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ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer.

Xu G, Chhangawala S, Cocco E, Razavi P, Cai Y, Otto JE, Ferrando L, Selenica P, Ladewig E, Chan C, Da Cruz Paula A, Witkin M, Cheng Y, Park J, Serna-Tamayo C, Zhao H, Wu F, Sallaku M, Qu X, Zhao A, Collings CK, D'Avino AR, Jhaveri K, Koche R, Levine RL, Reis-Filho JS, Kadoch C, Scaltriti M, Leslie CS, Baselga J, Toska E.

Nat Genet. 2020 Jan 13. doi: 10.1038/s41588-019-0554-0. [Epub ahead of print]


Overview of the relevance of PI3K pathway in HR-positive breast cancer.

Vasan N, Toska E, Scaltriti M.

Ann Oncol. 2019 Dec;30 Suppl 10:x3-x11. doi: 10.1093/annonc/mdz281. Review.


Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma.

Mondello P, Tadros S, Teater M, Fontan L, Chang AY, Jain N, Yang H, Singh S, Ying HY, Chu CS, Ma MCJ, Toska E, Alig S, Durant M, de Stanchina E, Ghosh S, Mottok A, Nastoupil L, Neelapu SS, Weigert O, Inghirami G, Baselga J, Younes A, Yee C, Dogan A, Scheinberg DA, Roeder RG, Melnick AM, Green MR.

Cancer Discov. 2020 Jan 8. pii: CD-19-0116. doi: 10.1158/2159-8290.CD-19-0116. [Epub ahead of print]


Overview of the relevance of PI3K pathway in HR-positive breast cancer.

Vasan N, Toska E, Scaltriti M.

Ann Oncol. 2019 Dec 1;30(Supplement_10):x3-x11. doi: 10.1093/annonc/mdz281.


Consistent Provisions Mitigate Exposure to Sexual Risk and HIV Among Young Adolescents in South Africa.

Toska E, Campeau L, Cluver L, Orkin FM, Berezin MN, Sherr L, Laurenzi CA, Bachman G.

AIDS Behav. 2019 Nov 20. doi: 10.1007/s10461-019-02735-x. [Epub ahead of print]


Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

Vasan N, Razavi P, Johnson JL, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Lin TY, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, Jhaveri K, Chandarlapaty S, Rabadan R, Reznik E, Smith ML, Sebra R, Schimmoller F, Wilson TR, Friedman LS, Cantley LC, Scaltriti M, Baselga J.

Science. 2019 Nov 8;366(6466):714-723. doi: 10.1126/science.aaw9032.


Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer.

Castel P, Toska E.

Mol Cell Oncol. 2019 Sep 2;6(6):e1625620. doi: 10.1080/23723556.2019.1625620. eCollection 2019.


Resistance to TRK inhibition mediated by convergent MAPK pathway activation.

Cocco E, Schram AM, Kulick A, Misale S, Won HH, Yaeger R, Razavi P, Ptashkin R, Hechtman JF, Toska E, Cownie J, Somwar R, Shifman S, Mattar M, Selçuklu SD, Samoila A, Guzman S, Tuch BB, Ebata K, de Stanchina E, Nagy RJ, Lanman RB, Houck-Loomis B, Patel JA, Berger MF, Ladanyi M, Hyman DM, Drilon A, Scaltriti M.

Nat Med. 2019 Sep;25(9):1422-1427. doi: 10.1038/s41591-019-0542-z. Epub 2019 Aug 12.


Transition Pathways Out of Pediatric Care and Associated HIV Outcomes for Adolescents Living With HIV in South Africa.

Haghighat R, Toska E, Cluver L, Gulaid L, Mark D, Bains A.

J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):166-174. doi: 10.1097/QAI.0000000000002125.


PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression.

Toska E, Castel P, Chhangawala S, Arruabarrena-Aristorena A, Chan C, Hristidis VC, Cocco E, Sallaku M, Xu G, Park J, Minuesa G, Shifman SG, Socci ND, Koche R, Leslie CS, Scaltriti M, Baselga J.

Cell Rep. 2019 Apr 2;27(1):294-306.e5. doi: 10.1016/j.celrep.2019.02.111.


Improving lives by accelerating progress towards the UN Sustainable Development Goals for adolescents living with HIV: a prospective cohort study.

Cluver LD, Orkin FM, Campeau L, Toska E, Webb D, Carlqvist A, Sherr L.

Lancet Child Adolesc Health. 2019 Apr;3(4):245-254. doi: 10.1016/S2352-4642(19)30033-1. Erratum in: Lancet Child Adolesc Health. 2019 Jun 12;:.


Screening and supporting through schools: educational experiences and needs of adolescents living with HIV in a South African cohort.

Toska E, Cluver L, Orkin M, Bains A, Sherr L, Berezin M, Gulaid L.

BMC Public Health. 2019 Mar 6;19(1):272. doi: 10.1186/s12889-019-6580-0.


Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations.

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A.

JCI Insight. 2018 Nov 15;3(22). pii: 125568. doi: 10.1172/jci.insight.125568. No abstract available.


Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy.

Franzese C, Comito T, Toska E, Tozzi A, Clerici E, De Rose F, Franceschini D, Navarria P, Reggiori G, Tomatis S, Scorsetti M.

Radiother Oncol. 2019 Apr;133:220-226. doi: 10.1016/j.radonc.2018.10.024. Epub 2018 Nov 7.


Suicidal thoughts and behaviour among South African adolescents living with HIV: Can social support buffer the impact of stigma?

Casale M, Boyes M, Pantelic M, Toska E, Cluver L.

J Affect Disord. 2019 Feb 15;245:82-90. doi: 10.1016/j.jad.2018.10.102. Epub 2018 Oct 14.


Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2).

Cocco E, Javier Carmona F, Razavi P, Won HH, Cai Y, Rossi V, Chan C, Cownie J, Soong J, Toska E, Shifman SG, Sarotto I, Savas P, Wick MJ, Papadopoulos KP, Moriarty A, Cutler RE Jr, Avogadri-Connors F, Lalani AS, Bryce RP, Chandarlapaty S, Hyman DM, Solit DB, Boni V, Loi S, Baselga J, Berger MF, Montemurro F, Scaltriti M.

Sci Signal. 2018 Oct 9;11(551). pii: eaat9773. doi: 10.1126/scisignal.aat9773.


STACKing the odds for adolescent survival: health service factors associated with full retention in care and adherence amongst adolescents living with HIV in South Africa.

Cluver L, Pantelic M, Toska E, Orkin M, Casale M, Bungane N, Sherr L.

J Int AIDS Soc. 2018 Sep;21(9):e25176. doi: 10.1002/jia2.25176.


Defining adolescence: priorities from a global health perspective.

Kinghorn A, Shanaube K, Toska E, Cluver L, Bekker LG.

Lancet Child Adolesc Health. 2018 May;2(5):e10. doi: 10.1016/S2352-4642(18)30096-8. Epub 2018 Mar 23. No abstract available.


'Yummy or crummy?' The multisensory components of medicines-taking among HIV-positive youth.

Hodes R, Vale B, Toska E, Cluver L, Dowse R, Ashorn M.

Glob Public Health. 2018 Aug 1:1-16. doi: 10.1080/17441692.2018.1504103. [Epub ahead of print]


Differing psychological vulnerabilities among behaviourally and perinatally HIV infected adolescents in South Africa - implications for targeted health service provision.

Sherr L, Cluver LD, Toska E, He E.

AIDS Care. 2018 Jun;30(sup2):92-101. doi: 10.1080/09540121.2018.1476664. Epub 2018 May 30.


Multitype violence exposures and adolescent antiretroviral nonadherence in South Africa.

Cluver L, Meinck F, Toska E, Orkin FM, Hodes R, Sherr L.

AIDS. 2018 May 15;32(8):975-983. doi: 10.1097/QAD.0000000000001795.


The stuff that dreams are made of: HIV-positive adolescents' aspirations for development.

Hodes R, Doubt J, Toska E, Vale B, Zungu N, Cluver L.

J Int AIDS Soc. 2018 Feb;21 Suppl 1. doi: 10.1002/jia2.25057.


Sustainable Survival for adolescents living with HIV: do SDG-aligned provisions reduce potential mortality risk?

Cluver L, Pantelic M, Orkin M, Toska E, Medley S, Sherr L.

J Int AIDS Soc. 2018 Feb;21 Suppl 1. doi: 10.1002/jia2.25056.


Beyond clinical trials: Cross-sectional associations of combination antiretroviral therapy with reports of multiple symptoms and non-adherence among adolescents in South Africa.

Natukunda HPM, Cluver LD, Toska E, Musiime V, Yakubovich AR.

S Afr Med J. 2017 Oct 31;107(11):965-975. doi: 10.7196/SAMJ.2017.v107i11.12405.


How front-line healthcare workers respond to stock-outs of essential medicines in the Eastern Cape Province of South Africa.

Hodes R, Price I, Bungane N, Toska E, Cluver L.

S Afr Med J. 2017 Aug 25;107(9):738-740. doi: 10.7196/SAMJ.2017.v107i9.12476.


Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations.

Norris SA, Daar A, Balasubramanian D, Byass P, Kimani-Murage E, Macnab A, Pauw C, Singhal A, Yajnik C, Akazili J, Levitt N, Maatoug J, Mkhwanazi N, Moore SE, Nyirenda M, Pulliam JRC, Rochat T, Said-Mohamed R, Seedat S, Sobngwi E, Tomlinson M, Toska E, van Schalkwyk C.

Glob Health Action. 2017;10(1):1334985. doi: 10.1080/16549716.2017.1334985.


Sex in the shadow of HIV: A systematic review of prevalence, risk factors, and interventions to reduce sexual risk-taking among HIV-positive adolescents and youth in sub-Saharan Africa.

Toska E, Pantelic M, Meinck F, Keck K, Haghighat R, Cluver L.

PLoS One. 2017 Jun 5;12(6):e0178106. doi: 10.1371/journal.pone.0178106. eCollection 2017. Review.


Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations.

Mondello P, Brea EJ, De Stanchina E, Toska E, Chang AY, Fennell M, Seshan V, Garippa R, Scheinberg DA, Baselga J, Wendel HG, Younes A.

JCI Insight. 2017 Mar 23;2(6):e90196. doi: 10.1172/jci.insight.90196. Erratum in: JCI Insight. 2018 Nov 15;3(22):.


PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

Toska E, Osmanbeyoglu HU, Castel P, Chan C, Hendrickson RC, Elkabets M, Dickler MN, Scaltriti M, Leslie CS, Armstrong SA, Baselga J.

Science. 2017 Mar 24;355(6331):1324-1330. doi: 10.1126/science.aah6893. Erratum in: Science. 2019 Jan 25;363(6425):.


Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs.

Osmanbeyoglu HU, Toska E, Chan C, Baselga J, Leslie CS.

Nat Commun. 2017 Jan 31;8:14249. doi: 10.1038/ncomms14249.


School, Supervision and Adolescent-Sensitive Clinic Care: Combination Social Protection and Reduced Unprotected Sex Among HIV-Positive Adolescents in South Africa.

Toska E, Cluver LD, Boyes ME, Isaacsohn M, Hodes R, Sherr L.

AIDS Behav. 2017 Sep;21(9):2746-2759. doi: 10.1007/s10461-016-1539-y.


TRI_tool: a web-tool for prediction of protein-protein interactions in human transcriptional regulation.

Perovic V, Sumonja N, Gemovic B, Toska E, Roberts SG, Veljkovic N.

Bioinformatics. 2017 Jan 15;33(2):289-291. doi: 10.1093/bioinformatics/btw590. Epub 2016 Sep 7.


PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Castel P, Ellis H, Bago R, Toska E, Razavi P, Carmona FJ, Kannan S, Verma CS, Dickler M, Chandarlapaty S, Brogi E, Alessi DR, Baselga J, Scaltriti M.

Cancer Cell. 2016 Aug 8;30(2):229-242. doi: 10.1016/j.ccell.2016.06.004. Epub 2016 Jul 21.


Resourcing resilience: social protection for HIV prevention amongst children and adolescents in Eastern and Southern Africa.

Toska E, Gittings L, Hodes R, Cluver LD, Govender K, Chademana KE, Gutiérrez VE.

Afr J AIDS Res. 2016 Jul;15(2):123-40. doi: 10.2989/16085906.2016.1194299. Review. Erratum in: Afr J AIDS Res. 2016 Sep;15(3):314.


Achieving equity in HIV-treatment outcomes: can social protection improve adolescent ART-adherence in South Africa?

Cluver LD, Toska E, Orkin FM, Meinck F, Hodes R, Yakubovich AR, Sherr L.

AIDS Care. 2016 Mar;28 Suppl 2:73-82. doi: 10.1080/09540121.2016.1179008.


Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors.

Toska E, Baselga J.

Clin Cancer Res. 2016 May 1;22(9):2099-101. doi: 10.1158/1078-0432.CCR-16-0038. Epub 2016 Mar 8. Erratum in: Clin Cancer Res. 2018 Nov 1;24(21):5487.


Sex and secrecy: How HIV-status disclosure affects safe sex among HIV-positive adolescents.

Toska E, Cluver LD, Hodes R, Kidia KK.

AIDS Care. 2015;27 Suppl 1:47-58. doi: 10.1080/09540121.2015.1071775.


Use of transvaginal ultrasound in females with primary bladder neck obstruction. A preliminary study.

Galica V, Toska E, Saldutto P, Galatioto GP, Vicentini C.

Arch Ital Urol Androl. 2015 Jul 7;87(2):158-60. doi: 10.4081/aiua.2015.2.158.


'HIV is like a tsotsi. ARVs are your guns': associations between HIV-disclosure and adherence to antiretroviral treatment among adolescents in South Africa.

Cluver LD, Hodes RJ, Toska E, Kidia KK, Orkin FM, Sherr L, Meinck F.

AIDS. 2015 Jun;29 Suppl 1:S57-65. doi: 10.1097/QAD.0000000000000695.


PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.

Bosch A, Li Z, Bergamaschi A, Ellis H, Toska E, Prat A, Tao JJ, Spratt DE, Viola-Villegas NT, Castel P, Minuesa G, Morse N, Rodón J, Ibrahim Y, Cortes J, Perez-Garcia J, Galvan P, Grueso J, Guzman M, Katzenellenbogen JA, Kharas M, Lewis JS, Dickler M, Serra V, Rosen N, Chandarlapaty S, Scaltriti M, Baselga J.

Sci Transl Med. 2015 Apr 15;7(283):283ra51. doi: 10.1126/scitranslmed.aaa4442. Erratum in: Sci Transl Med. 2018 Oct 24;10(464):.


Multiplex PCR assay for the rapid identification of human papillomavirus genotypes 16, 18, 45, 35, 66, 33, 51, 58, and 31 in clinical samples.

Tsakogiannis D, Diamantidou V, Toska E, Kyriakopoulou Z, Dimitriou TG, Ruether IG, Gortsilas P, Markoulatos P.

Arch Virol. 2015 Jan;160(1):207-14. doi: 10.1007/s00705-014-2261-6. Epub 2014 Oct 25.


Duplex Real-time PCR assay and SYBR green I melting curve analysis for molecular identification of HPV genotypes 16, 18, 31, 35, 51 and 66.

Tsakogiannis D, Papacharalampous M, Toska E, Kyriakopoulou Z, Dimitriou TG, Ruether IG, Komiotis D, Markoulatos P.

Mol Cell Probes. 2015 Feb;29(1):13-8. doi: 10.1016/j.mcp.2014.09.003. Epub 2014 Oct 2.


WT1 interacts with MAD2 and regulates mitotic checkpoint function.

Shandilya J, Toska E, Richard DJ, Medler KF, Roberts SG.

Nat Commun. 2014 Sep 18;5:4903. doi: 10.1038/ncomms5903.


Transcriptomic studies on liver toxicity of acetaminophen.

Toska E, Zagorsky R, Figler B, Cheng F.

Drug Dev Res. 2014 Sep;75(6):419-23. doi: 10.1002/ddr.21227. Review.


Medical pluralism predicts non-ART use among parents in need of ART: a community survey in KwaZulu-Natal, South Africa.

Pantelic M, Cluver L, Boyes M, Toska E, Kuo C, Moshabela M.

AIDS Behav. 2015 Jan;19(1):137-44. doi: 10.1007/s10461-014-0852-6.


Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment.

Castel P, Toska E, Zumsteg ZS, Carmona FJ, Elkabets M, Bosch A, Scaltriti M.

Mol Cell Oncol. 2014 Oct 29;1(3):e963447. doi: 10.4161/23723548.2014.963447. eCollection 2014 Jul-Sep. Review.


Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).

Toska E, Roberts SG.

Biochem J. 2014 Jul 1;461(1):15-32. doi: 10.1042/BJ20131587. Review.


WT1 regulates the development of the posterior taste field.

Gao Y, Toska E, Denmon D, Roberts SG, Medler KF.

Development. 2014 Jun;141(11):2271-8. doi: 10.1242/dev.105676. Epub 2014 May 6.

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