeutic?

Townsend EA, Banks ML.

CNS Drugs. 2020 Apr 4. doi: 10.1007/s40263-020-00722-8. [Epub ahead of print]


Monitoring outcome following hospital-presenting milder spectrum pediatric traumatic brain injury using the Glasgow Outcome Scale-Extended, Pediatric Revision.

Evans EA, Cook N, Iverson GL, Townsend E, Duhaime AC.

J Neurotrauma. 2020 Feb 27. doi: 10.1089/neu.2019.6893. [Epub ahead of print]


Exhaled Mycobacterium tuberculosis output and detection of subclinical disease by face-mask sampling: prospective observational studies.

Williams CM, Abdulwhhab M, Birring SS, De Kock E, Garton NJ, Townsend E, Pareek M, Al-Taie A, Pan J, Ganatra R, Stoltz AC, Haldar P, Barer MR.

Lancet Infect Dis. 2020 Feb 18. pii: S1473-3099(19)30707-8. doi: 10.1016/S1473-3099(19)30707-8. [Epub ahead of print]


Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.

Zamarripa CA, Naylor JE, Huskinson SL, Townsend EA, Prisinzano TE, Freeman KB.

Psychopharmacology (Berl). 2020 Jan 31. doi: 10.1007/s00213-020-05473-4. [Epub ahead of print]


Lorcaserin maintenance fails to attenuate heroin vs. food choice in rhesus monkeys.

Townsend EA, Negus SS, Poklis JL, Banks ML.

Drug Alcohol Depend. 2020 Mar 1;208:107848. doi: 10.1016/j.drugalcdep.2020.107848. Epub 2020 Jan 17.


Medications Development for Treatment of Opioid Use Disorder.

Townsend EA, Negus SS, Banks ML.

Cold Spring Harb Perspect Med. 2020 Jan 13. pii: a039263. doi: 10.1101/cshperspect.a039263. [Epub ahead of print]


Mortality in children and adolescents following presentation to hospital after non-fatal self-harm in the Multicentre Study of Self-harm: a prospective observational cohort study.

Hawton K, Bale L, Brand F, Townsend E, Ness J, Waters K, Clements C, Kapur N, Geulayov G.

Lancet Child Adolesc Health. 2020 Feb;4(2):111-120. doi: 10.1016/S2352-4642(19)30373-6. Epub 2020 Jan 8.


Comparison of chemotherapy effects on mechanical sensitivity and food-maintained operant responding in male and female rats.

Legakis LP, Diester CM, Townsend EA, Karim-Nejad L, Negus SS.

Behav Pharmacol. 2019 Dec 10. doi: 10.1097/FBP.0000000000000527. [Epub ahead of print]


Is Camouflaging Autistic Traits Associated with Suicidal Thoughts and Behaviours? Expanding the Interpersonal Psychological Theory of Suicide in an Undergraduate Student Sample.

Cassidy SA, Gould K, Townsend E, Pelton M, Robertson AE, Rodgers J.

J Autism Dev Disord. 2019 Dec 9. doi: 10.1007/s10803-019-04323-3. [Epub ahead of print]


Self-harm in midlife: analysis using data from the Multicentre Study of Self-harm in England - ADDENDUM.

Clements C, Hawton K, Geulayov G, Waters K, Ness J, Rehman M, Townsend E, Appleby L, Kapur N.

Br J Psychiatry. 2019 Nov 27:1. doi: 10.1192/bjp.2019.248. [Epub ahead of print] No abstract available.


Organothiol Monolayer Formation Directly on Muscovite Mica.

de Poel W, Brugman SJT, van de Ven KHA, Gasseling A, de Lange J, Townsend ER, Engwerda AHJ, Jankowski M, Blijlevens MAR, Werkhoven BL, Drnec J, Carlà F, Felici R, Tuladhar A, Adhikari NM, De Yoreo JJ, Elemans JAAW, van Enckevort WJP, Rowan AE, Vlieg E.

Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2323-2327. doi: 10.1002/anie.201913327. Epub 2019 Dec 18.


Examining risk factors for self-harm and suicide in LGBTQ+ young people: a systematic review protocol.

Williams AJ, Arcelus J, Townsend E, Michail M.

BMJ Open. 2019 Nov 11;9(11):e031541. doi: 10.1136/bmjopen-2019-031541.


Monovalent - divalent cation competition at the muscovite mica surface: Experiment and theory.

Brugman SJT, Werkhoven BL, Townsend ER, Accordini P, van Roij R, Vlieg E.

J Colloid Interface Sci. 2020 Feb 1;559:291-303. doi: 10.1016/j.jcis.2019.10.009. Epub 2019 Oct 9.


Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone.

Schwienteck KL, Blake S, Bremer PT, Poklis JL, Townsend EA, Negus SS, Banks ML.

Drug Alcohol Depend. 2019 Nov 1;204:107501. doi: 10.1016/j.drugalcdep.2019.06.006. Epub 2019 Aug 24.


Supporting young people with self-harm behaviour in primary care.

Mughal F, Troya MI, Townsend E, Chew-Graham CA.

Lancet Psychiatry. 2019 Sep;6(9):724. doi: 10.1016/S2215-0366(19)30280-9. No abstract available.


Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C.

Ali RO, Moon MS, Townsend EC, Hill K, Zhang GY, Bradshaw A, Guan H, Hamilton D, Kleiner DE, Auh S, Koh C, Heller T.

Dig Dis Sci. 2020 Feb;65(2):524-533. doi: 10.1007/s10620-019-05760-x. Epub 2019 Aug 12.


Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.

Moon MS, Quinn G, Townsend EC, Ali RO, Zhang GY, Bradshaw A, Hill K, Guan H, Hamilton D, Kleiner DE, Koh C, Heller T.

Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz255. doi: 10.1093/ofid/ofz255.


"These Things Don't Work." Young People's Views on Harm Minimization Strategies as a Proxy for Self-Harm: A Mixed Methods Approach.

Wadman R, Nielsen E, O'Raw L, Brown K, Williams AJ, Sayal K, Townsend E.

Arch Suicide Res. 2019 Jul 19:1-18. doi: 10.1080/13811118.2019.1624669. [Epub ahead of print]


Tunable Surface Area, Porosity, and Function in Conjugated Microporous Polymers.

Chen J, Yan W, Townsend EJ, Feng J, Pan L, Del Angel Hernandez V, Faul CFJ.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11715-11719. doi: 10.1002/anie.201905488. Epub 2019 Jul 17.


Self-harm in midlife: analysis using data from the Multicentre Study of Self-harm in England.

Clements C, Hawton K, Geulayov G, Waters K, Ness J, Rehman M, Townsend E, Appleby L, Kapur N.

Br J Psychiatry. 2019 May 30:1-8. doi: 10.1192/bjp.2019.90. [Epub ahead of print]


Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats.

Townsend EA, Blake S, Faunce KE, Hwang CS, Natori Y, Zhou B, Bremer PT, Janda KD, Banks ML.

Neuropsychopharmacology. 2019 Sep;44(10):1681-1689. doi: 10.1038/s41386-019-0385-9. Epub 2019 May 2.


Electroactive Amphiphiles for Addressable Supramolecular Nanostructures.

Townsend EJ, Alotaibi M, Mills BM, Watanabe K, Seddon AM, Faul CFJ.

ChemNanoMat. 2018 Aug;4(8):741-752. doi: 10.1002/cnma.201800194. Epub 2018 Jul 4. Review.


Do occupational justice concepts inform occupational therapists' practice? A scoping review.

Malfitano APS, de Souza RGDM, Townsend EA, Lopes RE.

Can J Occup Ther. 2019 Oct;86(4):299-312. doi: 10.1177/0008417419833409. Epub 2019 Apr 23.


Psychosocial Interventions for People Who Self-Harm: Methodological Issues Involved in Trials to Evaluate Effectiveness.

Witt K, Townsend E, Arensman E, Gunnell D, Hazell P, Taylor Salisbury T, Van Heeringen K, Hawton K.

Arch Suicide Res. 2019 Jul 10:1-62. doi: 10.1080/13811118.2019.1592043. [Epub ahead of print]


Time to take self-harm in young people seriously.

Townsend E.

Lancet Psychiatry. 2019 Apr;6(4):279-280. doi: 10.1016/S2215-0366(19)30101-4. Epub 2019 Mar 14. No abstract available.


Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats.

Townsend EA, Negus SS, Caine SB, Thomsen M, Banks ML.

Neuropsychopharmacology. 2019 Nov;44(12):2022-2029. doi: 10.1038/s41386-019-0356-1. Epub 2019 Feb 28.


Self-harm in young people: the exceptional potential of the general practice consultation.

Mughal F, Babatunde O, Dikomitis L, Shaw J, Townsend E, Troya MI, Chew-Graham CA.

Br J Gen Pract. 2019 Apr;69(681):168-169. doi: 10.3399/bjgp19X701393. Epub 2019 Feb 25. No abstract available.


Testing the 10 most wanted: a preclinical algorithm to screen candidate opioid use disorder medications.

Banks ML, Townsend EA, Negus SS.

Neuropsychopharmacology. 2019 May;44(6):1011-1012. doi: 10.1038/s41386-019-0336-5. Epub 2019 Feb 9. Review. No abstract available.


The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection.

Townsend EC, Zhang GY, Ali R, Firke M, Moon MS, Han MAT, Fram B, Glenn JS, Kleiner DE, Koh C, Heller T.

J Gastroenterol Hepatol. 2019 Apr;34(4):764-775. doi: 10.1111/jgh.14617. Epub 2019 Feb 25.


Feasibility of a randomised controlled trial of remotely delivered problem-solving cognitive behaviour therapy versus usual care for young people with depression and repeat self-harm: lessons learnt (e-DASH).

Sayal K, Roe J, Ball H, Atha C, Kaylor-Hughes C, Guo B, Townsend E, Morriss R.

BMC Psychiatry. 2019 Jan 24;19(1):42. doi: 10.1186/s12888-018-2005-3.


Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats.

Sakloth F, Leggett E, Moerke MJ, Townsend EA, Banks ML, Negus SS.

Exp Clin Psychopharmacol. 2019 Jun;27(3):215-226. doi: 10.1037/pha0000253. Epub 2019 Jan 10.


Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis.

Listenberger L, Townsend E, Rickertsen C, Hains A, Brown E, Inwards EG, Stoeckman AK, Matis MP, Sampathkumar RS, Osna NA, Kharbanda KK.

Cells. 2018 Nov 24;7(12). pii: E230. doi: 10.3390/cells7120230.


Commentary on "Stepping Activity in Children With Congenital Myotonic Dystrophy".

Kiefer MJ, Townsend EL.

Pediatr Phys Ther. 2018 Oct;30(4):340. doi: 10.1097/PEP.0000000000000545. No abstract available.


An interpretative phenomenological analysis of young people's self-harm in the context of interpersonal stressors and supports: Parents, peers, and clinical services.

Wadman R, Vostanis P, Sayal K, Majumder P, Harroe C, Clarke D, Armstrong M, Townsend E.

Soc Sci Med. 2018 Sep;212:120-128. doi: 10.1016/j.socscimed.2018.07.021. Epub 2018 Jul 19.


Additive Induced Formation of Ultrathin Sodium Chloride Needle Crystals.

Townsend ER, van Enckevort WJP, Tinnemans P, Blijlevens MAR, Meijer JAM, Vlieg E.

Cryst Growth Des. 2018 Feb 7;18(2):755-762. doi: 10.1021/acs.cgd.7b01170. Epub 2017 Dec 8.


The comparative efficacy of antiseptics against Candida auris biofilms.

Kean R, McKloud E, Townsend EM, Sherry L, Delaney C, Jones BL, Williams C, Ramage G.

Int J Antimicrob Agents. 2018 Nov;52(5):673-677. doi: 10.1016/j.ijantimicag.2018.05.007. Epub 2018 Oct 8.


What do young adolescents think about taking part in longitudinal self-harm research? Findings from a school-based study.

Lockwood J, Townsend E, Royes L, Daley D, Sayal K.

Child Adolesc Psychiatry Ment Health. 2018 May 2;12:23. doi: 10.1186/s13034-018-0230-7. eCollection 2018.


Traumatic Brain Injury-Related Symptoms Reported by Parents: Clinical, Imaging, and Host Predictors in Children with Impairments in Consciousness Less than 24 Hours.

Evans E, Asuzu D, Cook NE, Caruso P, Townsend E, Costine-Bartell B, Fortes-Monteiro C, Hotz G, Duhaime AC; TRACK-TBI Investigators.

J Neurotrauma. 2018 Oct 1;35(19):2287-2297. doi: 10.1089/neu.2017.5408. Epub 2018 Jun 29.


Treatment as usual (TAU) as a control condition in trials of cognitive behavioural-based psychotherapy for self-harm: Impact of content and quality on outcomes in a systematic review.

Witt K, de Moraes DP, Salisbury TT, Arensman E, Gunnell D, Hazell P, Townsend E, van Heeringen K, Hawton K.

J Affect Disord. 2018 Aug 1;235:434-447. doi: 10.1016/j.jad.2018.04.025. Epub 2018 Apr 4.


The structure of PbCl2 on the {100} surface of NaCl and its consequences for crystal growth.

Townsend ER, Brugman SJT, Blijlevens MAR, Smets MMH, de Poel W, van Enckevort WJP, Meijer JAM, Vlieg E.

J Chem Phys. 2018 Apr 14;148(14):144703. doi: 10.1063/1.5026455.


Concentration-Dependent Adsorption of CsI at the Muscovite-Electrolyte Interface.

Brugman SJT, Townsend ER, Smets MMH, Accordini P, Vlieg E.

Langmuir. 2018 Apr 3;34(13):3821-3826. doi: 10.1021/acs.langmuir.8b00038. Epub 2018 Mar 20.


Correction: Exploring the Relationship between Experiential Avoidance, Coping Functions and the Recency and Frequency of Self-Harm.

Nielsen E, Sayal K, Townsend E.

PLoS One. 2018 Feb 14;13(2):e0192795. doi: 10.1371/journal.pone.0192795. eCollection 2018.


Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models.

Defraine V, Verstraete L, Van Bambeke F, Anantharajah A, Townsend EM, Ramage G, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2017 Dec 22;8:2585. doi: 10.3389/fmicb.2017.02585. eCollection 2017.


Surface disinfection challenges for Candida auris: an in-vitro study.

Kean R, Sherry L, Townsend E, McKloud E, Short B, Akinbobola A, Mackay WG, Williams C, Jones BL, Ramage G.

J Hosp Infect. 2018 Apr;98(4):433-436. doi: 10.1016/j.jhin.2017.11.015. Epub 2017 Dec 2.


Correction to "Z-Selective Metathesis Homocoupling of 1,3-Dienes by Molybdenum and Tungsten Monoaryloxide Pyrrolide (MAP) Complexes".

Townsend EM, Schrock RR, Hoveyda AH.

J Am Chem Soc. 2017 Nov 15;139(45):16430. doi: 10.1021/jacs.7b11214. Epub 2017 Nov 7. No abstract available.


Dissociable effects of the kappa opioid receptor agonist nalfurafine on pain/itch-stimulated and pain/itch-depressed behaviors in male rats.

Lazenka ML, Moerke MJ, Townsend EA, Freeman KB, Carroll FI, Negus SS.

Psychopharmacology (Berl). 2018 Jan;235(1):203-213. doi: 10.1007/s00213-017-4758-7. Epub 2017 Oct 24.


Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.


Public Perceptions of Self-Harm: Perceived Motivations of (and Willingness to Help in Response to) Adolescent Self-Harm.

Nielsen E, Townsend E.

Arch Suicide Res. 2018 Jul-Sep;22(3):479-495. doi: 10.1080/13811118.2017.1358223. Epub 2017 Dec 11.


Exploring Thematic Nightmare Content and Associated Self-Harm Risk.

Hochard KD, Ashcroft S, Carroll J, Heym N, Townsend E.

Suicide Life Threat Behav. 2019 Feb;49(1):64-75. doi: 10.1111/sltb.12402. Epub 2017 Sep 28.


Clinical trial of L-Carnitine and valproic acid in spinal muscular atrophy type I.

Krosschell KJ, Kissel JT, Townsend EL, Simeone SD, Zhang RZ, Reyna SP, Crawford TO, Schroth MK, Acsadi G, Kishnani PS, Von Kleist-Retzow JC, Hero B, D'Anjou G, Smith EC, Elsheikh B, Simard LR, Prior TW, Scott CB, Lasalle B, Sakonju A, Wirth B, Swoboda KJ; Project Cure SMA Investigator's Network.

Muscle Nerve. 2018 Feb;57(2):193-199. doi: 10.1002/mus.25776. Epub 2017 Sep 18.


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