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Items: 22


Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis.

Velilla J, Marchetti MM, Toth-Petroczy A, Grosgogeat C, Bennett AH, Carmichael N, Estrella E, Darras BT, Frank NY, Krier J, Gaudet R, Gupta VA.

Neurol Genet. 2019 Mar 7;5(2):e312. doi: 10.1212/NXG.0000000000000312. eCollection 2019 Apr.


On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline.

Bilus M, Semanjski M, Mocibob M, Zivkovic I, Cvetesic N, Tawfik DS, Toth-Petroczy A, Macek B, Gruic-Sovulj I.

J Mol Biol. 2019 Mar 15;431(6):1284-1297. doi: 10.1016/j.jmb.2019.01.029. Epub 2019 Jan 31.


Simple yet functional phosphate-loop proteins.

Romero Romero ML, Yang F, Lin YR, Toth-Petroczy A, Berezovsky IN, Goncearenco A, Yang W, Wellner A, Kumar-Deshmukh F, Sharon M, Baker D, Varani G, Tawfik DS.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11943-E11950. doi: 10.1073/pnas.1812400115. Epub 2018 Nov 30.


The EVcouplings Python framework for coevolutionary sequence analysis.

Hopf TA, Green AG, Schubert B, Mersmann S, Schärfe CPI, Ingraham JB, Toth-Petroczy A, Brock K, Riesselman AJ, Palmedo P, Kang C, Sheridan R, Draizen EJ, Dallago C, Sander C, Marks DS.

Bioinformatics. 2019 May 1;35(9):1582-1584. doi: 10.1093/bioinformatics/bty862.


novoCaller: a Bayesian network approach for de novo variant calling from pedigree and population sequence data.

Mohanty AK, Vuzman D, Francioli L, Cassa C; Brigham Genomic Medicine; Undiagnosed Diseases Network; Brigham and Women’s Hospital FaceBase Project, Toth-Petroczy A, Sunyaev S.

Bioinformatics. 2019 Apr 1;35(7):1174-1180. doi: 10.1093/bioinformatics/bty749.


An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.

Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D; Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM).

NPJ Genom Med. 2018 Aug 13;3:21. doi: 10.1038/s41525-018-0060-9. eCollection 2018. Review.


Structured States of Disordered Proteins from Genomic Sequences.

Toth-Petroczy A, Palmedo P, Ingraham J, Hopf TA, Berger B, Sander C, Marks DS.

Cell. 2016 Sep 22;167(1):158-170.e12. doi: 10.1016/j.cell.2016.09.010.


An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors.

Laurino P, Tóth-Petróczy Á, Meana-Pañeda R, Lin W, Truhlar DG, Tawfik DS.

PLoS Biol. 2016 Mar 3;14(3):e1002396. doi: 10.1371/journal.pbio.1002396. eCollection 2016 Mar.


Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations.

Rockah-Shmuel L, Tóth-Petróczy Á, Tawfik DS.

PLoS Comput Biol. 2015 Aug 14;11(8):e1004421. doi: 10.1371/journal.pcbi.1004421. eCollection 2015 Aug.


Correction to disordered proteinaceous machines.

Fuxreiter M, Tóth-Petróczy Á, Kraut DA, Matouschek A, Lim RY, Xue B, Kurgan L, Uversky VN.

Chem Rev. 2015 Apr 8;115(7):2780. doi: 10.1021/acs.chemrev.5b00150. Epub 2015 Mar 26. No abstract available.


The robustness and innovability of protein folds.

Tóth-Petróczy A, Tawfik DS.

Curr Opin Struct Biol. 2014 Jun;26:131-8. doi: 10.1016/ Epub 2014 Jul 17. Review.


Hopeful (protein InDel) monsters?

Tóth-Petróczy A, Tawfik DS.

Structure. 2014 Jun 10;22(6):803-4. doi: 10.1016/j.str.2014.05.013.


Disordered proteinaceous machines.

Fuxreiter M, Tóth-Petróczy Á, Kraut DA, Matouschek A, Lim RY, Xue B, Kurgan L, Uversky VN.

Chem Rev. 2014 Jul 9;114(13):6806-43. doi: 10.1021/cr4007329. Epub 2014 Apr 4. Review. No abstract available. Erratum in: Chem Rev. 2015 Apr 8;115(7):2780. Matouschek, Andreas T [corrected to Matouschek, Andreas].


Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins.

Rockah-Shmuel L, Tóth-Petróczy Á, Sela A, Wurtzel O, Sorek R, Tawfik DS.

PLoS Genet. 2013 Oct;9(10):e1003882. doi: 10.1371/journal.pgen.1003882. Epub 2013 Oct 24.


What makes a protein fold amenable to functional innovation? Fold polarity and stability trade-offs.

Dellus-Gur E, Toth-Petroczy A, Elias M, Tawfik DS.

J Mol Biol. 2013 Jul 24;425(14):2609-21. doi: 10.1016/j.jmb.2013.03.033. Epub 2013 Mar 28.


Protein insertions and deletions enabled by neutral roaming in sequence space.

Tóth-Petróczy A, Tawfik DS.

Mol Biol Evol. 2013 Apr;30(4):761-71. doi: 10.1093/molbev/mst003. Epub 2013 Jan 11.


The origins and evolution of ubiquitination sites.

Hagai T, Tóth-Petróczy Á, Azia A, Levy Y.

Mol Biosyst. 2012 Jul 6;8(7):1865-77. doi: 10.1039/c2mb25052g. Epub 2012 May 15.


Intrinsic disorder in ubiquitination substrates.

Hagai T, Azia A, Tóth-Petróczy Á, Levy Y.

J Mol Biol. 2011 Sep 23;412(3):319-24. doi: 10.1016/j.jmb.2011.07.024. Epub 2011 Jul 23.


Slow protein evolutionary rates are dictated by surface-core association.

Tóth-Petróczy A, Tawfik DS.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11151-6. doi: 10.1073/pnas.1015994108. Epub 2011 Jun 20.


Disordered tails of homeodomains facilitate DNA recognition by providing a trade-off between folding and specific binding.

Tóth-Petróczy A, Simon I, Fuxreiter M, Levy Y.

J Am Chem Soc. 2009 Oct 28;131(42):15084-5. doi: 10.1021/ja9052784.


Malleable machines in transcription regulation: the mediator complex.

Tóth-Petróczy A, Oldfield CJ, Simon I, Takagi Y, Dunker AK, Uversky VN, Fuxreiter M.

PLoS Comput Biol. 2008 Dec;4(12):e1000243. doi: 10.1371/journal.pcbi.1000243. Epub 2008 Dec 19.


Validation of a tentative microsatellite marker for the dopamine D4 receptor gene by capillary gel electrophoresis.

Toth-Petroczy A, Szilagyi A, Ronai Z, Sasvari-Szekely M, Guttman A.

J Chromatogr A. 2006 Oct 20;1130(2):201-5. Epub 2006 May 8.


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