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Prevalence and loads of torquetenovirus (TTV) in the European MARK-AGE Study population.

Giacconi R, Maggi F, Macera L, Spezia PG, Pistello M, Provinciali M, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Dudkowska M, Janiszewska D, Toussaint O, Chainiaux FD, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2019 Dec 15. pii: glz293. doi: 10.1093/gerona/glz293. [Epub ahead of print]


Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Pinchuk I, Weber D, Kochlik B, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen EHJM, Gonos ES, Sikora E, Breusing N, Gradinaru D, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T, Lichtenberg D.

Redox Biol. 2019 Jun;24:101204. doi: 10.1016/j.redox.2019.101204. Epub 2019 Apr 15.


Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET.

Mech Ageing Dev. 2019 Jan;177:135-143. doi: 10.1016/j.mad.2018.04.007. Epub 2018 Apr 30.


Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753. doi: 10.1093/gerona/glx192.


Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study.

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B.

Exp Gerontol. 2018 May;105:109-112. doi: 10.1016/j.exger.2017.08.037. Epub 2017 Oct 7.


Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project.

Weber D, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen E, Gonos ES, Franceschi C, Sikora E, Hervonen A, Breusing N, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T.

Oxid Med Cell Longev. 2017;2017:1401452. doi: 10.1155/2017/1401452. Epub 2017 Jul 19.


Role of Prion protein in premature senescence of human fibroblasts.

Boilan E, Winant V, Dumortier E, ElMoualij B, Quatresooz P, Osiewacz HD, Debacq-Chainiaux F, Toussaint O.

Mech Ageing Dev. 2018 Mar;170:106-113. doi: 10.1016/j.mad.2017.08.002. Epub 2017 Aug 8.


Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles.

Piret JP, Bondarenko OM, Boyles MSP, Himly M, Ribeiro AR, Benetti F, Smal C, Lima B, Potthoff A, Simion M, Dumortier E, Leite PEC, Balottin LB, Granjeiro JM, Ivask A, Kahru A, Radauer-Preiml I, Tischler U, Duschl A, Saout C, Anguissola S, Haase A, Jacobs A, Nelissen I, Misra SK, Toussaint O.

Arch Toxicol. 2017 Jun;91(6):2315-2330. doi: 10.1007/s00204-016-1897-2. Epub 2016 Dec 10.


Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.

Stuetz W, Weber D, Dollé ME, Jansen E, Grubeck-Loebenstein B, Fiegl S, Toussaint O, Bernhardt J, Gonos ES, Franceschi C, Sikora E, Moreno-Villanueva M, Breusing N, Grune T, Bürkle A.

Nutrients. 2016 Sep 30;8(10). pii: E614.


Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study.

Valentini E, Zampieri M, Malavolta M, Bacalini MG, Calabrese R, Guastafierro T, Reale A, Franceschi C, Hervonen A, Koller B, Bernhardt J, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé ME, Moreno-Villanueva M, Sindlinger T, Bürkle A, Ciccarone F, Caiafa P.

Aging (Albany NY). 2016 Aug 29;8(9):1896-1922. doi: 10.18632/aging.101022.


Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.

Ciccarone F, Malavolta M, Calabrese R, Guastafierro T, Bacalini MG, Reale A, Franceschi C, Capri M, Hervonen A, Hurme M, Grubeck-Loebenstein B, Koller B, Bernhardt J, Schӧn C, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé M, Moreno-Villanueva M, Sindlinger T, Bürkle A, Zampieri M, Caiafa P.

Aging Cell. 2016 Aug;15(4):755-65. doi: 10.1111/acel.12485. Epub 2016 May 11.


Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation.

Contado C, Mejia J, Lozano García O, Piret JP, Dumortier E, Toussaint O, Lucas S.

Anal Bioanal Chem. 2016 Jan;408(1):271-86. doi: 10.1007/s00216-015-9101-8. Epub 2015 Oct 27.


Quality control data of physiological and immunological biomarkers measured in serum and plasma.

Jansen E, Beekhof P, Cremers J, Weinberger B, Fiegl S, Toussaint O, Bernhard J, Gonos E, Capri M, Franceschi C, Sikora E, Moreno-Villanueva M, Breusing N, Grune T, Bürkle A, Dollé ME.

Mech Ageing Dev. 2015 Nov;151:54-9. doi: 10.1016/j.mad.2015.06.004. Epub 2015 Jul 9.


Novel ageing-biomarker discovery using data-intensive technologies.

Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O.

Mech Ageing Dev. 2015 Nov;151:114-21. doi: 10.1016/j.mad.2015.05.010. Epub 2015 Jun 6. Review.


MARK-AGE population: From the human model to new insights.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craen AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C.

Mech Ageing Dev. 2015 Nov;151:13-7. doi: 10.1016/j.mad.2015.03.010. Epub 2015 Apr 2. Review. No abstract available.


MARK-AGE biomarkers of ageing.

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.

Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24. Review.


Can TiC nanoparticles produce toxicity in oral administration to rats?

Laloy J, Lozano O, Alpan L, Mejia J, Toussaint O, Masereel B, Dogné JM, Lucas S.

Toxicol Rep. 2014 May 12;1:172-187. doi: 10.1016/j.toxrep.2014.03.004. eCollection 2014.


Impact of Silver Nanoparticles on Haemolysis, Platelet Function and Coagulation.

Laloy J, Minet V, Alpan L, Mullier F, Beken S, Toussaint O, Lucas S, Dogné JM.

Nanobiomedicine (Rij). 2014 Jan 1;1:4. doi: 10.5772/59346. eCollection 2014 Jan-Dec.


The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.

Raule N, Sevini F, Li S, Barbieri A, Tallaro F, Lomartire L, Vianello D, Montesanto A, Moilanen JS, Bezrukov V, Blanché H, Hervonen A, Christensen K, Deiana L, Gonos ES, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Eline Slagboom P, Spazzafumo L, Antonietta Stazi M, Toussaint O, Vaupel JW, Rose G, Majamaa K, Perola M, Johnson TE, Bolund L, Yang H, Passarino G, Franceschi C.

Aging Cell. 2014 Jun;13(3):401-7. doi: 10.1111/acel.12186. Epub 2013 Dec 17. Erratum in: Aging Cell. 2015 Oct;14(5):919.


High-resolution quantitative metabolome analysis of urine by automated flow injection NMR.

Da Silva L, Godejohann M, Martin FP, Collino S, Bürkle A, Moreno-Villanueva M, Bernhardt J, Toussaint O, Grubeck-Loebenstein B, Gonos ES, Sikora E, Grune T, Breusing N, Franceschi C, Hervonen A, Spraul M, Moco S.

Anal Chem. 2013 Jun 18;85(12):5801-9. doi: 10.1021/ac4004776. Epub 2013 May 29.


Role of p38MAPK and oxidative stress in copper-induced senescence.

Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O.

Age (Dordr). 2013 Dec;35(6):2255-71. doi: 10.1007/s11357-013-9521-3. Epub 2013 Apr 12.


A comparison of six major platelet functional tests to assess the impact of carbon nanomaterials on platelet function: a practical guide.

Laloy J, Mullier F, Alpan L, Mejia J, Lucas S, Chatelain B, Toussaint O, Masereel B, Rolin S, Dogné JM.

Nanotoxicology. 2014 Mar;8(2):220-32. doi: 10.3109/17435390.2013.788750. Epub 2013 Apr 15.


UV, stress and aging.

Debacq-Chainiaux F, Leduc C, Verbeke A, Toussaint O.

Dermatoendocrinol. 2012 Jul 1;4(3):236-40. doi: 10.4161/derm.23652.


Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice.

Neyrinck AM, Van Hée VF, Piront N, De Backer F, Toussaint O, Cani PD, Delzenne NM.

Nutr Diabetes. 2012 Jan 23;2:e28. doi: 10.1038/nutd.2011.24.


Copper(II) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response.

Piret JP, Jacques D, Audinot JN, Mejia J, Boilan E, Noël F, Fransolet M, Demazy C, Lucas S, Saout C, Toussaint O.

Nanoscale. 2012 Nov 21;4(22):7168-84. doi: 10.1039/c2nr31785k.


Effects of SiC nanoparticles orally administered in a rat model: biodistribution, toxicity and elemental composition changes in feces and organs.

Lozano O, Laloy J, Alpan L, Mejia J, Rolin S, Toussaint O, Dogné JM, Lucas S, Masereel B.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):232-45. doi: 10.1016/j.taap.2012.08.004. Epub 2012 Aug 15.


Quantification of nanoparticles in aqueous food matrices using Particle-Induced X-ray Emission.

Lozano O, Mejia J, Tabarrant T, Masereel B, Dogné JM, Toussaint O, Lucas S.

Anal Bioanal Chem. 2012 Jul;403(10):2835-41. doi: 10.1007/s00216-012-5895-9. Epub 2012 Mar 13. Erratum in: Anal Bioanal Chem. 2012 Aug;404(2):623.


Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape.

Piret JP, Vankoningsloo S, Mejia J, Noël F, Boilan E, Lambinon F, Zouboulis CC, Masereel B, Lucas S, Saout C, Toussaint O.

Nanotoxicology. 2012 Nov;6(7):789-803. doi: 10.3109/17435390.2011.625127. Epub 2011 Oct 24.


Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal Caco-2 cell model.

Hollebeeck S, Raas T, Piront N, Schneider YJ, Toussaint O, Larondelle Y, During A.

Toxicol Lett. 2011 Oct 30;206(3):268-75. doi: 10.1016/j.toxlet.2011.08.010. Epub 2011 Aug 22.


Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium.

Exp Gerontol. 2011 Nov;46(11):934-45. doi: 10.1016/j.exger.2011.08.005. Epub 2011 Aug 16.


Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs.

Lozano O, Mejia J, Masereel B, Toussaint O, Lison D, Lucas S.

Nanotoxicology. 2012 May;6(3):263-71. doi: 10.3109/17435390.2011.572301. Epub 2011 Apr 20.


Validation of the calibrated thrombin generation test (cTGT) as the reference assay to evaluate the procoagulant activity of nanomaterials.

Laloy J, Robert S, Marbehant C, Mullier F, Mejia J, Piret JP, Lucas S, Chatelain B, Dogné JM, Toussaint O, Masereel B, Rolin S.

Nanotoxicology. 2012 Mar;6(2):213-32. doi: 10.3109/17435390.2011.569096. Epub 2011 Apr 13.


Pro-inflammatory effects of different MWCNTs dispersions in p16(INK4A)-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized sebocytes.

Vankoningsloo S, Piret JP, Saout C, Noel F, Mejia J, Coquette A, Zouboulis CC, Delhalle J, Lucas S, Toussaint O.

Nanotoxicology. 2012 Feb;6(1):77-93. doi: 10.3109/17435390.2011.558642. Epub 2011 Feb 28.


Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture.

Vo TK, de Saint-Hubert M, Morrhaye G, Godard P, Geenen V, Martens HJ, Debacq-Chainiaux F, Swine C, Toussaint O.

Mech Ageing Dev. 2011 Mar;132(3):131-9. doi: 10.1016/j.mad.2011.02.002. Epub 2011 Feb 16.


Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ, Toussaint O.

Exp Gerontol. 2011 Apr;46(4):257-64. doi: 10.1016/j.exger.2010.10.012. Epub 2010 Nov 11.


p38(MAPK) in the senescence of human and murine fibroblasts.

Debacq-Chainiaux F, Boilan E, Dedessus Le Moutier J, Weemaels G, Toussaint O.

Adv Exp Med Biol. 2010;694:126-37. Review.


Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.

Toussaint O, Weemaels G, Debacq-Chainiaux F, Scharffetter-Kochanek K, Wlaschek M.

J Cell Physiol. 2011 Feb;226(2):315-21. doi: 10.1002/jcp.22416. Review.


Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium.

Sergent T, Piront N, Meurice J, Toussaint O, Schneider YJ.

Chem Biol Interact. 2010 Dec 5;188(3):659-67. doi: 10.1016/j.cbi.2010.08.007.


Serum N-glycan profile shift during human ageing.

Vanhooren V, Dewaele S, Libert C, Engelborghs S, De Deyn PP, Toussaint O, Debacq-Chainiaux F, Poulain M, Glupczynski Y, Franceschi C, Jaspers K, van der Pluijm I, Hoeijmakers J, Chen CC.

Exp Gerontol. 2010 Oct;45(10):738-43. doi: 10.1016/j.exger.2010.08.009. Epub 2010 Aug 27.


Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: effects of sonication, dispersive agents and corneous layer of reconstructed epidermis.

Vankoningsloo S, Piret JP, Saout C, Noel F, Mejia J, Zouboulis CC, Delhalle J, Lucas S, Toussaint O.

Nanotoxicology. 2010 Mar;4(1):84-97. doi: 10.3109/17435390903428869.


Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Swine C, Geenen V, Martens HJ, Debacq-Chainiaux F, Toussaint O.

Immun Ageing. 2010 Aug 17;7:9. doi: 10.1186/1742-4933-7-9.


Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells.

Van De Walle J, During A, Piront N, Toussaint O, Schneider YJ, Larondelle Y.

Toxicol In Vitro. 2010 Oct;24(7):1890-8. doi: 10.1016/j.tiv.2010.07.008. Epub 2010 Jul 13.


Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor.

Bertrand-Vallery V, Belot N, Dieu M, Delaive E, Ninane N, Demazy C, Raes M, Salmon M, Poumay Y, Debacq-Chainiaux F, Toussaint O.

PLoS One. 2010 May 3;5(5):e10462. doi: 10.1371/journal.pone.0010462.


Serum IL-6 and IGF-1 improve clinical prediction of functional decline after hospitalization in older patients.

de Saint-Hubert M, Jamart J, Morrhaye G, Martens HJ, Geenen V, Duy Vo TK, Toussaint O, Swine C.

Aging Clin Exp Res. 2011 Apr;23(2):106-11. doi: 10.3275/7028. Epub 2010 May 6.


Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis.

De Walle JV, Sergent T, Piront N, Toussaint O, Schneider YJ, Larondelle Y.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):291-8. doi: 10.1016/j.taap.2010.03.012. Epub 2010 Apr 1.


Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O.

Nat Protoc. 2009;4(12):1798-806. doi: 10.1038/nprot.2009.191.


Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA.

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Bauwens E, Debacq-Chainiaux F, Glupczynski Y, Swine C, Geenen V, Martens HJ, Toussaint O.

Exp Gerontol. 2010 Mar;45(3):188-94. doi: 10.1016/j.exger.2009.12.001. Epub 2009 Dec 6.


Eco-, geno- and human toxicology of bio-active nanoparticles for biomedical applications.

Robbens J, Vanparys C, Nobels I, Blust R, Van Hoecke K, Janssen C, De Schamphelaere K, Roland K, Blanchard G, Silvestre F, Gillardin V, Kestemont P, Anthonissen R, Toussaint O, Vankoningsloo S, Saout C, Alfaro-Moreno E, Hoet P, Gonzalez L, Dubruel P, Troisfontaines P.

Toxicology. 2010 Mar 10;269(2-3):170-81. doi: 10.1016/j.tox.2009.11.002. Epub 2009 Nov 26.


Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16(INK-4A).

Bertrand-Vallery V, Boilan E, Ninane N, Demazy C, Friguet B, Toussaint O, Poumay Y, Debacq-Chainiaux F.

Biogerontology. 2010 Apr;11(2):167-81. doi: 10.1007/s10522-009-9238-y. Epub 2009 Jun 24.


Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts.

Scheckhuber CQ, Grief J, Boilan E, Luce K, Debacq-Chainiaux F, Rittmeyer C, Gredilla R, Kolbesen BO, Toussaint O, Osiewacz HD.

PLoS One. 2009;4(3):e4919. doi: 10.1371/journal.pone.0004919. Epub 2009 Mar 23.

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