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Items: 1 to 50 of 69

1.

Identity domains capture individual differences from across the behavioral repertoire.

Forkosh O, Karamihalev S, Roeh S, Alon U, Anpilov S, Touma C, Nussbaumer M, Flachskamm C, Kaplick PM, Shemesh Y, Chen A.

Nat Neurosci. 2019 Dec;22(12):2023-2028. doi: 10.1038/s41593-019-0516-y. Epub 2019 Nov 4.

PMID:
31686022
2.

Role of hypothalamus-pituitary-adrenal axis modulation in the stress-resilient phenotype of DPP4-deficient rats.

Golub Y, Schildbach EM, Touma C, Kratz O, Moll GH, von Hörsten S, Canneva F.

Behav Brain Res. 2019 Jan 1;356:243-249. doi: 10.1016/j.bbr.2018.08.029. Epub 2018 Aug 31.

PMID:
30176267
3.

Social stress shortens lifespan in mice.

Razzoli M, Nyuyki-Dufe K, Gurney A, Erickson C, McCallum J, Spielman N, Marzullo M, Patricelli J, Kurata M, Pope EA, Touma C, Palme R, Largaespada DA, Allison DB, Bartolomucci A.

Aging Cell. 2018 Aug;17(4):e12778. doi: 10.1111/acel.12778. Epub 2018 May 28.

4.

Impact of male presence on female sociality and stress endocrinology in wild house mice (Mus musculus domesticus).

Weidt A, Gygax L, Palme R, Touma C, König B.

Physiol Behav. 2018 May 15;189:1-9. doi: 10.1016/j.physbeh.2018.02.039. Epub 2018 Feb 21.

PMID:
29474839
5.

Enriched environment and stress exposure influence splenic B lymphocyte composition.

Gurfein BT, Hasdemir B, Milush JM, Touma C, Palme R, Nixon DF, Darcel N, Hecht FM, Bhargava A.

PLoS One. 2017 Jul 12;12(7):e0180771. doi: 10.1371/journal.pone.0180771. eCollection 2017.

6.

A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.

Touma C, Adams MN, Ashton NW, Mizzi M, El-Kamand S, Richard DJ, Cubeddu L, Gamsjaeger R.

Nucleic Acids Res. 2017 Aug 21;45(14):8609-8620. doi: 10.1093/nar/gkx526.

7.

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases.

Ashton NW, Paquet N, Shirran SL, Bolderson E, Kariawasam R, Touma C, Fallahbaghery A, Gamsjaeger R, Cubeddu L, Botting C, Pollock PM, O'Byrne KJ, Richard DJ.

DNA Repair (Amst). 2017 Jun;54:30-39. doi: 10.1016/j.dnarep.2017.03.006. Epub 2017 Apr 6.

8.

Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity.

McIlwrick S, Pohl T, Chen A, Touma C.

Front Cell Neurosci. 2017 Feb 14;11:9. doi: 10.3389/fncel.2017.00009. eCollection 2017.

9.

Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice.

Surget A, Van Nieuwenhuijzen PS, Heinzmann JM, Knapman A, McIlwrick S, Westphal WP, Touma C, Belzung C.

Neuropharmacology. 2016 Nov;110(Pt A):37-47. doi: 10.1016/j.neuropharm.2016.07.007. Epub 2016 Jul 7.

PMID:
27395785
10.

A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.

Touma C, Kariawasam R, Gimenez AX, Bernardo RE, Ashton NW, Adams MN, Paquet N, Croll TI, O'Byrne KJ, Richard DJ, Cubeddu L, Gamsjaeger R.

Nucleic Acids Res. 2016 Sep 19;44(16):7963-73. doi: 10.1093/nar/gkw617. Epub 2016 Jul 7.

11.

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.

Paquet N, Adams MN, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Leong V, Beard S, Bolderson E, Botting CH, O'Byrne KJ, Richard DJ.

Sci Rep. 2016 Jun 8;6:27446. doi: 10.1038/srep27446.

12.

Backbone (1)H, (13)C and (15)N resonance assignments of the OB domain of the single stranded DNA-binding protein hSSB1 (NABP2/OBFC2B) and chemical shift mapping of the DNA-binding interface.

Kariawasam R, Touma C, Cubeddu L, Gamsjaeger R.

Biomol NMR Assign. 2016 Oct;10(2):297-300. doi: 10.1007/s12104-016-9687-6. Epub 2016 May 18.

PMID:
27193589
13.

Genetic predisposition for high stress reactivity amplifies effects of early-life adversity.

McIlwrick S, Rechenberg A, Matthes M, Burgstaller J, Schwarzbauer T, Chen A, Touma C.

Psychoneuroendocrinology. 2016 Aug;70:85-97. doi: 10.1016/j.psyneuen.2016.04.023. Epub 2016 May 3.

PMID:
27179233
14.

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.

Paquet N, Adams MN, Leong V, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess JT, Bolderson E, O'Byrne KJ, Richard DJ.

Nucleic Acids Res. 2015 Oct 15;43(18):8817-29. doi: 10.1093/nar/gkv790. Epub 2015 Aug 10.

15.

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response.

Hennings JM, Uhr M, Klengel T, Weber P, Pütz B, Touma C, Czamara D, Ising M, Holsboer F, Lucae S.

Transl Psychiatry. 2015 Mar 31;5:e538. doi: 10.1038/tp.2015.9.

16.

A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies.

Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L.

Psychoneuroendocrinology. 2015 Feb;52:43-58. doi: 10.1016/j.psyneuen.2014.11.005. Epub 2014 Nov 11.

PMID:
25459892
17.

Selective inhibitors of the FK506-binding protein 51 by induced fit.

Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F.

Nat Chem Biol. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1.

PMID:
25436518
18.

The structural basis of DNA binding by the single-stranded DNA-binding protein from Sulfolobus solfataricus.

Gamsjaeger R, Kariawasam R, Gimenez AX, Touma C, McIlwain E, Bernardo RE, Shepherd NE, Ataide SF, Dong Q, Richard DJ, White MF, Cubeddu L.

Biochem J. 2015 Jan 15;465(2):337-46. doi: 10.1042/BJ20141140.

PMID:
25367669
19.

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach.

Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Schmidt MV, Palme R, Holsboer F, Uhr M, Ising M, Touma C.

Psychoneuroendocrinology. 2014 Nov;49:229-43. doi: 10.1016/j.psyneuen.2014.07.008. Epub 2014 Jul 23.

PMID:
25123105
20.

Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior.

Sotnikov S, Wittmann A, Bunck M, Bauer S, Deussing J, Schmidt M, Touma C, Landgraf R, Czibere L.

Psychoneuroendocrinology. 2014 Oct;48:41-51. doi: 10.1016/j.psyneuen.2014.06.006. Epub 2014 Jun 17.

PMID:
24995583
21.

Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.

Krohn J, Speed D, Palme R, Touma C, Mott R, Flint J.

PLoS One. 2014 May 8;9(5):e96450. doi: 10.1371/journal.pone.0096450. eCollection 2014.

22.

Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice.

Gurfein BT, Davidenko O, Premenko-Lanier M, Milush JM, Acree M, Dallman MF, Touma C, Palme R, York VA, Fromentin G, Darcel N, Nixon DF, Hecht FM.

Mol Med. 2014 Apr 22;20:179-90. doi: 10.2119/molmed.2013.00158.

23.

Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications.

Grimaldi D, Beccuti G, Touma C, Van Cauter E, Mokhlesi B.

Diabetes Care. 2014 Feb;37(2):355-63. doi: 10.2337/dc13-0933. Epub 2013 Oct 7.

24.

Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity.

Mattos GE, Heinzmann JM, Norkowski S, Helbling JC, Minni AM, Moisan MP, Touma C.

J Endocrinol. 2013 Oct 28;219(3):217-29. doi: 10.1530/JOE-13-0255. Print 2013 Dec.

PMID:
24048966
25.

S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence.

Buschert J, Hohoff C, Touma C, Palme R, Rothermundt M, Arolt V, Zhang W, Ambrée O.

J Psychiatr Res. 2013 Nov;47(11):1791-9. doi: 10.1016/j.jpsychires.2013.08.001. Epub 2013 Aug 22.

PMID:
23972702
26.

Backbone and side-chain ¹H, ¹³C and ¹⁵N resonance assignments of the OB domain of the single stranded DNA binding protein from Sulfolobus solfataricus and chemical shift mapping of the DNA-binding interface.

Gamsjaeger R, Kariawasam R, Touma C, Kwan AH, White MF, Cubeddu L.

Biomol NMR Assign. 2014 Oct;8(2):243-6. doi: 10.1007/s12104-013-9492-4. Epub 2013 Jun 8.

PMID:
23749431
27.

Semiquantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in surface plasmon resonance competition experiments.

Gamsjaeger R, Kariawasam R, Bang LH, Touma C, Nguyen CD, Matthews JM, Cubeddu L, Mackay JP.

Anal Biochem. 2013 Sep 15;440(2):178-85. doi: 10.1016/j.ab.2013.04.030. Epub 2013 May 31.

PMID:
23727560
28.

The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety.

Gonik M, Frank E, Keßler MS, Czamara D, Bunck M, Yen YC, Pütz B, Holsboer F, Bettecken T, Landgraf R, Müller-Myhsok B, Touma C, Czibere L.

BMC Genomics. 2012 Oct 31;13:579. doi: 10.1186/1471-2164-13-579.

29.

Do social statuses affect the startle reflex in male mice?

Coudereau JP, Sreng L, Palme R, Touma C, Pratte M.

Behav Brain Res. 2012 Sep 1;234(1):117-20. doi: 10.1016/j.bbr.2012.06.009. Epub 2012 Jun 20.

PMID:
22728306
30.

Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity.

Pillai AG, de Jong D, Kanatsou S, Krugers H, Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Joëls M, Touma C.

PLoS One. 2012;7(6):e38971. doi: 10.1371/journal.pone.0038971. Epub 2012 Jun 12.

31.

Urocortin 2 modulates aspects of social behaviour in mice.

Breu J, Touma C, Hölter SM, Knapman A, Wurst W, Deussing JM.

Behav Brain Res. 2012 Aug 1;233(2):331-6. doi: 10.1016/j.bbr.2012.05.031. Epub 2012 May 26.

PMID:
22640813
32.

The calm mouse: an animal model of stress reduction.

Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM, Nixon DF.

Mol Med. 2012 May 9;18:606-17. doi: 10.2119/molmed.2012.00053.

33.

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism.

Knapman A, Kaltwasser SF, Martins-de-Souza D, Holsboer F, Landgraf R, Turck CW, Czisch M, Touma C.

Eur J Neurosci. 2012 Feb;35(3):412-22. doi: 10.1111/j.1460-9568.2011.07968.x.

PMID:
22288479
34.

Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice.

Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM.

Cell Mol Neurobiol. 2012 Jul;32(5):815-28. doi: 10.1007/s10571-011-9784-0. Epub 2011 Dec 25.

PMID:
22198557
35.

FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior.

Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T.

Biol Psychiatry. 2011 Nov 15;70(10):928-36. doi: 10.1016/j.biopsych.2011.07.023. Epub 2011 Sep 10.

PMID:
21907973
36.

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM.

Science. 2011 Sep 30;333(6051):1903-7. doi: 10.1126/science.1202107. Epub 2011 Sep 1.

37.

Repeated use of surrogate mothers for embryo transfer in the mouse.

Kolbe T, Palme R, Touma C, Rülicke T.

Biol Reprod. 2012 Jan 30;86(1):1-6. doi: 10.1095/biolreprod.111.092445. Print 2012 Jan.

PMID:
21880946
38.

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.

Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV.

Neuropharmacology. 2012 Jan;62(1):332-9. doi: 10.1016/j.neuropharm.2011.07.041. Epub 2011 Aug 4.

PMID:
21839098
39.

Does lack of sleep cause diabetes?

Touma C, Pannain S.

Cleve Clin J Med. 2011 Aug;78(8):549-58. doi: 10.3949/ccjm.78a.10165. Review.

PMID:
21807927
40.

Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions.

Touma C.

Pharmacopsychiatry. 2011 May;44 Suppl 1:S15-26. doi: 10.1055/s-0031-1271702. Epub 2011 May 4. Review.

PMID:
21544741
41.

Antidepressants recruit new neurons to improve stress response regulation.

Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, Palme R, Griebel G, Ibarguen-Vargas Y, Hen R, Belzung C.

Mol Psychiatry. 2011 Dec;16(12):1177-88. doi: 10.1038/mp.2011.48. Epub 2011 May 3.

42.

Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression.

Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M, Yassouridis A.

BMC Neurosci. 2011 Mar 24;12:29. doi: 10.1186/1471-2202-12-29.

43.

Increased anxiety-related behaviour in Hint1 knockout mice.

Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard Weinstein I, Li H, Holsboer F, Turck CW, Touma C.

Behav Brain Res. 2011 Jul 7;220(2):305-11. doi: 10.1016/j.bbr.2011.02.012. Epub 2011 Feb 21.

PMID:
21316396
44.

Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study.

Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Võikar V, Wolfer DP, Würbel H.

PLoS One. 2011 Jan 31;6(1):e16461. doi: 10.1371/journal.pone.0016461.

45.

Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1.

Edgar NM, Touma C, Palme R, Sibille E.

Transl Psychiatry. 2011 Sep 20;1:e42. doi: 10.1038/tp.2011.40.

46.

Assessment of carprofen and buprenorphine on recovery of mice after surgical removal of the mammary fat pad.

Adamson TW, Kendall LV, Goss S, Grayson K, Touma C, Palme R, Chen JQ, Borowsky AD.

J Am Assoc Lab Anim Sci. 2010 Sep;49(5):610-6.

47.

Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study.

Heinzmann JM, Thoeringer CK, Knapman A, Palme R, Holsboer F, Uhr M, Landgraf R, Touma C.

J Neuroendocrinol. 2010 Nov;22(11):1187-97. doi: 10.1111/j.1365-2826.2010.02062.x.

PMID:
20735798
48.

Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice.

Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Touma C.

Neurobiol Learn Mem. 2010 Sep;94(2):145-52. doi: 10.1016/j.nlm.2010.04.010. Epub 2010 May 6.

PMID:
20451634
49.

Faecal glucocorticoid metabolites: how to express yourself - comparison of absolute amounts versus concentrations in samples from a study in laboratory rats.

Lepschy M, Touma C, Palme R.

Lab Anim. 2010 Jul;44(3):192-8. doi: 10.1258/la.2009.009082. Epub 2010 Jan 13.

PMID:
20071410
50.

Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders.

Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R, Touma C.

J Psychiatr Res. 2010 Jul;44(9):566-75. doi: 10.1016/j.jpsychires.2009.11.014. Epub 2009 Dec 24.

PMID:
20035953

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