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Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma.

Vaclavikova R, Klajic J, Brynychova V, Elsnerova K, Alnaes GIG, Tost J, Kristensen VN, Rob L, Kodet R, Skapa P, Mrhalova M, Soucek P.

Oncol Rep. 2019 Aug;42(2):763-774. doi: 10.3892/or.2019.7186. Epub 2019 Jun 5.


Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes.

Javaloyes P, Miró Ò, Gil V, Martín-Sánchez FJ, Jacob J, Herrero P, Takagi K, Alquézar-Arbé A, López Díez MP, Martín E, Bibiano C, Escoda R, Gil C, Fuentes M, Llopis García G, Álvarez Pérez JM, Jerez A, Tost J, Llauger L, Romero R, Garrido JM, Rodríguez-Adrada E, Sánchez C, Rossello X, Parissis J, Mebazaa A, Chioncel O, Llorens P; ICA-SEMES Research Group.

Eur J Heart Fail. 2019 May 24. doi: 10.1002/ejhf.1502. [Epub ahead of print]


Deregulation of microRNA expression in monocytes and CD4+ T lymphocytes from patients with axial spondyloarthritis.

Fogel O, Bugge Tinggaard A, Fagny M, Sigrist N, Roche E, Leclere L, Deleuze JF, Batteux F, Dougados M, Miceli-Richard C, Tost J.

Arthritis Res Ther. 2019 Feb 12;21(1):51. doi: 10.1186/s13075-019-1829-7.


Demethylation by low-dose 5-aza-2'-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma.

Desjobert C, Carrier A, Delmas A, Marzese DM, Daunay A, Busato F, Pillon A, Tost J, Riond J, Favre G, Etievant C, Arimondo PB.

Clin Epigenetics. 2019 Jan 16;11(1):9. doi: 10.1186/s13148-018-0600-2.


Methylation of imprinted IGF2 regions is associated with total, visceral, and hepatic adiposity in postmenopausal women.

Song MA, Ernst T, Tiirikainen M, Tost J, Wilkens LR, Chang L, Kolonel LN, Le Marchand L, Lim U.

Epigenetics. 2018;13(8):858-865. doi: 10.1080/15592294.2018.1518100. Epub 2018 Oct 2.


Relationship of Christian Beliefs to Attitudes Toward People With Mental Illness.

Adams KS, Tost JR, Whatley MA, Brown MC, Dochney BJ, Taylor JM, Neal MH.

Am J Psychother. 2018 Nov 1;71(3):104-109. doi: 10.1176/appi.psychotherapy.20180022. Epub 2018 Sep 12.


A translational perspective on epigenetics in allergic diseases.

Tost J.

J Allergy Clin Immunol. 2018 Sep;142(3):715-726. doi: 10.1016/j.jaci.2018.07.009. Review.


Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease.

Magalhães M, Tost J, Pineau F, Rivals I, Busato F, Alary N, Mely L, Leroy S, Murris M, Caimmi D, Claustres M, Chiron R, De Sario A.

Epigenomics. 2018 Aug;10(8):1131-1145. doi: 10.2217/epi-2018-0005. Epub 2018 Jul 27.


Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.

Weber A, Schwarz SC, Tost J, Trümbach D, Winter P, Busato F, Tacik P, Windhorst AC, Fagny M, Arzberger T, McLean C, van Swieten JC, Schwarz J, Vogt Weisenhorn D, Wurst W, Adhikary T, Dickson DW, Höglinger GU, Müller U.

Nat Commun. 2018 Jul 26;9(1):2929. doi: 10.1038/s41467-018-05325-y.


Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation.

Abraham E, Rousseaux S, Agier L, Giorgis-Allemand L, Tost J, Galineau J, Hulin A, Siroux V, Vaiman D, Charles MA, Heude B, Forhan A, Schwartz J, Chuffart F, Bourova-Flin E, Khochbin S, Slama R, Lepeule J; EDEN mother-child cohort study group.

Environ Int. 2018 Sep;118:334-347. doi: 10.1016/j.envint.2018.05.007. Epub 2018 Jun 21.


Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice.

Mondoulet L, Dioszeghy V, Busato F, Plaquet C, Dhelft V, Bethune K, Leclere L, Daviaud C, Ligouis M, Sampson H, Dupont C, Tost J.

Allergy. 2019 Jan;74(1):152-164. doi: 10.1111/all.13479. Epub 2018 Oct 8.


A General Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes.

Perron G, Jandaghi P, Solanki S, Safisamghabadi M, Storoz C, Karimzadeh M, Papadakis AI, Arseneault M, Scelo G, Banks RE, Tost J, Lathrop M, Tanguay S, Brazma A, Huang S, Brimo F, Najafabadi HS, Riazalhosseini Y.

Cell Rep. 2018 May 8;23(6):1639-1650. doi: 10.1016/j.celrep.2018.04.031.


Enrichment of methylated molecules using enhanced-ice-co-amplification at lower denaturation temperature-PCR (E-ice-COLD-PCR) for the sensitive detection of disease-related hypermethylation.

Mauger F, Kernaleguen M, Lallemand C, Kristensen VN, Deleuze JF, Tost J.

Epigenomics. 2018 May;10(5):525-537. doi: 10.2217/epi-2017-0166. Epub 2018 Apr 26.


Whole-Genome Bisulfite Sequencing for the Analysis of Genome-Wide DNA Methylation and Hydroxymethylation Patterns at Single-Nucleotide Resolution.

Kernaleguen M, Daviaud C, Shen Y, Bonnet E, Renault V, Deleuze JF, Mauger F, Tost J.

Methods Mol Biol. 2018;1767:311-349. doi: 10.1007/978-1-4939-7774-1_18.


Epigenetic plasticity of eosinophils and other immune cell subsets in childhood asthma.

Tost J.

Lancet Respir Med. 2018 May;6(5):322-324. doi: 10.1016/S2213-2600(18)30051-1. Epub 2018 Feb 26. No abstract available.


Consequences of VHL Loss on Global DNA Methylome.

Robinson CM, Lefebvre F, Poon BP, Bousard A, Fan X, Lathrop M, Tost J, Kim WY, Riazalhosseini Y, Ohh M.

Sci Rep. 2018 Feb 20;8(1):3313. doi: 10.1038/s41598-018-21524-5.


Twin DNA Methylation Profiling Reveals Flare-Dependent Interferon Signature and B Cell Promoter Hypermethylation in Systemic Lupus Erythematosus.

Ulff-Møller CJ, Asmar F, Liu Y, Svendsen AJ, Busato F, Grønbaek K, Tost J, Jacobsen S.

Arthritis Rheumatol. 2018 Jun;70(6):878-890. doi: 10.1002/art.40422. Epub 2018 May 9.


White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk.

Lønning PE, Berge EO, Bjørnslett M, Minsaas L, Chrisanthar R, Høberg-Vetti H, Dulary C, Busato F, Bjørneklett S, Eriksen C, Kopperud R, Axcrona U, Davidson B, Bjørge L, Evans G, Howell A, Salvesen HB, Janszky I, Hveem K, Romundstad PR, Vatten LJ, Tost J, Dørum A, Knappskog S.

Ann Intern Med. 2018 Mar 6;168(5):326-334. doi: 10.7326/M17-0101. Epub 2018 Jan 16.


aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations.

Renault V, Tost J, Pichon F, Wang-Renault SF, Letouzé E, Imbeaud S, Zucman-Rossi J, Deleuze JF, How-Kit A.

PLoS One. 2017 Dec 19;12(12):e0189334. doi: 10.1371/journal.pone.0189334. eCollection 2017.


Quantitative DNA Methylation Analysis at Single-Nucleotide Resolution by Pyrosequencing®.

Busato F, Dejeux E, El Abdalaoui H, Gut IG, Tost J.

Methods Mol Biol. 2018;1708:427-445. doi: 10.1007/978-1-4939-7481-8_22.


Whole-Genome Bisulfite Sequencing Using the Ovation® Ultralow Methyl-Seq Protocol.

Daviaud C, Renault V, Mauger F, Deleuze JF, Tost J.

Methods Mol Biol. 2018;1708:83-104. doi: 10.1007/978-1-4939-7481-8_5.


A Summary of the Biological Processes, Disease-Associated Changes, and Clinical Applications of DNA Methylation.

Andersen GB, Tost J.

Methods Mol Biol. 2018;1708:3-30. doi: 10.1007/978-1-4939-7481-8_1. Review.


DNA methylation at enhancers identifies distinct breast cancer lineages.

Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E; Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN.

Nat Commun. 2017 Nov 9;8(1):1379. doi: 10.1038/s41467-017-00510-x.


miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts.

Andersen GB, Knudsen A, Hager H, Hansen LL, Tost J.

Mol Oncol. 2018 Jan;12(1):114-131. doi: 10.1002/1878-0261.12154. Epub 2017 Dec 1.


The BRONCH-AHF study: effects on short-term outcome of nebulized bronchodilators in emergency department patients diagnosed with acute heart failure.

Miró Ò, Tost J, Gil V, Martín-Sánchez FJ, Llorens P, Herrero P, Mebazaa A, Harjola VP, Ríos J, Marco-Hernández J, Collins SP, Peacock WF, Hollander JE, Lorca MT, Jacob J; ICA-SEMES Research Group.

Eur J Heart Fail. 2018 Apr;20(4):822-826. doi: 10.1002/ejhf.1028. Epub 2017 Oct 16. No abstract available.


Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sjögren's syndrome.

Wang-Renault SF, Boudaoud S, Nocturne G, Roche E, Sigrist N, Daviaud C, Bugge Tinggaard A, Renault V, Deleuze JF, Mariette X, Tost J.

Ann Rheum Dis. 2018 Jan;77(1):133-140. doi: 10.1136/annrheumdis-2017-211417. Epub 2017 Sep 15.


Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension.

Hautefort A, Chesné J, Preussner J, Pullamsetti SS, Tost J, Looso M, Antigny F, Girerd B, Riou M, Eddahibi S, Deleuze JF, Seeger W, Fadel E, Simonneau G, Montani D, Humbert M, Perros F.

Oncotarget. 2017 May 19;8(32):52995-53016. doi: 10.18632/oncotarget.18031. eCollection 2017 Aug 8.


Clinical value of early detection of circulating tumour DNA-BRAFV600mut in patients with metastatic melanoma treated with a BRAF inhibitor.

Louveau B, Tost J, Mauger F, Sadoux A, Podgorniak MP, How-Kit A, Pages C, Roux J, Da Meda L, Lebbe C, Mourah S.

ESMO Open. 2017 Jun 21;2(2):e000173. doi: 10.1136/esmoopen-2017-000173. eCollection 2017. No abstract available.


NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas.

Su X, Zhang J, Mouawad R, Compérat E, Rouprêt M, Allanic F, Parra J, Bitker MO, Thompson EJ, Gowrishankar B, Houldsworth J, Weinstein JN, Tost J, Broom BM, Khayat D, Spano JP, Tannir NM, Malouf GG.

Cancer Res. 2017 Sep 15;77(18):4835-4845. doi: 10.1158/0008-5472.CAN-17-0143. Epub 2017 Jul 28.


Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization.

Wolff N, Buse J, Tost J, Roessner V, Beste C.

J Child Psychol Psychiatry. 2017 Aug;58(8):939-949. doi: 10.1111/jcpp.12733. Epub 2017 Apr 28.


Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children.

Fradin D, Boëlle PY, Belot MP, Lachaux F, Tost J, Besse C, Deleuze JF, De Filippo G, Bougnères P.

Sci Rep. 2017 Apr 7;7:46311. doi: 10.1038/srep46311.


Epigenetics of the immune system and alterations in inflammation and autoimmunity.

Tost J, Gay S, Firestein G.

Epigenomics. 2017 Apr;9(4):371-373. doi: 10.2217/epi-2017-0026. No abstract available.


Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma.

Arseneault M, Monlong J, Vasudev NS, Laskar RS, Safisamghabadi M, Harnden P, Egevad L, Nourbehesht N, Panichnantakul P, Holcatova I, Brisuda A, Janout V, Kollarova H, Foretova L, Navratilova M, Mates D, Jinga V, Zaridze D, Mukeria A, Jandaghi P, Brennan P, Brazma A, Tost J, Scelo G, Banks RE, Lathrop M, Bourque G, Riazalhosseini Y.

Sci Rep. 2017 Mar 23;7:44876. doi: 10.1038/srep44876.


Epigenetics and allergy: from basic mechanisms to clinical applications.

Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J.

Epigenomics. 2017 Apr;9(4):539-571. doi: 10.2217/epi-2016-0162. Epub 2017 Mar 21. Review.


COLD-PCR Technologies in the Area of Personalized Medicine: Methodology and Applications.

Mauger F, How-Kit A, Tost J.

Mol Diagn Ther. 2017 Jun;21(3):269-283. doi: 10.1007/s40291-016-0254-8. Review.


Epigenetic Changes in Chronic Inflammatory Diseases.

Fogel O, Richard-Miceli C, Tost J.

Adv Protein Chem Struct Biol. 2017;106:139-189. doi: 10.1016/bs.apcsb.2016.09.003. Epub 2016 Oct 18. Review.


Comparison of the quantification of KRAS mutations by digital PCR and E-ice-COLD-PCR in circulating-cell-free DNA from metastatic colorectal cancer patients.

Sefrioui D, Mauger F, Leclere L, Beaussire L, Di Fiore F, Deleuze JF, Sarafan-Vasseur N, Tost J.

Clin Chim Acta. 2017 Feb;465:1-4. doi: 10.1016/j.cca.2016.12.004. Epub 2016 Dec 7.


DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.

Fleischer T, Klajic J, Aure MR, Louhimo R, Pladsen AV, Ottestad L, Touleimat N, Laakso M, Halvorsen AR, Grenaker Alnæs GI, Riis ML, Helland Å, Hautaniemi S, Lønning PE, Naume B, Børresen-Dale AL, Tost J, Kristensen VN.

Oncotarget. 2017 Jan 3;8(1):1074-1082. doi: 10.18632/oncotarget.13718.


Impact of chronic obstructive pulmonary disease on clinical course after an episode of acute heart failure. EAHFE-COPD study.

Jacob J, Tost J, Miró Ò, Herrero P, Martín-Sánchez FJ, Llorens P; ICA-SEMES Research Group.

Int J Cardiol. 2017 Jan 15;227:450-456. doi: 10.1016/j.ijcard.2016.11.013. Epub 2016 Nov 8.


Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation.

Meems LM, Mahmud H, Buikema H, Tost J, Michel S, Takens J, Verkaik-Schakel RN, Vreeswijk-Baudoin I, Mateo-Leach IV, van der Harst P, Plösch T, de Boer RA.

Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1459-H1469. doi: 10.1152/ajpheart.00141.2016. Epub 2016 Oct 21. Erratum in: Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1571.


Short-term predictive capacity of two different triage systems in patients with acute heart failure: TRICA-EAHFE study.

Miró Ò, Tost J, Herrero P, Jacob J, Martín-Sánchez FJ, Gil V, Fernández-Pérez C, Escoda R, Llorens P; ICA-SEMES Research Group.

Eur J Emerg Med. 2016 Dec;23(6):435-441.


Epigenome-wide DNA methylation analysis in siblings and monozygotic twins discordant for sporadic Parkinson's disease revealed different epigenetic patterns in peripheral blood mononuclear cells.

Kaut O, Schmitt I, Tost J, Busato F, Liu Y, Hofmann P, Witt SH, Rietschel M, Fröhlich H, Wüllner U.

Neurogenetics. 2017 Jan;18(1):7-22. doi: 10.1007/s10048-016-0497-x. Epub 2016 Oct 6.


Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.

Yaghi L, Poras I, Simoes RT, Donadi EA, Tost J, Daunay A, de Almeida BS, Carosella ED, Moreau P.

Oncotarget. 2016 Sep 27;7(39):63690-63707. doi: 10.18632/oncotarget.11628.


Follow the trace of death: methylation analysis of cell-free DNA for clinical applications in non-cancerous diseases.

Tost J.

Epigenomics. 2016 Sep;8(9):1169-72. doi: 10.2217/epi-2016-0080. Epub 2016 Aug 16. No abstract available.


Sustained response to salvage therapy for dabrafenib-resistant metastatic Langerhans cell sarcoma.

Lorillon G, Mourah S, Vercellino L, de Margerie-Mellon C, Pagès C, Goldwirt L, Lebbe C, Tost J, Tazi A.

Ann Oncol. 2016 Dec;27(12):2305-2307. doi: 10.1093/annonc/mdw299. Epub 2016 Aug 8. No abstract available.


Systemic epigenetic response to recombinant lentiviral vectors independent of proviral integration.

Aranyi T, Stockholm D, Yao R, Poinsignon C, Wiart T, Corre G, Touleimat N, Tost J, Galy A, Paldi A.

Epigenetics Chromatin. 2016 Jul 11;9:29. doi: 10.1186/s13072-016-0077-1. eCollection 2016.


Multiplexing of E-ice-COLD-PCR Assays for Mutation Detection and Identification.

Mauger F, Daunay A, Deleuze JF, Tost J, How-Kit A.

Clin Chem. 2016 Aug;62(8):1155-8. doi: 10.1373/clinchem.2016.258830. Epub 2016 Jun 22. No abstract available.


Recurrent NRAS mutations in pulmonary Langerhans cell histiocytosis.

Mourah S, How-Kit A, Meignin V, Gossot D, Lorillon G, Bugnet E, Mauger F, Lebbe C, Chevret S, Tost J, Tazi A.

Eur Respir J. 2016 Jun;47(6):1785-96. doi: 10.1183/13993003.01677-2015. Epub 2016 Apr 13.


DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard EG, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E, London SJ.

Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.

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