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Items: 1 to 50 of 51

1.

Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets.

Doucet MS, Jougleux JL, Poirier SJ, Cormier M, Leger JL, Surette ME, Pichaud N, Touaibia M, Boudreau LH.

Mol Pharmacol. 2018 Nov 7. pii: mol.118.113480. doi: 10.1124/mol.118.113480. [Epub ahead of print]

2.

Development of Mannopyranoside Therapeutics against Adherent-Invasive Escherichia coli Infections.

Mousavifar L, Touaibia M, Roy R.

Acc Chem Res. 2018 Oct 5. doi: 10.1021/acs.accounts.8b00397. [Epub ahead of print]

PMID:
30289687
3.

Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.

D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC.

J Lipid Res. 2018 Oct;59(10):1805-1817. doi: 10.1194/jlr.M082008. Epub 2018 Aug 2.

PMID:
30072447
4.

Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship.

Touaibia M, Hébert MJG, Levesque NA, Doiron JA, Doucet MS, Jean-François J, Cormier M, Boudreau LH, Surette ME.

Chem Biol Drug Des. 2018 Nov;92(5):1876-1887. doi: 10.1111/cbdd.13360. Epub 2018 Jul 18.

PMID:
29953727
5.

Are the Wells Score and the Revised Geneva Score valuable for the diagnosis of pulmonary embolism in pregnancy?

Touhami O, Marzouk SB, Bennasr L, Touaibia M, Souli I, Felfel MA, Kehila M, Channoufi MB, Magherbi HE.

Eur J Obstet Gynecol Reprod Biol. 2018 Feb;221:166-171. doi: 10.1016/j.ejogrb.2017.12.049. Epub 2017 Dec 28.

PMID:
29310042
6.

Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity.

Morin P, St-Coeur PD, Doiron JA, Cormier M, Poitras JJ, Surette ME, Touaibia M.

Molecules. 2017 Jul 6;22(7). pii: E1124. doi: 10.3390/molecules22071124.

7.

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis.

Boudreau LH, Lassalle-Claux G, Cormier M, Blanchard S, Doucet MS, Surette ME, Touaibia M.

Mediators Inflamm. 2017;2017:6904634. doi: 10.1155/2017/6904634. Epub 2017 Jun 7.

8.

Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin.

Touaibia M, Krammer EM, Shiao TC, Yamakawa N, Wang Q, Glinschert A, Papadopoulos A, Mousavifar L, Maes E, Oscarson S, Vergoten G, Lensink MF, Roy R, Bouckaert J.

Molecules. 2017 Jul 3;22(7). pii: E1101. doi: 10.3390/molecules22071101.

9.

Influence of flavonols and quercetin derivative compounds on MA-10 Leydig cells steroidogenic genes expressions.

Cormier M, Ghouili F, Roumaud P, Martin LJ, Touaibia M.

Toxicol In Vitro. 2017 Oct;44:111-121. doi: 10.1016/j.tiv.2017.06.027. Epub 2017 Jun 28.

PMID:
28668616
10.

Influences of flavones on cell viability and cAMP-dependent steroidogenic gene regulation in MA-10 Leydig cells.

Cormier M, Ghouili F, Roumaud P, Bauer W, Touaibia M, Martin LJ.

Cell Biol Toxicol. 2018 Feb;34(1):23-38. doi: 10.1007/s10565-017-9395-8. Epub 2017 Apr 28.

PMID:
28455626
11.

Evaluation of the simplified acute physiology score (SAPS-OB) in critically ill obstetric patients.

Ben Marzouk S, Touaibia M, Achour-Jenayah A, Bennasr L, Shili A, BelHaj Amor H, Maghrebi H.

J Obstet Gynaecol. 2017 Aug;37(6):799-800. doi: 10.1080/01443615.2017.1299699. Epub 2017 Apr 19. No abstract available.

PMID:
28421856
12.

Autotaxin Is Regulated by Glucose and Insulin in Adipocytes.

D'Souza K, Kane DA, Touaibia M, Kershaw EE, Pulinilkunnil T, Kienesberger PC.

Endocrinology. 2017 Apr 1;158(4):791-803. doi: 10.1210/en.2017-00035.

PMID:
28324037
13.

Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors.

Doiron JA, Leblanc LM, Hébert MJ, Levesque NA, Paré AF, Jean-François J, Cormier M, Surette ME, Touaibia M.

Chem Biol Drug Des. 2017 Apr;89(4):514-528. doi: 10.1111/cbdd.12874. Epub 2016 Nov 15.

PMID:
27717142
14.

Effect of O6-Substituted Guanine Analogs on O6-methylguanine DNA-methyltransferase Expression and Glioblastoma Cells Viability.

St-Coeur PD, Cormier M, LeBlanc VC, Morin PJ, Touaibia M.

Med Chem. 2016;13(1):28-39. doi: 10.2174/1573406412666160710210907.

PMID:
27396904
15.

Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors.

Belkaid A, Čuperlović-Culf M, Touaibia M, Ouellette RJ, Surette ME.

Metabolites. 2016 May 26;6(2). pii: E16. doi: 10.3390/metabo6020016.

16.

New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.

Roy PP, D'Souza K, Cuperlovic-Culf M, Kienesberger PC, Touaibia M.

Eur J Med Chem. 2016 Aug 8;118:290-8. doi: 10.1016/j.ejmech.2016.04.021. Epub 2016 Apr 10.

PMID:
27155760
17.

(1)H NMR metabolomics analysis of renal cell carcinoma cells: Effect of VHL inactivation on metabolism.

Cuperlovic-Culf M, Cormier K, Touaibia M, Reyjal J, Robichaud S, Belbraouet M, Turcotte S.

Int J Cancer. 2016 May 15;138(10):2439-49. doi: 10.1002/ijc.29947. Epub 2016 Jan 29.

18.

Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts.

Zhao C, Moreno-Nieves U, Di Battista JA, Fernandes MJ, Touaibia M, Bourgoin SG.

Mediators Inflamm. 2015;2015:436525. doi: 10.1155/2015/436525. Epub 2015 Oct 18.

19.

Chromatographic, NMR and vibrational spectroscopic investigations of astaxanthin esters: application to "Astaxanthin-rich shrimp oil" obtained from processing of Nordic shrimps.

Subramanian B, Thibault MH, Djaoued Y, Pelletier C, Touaibia M, Tchoukanova N.

Analyst. 2015 Nov 7;140(21):7423-33. doi: 10.1039/c5an01261a.

PMID:
26393239
20.

Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.

St-Coeur PD, Poitras JJ, Cuperlovic-Culf M, Touaibia M, Morin P Jr.

J Neurooncol. 2015 Oct;125(1):91-102. doi: 10.1007/s11060-015-1899-6. Epub 2015 Aug 28.

PMID:
26311249
21.

CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells.

Beauregard AP, Harquail J, Lassalle-Claux G, Belbraouet M, Jean-Francois J, Touaibia M, Robichaud GA.

Molecules. 2015 Jul 10;20(7):12576-89. doi: 10.3390/molecules200712576.

22.

Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester.

Hébert MJ, Flewelling AJ, Clark TN, Levesque NA, Jean-François J, Surette ME, Gray CA, Vogels CM, Touaibia M, Westcott SA.

Int J Med Chem. 2015;2015:418362. doi: 10.1155/2015/418362. Epub 2015 Mar 5.

23.

Clicked cinnamic/caffeic esters and amides as radical scavengers and 5-lipoxygenase inhibitors.

Doiron JA, Métayer B, Richard RR, Desjardins D, Boudreau LH, Levesque NA, Jean-François J, Poirier SJ, Surette ME, Touaibia M.

Int J Med Chem. 2014;2014:931756. doi: 10.1155/2014/931756. Epub 2014 Feb 18.

24.

Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide.

Cuperlovic-Culf M, Touaibia M, St-Coeur PD, Poitras J, Morin P, Culf AS.

Metabolites. 2014 Sep 12;4(3):807-30. doi: 10.3390/metabo4030807.

25.

Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH.

Roos G, Wellens A, Touaibia M, Yamakawa N, Geerlings P, Roy R, Wyns L, Bouckaert J.

ACS Med Chem Lett. 2013 Sep 13;4(11):1085-90. doi: 10.1021/ml400269v. eCollection 2013 Nov 14.

26.

Antihypertensive effect of caffeic acid and its analogs through dual renin-angiotensin-aldosterone system inhibition.

Bhullar KS, Lassalle-Claux G, Touaibia M, Rupasinghe HP.

Eur J Pharmacol. 2014 May 5;730:125-32. doi: 10.1016/j.ejphar.2014.02.038. Epub 2014 Mar 11.

PMID:
24631256
27.

Laser beam diffraction at the edge of a film and application to thin film metrology.

Do PA, Touaibia M, Haché A.

Appl Opt. 2013 Aug 20;52(24):5979-84. doi: 10.1364/AO.52.005979.

PMID:
24085002
28.

Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells.

Sanderson JT, Clabault H, Patton C, Lassalle-Claux G, Jean-François J, Paré AF, Hébert MJ, Surette ME, Touaibia M.

Bioorg Med Chem. 2013 Nov 15;21(22):7182-93. doi: 10.1016/j.bmc.2013.08.057. Epub 2013 Sep 6.

PMID:
24080105
29.

¹H NMR metabolomics analysis of the effect of dichloroacetate and allopurinol on breast cancers.

Lefort N, Brown A, Lloyd V, Ouellette R, Touaibia M, Culf AS, Cuperlovic-Culf M.

J Pharm Biomed Anal. 2014 May;93:77-85. doi: 10.1016/j.jpba.2013.08.017. Epub 2013 Sep 8.

PMID:
24074721
30.

Leveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomas.

St-Coeur PD, Touaibia M, Cuperlovic-Culf M, Morin P Jr.

Genomics Proteomics Bioinformatics. 2013 Aug;11(4):199-206. doi: 10.1016/j.gpb.2013.04.003. Epub 2013 Jun 1. Review.

31.

NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas.

Morin P Jr, Ferguson D, LeBlanc LM, Hébert MJ, Paré AF, Jean-François J, Surette ME, Touaibia M, Cuperlovic-Culf M.

J Proteome Res. 2013 May 3;12(5):2165-76. doi: 10.1021/pr400026q. Epub 2013 Apr 22.

PMID:
23557402
32.

PF-8380 and closely related analogs: synthesis and structure-activity relationship towards autotaxin inhibition and glioma cell viability.

St-Cœur PD, Ferguson D, Morin P Jr, Touaibia M.

Arch Pharm (Weinheim). 2013 Feb;346(2):91-7. doi: 10.1002/ardp.201200395. Epub 2013 Jan 8.

PMID:
23300119
33.

Synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues.

LeBlanc LM, Paré AF, Jean-François J, Hébert MJ, Surette ME, Touaibia M.

Molecules. 2012 Dec 10;17(12):14637-50. doi: 10.3390/molecules171214637.

34.

Targeting the latest hallmark of cancer: another attempt at 'magic bullet' drugs targeting cancers' metabolic phenotype.

Cuperlovic-Culf M, Culf AS, Touaibia M, Lefort N.

Future Oncol. 2012 Oct;8(10):1315-30. doi: 10.2217/fon.12.121. Review.

PMID:
23130930
35.

The tyrosine gate as a potential entropic lever in the receptor-binding site of the bacterial adhesin FimH.

Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J.

Biochemistry. 2012 Jun 19;51(24):4790-9. doi: 10.1021/bi300251r. Epub 2012 Jun 7.

PMID:
22657089
36.

1H NMR metabolomics analysis of glioblastoma subtypes: correlation between metabolomics and gene expression characteristics.

Cuperlovic-Culf M, Ferguson D, Culf A, Morin P Jr, Touaibia M.

J Biol Chem. 2012 Jun 8;287(24):20164-75. doi: 10.1074/jbc.M111.337196. Epub 2012 Apr 23.

37.

Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.

Boudreau LH, Maillet J, LeBlanc LM, Jean-François J, Touaibia M, Flamand N, Surette ME.

PLoS One. 2012;7(2):e31833. doi: 10.1371/journal.pone.0031833. Epub 2012 Feb 9.

38.

Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors.

Doiron J, Soultan AH, Richard R, Touré MM, Picot N, Richard R, Cuperlović-Culf M, Robichaud GA, Touaibia M.

Eur J Med Chem. 2011 Sep;46(9):4010-24. doi: 10.1016/j.ejmech.2011.05.074. Epub 2011 Jun 12.

PMID:
21703734
39.

Caffeic Acid, a versatile pharmacophore: an overview.

Touaibia M, Jean-François J, Doiron J.

Mini Rev Med Chem. 2011 Jul;11(8):695-713. Review.

PMID:
21679136
40.

Synthesis of 17 alpha-substituted ethynylestradiols: potential ligands for drug vectors.

Yaya AR, Touaibia M, Massarweh G, Rochon FD, Breau L.

Steroids. 2010 Jul;75(7):489-98. doi: 10.1016/j.steroids.2010.03.004. Epub 2010 Mar 17.

PMID:
20302883
41.

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.

Doiron J, Boudreau LH, Picot N, Villebonet B, Surette ME, Touaibia M.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1118-21. doi: 10.1016/j.bmcl.2008.12.108. Epub 2009 Jan 3.

PMID:
19152786
42.
43.

Glycodendrimers as anti-adhesion drugs against type 1 fimbriated E. coli uropathogenic infections.

Touaibia M, Roy R.

Mini Rev Med Chem. 2007 Dec;7(12):1270-83. Review.

PMID:
18220979
44.

Glycosylation of HIV-1 gp120 V3 loop: towards the rational design of a synthetic carbohydrate vaccine.

Sirois S, Touaibia M, Chou KC, Roy R.

Curr Med Chem. 2007;14(30):3232-42. Review.

PMID:
18220757
45.
46.

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines.

Boukli L, Touaibia M, Meddad-Belhabich N, Djimdé A, Park CH, Kim JJ, Yoon JH, Lamouri A, Heymans F.

Bioorg Med Chem. 2008 Feb 1;16(3):1242-53. Epub 2007 Nov 13.

PMID:
17993277
47.

Mannosylated G(0) dendrimers with nanomolar affinities to Escherichia coli FimH.

Touaibia M, Wellens A, Shiao TC, Wang Q, Sirois S, Bouckaert J, Roy R.

ChemMedChem. 2007 Aug;2(8):1190-201.

PMID:
17589887
48.

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.

Touaibia M, Djimdé A, Cao F, Boilard E, Bezzine S, Lambeau G, Redeuilh C, Lamouri A, Massicot F, Chau F, Dong CZ, Heymans F.

J Med Chem. 2007 Apr 5;50(7):1618-26. Epub 2007 Mar 3.

PMID:
17335183
49.

Tri- and hexavalent mannoside clusters as potential inhibitors of type 1 fimbriated bacteria using pentaerythritol and triazole linkages.

Touaibia M, Shiao TC, Papadopoulos A, Vaucher J, Wang Q, Benhamioud K, Roy R.

Chem Commun (Camb). 2007 Jan 28;(4):380-2. Epub 2006 Nov 23.

PMID:
17220977
50.

Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata.

Ngameni B, Touaibia M, Patnam R, Belkaid A, Sonna P, Ngadjui BT, Annabi B, Roy R.

Phytochemistry. 2006 Dec;67(23):2573-9. Epub 2006 Oct 30.

PMID:
17070879

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