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Items: 1 to 50 of 101

1.

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN.

Mol Metab. 2013 May 9;2(3):194-204. doi: 10.1016/j.molmet.2013.05.001. eCollection 2013.

2.

Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.

Petrie JL, Al-Oanzi ZH, Arden C, Tudhope SJ, Mann J, Kieswich J, Yaqoob MM, Towle HC, Agius L.

Mol Cell Biol. 2013 Feb;33(4):725-38. doi: 10.1128/MCB.01576-12. Epub 2012 Dec 3.

3.

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α.

Hanse EA, Mashek DG, Becker JR, Solmonson AD, Mullany LK, Mashek MT, Towle HC, Chau AT, Albrecht JH.

Cell Cycle. 2012 Jul 15;11(14):2681-90. doi: 10.4161/cc.21019. Epub 2012 Jul 15.

4.

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.

Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L.

Biochem J. 2012 Apr 1;443(1):111-23. doi: 10.1042/BJ20111280.

PMID:
22214556
5.

Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.

Arden C, Petrie JL, Tudhope SJ, Al-Oanzi Z, Claydon AJ, Beynon RJ, Towle HC, Agius L.

Diabetes. 2011 Dec;60(12):3110-20. doi: 10.2337/db11-0061. Epub 2011 Oct 19.

6.

Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner.

Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM.

J Biol Chem. 2011 Apr 29;286(17):15116-25. doi: 10.1074/jbc.M110.216234. Epub 2011 Feb 27.

7.

Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region.

Davies MN, O'Callaghan BL, Towle HC.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E665-74. doi: 10.1152/ajpendo.00349.2010. Epub 2010 Aug 3.

8.

Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.

Aipoalani DL, O'Callaghan BL, Mashek DG, Mariash CN, Towle HC.

Endocrinology. 2010 May;151(5):2071-7. doi: 10.1210/en.2009-1058. Epub 2010 Mar 16.

9.

Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.

Davies MN, O'Callaghan BL, Towle HC.

J Biol Chem. 2008 Aug 29;283(35):24029-38. doi: 10.1074/jbc.M801539200. Epub 2008 Jun 30.

10.

Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate.

Tsatsos NG, Augustin LB, Anderson GW, Towle HC, Mariash CN.

Endocrinology. 2008 Oct;149(10):5155-61. doi: 10.1210/en.2008-0215. Epub 2008 Jun 12.

11.

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.

Tsatsos NG, Davies MN, O'Callaghan BL, Towle HC.

Biochem J. 2008 Apr 15;411(2):261-70. doi: 10.1042/BJ20071156.

PMID:
18215143
12.

The metabolic sensor GCN2 branches out.

Towle HC.

Cell Metab. 2007 Feb;5(2):85-7.

13.
14.

ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.

Ma L, Robinson LN, Towle HC.

J Biol Chem. 2006 Sep 29;281(39):28721-30. Epub 2006 Aug 2.

15.

Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism.

Tsatsos NG, Towle HC.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):449-56. Epub 2005 Dec 15.

PMID:
16375857
16.

Glucose as a regulator of eukaryotic gene transcription.

Towle HC.

Trends Endocrinol Metab. 2005 Dec;16(10):489-94. Epub 2005 Nov 2. Review.

PMID:
16269245
17.

Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma L, Tsatsos NG, Towle HC.

J Biol Chem. 2005 Mar 25;280(12):12019-27. Epub 2005 Jan 20.

18.
19.

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.

PMID:
14617577
20.

The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression.

Stoeckman AK, Towle HC.

J Biol Chem. 2002 Jul 26;277(30):27029-35. Epub 2002 May 16.

21.

Glucose and cAMP: adversaries in the regulation of hepatic gene expression.

Towle HC.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13476-8. Review. No abstract available.

22.

Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway.

Armstrong MB, Towle HC.

Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1197-204.

23.

Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes.

O'Callaghan BL, Koo SH, Wu Y, Freake HC, Towle HC.

J Biol Chem. 2001 May 11;276(19):16033-9. Epub 2001 Feb 28.

24.

Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription.

Rufo C, Teran-Garcia M, Nakamura MT, Koo SH, Towle HC, Clarke SD.

J Biol Chem. 2001 Jun 15;276(24):21969-75. Epub 2001 Mar 28.

25.
26.

Inhibition of growth hormone action in models of inflammation.

Bergad PL, Schwarzenberg SJ, Humbert JT, Morrison M, Amarasinghe S, Towle HC, Berry SA.

Am J Physiol Cell Physiol. 2000 Dec;279(6):C1906-17.

27.

An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression.

Kaytor EN, Qian J, Towle HC, Olson LK.

Mol Cell Biochem. 2000 Jul;210(1-2):13-21.

PMID:
10976753
30.
31.

Definition of a high affinity growth hormone DNA response element.

Bergad PL, Towle HC, Berry SA.

Mol Cell Endocrinol. 1999 Apr 25;150(1-2):151-9.

PMID:
10411309
32.

Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells.

Qian J, Kaytor EN, Towle HC, Olson LK.

Biochem J. 1999 Jul 15;341 ( Pt 2):315-22.

33.

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6.

Berry SA, Bergad PL, Stolz AM, Towle HC, Schwarzenberg SJ.

Am J Physiol. 1999 Jun;276(6):C1374-82. doi: 10.1152/ajpcell.1999.276.6.C1374.

PMID:
10362600
34.
35.
36.

Regulation of the expression of lipogenic enzyme genes by carbohydrate.

Towle HC, Kaytor EN, Shih HM.

Annu Rev Nutr. 1997;17:405-33. Review.

PMID:
9240934
37.

Metabolic regulation of hepatic gene expression.

Towle HC, Kaytor EN, Shih HM.

Biochem Soc Trans. 1996 May;24(2):364-8. Review. No abstract available.

PMID:
8736764
38.
39.

Metabolic regulation of gene transcription in mammals.

Towle HC.

J Biol Chem. 1995 Oct 6;270(40):23235-8. Review. No abstract available.

40.

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9127-31. Erratum in: Proc Natl Acad Sci U S A 1995 Nov 21;92(24):11322.

41.
42.
43.

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.

Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM.

Mol Cell Biol. 1995 May;15(5):2582-8.

44.

Matrigel treatment of primary hepatocytes following DNA transfection enhances responsiveness to extracellular stimuli.

Shih HM, Towle HC.

Biotechniques. 1995 May;18(5):813-4, 816. No abstract available.

PMID:
7619486
46.

Binding of a growth hormone-inducible nuclear factor is mediated by tyrosine phosphorylation.

Berry SA, Bergad PL, Whaley CD, Towle HC.

Mol Endocrinol. 1994 Dec;8(12):1714-9.

PMID:
7535894
47.
48.
49.

Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin.

Redmon JB, Towle HC, Robertson RP.

Diabetes. 1994 Apr;43(4):546-51.

PMID:
7907998

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