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Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications.

Totland MZ, Rasmussen NL, Knudsen LM, Leithe E.

Cell Mol Life Sci. 2019 Sep 9. doi: 10.1007/s00018-019-03285-0. [Epub ahead of print] Review.


The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E.

J Cell Sci. 2017 Sep 1;130(17):2867-2882. doi: 10.1242/jcs.202408. Epub 2017 Jul 21.


Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.

Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E.

Cell Cycle. 2016 Nov;15(21):2943-2957. Epub 2016 Sep 13.

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