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Cross-cultural invariances in the architecture of shame.

Sznycer D, Xygalatas D, Agey E, Alami S, An XF, Ananyeva KI, Atkinson QD, Broitman BR, Conte TJ, Flores C, Fukushima S, Hitokoto H, Kharitonov AN, Onyishi CN, Onyishi IE, Romero PP, Schrock JM, Snodgrass JJ, Sugiyama LS, Takemura K, Townsend C, Zhuang JY, Aktipis CA, Cronk L, Cosmides L, Tooby J.

Proc Natl Acad Sci U S A. 2018 Sep 10. pii: 201805016. doi: 10.1073/pnas.1805016115. [Epub ahead of print]


The architectures of iterative type I PKS and FAS.

Herbst DA, Townsend CA, Maier T.

Nat Prod Rep. 2018 Aug 23. doi: 10.1039/c8np00039e. [Epub ahead of print] Review.


Control Limitations in Models of T1DM and the Robustness of Optimal Insulin Delivery.

Townsend C, Seron MM, Goodwin GC, King BR.

J Diabetes Sci Technol. 2018 Sep;12(5):926-936. doi: 10.1177/1932296818789950. Epub 2018 Jul 31.


Immunoglobulin gene analysis as a tool for investigating human immune responses.

Dunn-Walters D, Townsend C, Sinclair E, Stewart A.

Immunol Rev. 2018 Jul;284(1):132-147. doi: 10.1111/imr.12659.


Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum.

de Jonge R, Ebert MK, Huitt-Roehl CR, Pal P, Suttle JC, Spanner RE, Neubauer JD, Jurick WM 2nd, Stott KA, Secor GA, Thomma BPHJ, Van de Peer Y, Townsend CA, Bolton MD.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5459-E5466. doi: 10.1073/pnas.1712798115. Epub 2018 May 29. Erratum in: Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8324.


FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice.

Li J, Song J, Li X, Rock SB, Sinner HF, Weiss HL, Weiss T, Townsend CM Jr, Gao T, Evers BM.

Endocrinology. 2018 Aug 1;159(8):2939-2952. doi: 10.1210/en.2018-00284.


Mechanism of Integrated β-Lactam Formation by a Nonribosomal Peptide Synthetase during Antibiotic Synthesis.

Long DH, Townsend CA.

Biochemistry. 2018 Jun 19;57(24):3353-3358. doi: 10.1021/acs.biochem.8b00411. Epub 2018 May 3.


Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.

Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G.

Sci Rep. 2018 Apr 18;8(1):6176. doi: 10.1038/s41598-018-24296-0.


BRepertoire: a user-friendly web server for analysing antibody repertoire data.

Margreitter C, Lu HC, Townsend C, Stewart A, Dunn-Walters DK, Fraternali F.

Nucleic Acids Res. 2018 Jul 2;46(W1):W264-W270. doi: 10.1093/nar/gky276.


The structural organization of substrate loading in iterative polyketide synthases.

Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, Townsend CA, Maier T.

Nat Chem Biol. 2018 May;14(5):474-479. doi: 10.1038/s41589-018-0026-3. Epub 2018 Apr 2.


Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.

Cohen DR, Townsend CA.

Angew Chem Int Ed Engl. 2018 May 14;57(20):5650-5654. doi: 10.1002/anie.201802036. Epub 2018 Mar 24.


Predicting intention to use nicotine replacement therapy in people attending residential treatment for substance dependency.

Kelly PJ, Townsend CJ, Osborne BA, Baker AL, Deane FP, Keane C, Ingram I, Lunn J.

J Dual Diagn. 2018 Feb 28:1-29. doi: 10.1080/15504263.2018.1442951. [Epub ahead of print]


CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.

Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS.

Bioorg Med Chem. 2018 Mar 15;26(6):1232-1238. doi: 10.1016/j.bmc.2018.01.027. Epub 2018 Feb 3.


A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis.

Cohen DR, Townsend CA.

Nat Chem. 2018 Feb;10(2):231-236. doi: 10.1038/nchem.2876. Epub 2017 Nov 20.


A pilot study to understand feasibility and acceptability of stool and cord blood sample collection for a large-scale longitudinal birth cohort.

Bailey SR, Townsend CL, Dent H, Mallet C, Tsaliki E, Riley EM, Noursadeghi M, Lawley TD, Rodger AJ, Brocklehurst P, Field N.

BMC Pregnancy Childbirth. 2017 Dec 28;17(1):439. doi: 10.1186/s12884-017-1627-7.


Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration.

Kim JT, Napier DL, Weiss HL, Lee EY, Townsend CM Jr, Evers BM.

Neoplasia. 2018 Feb;20(2):175-181. doi: 10.1016/j.neo.2017.11.012. Epub 2017 Dec 19.


In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.

Storm PA, Townsend CA.

Chem Commun (Camb). 2017 Dec 19;54(1):50-53. doi: 10.1039/c7cc07079a.


Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase.

Oliver RA, Li R, Townsend CA.

Nat Chem Biol. 2018 Jan;14(1):5-7. doi: 10.1038/nchembio.2526. Epub 2017 Nov 20.


Protease inhibitors and preterm delivery: another piece in the puzzle.

Favarato G, Townsend CL, Bailey H, Peters H, Tookey PA, Taylor GP, Thorne C.

AIDS. 2018 Jan 14;32(2):243-252. doi: 10.1097/QAD.0000000000001694.


Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search.

Donovan BT, Bandyopadhyay D, Duraiswami C, Nixon CJ, Townsend CY, Martens SF.

Eur J Pharmacol. 2018 Jan 5;818:306-327. doi: 10.1016/j.ejphar.2017.10.015. Epub 2017 Oct 16.


Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster.

Horsman ME, Marous DR, Li R, Oliver RA, Byun B, Emrich SJ, Boggess B, Townsend CA, Mobashery S.

ACS Chem Biol. 2017 Oct 20;12(10):2552-2557. doi: 10.1021/acschembio.7b00687. Epub 2017 Sep 26.


Presidential Address: Do what’s right for the patient: Franklin H. Martin and the American College of Surgeons.

Townsend CM.

Bull Am Coll Surg. 2016 Dec;101(12):12-21. No abstract available.


Traumatic brain injury amongst indigenous people: a systematic review.

Lakhani A, Townsend C, Bishara J.

Brain Inj. 2017;31(13-14):1718-1730. doi: 10.1080/02699052.2017.1374468. Epub 2017 Sep 19. Review.


SAGES rebuttal.

Jones DB, Hunter JG, Townsend CM, Minter RM, Roberts PL, Brethauer S, Soper NJ.

Gastrointest Endosc. 2017 Oct;86(4):751-754. doi: 10.1016/j.gie.2017.06.007. No abstract available.


Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indolizines.

Outlaw VK, Zhou J, Bragg AE, Townsend CA.

RSC Adv. 2016 Jul 8;6(66):61249-61253. doi: 10.1039/C6RA10605F. Epub 2016 Jun 3.


LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems.

Mattoo R, Lloyd EP, Kaushik A, Kumar P, Brunelle JL, Townsend CA, Lamichhane G.

Future Microbiol. 2017 Jun;12:595-607. doi: 10.2217/fmb-2016-0208. Epub 2017 May 30.


Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.

Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G.

BMC Biochem. 2017 May 25;18(1):8. doi: 10.1186/s12858-017-0082-4.


The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain.

Hooten WM, Townsend CO, Sletten CD.

J Pain Res. 2017 May 9;10:1071-1078. doi: 10.2147/JPR.S134231. eCollection 2017.


Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.

Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8.


Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.

Storm PA, Herbst DA, Maier T, Townsend CA.

Cell Chem Biol. 2017 Mar 16;24(3):316-325. doi: 10.1016/j.chembiol.2017.01.008. Epub 2017 Feb 23.


Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.

Pye CR, Hewitt WM, Schwochert J, Haddad TD, Townsend CE, Etienne L, Lao Y, Limberakis C, Furukawa A, Mathiowetz AM, Price DA, Liras S, Lokey RS.

J Med Chem. 2017 Mar 9;60(5):1665-1672. doi: 10.1021/acs.jmedchem.6b01483. Epub 2017 Jan 25.


Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster.

Li R, Oliver RA, Townsend CA.

Cell Chem Biol. 2017 Jan 19;24(1):24-34. doi: 10.1016/j.chembiol.2016.11.010. Epub 2016 Dec 22.


Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm?

Martin VG, Wu YB, Townsend CL, Lu GH, O'Hare JS, Mozeika A, Coolen AC, Kipling D, Fraternali F, Dunn-Walters DK.

Front Immunol. 2016 Dec 2;7:546. eCollection 2016.


Implementing Huddles Improves Care Coordination in an Academic Health Center.

Townsend CS, McNulty M, Grillo-Peck A.

Prof Case Manag. 2017 Jan/Feb;22(1):29-35.


Pregnancies in older women living with HIV in the UK and Ireland.

Townsend CL, de Ruiter A, Peters H, Nelson-Piercy C, Tookey P, Thorne C.

HIV Med. 2017 Aug;18(7):507-512. doi: 10.1111/hiv.12469. Epub 2016 Nov 16.


Non-classical transpeptidases yield insight into new antibacterials.

Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Bell DT, Perryman AL, Zandi TA, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G.

Nat Chem Biol. 2017 Jan;13(1):54-61. doi: 10.1038/nchembio.2237. Epub 2016 Nov 7.


Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.

Chande N, Townsend CM, Parker CE, MacDonald JK.

Cochrane Database Syst Rev. 2016 Oct 26;10:CD000545. Review.


Characterization of Mentorship Programs in Departments of Surgery in the United States.

Kibbe MR, Pellegrini CA, Townsend CM Jr, Helenowski IB, Patti MG.

JAMA Surg. 2016 Oct 1;151(10):900-906. doi: 10.1001/jamasurg.2016.1670.


Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.

Townsend CL, Laffy JM, Wu YB, Silva O'Hare J, Martin V, Kipling D, Fraternali F, Dunn-Walters DK.

Front Immunol. 2016 Sep 27;7:388. eCollection 2016.


Convergent biosynthetic pathways to β-lactam antibiotics.

Townsend CA.

Curr Opin Chem Biol. 2016 Dec;35:97-108. doi: 10.1016/j.cbpa.2016.09.013. Epub 2016 Sep 29. Review.


Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.

Furukawa A, Townsend CE, Schwochert J, Pye CR, Bednarek MA, Lokey RS.

J Med Chem. 2016 Oct 27;59(20):9503-9512. Epub 2016 Oct 11.


Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13005-13009. doi: 10.1002/anie.201605401.


Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back.

Laffy JMJ, Dodev T, Macpherson JA, Townsend C, Lu HC, Dunn-Walters D, Fraternali F.

Prog Biophys Mol Biol. 2017 Sep;128:47-56. doi: 10.1016/j.pbiomolbio.2016.09.002. Epub 2016 Sep 14.


Quenching of pH-Responsive Luminescence of a Benzoindolizine Sensor by an Ultrafast Hydrogen Shift.

Zhou J, Outlaw VK, Townsend CA, Bragg AE.

Chemistry. 2016 Oct 17;22(43):15212-15215. doi: 10.1002/chem.201603284. Epub 2016 Sep 13.


Developing and Evaluating Multimedia Patient Education Tools to Better Prepare Prostate-Cancer Patients for Radiotherapy Treatment (Randomized Study).

Dawdy K, Bonin K, Russell S, Ryzynski A, Harth T, Townsend C, Liu S, Chu W, Cheung P, Chung H, Morton G, Vesprini D, Loblaw A, Cao X, Szumacher E.

J Cancer Educ. 2018 Jun;33(3):551-556. doi: 10.1007/s13187-016-1091-5.


The PILI@Work Program: a translation of the diabetes prevention program to Native Hawaiian-serving worksites in Hawai'i.

Townsend CK, Miyamoto RE, Antonio M, Zhang G, Paloma D, Basques D, Braun KL, Kaholokula JK.

Transl Behav Med. 2016 Jun;6(2):190-201. doi: 10.1007/s13142-015-0383-3.


Syphilis screening in pregnancy in the United Kingdom, 2010-2011: a national surveillance study.

Townsend CL, Francis K, Peckham CS, Tookey PA.

BJOG. 2017 Jan;124(1):79-86. doi: 10.1111/1471-0528.14053. Epub 2016 May 24.


Prevalence of depressive symptoms in pregnant and postnatal HIV-positive women in Ukraine: a cross-sectional survey.

Bailey H, Malyuta R, Semenenko I, Townsend CL, Cortina-Borja M, Thorne C; Ukraine European Collaborative Study in EuroCoord.

Reprod Health. 2016 Mar 22;13:27. doi: 10.1186/s12978-016-0150-z.


Study protocol: developing a decision system for inclusive housing: applying a systematic, mixed-method quasi-experimental design.

Zeeman H, Kendall E, Whitty JA, Wright CJ, Townsend C, Smith D, Lakhani A, Kennerley S.

BMC Public Health. 2016 Mar 15;16:261. doi: 10.1186/s12889-016-2936-x.

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