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Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis.

Rios FJ, Zou ZG, Harvey AP, Harvey KY, Nosalski R, Anyfanti P, Camargo LL, Lacchini S, Ryazanov AG, Ryazanova L, McGrath S, Guzik TJ, Goodyear CS, Montezano AC, Touyz RM.

Cardiovasc Res. 2019 Jun 28. pii: cvz164. doi: 10.1093/cvr/cvz164. [Epub ahead of print]


Extracellular Vesicles as Biomarkers and Biovectors in Primary Aldosteronism.

Neves KB, Touyz RM.

Hypertension. 2019 Aug;74(2):250-252. doi: 10.1161/HYPERTENSIONAHA.119.13088. Epub 2019 Jun 24. No abstract available.


Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.

Jha JC, Dai A, Holterman CE, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm KAM.

Diabetologia. 2019 Jun 20. doi: 10.1007/s00125-019-4924-z. [Epub ahead of print]


Hypertension Guidelines: Effect of Blood Pressure Targets.

Touyz RM.

Can J Cardiol. 2019 May;35(5):564-569. doi: 10.1016/j.cjca.2019.03.014. Epub 2019 Mar 21.


TRPM7, Magnesium, and Signaling.

Zou ZG, Rios FJ, Montezano AC, Touyz RM.

Int J Mol Sci. 2019 Apr 16;20(8). pii: E1877. doi: 10.3390/ijms20081877. Review.


Muscarinic Receptor Type-3 in Hypertension and Cholinergic-Adrenergic Crosstalk: Genetic Insights and Potential for New Antihypertensive Targets.

Alves-Lopes R, Neves KB, Touyz RM.

Can J Cardiol. 2019 May;35(5):555-557. doi: 10.1016/j.cjca.2019.02.003. Epub 2019 Feb 13. No abstract available.


Response to the letter regarding the hypothesis paper "Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema".

Rossitto G, Touyz RM, Petrie MC, Delles C.

Clin Sci (Lond). 2019 Mar 19;133(6):761. doi: 10.1042/CS20190154. Print 2019 Mar 29.


Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Lerman LO, Kurtz TW, Touyz RM, Ellison DH, Chade AR, Crowley SD, Mattson DL, Mullins JJ, Osborn J, Eirin A, Reckelhoff JF, Iadecola C, Coffman TM.

Hypertension. 2019 Jun;73(6):e87-e120. doi: 10.1161/HYP.0000000000000090.


Microglia, the Missing Link in the Brain-Gut-Hypertension Axis.

Touyz RM, Camargo LL.

Circ Res. 2019 Mar;124(5):671-673. doi: 10.1161/CIRCRESAHA.119.314718. No abstract available.


NOX5: Molecular biology and pathophysiology.

Touyz RM, Anagnostopoulou A, Rios F, Montezano AC, Camargo LL.

Exp Physiol. 2019 May;104(5):605-616. doi: 10.1113/EP086204. Epub 2019 Mar 18.


Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury.

Neves KB, Rios FJ, Jones R, Evans TRJ, Montezano AC, Touyz RM.

Cardiovasc Res. 2019 Apr 15;115(5):978-988. doi: 10.1093/cvr/cvz021.


Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress.

Bruder-Nascimento T, Callera GE, Montezano AC, Belin de Chantemele EJ, Tostes RC, Touyz RM.

Life Sci. 2019 Mar 15;221:29-34. doi: 10.1016/j.lfs.2019.01.043. Epub 2019 Feb 2.


Small-Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need, and Future Directions.

Berry C, Sidik N, Pereira AC, Ford TJ, Touyz RM, Kaski JC, Hainsworth AH.

J Am Heart Assoc. 2019 Feb 5;8(3):e011104. doi: 10.1161/JAHA.118.011104. No abstract available.


Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study.

Corcoran D, Ford TJ, Hsu LY, Chiribiri A, Orchard V, Mangion K, McEntegart M, Rocchiccioli P, Watkins S, Good R, Brooksbank K, Padmanabhan S, Sattar N, McConnachie A, Oldroyd KG, Touyz RM, Arai A, Berry C.

Open Heart. 2018 Dec 30;5(2):e000924. doi: 10.1136/openhrt-2018-000924. eCollection 2018.


Aldosterone and Ion Channels.

Valinsky WC, Touyz RM, Shrier A.

Vitam Horm. 2019;109:105-131. doi: 10.1016/bs.vh.2018.10.004. Epub 2018 Dec 1. Review.


Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.


Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema.

Rossitto G, Touyz RM, Petrie MC, Delles C.

Clin Sci (Lond). 2018 Dec 13;132(24):2609-2613. doi: 10.1042/CS20180575. Print 2018 Dec 21. Review.


PARP-1 (Poly[ADP-Ribose] Polymerase-1).

Alves-Lopes R, Touyz RM.

Hypertension. 2018 Nov;72(5):1087-1089. doi: 10.1161/HYPERTENSIONAHA.118.11830. No abstract available.


The Meaning of Mas.

Bader M, Alenina N, Young D, Santos RAS, Touyz RM.

Hypertension. 2018 Nov;72(5):1072-1075. doi: 10.1161/HYPERTENSIONAHA.118.10918. Review. No abstract available.


Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease.

Touyz RM, Anagnostopoulou A, Camargo LL, Rios FJ, Montezano AC.

Antioxid Redox Signal. 2019 Mar 1;30(7):1027-1040. doi: 10.1089/ars.2018.7583. Epub 2018 Nov 15.


Stratified Medical Therapy Using Invasive Coronary Function Testing in Angina: The CorMicA Trial.

Ford TJ, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Yii E, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz RM, Oldroyd KG, Berry C.

J Am Coll Cardiol. 2018 Dec 11;72(23 Pt A):2841-2855. doi: 10.1016/j.jacc.2018.09.006. Epub 2018 Sep 25.


Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors.

Dobbin SJH, Cameron AC, Petrie MC, Jones RJ, Touyz RM, Lang NN.

Heart. 2018 Dec;104(24):1995-2002. doi: 10.1136/heartjnl-2018-313726. Epub 2018 Sep 18. Review.


Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways.

Neves KB, Nguyen Dinh Cat A, Alves-Lopes R, Harvey KY, Costa RMD, Lobato NS, Montezano AC, Oliveira AM, Touyz RM, Tostes RC.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1851-H1860. doi: 10.1152/ajpheart.00285.2018. Epub 2018 Sep 14.


Cardiotoxicity with vascular endothelial growth factor inhibitor therapy.

Touyz RM, Herrmann J.

NPJ Precis Oncol. 2018 May 8;2:13. doi: 10.1038/s41698-018-0056-z. eCollection 2018. Review.


Systemic microvascular dysfunction in microvascular and vasospastic angina.

Ford TJ, Rocchiccioli P, Good R, McEntegart M, Eteiba H, Watkins S, Shaukat A, Lindsay M, Robertson K, Hood S, Yii E, Sidik N, Harvey A, Montezano AC, Beattie E, Haddow L, Oldroyd KG, Touyz RM, Berry C.

Eur Heart J. 2018 Dec 7;39(46):4086-4097. doi: 10.1093/eurheartj/ehy529.


Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice.

Neves KB, Montezano AC, Alves-Lopes R, Bruder-Nascimento T, Costa RM, Costa RS, Touyz RM, Tostes RC.

Int J Mol Sci. 2018 Aug 19;19(8). pii: E2454. doi: 10.3390/ijms19082454.


Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study.

Kerr DMI, Brooksbank KJM, Taylor RG, Pinel K, Rios FJ, Touyz RM, Delles C.

J Hypertens. 2019 Jan;37(1):154-166. doi: 10.1097/HJH.0000000000001890.


Are the American Heart Association/American College of Cardiology High Blood Pressure Guidelines Fit for Global Purpose?: Thoughts From the International Society of Hypertension.

Poulter NR, Castillo R, Charchar FJ, Schlaich MP, Schutte AE, Tomaszewski M, Touyz RM, Wang JG.

Hypertension. 2018 Aug;72(2):260-262. doi: 10.1161/HYPERTENSIONAHA.118.11452. Epub 2018 Jul 2. Review. No abstract available.


NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function.

Montezano AC, De Lucca Camargo L, Persson P, Rios FJ, Harvey AP, Anagnostopoulou A, Palacios R, Gandara ACP, Alves-Lopes R, Neves KB, Dulak-Lis M, Holterman CE, de Oliveira PL, Graham D, Kennedy C, Touyz RM.

J Am Heart Assoc. 2018 Jun 15;7(12). pii: e009388. doi: 10.1161/JAHA.118.009388.


Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension.

Camargo LL, Harvey AP, Rios FJ, Tsiropoulou S, Da Silva RNO, Cao Z, Graham D, McMaster C, Burchmore RJ, Hartley RC, Bulleid N, Montezano AC, Touyz RM.

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.


Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events.

Touyz RM, Herrmann SMS, Herrmann J.

J Am Soc Hypertens. 2018 Jun;12(6):409-425. doi: 10.1016/j.jash.2018.03.008. Epub 2018 Mar 21. Review.


Resistant Hypertension: Trials and Tribulations.

George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A.

Hypertension. 2018 May;71(5):772-780. doi: 10.1161/HYPERTENSIONAHA.118.10864. Epub 2018 Apr 2. Review. No abstract available.


Case of Severe Hypertension and Nephrotic Range Proteinuria.

Bursztyn M, Touyz RM, Laffer CL, Carey RM, Dominiczak AF.

Hypertension. 2018 Jun;71(6):956-961. doi: 10.1161/HYPERTENSIONAHA.118.11045. Epub 2018 Apr 2. No abstract available.


Management of a Pregnant Woman With Fibromuscular Dysplasia.

Berra E, Dominiczak AF, Touyz RM, Pierard S, Hammer F, Rossi GP, Micali RG, Staessen JA, Bursztyn M, Kahan T, Persu A.

Hypertension. 2018 Apr;71(4):540-547. doi: 10.1161/HYPERTENSIONAHA.118.10819. Epub 2018 Feb 26. No abstract available.


VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes.

Neves KB, Rios FJ, van der Mey L, Alves-Lopes R, Cameron AC, Volpe M, Montezano AC, Savoia C, Touyz RM.

Hypertension. 2018 Apr;71(4):638-647. doi: 10.1161/HYPERTENSIONAHA.117.10490. Epub 2018 Feb 26.


High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.

Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S.

Front Physiol. 2018 Feb 9;9:51. doi: 10.3389/fphys.2018.00051. eCollection 2018.


Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms.

Petrie JR, Guzik TJ, Touyz RM.

Can J Cardiol. 2018 May;34(5):575-584. doi: 10.1016/j.cjca.2017.12.005. Epub 2017 Dec 11. Review.


Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension.

Jae SY, Bunsawat K, Choi YH, Kim YS, Touyz RM, Park JB, Franklin BA.

J Clin Hypertens (Greenwich). 2018 Mar;20(3):551-556. doi: 10.1111/jch.13219. Epub 2018 Feb 19.


Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling.

Nguyen Dinh Cat A, Callera GE, Friederich-Persson M, Sanchez A, Dulak-Lis MG, Tsiropoulou S, Montezano AC, He Y, Briones AM, Jaisser F, Touyz RM.

Sci Rep. 2018 Feb 13;8(1):2952. doi: 10.1038/s41598-018-21087-5.


Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary Aldosteronism.

Liu P, Zhang S, Gao J, Lin Y, Shi G, He W, Touyz RM, Yan L, Huang H.

Hypertension. 2018 Apr;71(4):592-598. doi: 10.1161/HYPERTENSIONAHA.117.10644. Epub 2018 Feb 12.


Vascular smooth muscle contraction in hypertension.

Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC.

Cardiovasc Res. 2018 Mar 15;114(4):529-539. doi: 10.1093/cvr/cvy023.


Aldosterone, SGK1, and ion channels in the kidney.

Valinsky WC, Touyz RM, Shrier A.

Clin Sci (Lond). 2018 Jan 19;132(2):173-183. doi: 10.1042/CS20171525. Print 2018 Jan 31. Review.


Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction.

Silva SD Jr, Jara ZP, Peres R, Lima LS, Scavone C, Montezano AC, Touyz RM, Casarini DE, Michelini LC.

PLoS One. 2017 Dec 12;12(12):e0189535. doi: 10.1371/journal.pone.0189535. eCollection 2017.


Angiotensin-(1-7) and Vascular Function: The Clinical Context.

Touyz RM, Montezano AC.

Hypertension. 2018 Jan;71(1):68-69. doi: 10.1161/HYPERTENSIONAHA.117.10406. Epub 2017 Dec 4. No abstract available. Erratum in: Hypertension. 2018 Mar;71(3):e9.


Hypertension Editors Welcome Comments From Regional Hypertension Societies.

Dominiczak AF, Touyz RM.

Hypertension. 2018 Jun;71(6):962. doi: 10.1161/HYPERTENSIONAHA.117.10427. Epub 2017 Nov 13. No abstract available.


Magnesium and Other Biometals in Oxidative Medicine and Redox Biology.

Kolisek M, Touyz RM, Romani A, Barbagallo M.

Oxid Med Cell Longev. 2017;2017:7428796. doi: 10.1155/2017/7428796. Epub 2017 Oct 4. No abstract available.


Personalized medicine-a modern approach for the diagnosis and management of hypertension.

Savoia C, Volpe M, Grassi G, Borghi C, Agabiti Rosei E, Touyz RM.

Clin Sci (Lond). 2017 Nov 6;131(22):2671-2685. doi: 10.1042/CS20160407. Print 2017 Nov 15. Review.


Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.

Redox Biol. 2018 Apr;14:694-696. doi: 10.1016/j.redox.2017.10.001. Epub 2017 Oct 26. No abstract available.


Interleukin-18 Enhances Vascular Calcification and Osteogenic Differentiation of Vascular Smooth Muscle Cells Through TRPM7 Activation.

Zhang K, Zhang Y, Feng W, Chen R, Chen J, Touyz RM, Wang J, Huang H.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1933-1943. doi: 10.1161/ATVBAHA.117.309161. Epub 2017 Aug 31.


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