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Items: 20

1.

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.

Levell JR, Caferro T, Chenail G, Dix I, Dooley J, Firestone B, Fortin PD, Giraldes J, Gould T, Growney JD, Jones MD, Kulathila R, Lin F, Liu G, Mueller A, van der Plas S, Slocum K, Smith T, Terranova R, Touré BB, Tyagi V, Wagner T, Xie X, Xu M, Yang FS, Zhou LX, Pagliarini R, Cho YS.

ACS Med Chem Lett. 2016 Dec 16;8(2):151-156. doi: 10.1021/acsmedchemlett.6b00334. eCollection 2017 Feb 9.

2.

"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.

Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K, Yuan Y, Shao W, Touré BB.

J Med Chem. 2017 Mar 9;60(5):2155-2161. doi: 10.1021/acs.jmedchem.7b00033. Epub 2017 Feb 24.

PMID:
28186750
3.

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.

Xie X, Baird D, Bowen K, Capka V, Chen J, Chenail G, Cho Y, Dooley J, Farsidjani A, Fortin P, Kohls D, Kulathila R, Lin F, McKay D, Rodrigues L, Sage D, Touré BB, van der Plas S, Wright K, Xu M, Yin H, Levell J, Pagliarini RA.

Structure. 2017 Mar 7;25(3):506-513. doi: 10.1016/j.str.2016.12.017. Epub 2017 Jan 26.

4.

Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.

Genovino J, Sames D, Hamann LG, Touré BB.

Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14218-14238. doi: 10.1002/anie.201602644. Epub 2016 Oct 10. Review.

PMID:
27723189
5.

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W.

J Med Chem. 2016 May 26;59(10):4711-23. doi: 10.1021/acs.jmedchem.6b00052. Epub 2016 May 17.

PMID:
27187609
6.

Complementation of biotransformations with chemical C-H oxidation: copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals.

Genovino J, Lütz S, Sames D, Touré BB.

J Am Chem Soc. 2013 Aug 21;135(33):12346-52. doi: 10.1021/ja405471h. Epub 2013 Aug 12.

PMID:
23875728
7.

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

Shultz MD, Cheung AK, Kirby CA, Firestone B, Fan J, Chen CH, Chen Z, Chin DN, Dipietro L, Fazal A, Feng Y, Fortin PD, Gould T, Lagu B, Lei H, Lenoir F, Majumdar D, Ochala E, Palermo MG, Pham L, Pu M, Smith T, Stams T, Tomlinson RC, Touré BB, Visser M, Wang RM, Waters NJ, Shao W.

J Med Chem. 2013 Aug 22;56(16):6495-511. doi: 10.1021/jm400807n. Epub 2013 Aug 13.

PMID:
23844574
8.

The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.

Touré BB, Miller-Moslin K, Yusuff N, Perez L, Doré M, Joud C, Michael W, DiPietro L, van der Plas S, McEwan M, Lenoir F, Hoe M, Karki R, Springer C, Sullivan J, Levine K, Fiorilla C, Xie X, Kulathila R, Herlihy K, Porter D, Visser M.

ACS Med Chem Lett. 2013 Jan 4;4(2):186-90. doi: 10.1021/ml300321d. eCollection 2013 Feb 14.

9.

Lipophilic Isosteres of a π-π Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction.

Yusuff N, Doré M, Joud C, Visser M, Springer C, Xie X, Herlihy K, Porter D, Touré BB.

ACS Med Chem Lett. 2012 May 27;3(7):579-83. doi: 10.1021/ml300095a. eCollection 2012 Jul 12.

10.

Synthesis of sterically hindered enamides via a Ti-mediated condensation of amides with aldehydes and ketones.

Genovino J, Lagu B, Wang Y, Touré BB.

Chem Commun (Camb). 2012 Jul 7;48(53):6735-7. doi: 10.1039/c2cc32538a. Epub 2012 May 29.

PMID:
22643736
12.

Copper-mediated N-heteroarylation of primary sulfonamides: synthesis of mono-N-heteroaryl sulfonamides.

Baffoe J, Hoe MY, Touré BB.

Org Lett. 2010 Apr 2;12(7):1532-5. doi: 10.1021/ol100263r.

PMID:
20196553
13.

Natural product synthesis using multicomponent reaction strategies.

Touré BB, Hall DG.

Chem Rev. 2009 Sep;109(9):4439-86. doi: 10.1021/cr800296p. Review. No abstract available.

PMID:
19480390
14.

Catalytic C-H arylation of SEM-protected azoles with palladium complexes of NHCs and phosphines.

Touré BB, Lane BS, Sames D.

Org Lett. 2006 May 11;8(10):1979-82.

PMID:
16671761
17.
18.

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

Touré BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chrétien M, Seidah NG.

J Biol Chem. 2000 Jan 28;275(4):2349-58.

19.

Enzymic characterization in vitro of recombinant proprotein convertase PC4.

Basak A, Touré BB, Lazure C, Mbikay M, Chrétien M, Seidah NG.

Biochem J. 1999 Oct 1;343 Pt 1:29-37.

20.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1321-6.

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