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Items: 21

1.

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.

Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Noordegraaf AV, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW.

Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-585. doi: 10.1164/rccm.201906-1141OC.

PMID:
31661308
2.

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.

Sofianopoulou E, Kaptoge S, Gräf S, Hadinnapola C, Treacy CM, Church C, Coghlan G, Gibbs JSR, Haimel M, Howard LS, Johnson M, Kiely DG, Lawrie A, Lordan J, MacKenzie Ross RV, Martin JM, Moledina S, Newnham M, Peacock AJ, Price LC, Rhodes CJ, Suntharalingam J, Swietlik EM, Toshner MR, Wharton J, Wilkins MR, Wort SJ, Pepke-Zaba J, Condliffe R, Corris PA, Di Angelantonio E, Provencher S, Morrell NW.

Eur Respir J. 2019 May 30;53(5). pii: 1801429. doi: 10.1183/13993003.01429-2018. Print 2019 May.

PMID:
30923185
3.

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR; UK NIHR BioResource Rare Diseases Consortium; UK PAH Cohort Study Consortium; US PAH Biobank Consortium.

Lancet Respir Med. 2019 Mar;7(3):227-238. doi: 10.1016/S2213-2600(18)30409-0. Epub 2018 Dec 5.

4.

Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension.

Swietlik EM, Ruggiero A, Fletcher AJ, Taboada D, Knightbridge E, Harlow L, Harvey I, Screaton N, Cannon JE, Sheares KKK, Ng C, Jenkins DP, Pepke-Zaba J, Toshner MR.

Eur Respir J. 2019 Jan 17;53(1). pii: 1801787. doi: 10.1183/13993003.01787-2018. Print 2019 Jan. No abstract available.

PMID:
30409818
5.

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.

Crosby A, Toshner MR, Southwood MR, Soon E, Dunmore BJ, Groves E, Moore S, Wright P, Ottersbach K, Bennett C, Guerrero J, Ghevaert C, Morrell NW.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018801642. doi: 10.1177/2045894018801642. Epub 2018 Aug 30.

6.

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.

Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Aldred M, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, MacKenzie Ross RV, Moledina S, Montani D, Newnham M, Olschewski A, Olschewski H, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Stein DF, Suntharalingam J, Swietlik EM, Toshner MR, van Heel DA, Vonk Noordegraaf A, Waisfisz Q, Wharton J, Wort SJ, Ouwehand WH, Soranzo N, Lawrie A, Upton PD, Wilkins MR, Trembath RC, Morrell NW.

Nat Commun. 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4.

7.

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Rhodes CJ, Ghataorhe P, Wharton J, Rue-Albrecht KC, Hadinnapola C, Watson G, Bleda M, Haimel M, Coghlan G, Corris PA, Howard LS, Kiely DG, Peacock AJ, Pepke-Zaba J, Toshner MR, Wort SJ, Gibbs JS, Lawrie A, Gräf S, Morrell NW, Wilkins MR.

Circulation. 2017 Jan 31;135(5):460-475. doi: 10.1161/CIRCULATIONAHA.116.024602. Epub 2016 Nov 21.

8.

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities.

Millar FR, Summers C, Griffiths MJ, Toshner MR, Proudfoot AG.

Thorax. 2016 May;71(5):462-73. doi: 10.1136/thoraxjnl-2015-207461. Epub 2016 Mar 11. Review.

PMID:
26968969
9.

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood.

Ormiston ML, Toshner MR, Kiskin FN, Huang CJ, Groves E, Morrell NW, Rana AA.

J Vis Exp. 2015 Dec 23;(106):e53384. doi: 10.3791/53384.

10.

Hepatic Shunting of Eggs and Pulmonary Vascular Remodeling in Bmpr2(+/-) Mice with Schistosomiasis.

Crosby A, Soon E, Jones FM, Southwood MR, Haghighat L, Toshner MR, Raine T, Horan I, Yang P, Moore S, Ferrer E, Wright P, Ormiston ML, White RJ, Haight DA, Dunne DW, Morrell NW.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1355-65. doi: 10.1164/rccm.201412-2262OC.

11.

Reply to "Letter to the editor: 'Pulsatile pulmonary artery pressure: are fluid-filled catheters accurate in pulmonary hypertension?'".

Mackenzie Ross RV, Toshner MR, Soon E, Naeije R, Pepke-Zaba J.

Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1682. doi: 10.1152/ajpheart.00763.2013. No abstract available.

12.

Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension.

MacKenzie Ross RV, Toshner MR, Soon E, Naeije R, Pepke-Zaba J.

Am J Physiol Heart Circ Physiol. 2013 Jul 15;305(2):H259-64. doi: 10.1152/ajpheart.00128.2013. Epub 2013 May 17.

13.

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.

Dunmore BJ, Drake KM, Upton PD, Toshner MR, Aldred MA, Morrell NW.

Hum Mol Genet. 2013 Sep 15;22(18):3667-79. doi: 10.1093/hmg/ddt216. Epub 2013 May 12.

14.

Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension.

Ormiston ML, Chang C, Long LL, Soon E, Jones D, Machado R, Treacy C, Toshner MR, Campbell K, Riding A, Southwood M, Pepke-Zaba J, Exley A, Trembath RC, Colucci F, Wills M, Trowsdale J, Morrell NW.

Circulation. 2012 Aug 28;126(9):1099-109. doi: 10.1161/CIRCULATIONAHA.112.110619. Epub 2012 Jul 25.

PMID:
22832786
15.

The fibrocyte in pulmonary hypertension: we seek him here, we seek him there.

Toshner MR, Morrell NW.

Eur Respir J. 2012 Jan;39(1):5-6. doi: 10.1183/09031936.00127111. No abstract available.

16.

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension.

Soon E, Treacy CM, Toshner MR, MacKenzie-Ross R, Manglam V, Busbridge M, Sinclair-McGarvie M, Arnold J, Sheares KK, Morrell NW, Pepke-Zaba J.

Thorax. 2011 Apr;66(4):326-32. doi: 10.1136/thx.2010.147272. Epub 2011 Feb 5.

PMID:
21297151
17.

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension.

Toshner MR, Gopalan D, Suntharalingam J, Treacy C, Soon E, Sheares KK, Morrell NW, Screaton N, Pepke-Zaba J.

J Heart Lung Transplant. 2010 Jun;29(6):610-5. doi: 10.1016/j.healun.2009.12.014. Epub 2010 Mar 15.

18.

NT-proBNP does not rise on acute ascent to high altitude.

Toshner MR, Thompson AA, Irving JB, Baillie JK, Morton JJ, Peacock AJ.

High Alt Med Biol. 2008 Winter;9(4):307-10. doi: 10.1089/ham.2008.1054.

PMID:
19115915
19.

Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Treacy CM, Doughty NJ, Goldsmith K, Soon E, Toshner MR, Sheares KK, Hughes R, Morrell NW, Pepke-Zaba J.

Chest. 2008 Aug;134(2):229-236. doi: 10.1378/chest.07-2681. Epub 2008 Feb 8.

PMID:
18263674
20.

Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Goldsmith K, van Marion V, Long L, Treacy CM, Dudbridge F, Toshner MR, Pepke-Zaba J, Eikenboom JC, Morrell NW.

Eur Respir J. 2008 Apr;31(4):736-41. Epub 2007 Dec 5.

21.

Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Machado RD, Sharples LD, Toshner MR, Sheares KK, Hughes RJ, Jenkins DP, Trembath RC, Morrell NW, Pepke-Zaba J.

Thorax. 2007 Jul;62(7):617-22. Epub 2007 Feb 7.

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