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Items: 12


Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL, Thorburn A.

Dev Cell. 2019 Sep 23;50(6):690-703.e6. doi: 10.1016/j.devcel.2019.07.010. Epub 2019 Aug 1.


Mechanistic insight into the regulation of SQSTM1/p62.

Zhang Y, Mun SR, Linares JF, Towers CG, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG.

Autophagy. 2019 Apr;15(4):735-737. doi: 10.1080/15548627.2019.1569935. Epub 2019 Jan 22.


ZZ-dependent regulation of p62/SQSTM1 in autophagy.

Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG.

Nat Commun. 2018 Oct 22;9(1):4373. doi: 10.1038/s41467-018-06878-8.


The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.

Guarnieri AL, Towers CG, Drasin DJ, Oliphant MUJ, Andrysik Z, Hotz TJ, Vartuli RL, Linklater ES, Pandey A, Khanal S, Espinosa JM, Ford HL.

Oncogene. 2018 Jul;37(28):3879-3893. doi: 10.1038/s41388-018-0239-7. Epub 2018 Apr 17.


Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.

Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A.

Dev Cell. 2018 Mar 12;44(5):555-565.e3. doi: 10.1016/j.devcel.2018.02.014.


Targeting the Lysosome for Cancer Therapy.

Towers CG, Thorburn A.

Cancer Discov. 2017 Nov;7(11):1218-1220. doi: 10.1158/2159-8290.CD-17-0996.


Targeting autophagy in cancer.

Levy JMM, Towers CG, Thorburn A.

Nat Rev Cancer. 2017 Sep;17(9):528-542. doi: 10.1038/nrc.2017.53. Epub 2017 Jul 28. Review.


A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.

Dimberg LY, Towers CG, Behbakht K, Hotz TJ, Kim J, Fosmire S, Porter CC, Tan AC, Thorburn A, Ford HL.

Mol Cancer Res. 2017 Apr;15(4):382-394. doi: 10.1158/1541-7786.MCR-16-0234. Epub 2017 Jan 20.


Therapeutic Targeting of Autophagy.

Towers CG, Thorburn A.

EBioMedicine. 2016 Dec;14:15-23. doi: 10.1016/j.ebiom.2016.10.034. Epub 2016 Oct 23. Review.


A tale of two ends.

Towers CG, Ford HL.

Cell Cycle. 2016 Jun 17;15(12):1523-4. doi: 10.1080/15384101.2016.1171652. Epub 2016 Apr 21. No abstract available.


The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.

Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MUJ, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, Ford HL.

Nat Commun. 2015 Dec 21;6:10077. doi: 10.1038/ncomms10077.


The SIX1-EYA transcriptional complex as a therapeutic target in cancer.

Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL.

Expert Opin Ther Targets. 2015 Feb;19(2):213-25. doi: 10.1517/14728222.2014.978860. Epub 2015 Jan 2. Review.

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