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Items: 1 to 50 of 287

1.

Functional Characterization of Secreted Aspartyl Proteases in Candida parapsilosis.

Singh DK, Németh T, Papp A, Tóth R, Lukácsi S, Heidingsfeld O, Dostal J, Vágvölgyi C, Bajtay Z, Józsi M, Gácser A.

mSphere. 2019 Aug 21;4(4). pii: e00484-19. doi: 10.1128/mSphere.00484-19.

2.

Recombinant subunit rotavirus trivalent vaccine candidate: physicochemical comparisons and stability evaluations of three protein antigens.

Agarwal S, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB.

J Pharm Sci. 2019 Aug 7. pii: S0022-3549(19)30495-2. doi: 10.1016/j.xphs.2019.08.002. [Epub ahead of print]

3.

Quality attributes and evaluation of pharmaceutical glass containers for parenterals.

Srinivasan C, Ma Y, Liu Y, Wang Y, Hengst L, Liu X, Toth R, Rodriguez J, Mohammad A, Bandaranayake BMB, Simon D, Beekman C, Korang-Yeboah M, Sivan S, Lee SL, Cruz CN.

Int J Pharm. 2019 Sep 10;568:118510. doi: 10.1016/j.ijpharm.2019.118510. Epub 2019 Jul 11.

PMID:
31302170
4.

Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among colorectal cancer patients.

Haffa M, Lin T, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Böhm J, Brenner H, Schneider M, Ulrich A, Herpel E, Schirmacher P, Straub BK, Nattenmüller J, Kauczor HU, Ball CR, Ulrich CM, Glimm H, Scherer D.

J Clin Endocrinol Metab. 2019 Jun 21. pii: jc.2019-00461. doi: 10.1210/jc.2019-00461. [Epub ahead of print]

PMID:
31225875
5.

Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2.

Hu Y, Toth RT 4th, Joshi SB, Esfandiary R, Middaugh CR, Volkin DB, Weis DD.

J Pharm Sci. 2019 Jun 11. pii: S0022-3549(19)30368-5. doi: 10.1016/j.xphs.2019.06.001. [Epub ahead of print]

PMID:
31195015
6.

Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins.

Chaugule VK, Arkinson C, Toth R, Walden H.

Methods Enzymol. 2019;618:73-104. doi: 10.1016/bs.mie.2018.12.021. Epub 2019 Feb 11.

PMID:
30850063
7.

Candida parapsilosis: from Genes to the Bedside.

Tóth R, Nosek J, Mora-Montes HM, Gabaldon T, Bliss JM, Nosanchuk JD, Turner SA, Butler G, Vágvölgyi C, Gácser A.

Clin Microbiol Rev. 2019 Feb 27;32(2). pii: e00111-18. doi: 10.1128/CMR.00111-18. Print 2019 Mar 20. Review.

PMID:
30814115
8.

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Van Slyke G, Angalakurthi SK, Toth RT 4th, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Immunohorizons. 2018 Sep;2(8):262-273. doi: 10.4049/immunohorizons.1800042.

9.

Methylation Status of the Adeno-Associated Virus Type 2 (AAV2).

Tóth R, Mészáros I, Hüser D, Forró B, Marton S, Olasz F, Bányai K, Heilbronn R, Zádori Z.

Viruses. 2019 Jan 9;11(1). pii: E38. doi: 10.3390/v11010038.

10.

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.

Goeppert B, Toth R, Singer S, Albrecht T, Lipka DB, Lutsik P, Brocks D, Baehr M, Muecke O, Assenov Y, Gu L, Endris V, Stenzinger A, Mehrabi A, Schirmacher P, Plass C, Weichenhan D, Roessler S.

Hepatology. 2019 May;69(5):2091-2106. doi: 10.1002/hep.30493. Epub 2019 Feb 28.

11.

Enhancement of chicken primordial germ cell in vitro maintenance using an automated cell image analyser.

Anand M, Lázár B, Tóth R, Páll E, Patakiné Várkonyi E, Liptói K, Homolya L, Hegyi Z, Hidas A, Gócza E.

Acta Vet Hung. 2018 Dec;66(4):518-529. doi: 10.1556/004.2018.046.

PMID:
30580540
12.

Eicosanoid production by Candida parapsilosis and other pathogenic yeasts.

Chakraborty T, Tóth R, Gácser A.

Virulence. 2018 Dec 17. doi: 10.1080/21505594.2018.1559674. [Epub ahead of print]

PMID:
30558484
13.

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz EM, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J.

Cancer Cell. 2018 Dec 10;34(6):996-1011.e8. doi: 10.1016/j.ccell.2018.10.016.

PMID:
30537516
14.

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.

Arkinson C, Chaugule VK, Toth R, Walden H.

Life Sci Alliance. 2018 Oct 12;1(5):e201800162. doi: 10.26508/lsa.201800162. eCollection 2018 Oct.

15.

[The Semmelweis University extracorporeal membrane oxygenation program - 5 years' results and perspectives].

Hartyánszky I, Koppányi Á, Szabolcs Z, Horkay F, Fazekas L, Hüttl T, Pólos M, Daróczi L, Kőszegi A, Benke K, Tóth R, Kovács P, Barabás JI, Németh E, Édes IF, Merkely B.

Orv Hetil. 2018 Nov;159(46):1876-1881. doi: 10.1556/650.2018.31298. Hungarian.

PMID:
30450938
16.

Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance.

Papp C, Kocsis K, Tóth R, Bodai L, Willis JR, Ksiezopolska E, Lozoya-Pérez NE, Vágvölgyi C, Mora Montes H, Gabaldón T, Nosanchuk JD, Gácser A.

mSphere. 2018 Nov 14;3(6). pii: e00547-18. doi: 10.1128/mSphere.00547-18.

17.

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.

Andersen JL, Gesser B, Funder ED, Nielsen CJF, Gotfred-Rasmussen H, Rasmussen MK, Toth R, Gothelf KV, Arthur JSC, Iversen L, Nissen P.

Nat Commun. 2018 Oct 19;9(1):4344. doi: 10.1038/s41467-018-06787-w.

18.

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.

Muñoz IM, Morgan ME, Peltier J, Weiland F, Gregorczyk M, Brown FC, Macartney T, Toth R, Trost M, Rouse J.

EMBO J. 2018 Dec 14;37(24). pii: e99559. doi: 10.15252/embj.201899559. Epub 2018 Sep 28.

19.

Comparison of the MicroRNA Expression Profiles of Male and Female Avian Primordial Germ Cell Lines.

Lázár B, Anand M, Tóth R, Várkonyi EP, Liptói K, Gócza E.

Stem Cells Int. 2018 Jul 10;2018:1780679. doi: 10.1155/2018/1780679. eCollection 2018.

20.

Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization.

Menyhárt Á, Farkas AE, Varga DP, Frank R, Tóth R, Bálint AR, Makra P, Dreier JP, Bari F, Krizbai IA, Farkas E.

Neurobiol Dis. 2018 Nov;119:41-52. doi: 10.1016/j.nbd.2018.07.026. Epub 2018 Jul 24.

PMID:
30053571
21.

Eicosanoid biosynthesis influences the virulence of Candida parapsilosis.

Chakraborty T, Thuer E, Heijink M, Tóth R, Bodai L, Vágvölgyi C, Giera M, Gabaldón T, Gácser A.

Virulence. 2018;9(1):1019-1035. doi: 10.1080/21505594.2018.1475797.

22.

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.

Toth RP, Atkin JD.

Front Immunol. 2018 May 23;9:1017. doi: 10.3389/fimmu.2018.01017. eCollection 2018. Review.

23.

Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry.

More AS, Toth RT 4th, Okbazghi SZ, Middaugh CR, Joshi SB, Tolbert TJ, Volkin DB, Weis DD.

J Pharm Sci. 2018 Sep;107(9):2315-2324. doi: 10.1016/j.xphs.2018.04.026. Epub 2018 May 8.

PMID:
29751008
24.

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM.

Cell Rep. 2018 May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022.

25.

Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.

Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich CM, Michels KB, Busch H, Boerries M.

Epigenetics. 2018;13(4):386-397. doi: 10.1080/15592294.2018.1460034. Epub 2018 May 3.

26.

Anti-Candidal Activity and Functional Mapping of Recombinant and Synthetic Neosartorya fischeri Antifungal Protein 2 (NFAP2).

Tóth L, Váradi G, Borics A, Batta G, Kele Z, Vendrinszky Á, Tóth R, Ficze H, Tóth GK, Vágvölgyi C, Marx F, Galgóczy L.

Front Microbiol. 2018 Mar 7;9:393. doi: 10.3389/fmicb.2018.00393. eCollection 2018.

27.

Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544].

Jowsey P, Morrice NA, Hastie CJ, MacLauchlan H, Toth R, Rouse J.

DNA Repair (Amst). 2018 May;65:80. doi: 10.1016/j.dnarep.2017.10.012. Epub 2018 Feb 12. No abstract available.

PMID:
29449168
28.

The ratio of ADSCs to HSC-progenitors in adipose tissue derived SVF may provide the key to predict the outcome of stem-cell therapy.

Kilinc MO, Santidrian A, Minev I, Toth R, Draganov D, Nguyen D, Lander E, Berman M, Minev B, Szalay AA.

Clin Transl Med. 2018 Feb 7;7(1):5. doi: 10.1186/s40169-018-0183-8.

29.

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis.

Parakh S, Jagaraj CJ, Vidal M, Ragagnin AMG, Perri ER, Konopka A, Toth RP, Galper J, Blair IP, Thomas CJ, Walker AK, Yang S, Spencer DM, Atkin JD.

Hum Mol Genet. 2018 Apr 15;27(8):1311-1331. doi: 10.1093/hmg/ddy041.

PMID:
29409023
30.

Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction.

Tóth R, Cabral V, Thuer E, Bohner F, Németh T, Papp C, Nimrichter L, Molnár G, Vágvölgyi C, Gabaldón T, Nosanchuk JD, Gácser A.

Sci Rep. 2018 Jan 22;8(1):1346. doi: 10.1038/s41598-018-19453-4.

31.

Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody.

Toth RT 4th, Pace SE, Mills BJ, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB.

J Pharm Sci. 2018 Apr;107(4):1009-1019. doi: 10.1016/j.xphs.2017.12.009. Epub 2017 Dec 18.

PMID:
29269271
32.

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.

Nat Commun. 2017 Dec 19;8(1):2126. doi: 10.1038/s41467-017-02177-w.

33.

Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.

Gigic B, Boeing H, Toth R, Böhm J, Habermann N, Scherer D, Schrotz-King P, Abbenhardt-Martin C, Skender S, Brenner H, Chang-Claude J, Hoffmeister M, Syrjala K, Jacobsen PB, Schneider M, Ulrich A, Ulrich CM.

Nutr Cancer. 2018 Jan;70(1):51-60. doi: 10.1080/01635581.2018.1397707. Epub 2017 Dec 15.

34.

Correction to Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Toth RT 4th, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD.

Anal Chem. 2017 Dec 19;89(24):13673. doi: 10.1021/acs.analchem.7b04690. Epub 2017 Dec 6. No abstract available.

PMID:
29210567
35.

Corrigendum: Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.

Munoz IM, Jowsey PA, Toth R, Rouse J.

Nucleic Acids Res. 2017 Dec 15;45(22):13094. doi: 10.1093/nar/gkx1140. No abstract available.

36.

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Jäkel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, Hank T, Klöppel G, Dorrell C, Grompe M, Moss J, Dor Y, Schirmacher P, Plass C, Popanda O, Schmezer P.

Nat Commun. 2017 Nov 6;8(1):1323. doi: 10.1038/s41467-017-01118-x.

37.

Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.

Casillas AL, Toth RK, Sainz AG, Singh N, Desai AA, Kraft AS, Warfel NA.

Clin Cancer Res. 2018 Jan 1;24(1):169-180. doi: 10.1158/1078-0432.CCR-17-1318. Epub 2017 Oct 30.

38.

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec.

39.

Eukaryotic transporters for hydroxyderivatives of benzoic acid.

Cillingová A, Zeman I, Tóth R, Neboháčová M, Dunčková I, Hölcová M, Jakúbková M, Gérecová G, Pryszcz LP, Tomáška Ľ, Gabaldón T, Gácser A, Nosek J.

Sci Rep. 2017 Aug 21;7(1):8998. doi: 10.1038/s41598-017-09408-6.

40.

Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases.

Nagy LG, Tóth R, Kiss E, Slot J, Gácser A, Kovács GM.

Microbiol Spectr. 2017 Jul;5(4). doi: 10.1128/microbiolspec.FUNK-0036-2016.

PMID:
28820115
41.

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.

Barrow TM, Klett H, Toth R, Böhm J, Gigic B, Habermann N, Scherer D, Schrotz-King P, Skender S, Abbenhardt-Martin C, Zielske L, Schneider M, Ulrich A, Schirmacher P, Herpel E, Brenner H, Busch H, Boerries M, Ulrich CM, Michels KB.

J Pathol. 2017 Nov;243(3):366-375. doi: 10.1002/path.4955. Epub 2017 Sep 29.

42.

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant.

Toprani VM, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Middaugh CR, Joshi SB, Volkin DB.

J Pharm Sci. 2017 Dec;106(12):3474-3485. doi: 10.1016/j.xphs.2017.07.019. Epub 2017 Aug 2.

43.

Changes in illicit, licit and stimulant designer drug use patterns in South-East Hungary between 2008 and 2015.

Árok Z, Csesztregi T, Sija É, Varga T, Kereszty ÉM, Tóth RA, Institóris L.

Leg Med (Tokyo). 2017 Sep;28:37-44. doi: 10.1016/j.legalmed.2017.07.001. Epub 2017 Jul 8.

PMID:
28759769
44.

Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer.

Heilmann K, Toth R, Bossmann C, Klimo K, Plass C, Gerhauser C.

Oncogene. 2017 Nov 16;36(46):6446-6461. doi: 10.1038/onc.2017.246. Epub 2017 Jul 31.

45.

Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Toth RT 4th, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD.

Anal Chem. 2017 Sep 5;89(17):8931-8941. doi: 10.1021/acs.analchem.7b01396. Epub 2017 Aug 11. Erratum in: Anal Chem. 2017 Dec 19;89(24):13673.

PMID:
28753295
46.

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ.

Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4.

47.

Investigation of OCH1 in the Virulence of Candida parapsilosis Using a New Neonatal Mouse Model.

Csonka K, Vadovics M, Marton A, Vágvölgyi C, Zajta E, Tóth A, Tóth R, Vizler C, Tiszlavicz L, Mora-Montes HM, Gácser A.

Front Microbiol. 2017 Jun 30;8:1197. doi: 10.3389/fmicb.2017.01197. eCollection 2017.

48.

MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.

Hunter CJ, Remenyi J, Correa SA, Privitera L, Reyskens KMSE, Martin KJ, Toth R, Frenguelli BG, Arthur JSC.

FEBS Open Bio. 2017 May 11;7(6):821-834. doi: 10.1002/2211-5463.12232. eCollection 2017 Jun.

49.

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.

Feeney L, Muñoz IM, Lachaud C, Toth R, Appleton PL, Schindler D, Rouse J.

Mol Cell. 2017 Jun 1;66(5):610-621.e4. doi: 10.1016/j.molcel.2017.04.021.

50.

The SAT Protein of Porcine Parvovirus Accelerates Viral Spreading through Induction of Irreversible Endoplasmic Reticulum Stress.

Mészáros I, Tóth R, Olasz F, Tijssen P, Zádori Z.

J Virol. 2017 Jul 27;91(16). pii: e00627-17. doi: 10.1128/JVI.00627-17. Print 2017 Aug 15.

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