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Items: 11


A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.

Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M.

Sci Adv. 2019 Sep 11;5(9):eaaw7781. doi: 10.1126/sciadv.aaw7781. eCollection 2019 Sep.


Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA.

Lee JK, Bosnakovski D, Toso EA, Dinh T, Banerjee S, Bohl TE, Shi K, Orellana K, Kyba M, Aihara H.

Cell Rep. 2018 Dec 11;25(11):2955-2962.e3. doi: 10.1016/j.celrep.2018.11.060.


Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression.

Bosnakovski D, Gearhart MD, Toso EA, Ener ET, Choi SH, Kyba M.

Sci Rep. 2018 Nov 16;8(1):16957. doi: 10.1038/s41598-018-35150-8.


The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

Bosnakovski D, Toso EA, Hartweck LM, Magli A, Lee HA, Thompson ER, Dandapat A, Perlingeiro RCR, Kyba M.

J Cell Sci. 2017 Nov 1;130(21):3685-3697. doi: 10.1242/jcs.205427. Epub 2017 Sep 21.


p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M.

Dis Model Mech. 2017 Oct 1;10(10):1211-1216. doi: 10.1242/dmm.030064. Epub 2017 Jul 28.


Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.

Choi SH, Bosnakovski D, Strasser JM, Toso EA, Walters MA, Kyba M.

J Biomol Screen. 2016 Aug;21(7):680-8. doi: 10.1177/1087057116651868. Epub 2016 May 31.


DNA-binding sequence specificity of DUX4.

Zhang Y, Lee JK, Toso EA, Lee JS, Choi SH, Slattery M, Aihara H, Kyba M.

Skelet Muscle. 2016 Jan 28;6:8. doi: 10.1186/s13395-016-0080-z. eCollection 2016.


Pax3-induced expansion enables the genetic correction of dystrophic satellite cells.

Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA, Miller AZ, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC.

Skelet Muscle. 2015 Oct 26;5:36. doi: 10.1186/s13395-015-0061-7. eCollection 2015.


High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity.

Bosnakovski D, Choi SH, Strasser JM, Toso EA, Walters MA, Kyba M.

Skelet Muscle. 2014 Feb 1;4(1):4. doi: 10.1186/2044-5040-4-4.


A focal domain of extreme demethylation within D4Z4 in FSHD2.

Hartweck LM, Anderson LJ, Lemmers RJ, Dandapat A, Toso EA, Dalton JC, Tawil R, Day JW, van der Maarel SM, Kyba M.

Neurology. 2013 Jan 22;80(4):392-9. doi: 10.1212/WNL.0b013e31827f075c. Epub 2013 Jan 2.


Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.

Brady SN, Maggi LB Jr, Winkeler CL, Toso EA, Gwinn AS, Pelletier CL, Weber JD.

Oncogene. 2009 Sep 10;28(36):3209-20. doi: 10.1038/onc.2009.178. Epub 2009 Jun 29.

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