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Items: 1 to 50 of 129

1.

Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.

Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T.

J Biol Chem. 2019 Feb 22;294(8):2714-2731. doi: 10.1074/jbc.RA118.004280. Epub 2018 Dec 18.

PMID:
30563837
2.

Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer's Disease Pathogenesis.

Meyer PF, Savard M, Poirier J, Labonté A, Rosa-Neto P, Weitz TM, Town T, Breitner J; Alzheimer’s Disease Neuroimaging Initiative; PREVENT-AD Research Group.

J Alzheimers Dis. 2018;63(2):577-590. doi: 10.3233/JAD-170887.

3.

Let's make microglia great again in neurodegenerative disorders.

Guillot-Sestier MV, Town T.

J Neural Transm (Vienna). 2018 May;125(5):751-770. doi: 10.1007/s00702-017-1792-x. Epub 2017 Oct 12. Review.

4.

Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.

Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T.

J Biol Chem. 2017 Jul 7;292(27):11310-11325. doi: 10.1074/jbc.M116.762658. Epub 2017 May 16.

5.
6.

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

Breunig JJ, Levy R, Antonuk CD, Molina J, Dutra-Clarke M, Park H, Akhtar AA, Kim GB, Town T, Hu X, Bannykh SI, Verhaak RGW, Danielpour M.

Cell Rep. 2016 Dec 20;17(12):3407. doi: 10.1016/j.celrep.2016.12.026. No abstract available.

7.

TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice.

Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F.

J Immunol. 2016 Dec 1;197(11):4425-4435. Epub 2016 Oct 21.

8.

Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F.

J Virol. 2016 Dec 16;91(1). pii: e01529-16. doi: 10.1128/JVI.01529-16. Print 2017 Jan 1.

9.

Amyloid Cascade into Clarity.

Weitz TM, Town T.

Immunity. 2016 Oct 18;45(4):717-718. doi: 10.1016/j.immuni.2016.10.006. Review.

10.

Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice.

Matundan HH, Mott KR, Allen SJ, Wang S, Bresee CJ, Ghiasi YN, Town T, Wechsler SL, Ghiasi H.

J Virol. 2016 Sep 29;90(20):9533-42. doi: 10.1128/JVI.01373-16. Print 2016 Oct 15.

11.

Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ.

J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. Review. Erratum in: J Neurochem. 2017 Apr;141(1):151.

12.

CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1.

Mott KR, Gate D, Matundan HH, Ghiasi YN, Town T, Ghiasi H.

J Virol. 2016 Apr 29;90(10):5059-5067. doi: 10.1128/JVI.00255-16. Print 2016 May 15.

13.

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats.

Daianu M, Jacobs RE, Weitz TM, Town TC, Thompson PM.

PLoS One. 2015 Dec 18;10(12):e0145205. doi: 10.1371/journal.pone.0145205. eCollection 2015.

14.

Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection.

Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Müller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY.

PLoS Pathog. 2015 Nov 30;11(11):e1005292. doi: 10.1371/journal.ppat.1005292. eCollection 2015.

15.

Innate Immunity Fights Alzheimer's Disease.

Guillot-Sestier MV, Doty KR, Town T.

Trends Neurosci. 2015 Nov;38(11):674-681. doi: 10.1016/j.tins.2015.08.008. Review.

16.

Characterization of cancer stem cells and primary cilia in medulloblastoma.

Gate D, Danielpour M, Bannykh S, Town T.

CNS Neurol Disord Drug Targets. 2015;14(5):600-11.

PMID:
25921740
17.

Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.

18.

Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression.

Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell RA, Spilianakis CG.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1577-86. doi: 10.1073/pnas.1502182112. Epub 2015 Mar 13.

19.

Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.

Guillot-Sestier MV, Doty KR, Gate D, Rodriguez J Jr, Leung BP, Rezai-Zadeh K, Town T.

Neuron. 2015 Feb 4;85(3):534-48. doi: 10.1016/j.neuron.2014.12.068. Epub 2015 Jan 22.

20.

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

Doty KR, Guillot-Sestier MV, Town T.

Brain Res. 2015 Aug 18;1617:155-73. doi: 10.1016/j.brainres.2014.09.008. Epub 2014 Sep 8. Review.

21.

MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice.

Weitz TM, Gate D, Rezai-Zadeh K, Town T.

Am J Pathol. 2014 Nov;184(11):2855-61. doi: 10.1016/j.ajpath.2014.07.004. Epub 2014 Aug 28.

22.

Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.

Mori T, Koyama N, Segawa T, Maeda M, Maruyama N, Kinoshita N, Hou H, Tan J, Town T.

J Biol Chem. 2014 Oct 31;289(44):30303-17. doi: 10.1074/jbc.M114.568212. Epub 2014 Aug 25.

23.

T-cell TGF-β signaling abrogation restricts medulloblastoma progression.

Gate D, Danielpour M, Rodriguez J Jr, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3458-66. doi: 10.1073/pnas.1412489111. Epub 2014 Jul 31.

24.

CD8α dendritic cells drive establishment of HSV-1 latency.

Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H.

PLoS One. 2014 Apr 2;9(4):e93444. doi: 10.1371/journal.pone.0093444. eCollection 2014.

25.

Brain injury, neuroinflammation and Alzheimer's disease.

Breunig JJ, Guillot-Sestier MV, Town T.

Front Aging Neurosci. 2013 Jul 11;5:26. doi: 10.3389/fnagi.2013.00026. eCollection 2013.

26.

A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.

Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T.

J Neurosci. 2013 Apr 10;33(15):6245-56. doi: 10.1523/JNEUROSCI.3672-12.2013.

27.

Innate immunity in Alzheimer's disease: a complex affair.

Guillot-Sestier MV, Town T.

CNS Neurol Disord Drug Targets. 2013 Aug;12(5):593-607. Review.

28.

Increasing hematopoietic stem cell yield to develop mice with human immune systems.

Biancotti JC, Town T.

Biomed Res Int. 2013;2013:740892. doi: 10.1155/2013/740892. Epub 2013 Feb 14. Review.

29.

Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice.

Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T.

PLoS One. 2013;8(2):e55774. doi: 10.1371/journal.pone.0055774. Epub 2013 Feb 8.

30.

IL-22 signaling contributes to West Nile encephalitis pathogenesis.

Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E.

PLoS One. 2012;7(8):e44153. doi: 10.1371/journal.pone.0044153. Epub 2012 Aug 28.

31.

Microglia in Alzheimer's Disease: It's All About Context.

Weitz TM, Town T.

Int J Alzheimers Dis. 2012;2012:314185. doi: 10.1155/2012/314185. Epub 2012 Jun 20.

32.

Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.

Breunig JJ, Gate D, Levy R, Rodriguez J Jr, Kim GB, Danielpour M, Svendsen CN, Town T.

Neural Dev. 2012 Jul 10;7:26. doi: 10.1186/1749-8104-7-26.

33.

Basic biology and mechanisms of neural ciliogenesis and the B9 family.

Gate D, Danielpour M, Levy R, Breunig JJ, Town T.

Mol Neurobiol. 2012 Jun;45(3):564-70. doi: 10.1007/s12035-012-8276-7. Epub 2012 May 30. Review.

PMID:
22644387
34.

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M.

Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16.

35.

Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice.

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T.

J Biol Chem. 2012 Feb 24;287(9):6912-27. doi: 10.1074/jbc.M111.294025. Epub 2012 Jan 4.

36.

Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.

Gray P, Dagvadorj J, Michelsen KS, Brikos C, Rentsendorj A, Town T, Crother TR, Arditi M.

J Immunol. 2011 Oct 15;187(8):4331-7. doi: 10.4049/jimmunol.1100890. Epub 2011 Sep 14.

37.

Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.

Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H.

J Virol. 2011 Nov;85(21):11448-56. doi: 10.1128/JVI.00678-11. Epub 2011 Aug 31.

38.

Control of TH17 cells occurs in the small intestine.

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA.

Nature. 2011 Jul 17;475(7357):514-8. doi: 10.1038/nature10228.

39.

How to get from here to there: macrophage recruitment in Alzheimer's disease.

Rezai-Zadeh K, Gate D, Gowing G, Town T.

Curr Alzheimer Res. 2011 Mar;8(2):156-63. Review.

40.

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.

Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H.

J Virol. 2011 May;85(9):4184-97. doi: 10.1128/JVI.02290-10. Epub 2011 Feb 9.

41.

CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.

Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J.

J Neurosci. 2011 Jan 26;31(4):1355-65. doi: 10.1523/JNEUROSCI.3268-10.2011.

42.

Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.

Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H.

Invest Ophthalmol Vis Sci. 2011 Apr 8;52(5):2321-33. doi: 10.1167/iovs.10-6536. Print 2011 Apr.

43.

Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease.

Mori T, Asano T, Town T.

Cardiovasc Psychiatry Neurol. 2010;2010. pii: 687067. doi: 10.1155/2010/687067. Epub 2010 Sep 2.

44.

Macrophages in Alzheimer's disease: the blood-borne identity.

Gate D, Rezai-Zadeh K, Jodry D, Rentsendorj A, Town T.

J Neural Transm (Vienna). 2010 Aug;117(8):961-70. doi: 10.1007/s00702-010-0422-7. Epub 2010 Jun 2. Review.

45.

Alzheimer's Disease Beyond Abeta.

Town T.

Expert Rev Neurother. 2010 May;10(5):671-5.

46.

Inflammation, immunity, and Alzheimer's disease.

Town T.

CNS Neurol Disord Drug Targets. 2010 Apr;9(2):129-31.

47.

Can peripheral leukocytes be used as Alzheimer's disease biomarkers?

Rezai-Zadeh K, Gate D, Szekely CA, Town T.

Expert Rev Neurother. 2009 Nov;9(11):1623-33. doi: 10.1586/ern.09.118. Review.

48.

Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.

Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J.

J Cell Mol Med. 2011 Feb;15(2):327-38. doi: 10.1111/j.1582-4934.2009.00962.x.

49.

IL-10 signaling blockade controls murine West Nile virus infection.

Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E.

PLoS Pathog. 2009 Oct;5(10):e1000610. doi: 10.1371/journal.ppat.1000610. Epub 2009 Oct 9.

50.

SOLUBLE CD40 LIGAND IN DEMENTIA.

Giunta B, Figueroa KP, Town T, Tan J.

Drugs Future. 2009 Apr 1;34(4):333-340.

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