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Items: 17

1.

Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens.

Agarwal S, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB.

J Pharm Sci. 2019 Aug 7. pii: S0022-3549(19)30495-2. doi: 10.1016/j.xphs.2019.08.002. [Epub ahead of print]

2.

Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2.

Hu Y, Toth RT 4th, Joshi SB, Esfandiary R, Middaugh CR, Volkin DB, Weis DD.

J Pharm Sci. 2019 Jun 11. pii: S0022-3549(19)30368-5. doi: 10.1016/j.xphs.2019.06.001. [Epub ahead of print]

PMID:
31195015
3.

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Van Slyke G, Angalakurthi SK, Toth RT 4th, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Immunohorizons. 2018 Sep;2(8):262-273. doi: 10.4049/immunohorizons.1800042.

4.

Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry.

More AS, Toth RT 4th, Okbazghi SZ, Middaugh CR, Joshi SB, Tolbert TJ, Volkin DB, Weis DD.

J Pharm Sci. 2018 Sep;107(9):2315-2324. doi: 10.1016/j.xphs.2018.04.026. Epub 2018 May 8.

5.

Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody.

Toth RT 4th, Pace SE, Mills BJ, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB.

J Pharm Sci. 2018 Apr;107(4):1009-1019. doi: 10.1016/j.xphs.2017.12.009. Epub 2017 Dec 18.

PMID:
29269271
6.

Correction to Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Toth RT 4th, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD.

Anal Chem. 2017 Dec 19;89(24):13673. doi: 10.1021/acs.analchem.7b04690. Epub 2017 Dec 6. No abstract available.

PMID:
29210567
7.

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec.

8.

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant.

Toprani VM, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Middaugh CR, Joshi SB, Volkin DB.

J Pharm Sci. 2017 Dec;106(12):3474-3485. doi: 10.1016/j.xphs.2017.07.019. Epub 2017 Aug 2.

9.

Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Toth RT 4th, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD.

Anal Chem. 2017 Sep 5;89(17):8931-8941. doi: 10.1021/acs.analchem.7b01396. Epub 2017 Aug 11. Erratum in: Anal Chem. 2017 Dec 19;89(24):13673.

PMID:
28753295
10.

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ.

Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4.

11.

Challenges and opportunities of using liquid chromatography and mass spectrometry methods to develop complex vaccine antigens as pharmaceutical dosage forms.

Hickey JM, Sahni N, Toth RT 4th, Kumru OS, Joshi SB, Middaugh CR, Volkin DB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:23-38. doi: 10.1016/j.jchromb.2016.04.001. Epub 2016 Apr 4. Review.

PMID:
27071526
12.

Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri.

Burgess JL, Jones HB, Kumar P, Toth RT 4th, Middaugh CR, Antony E, Dickenson NE.

Protein Sci. 2016 May;25(5):1037-48. doi: 10.1002/pro.2917. Epub 2016 Mar 22.

13.

Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1.

Mozziconacci O, Arora J, Toth RT 4th, Joshi SB, Zhou S, Volkin DB, Schöneich C.

Mol Pharm. 2016 Apr 4;13(4):1317-28. doi: 10.1021/acs.molpharmaceut.5b00944. Epub 2016 Mar 11.

PMID:
26942274
14.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

Chen X, Choudhari SP, Kumar P, Toth RT 4th, Kim JH, Van Roosmalen ML, Leenhouts K, Middaugh CR, Picking WL, Picking WD.

J Pharm Sci. 2015 Dec;104(12):4065-4073. doi: 10.1002/jps.24659. Epub 2015 Sep 30.

PMID:
26422758
15.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

16.

Impact of detergent on biophysical properties and immune response of the IpaDB fusion protein, a candidate subunit vaccine against Shigella species.

Chen X, Choudhari SP, Martinez-Becerra FJ, Kim JH, Dickenson NE, Toth RT 4th, Joshi SB, Greenwood JC 2nd, Clements JD, Picking WD, Middaugh CR, Picking WL.

Infect Immun. 2015 Jan;83(1):292-9. doi: 10.1128/IAI.02457-14. Epub 2014 Nov 3.

17.

N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD.

Dickenson NE, Arizmendi O, Patil MK, Toth RT 4th, Middaugh CR, Picking WD, Picking WL.

Biochemistry. 2013 Dec 10;52(49):8790-9. doi: 10.1021/bi400755f. Epub 2013 Nov 20.

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