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Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism.

Owino S, Buonfiglio DDC, Tchio C, Tosini G.

Front Endocrinol (Lausanne). 2019 Jul 17;10:488. doi: 10.3389/fendo.2019.00488. eCollection 2019. Review.


Retinal Circadian Clocks are Major Players in the Modulation of Retinal Functions and Photoreceptor Viability.

DeVera C, Baba K, Tosini G.

Yale J Biol Med. 2019 Jun 27;92(2):233-240. eCollection 2019 Jun. Review.


Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus.

Buonfiglio D, Tchio C, Furigo I, Donato J Jr, Baba K, Cipolla-Neto J, Tosini G.

J Pineal Res. 2019 Sep;67(2):e12580. doi: 10.1111/jpi.12580. Epub 2019 Apr 29.


Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.

Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH.

J Pineal Res. 2019 Apr;66(3):e12553. doi: 10.1111/jpi.12553. Epub 2019 Feb 14.


Removal of clock gene Bmal1 from the retina affects retinal development and accelerates cone photoreceptor degeneration during aging.

Baba K, Piano I, Lyuboslavsky P, Chrenek MA, Sellers JT, Zhang S, Gargini C, He L, Tosini G, Iuvone PM.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13099-13104. doi: 10.1073/pnas.1808137115. Epub 2018 Nov 29.


Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.

Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G.

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4856-4870. doi: 10.1167/iovs.18-24957. Review.


Heteromeric MT1/MT2 melatonin receptors modulate the scotopic electroretinogram via PKCζ in mice.

Piano I, Baba K, Claudia Gargini, Tosini G.

Exp Eye Res. 2018 Dec;177:50-54. doi: 10.1016/j.exer.2018.07.026. Epub 2018 Jul 27.


Aging Alters Circadian Rhythms in the Mouse Eye.

Baba K, Tosini G.

J Biol Rhythms. 2018 Aug;33(4):441-445. doi: 10.1177/0748730418783648. Epub 2018 Jun 25.


The Retinal Circadian Clock and Photoreceptor Viability.

Baba K, Ribelayga CP, Michael Iuvone P, Tosini G.

Adv Exp Med Biol. 2018;1074:345-350. doi: 10.1007/978-3-319-75402-4_42. Review.


Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3.

Sánchez-Bretaño A, Baba K, Janjua U, Piano I, Gargini C, Tosini G.

Mol Vis. 2017 Dec 3;23:844-852. eCollection 2017.


Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.

Owino S, Sánchez-Bretaño A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12462. Epub 2018 Jan 9.


Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors.

Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone PM, Spessert R.

PLoS One. 2017 Oct 31;12(10):e0187411. doi: 10.1371/journal.pone.0187411. eCollection 2017.


Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium.

Laurent V, Sengupta A, Sánchez-Bretaño A, Hicks D, Tosini G.

Exp Eye Res. 2017 Dec;165:90-95. doi: 10.1016/j.exer.2017.09.007. Epub 2017 Sep 21.


Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium.

Baba K, DeBruyne JP, Tosini G.

Sci Rep. 2017 Jul 11;7(1):5103. doi: 10.1038/s41598-017-05394-x.


Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.

Vancura P, Wolloscheck T, Baba K, Tosini G, Iuvone PM, Spessert R.

PLoS One. 2016 Oct 11;11(10):e0164665. doi: 10.1371/journal.pone.0164665. eCollection 2016.


Update on melatonin receptors: IUPHAR Review 20.

Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP.

Br J Pharmacol. 2016 Sep;173(18):2702-25. doi: 10.1111/bph.13536. Epub 2016 Aug 8. Review.


Effects of blue light on the circadian system and eye physiology.

Tosini G, Ferguson I, Tsubota K.

Mol Vis. 2016 Jan 24;22:61-72. eCollection 2016. Review.


Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.

Owino S, Contreras-Alcantara S, Baba K, Tosini G.

PLoS One. 2016 Jan 29;11(1):e0148214. doi: 10.1371/journal.pone.0148214. eCollection 2016.


Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.

Gianesini C, Hiragaki S, Laurent V, Hicks D, Tosini G.

Invest Ophthalmol Vis Sci. 2016 Jan 1;57(1):94-104. doi: 10.1167/iovs.15-18235.


Pgc-1α and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina.

Kunst S, Wolloscheck T, Kelleher DK, Wolfrum U, Sargsyan SA, Iuvone PM, Baba K, Tosini G, Spessert R.

Invest Ophthalmol Vis Sci. 2015 Sep;56(10):6084-94. doi: 10.1167/iovs.15-17503.


Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea.

Baba K, Davidson AJ, Tosini G.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4753-8. doi: 10.1167/iovs.15-17124.


Unique Regulation of the Melatonin Synthetic Pathway in the Retina of Diurnal Female Arvicanthis ansorgei (Rodentia).

Gianesini C, Clesse D, Tosini G, Hicks D, Laurent V.

Endocrinology. 2015 Sep;156(9):3292-308. doi: 10.1210/EN.2015-1267. Epub 2015 Jul 8.


Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.

Evans JA, Suen TC, Callif BL, Mitchell AS, Castanon-Cervantes O, Baker KM, Kloehn I, Baba K, Teubner BJ, Ehlen JC, Paul KN, Bartness TJ, Tosini G, Leise T, Davidson AJ.

BMC Biol. 2015 Jun 23;13:43. doi: 10.1186/s12915-015-0157-x.


Melatonin signaling modulates clock genes expression in the mouse retina.

Hiragaki S, Baba K, Coulson E, Kunst S, Spessert R, Tosini G.

PLoS One. 2014 Sep 9;9(9):e106819. doi: 10.1371/journal.pone.0106819. eCollection 2014.


Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease.

Tosini G, Owino S, Guillaume JL, Jockers R.

Bioessays. 2014 Aug;36(8):778-87. doi: 10.1002/bies.201400017. Epub 2014 Jun 5. Review.


N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.

Iuvone PM, Boatright JH, Tosini G, Ye K.

Adv Exp Med Biol. 2014;801:765-71. doi: 10.1007/978-1-4614-3209-8_96.


Circadian organization of the mammalian retina: from gene regulation to physiology and diseases.

McMahon DG, Iuvone PM, Tosini G.

Prog Retin Eye Res. 2014 Mar;39:58-76. doi: 10.1016/j.preteyeres.2013.12.001. Epub 2013 Dec 12. Review.


Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.

Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G.

Sci Signal. 2013 Oct 8;6(296):ra89. doi: 10.1126/scisignal.2004302.


Is the melatonin receptor type 1 involved in the pathogenesis of glaucoma?

Tosini G, Iuvone M, Boatright JH.

J Glaucoma. 2013 Jun-Jul;22 Suppl 5:S49-50. doi: 10.1097/IJG.0b013e3182934bb4. Review. Erratum in: J Glaucoma. 2013 Sep;22(7):598. Iuvone, Michael [added].


Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells.

Dortch-Carnes J, Tosini G.

Exp Eye Res. 2013 Feb;107:1-10. doi: 10.1016/j.exer.2012.11.007. Epub 2012 Nov 29.


Melatonin: an underappreciated player in retinal physiology and pathophysiology.

Tosini G, Baba K, Hwang CK, Iuvone PM.

Exp Eye Res. 2012 Oct;103:82-9. doi: 10.1016/j.exer.2012.08.009. Epub 2012 Aug 31. Review.


Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain.

Baba K, Mazzoni F, Owino S, Contreras-Alcantara S, Strettoi E, Tosini G.

PLoS One. 2012;7(5):e37799. doi: 10.1371/journal.pone.0037799. Epub 2012 May 22.


N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.

Tosini G, Ye K, Iuvone PM.

Neuroscientist. 2012 Dec;18(6):645-53. doi: 10.1177/1073858412446634. Epub 2012 May 14. Review.


GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness.

Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P Jr, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AF, Nishina PM, Lachapelle P, McCall MA, Koenekoop RK, Bergen AA, Kamermans M, Gregg RG.

Am J Hum Genet. 2012 Feb 10;90(2):331-9. doi: 10.1016/j.ajhg.2011.12.006.


Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels.

Sengupta A, Baba K, Mazzoni F, Pozdeyev NV, Strettoi E, Iuvone PM, Tosini G.

PLoS One. 2011;6(9):e24483. doi: 10.1371/journal.pone.0024483. Epub 2011 Sep 7.


N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice.

Sompol P, Liu X, Baba K, Paul KN, Tosini G, Iuvone PM, Ye K.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8844-9. doi: 10.1073/pnas.1105114108. Epub 2011 May 9.


Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.

Alcantara-Contreras S, Baba K, Tosini G.

Neurosci Lett. 2011 Apr 20;494(1):61-4. doi: 10.1016/j.neulet.2011.02.056.


Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid.

Baba K, Sengupta A, Tosini M, Contreras-Alcantara S, Tosini G.

Mol Vis. 2010 Dec 7;16:2605-11.


Chronic sleep deprivation markedly reduces coagulation factor VII expression.

Pinotti M, Bertolucci C, Frigato E, Branchini A, Cavallari N, Baba K, Contreras-Alcantara S, Ehlen JC, Bernardi F, Paul KN, Tosini G.

Haematologica. 2010 Aug;95(8):1429-32. doi: 10.3324/haematol.2010.022475. Epub 2010 Apr 23.


Removal of melatonin receptor type 1 induces insulin resistance in the mouse.

Contreras-Alcantara S, Baba K, Tosini G.

Obesity (Silver Spring). 2010 Sep;18(9):1861-3. doi: 10.1038/oby.2010.24. Epub 2010 Feb 18.


N-acetylserotonin activates TrkB receptor in a circadian rhythm.

Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM, Ye K.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81. doi: 10.1073/pnas.0912531107. Epub 2010 Feb 4.


The role of retinal photoreceptors in the regulation of circadian rhythms.

Paul KN, Saafir TB, Tosini G.

Rev Endocr Metab Disord. 2009 Dec;10(4):271-8. doi: 10.1007/s11154-009-9120-x. Review.


Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.

Baba K, Pozdeyev N, Mazzoni F, Contreras-Alcantara S, Liu C, Kasamatsu M, Martinez-Merlos T, Strettoi E, Iuvone PM, Tosini G.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15043-8. doi: 10.1073/pnas.0904400106. Epub 2009 Aug 14.


Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina.

Pozdeyev N, Tosini G, Li L, Ali F, Rozov S, Lee RH, Iuvone PM.

Eur J Neurosci. 2008 May;27(10):2691-700. doi: 10.1111/j.1460-9568.2008.06224.x.


The circadian clock system in the mammalian retina.

Tosini G, Pozdeyev N, Sakamoto K, Iuvone PM.

Bioessays. 2008 Jul;30(7):624-33. doi: 10.1002/bies.20777. Review.


Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.

Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Foá A, Tosini G, Bernardi F, Pinotti M.

Mol Cell Biol. 2008 May;28(9):3070-5. doi: 10.1128/MCB.01931-07. Epub 2008 Mar 3.


Analysis of daily and circadian gene expression in the rat pineal gland.

Fukuhara C, Tosini G.

Neurosci Res. 2008 Feb;60(2):192-8. Epub 2007 Nov 6.


Localization of a circadian clock in mammalian photoreceptors.

Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O.

FASEB J. 2007 Dec;21(14):3866-71. Epub 2007 Jul 9. Erratum in: FASEB J. 2008 Mar;22(3):941. FASEB J. 2008 Mar;22(3):941.


Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration.

Tosini G, Kasamatsu M, Sakamoto K.

Brain Res. 2007 Jul 23;1159:134-40. Epub 2007 May 23.


Locomotor activity in rodents.

Tosini G.

Methods Mol Biol. 2007;362:95-101.


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