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Items: 1 to 50 of 54

1.

Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions.

Thillaiappan NB, Chavda AP, Tovey SC, Prole DL, Taylor CW.

Nat Commun. 2017 Nov 15;8(1):1505. doi: 10.1038/s41467-017-01644-8.

2.

Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors.

Konieczny V, Tovey SC, Mataragka S, Prole DL, Taylor CW.

Cell Rep. 2017 Jan 17;18(3):711-722. doi: 10.1016/j.celrep.2016.12.058.

3.

Fluorescence methods for analysis of interactions between Ca(2+) signaling, lysosomes, and endoplasmic reticulum.

Prole DL, López-Sanjurjo CI, Tovey SC, Taylor CW.

Methods Cell Biol. 2015;126:237-59. doi: 10.1016/bs.mcb.2014.10.024. Epub 2015 Jan 16.

PMID:
25665449
4.

Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.

Meena A, Tovey SC, Taylor CW.

J Cell Sci. 2015 Jan 15;128(2):408-20. doi: 10.1242/jcs.163071. Epub 2014 Nov 27.

5.

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.

López Sanjurjo CI, Tovey SC, Taylor CW.

PLoS One. 2014 Oct 22;9(10):e111275. doi: 10.1371/journal.pone.0111275. eCollection 2014.

6.

Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.

Thurley K, Tovey SC, Moenke G, Prince VL, Meena A, Thomas AP, Skupin A, Taylor CW, Falcke M.

Sci Signal. 2014 Jun 24;7(331):ra59. doi: 10.1126/scisignal.2005237.

7.

Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.

Saleem H, Tovey SC, Molinski TF, Taylor CW.

Br J Pharmacol. 2014 Jul;171(13):3298-312. doi: 10.1111/bph.12685.

8.

Structural organization of signalling to and from IP3 receptors.

Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T.

Biochem Soc Trans. 2014 Feb;42(1):63-70. doi: 10.1042/BST20130205. Review.

PMID:
24450629
9.

High-throughput functional assays of IP3-evoked Ca2+ release.

Tovey SC, Taylor CW.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):930-7. doi: 10.1101/pdb.prot073072.

PMID:
24086049
10.

High-throughput analyses of IP3 receptor behavior.

Taylor CW, Tovey SC, Rossi AM.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):914-7. doi: 10.1101/pdb.top066100.

PMID:
24086047
11.

Cyclic AMP directs inositol (1,4,5)-trisphosphate-evoked Ca2+ signalling to different intracellular Ca2+ stores.

Tovey SC, Taylor CW.

J Cell Sci. 2013 May 15;126(Pt 10):2305-13. doi: 10.1242/jcs.126144. Epub 2013 Mar 22.

12.

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues.

Saleem H, Tovey SC, Riley AM, Potter BV, Taylor CW.

PLoS One. 2013;8(2):e58027. doi: 10.1371/journal.pone.0058027. Epub 2013 Feb 28.

13.

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3.

Saleem H, Tovey SC, Rahman T, Riley AM, Potter BV, Taylor CW.

PLoS One. 2013;8(1):e54877. doi: 10.1371/journal.pone.0054877. Epub 2013 Jan 25.

14.

Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.

López-Sanjurjo CI, Tovey SC, Prole DL, Taylor CW.

J Cell Sci. 2013 Jan 1;126(Pt 1):289-300. doi: 10.1242/jcs.116103. Epub 2012 Oct 24.

15.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Bampton ET, Huang Y, Willars GB.

Methods Mol Biol. 2013;937:51-93.

PMID:
23007579
16.

Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level.

Thurley K, Smith IF, Tovey SC, Taylor CW, Parker I, Falcke M.

Biophys J. 2011 Dec 7;101(11):2638-44. doi: 10.1016/j.bpj.2011.10.030.

17.

From parathyroid hormone to cytosolic Ca2+ signals.

Taylor CW, Tovey SC.

Biochem Soc Trans. 2012 Feb;40(1):147-52. doi: 10.1042/BST20110615. Review.

PMID:
22260681
18.

Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A.

Sureshan KM, Riley AM, Thomas MP, Tovey SC, Taylor CW, Potter BV.

J Med Chem. 2012 Feb 23;55(4):1706-20. doi: 10.1021/jm201571p. Epub 2012 Feb 8.

19.

Analysis of IP3 receptors in and out of cells.

Rossi AM, Tovey SC, Rahman T, Prole DL, Taylor CW.

Biochim Biophys Acta. 2012 Aug;1820(8):1214-27. doi: 10.1016/j.bbagen.2011.10.004. Epub 2011 Oct 14. Review.

PMID:
22033379
20.

IP(3) receptors: toward understanding their activation.

Taylor CW, Tovey SC.

Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a004010. doi: 10.1101/cshperspect.a004010. Epub 2010 Oct 27. Review.

21.

Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.

Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW.

J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26.

22.

IP3 receptors: some lessons from DT40 cells.

Taylor CW, Rahman T, Tovey SC, Dedos SG, Taylor EJ, Velamakanni S.

Immunol Rev. 2009 Sep;231(1):23-44. doi: 10.1111/j.1600-065X.2009.00807.x. Review.

PMID:
19754888
23.

Synthetic partial agonists reveal key steps in IP3 receptor activation.

Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW.

Nat Chem Biol. 2009 Sep;5(9):631-9. doi: 10.1038/nchembio.195. Epub 2009 Aug 9.

24.

Activation of IP(3) receptors by synthetic bisphosphate ligands.

Sureshan KM, Riley AM, Rossi AM, Tovey SC, Dedos SG, Taylor CW, Potter BV.

Chem Commun (Camb). 2009 Mar 14;(10):1204-6. doi: 10.1039/b819328b. Epub 2009 Feb 4.

25.

Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.

Tovey SC, Dedos SG, Taylor EJ, Church JE, Taylor CW.

J Cell Biol. 2008 Oct 20;183(2):297-311. doi: 10.1083/jcb.200803172.

26.

Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11.

Karakoula A, Tovey SC, Brighton PJ, Willars GB.

Eur J Pharmacol. 2008 Jun 10;587(1-3):16-24. doi: 10.1016/j.ejphar.2008.03.047. Epub 2008 Apr 4.

PMID:
18457830
27.

2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.

Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV.

J Org Chem. 2008 Mar 7;73(5):1682-92. doi: 10.1021/jo702617c. Epub 2008 Feb 2.

PMID:
18247493
28.

How does intracellular Ca2+ oscillate: by chance or by the clock?

Skupin A, Kettenmann H, Winkler U, Wartenberg M, Sauer H, Tovey SC, Taylor CW, Falcke M.

Biophys J. 2008 Mar 15;94(6):2404-11. Epub 2007 Dec 7.

29.

Rapid functional assays of intracellular Ca2+ channels.

Tovey SC, Sun Y, Taylor CW.

Nat Protoc. 2006;1(1):259-63.

PMID:
17406242
30.

Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.

Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S.

J Med Chem. 2006 Sep 21;49(19):5750-8.

PMID:
16970399
31.

Signalling from parathyroid hormone.

Tovey SC, Dedos SG, Taylor CW.

Biochem Soc Trans. 2006 Aug;34(Pt 4):515-7. Review.

PMID:
16856848
32.

Ca2+ entry through plasma membrane IP3 receptors.

Dellis O, Dedos SG, Tovey SC, Taufiq-Ur-Rahman, Dubel SJ, Taylor CW.

Science. 2006 Jul 14;313(5784):229-33.

33.

Guanophostin A: Synthesis and evaluation of a high affinity agonist of the D-myo-inositol 1,4,5-trisphosphate receptor.

Sureshan KM, Trusselle M, Tovey SC, Taylor CW, Potter BV.

Chem Commun (Camb). 2006 May 21;(19):2015-7. Epub 2006 Mar 31.

PMID:
16767260
34.

A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.

Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S.

J Med Chem. 2006 Mar 23;49(6):1900-9.

PMID:
16539376
35.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Willars GB.

Methods Mol Biol. 2006;312:57-85. No abstract available.

PMID:
16422191
36.

Rapid functional assays of recombinant IP3 receptors.

Laude AJ, Tovey SC, Dedos SG, Potter BV, Lummis SC, Taylor CW.

Cell Calcium. 2005 Jul;38(1):45-51.

PMID:
15963563
37.

Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.

Moneer Z, Pino I, Taylor EJ, Broad LM, Liu Y, Tovey SC, Staali L, Taylor CW.

Biochem J. 2005 Aug 1;389(Pt 3):821-9.

38.

Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity.

Borissow CN, Black SJ, Paul M, Tovey SC, Dedos SG, Taylor CW, Potter BV.

Org Biomol Chem. 2005 Jan 21;3(2):245-52. Epub 2004 Dec 13.

PMID:
15632966
39.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Willars GB.

Methods Mol Biol. 2005;312:57-85. doi: 10.1385/1-59259-949-4:057. Review.

PMID:
21341092
40.

What's in store for Ca2+ oscillations?

Taylor CW, Tovey SC.

J Physiol. 2005 Feb 1;562(Pt 3):645. Epub 2004 Nov 11. No abstract available.

42.

G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction.

Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ.

J Biol Chem. 2003 Jun 6;278(23):21307-13. Epub 2003 Apr 1.

44.

Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses.

Tovey SC, de Smet P, Lipp P, Thomas D, Young KW, Missiaen L, De Smedt H, Parys JB, Berridge MJ, Thuring J, Holmes A, Bootman MD.

J Cell Sci. 2001 Nov;114(Pt 22):3979-89.

45.

Calcium signalling--an overview.

Bootman MD, Collins TJ, Peppiatt CM, Prothero LS, MacKenzie L, De Smet P, Travers M, Tovey SC, Seo JT, Berridge MJ, Ciccolini F, Lipp P.

Semin Cell Dev Biol. 2001 Feb;12(1):3-10. Review.

PMID:
11162741
46.

Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps.

Hughes PJ, McLellan H, Lowes DA, Kahn SZ, Bilmen JG, Tovey SC, Godfrey RE, Michell RH, Kirk CJ, Michelangeli F.

Biochem Biophys Res Commun. 2000 Nov 2;277(3):568-74.

PMID:
11061995
47.

Subtype identification and functional properties of inositol 1,4, 5-trisphosphate receptors in heart and aorta.

Tovey SC, Dyer JL, Godfrey RE, Khan SZ, Bilmen JG, Mezna M, Michelangeli F.

Pharmacol Res. 2000 Dec;42(6):581-90.

PMID:
11058412
48.

A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals.

Thomas D, Tovey SC, Collins TJ, Bootman MD, Berridge MJ, Lipp P.

Cell Calcium. 2000 Oct;28(4):213-23.

PMID:
11032777
49.

Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release.

Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ.

Biochem Biophys Res Commun. 2000 Sep 16;276(1):97-100.

PMID:
11006089
50.

Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart.

Lipp P, Laine M, Tovey SC, Burrell KM, Berridge MJ, Li W, Bootman MD.

Curr Biol. 2000 Jul 27-Aug 10;10(15):939-42.

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