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Items: 44

1.

Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy.

Mett V, Komarova EA, Greene K, Bespalov I, Brackett C, Gillard B, Gleiberman AS, Toshkov IA, Aygün-Sunar S, Johnson C, Karasik E, Bapardekar-Nair M, Kurnasov OV, Osterman AL, Stanhope-Baker PS, Morrison C, Moser MT, Foster BA, Gudkov AV.

Oncogene. 2018 Jan 25;37(4):439-449. doi: 10.1038/onc.2017.346. Epub 2017 Oct 2.

2.

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.

Antoch MP, Wrobel M, Kuropatwinski KK, Gitlin I, Leonova KI, Toshkov I, Gleiberman AS, Hutson AD, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Mar 19;9(3):615-626. doi: 10.18632/aging.101206.

3.

Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation.

Toshkov IA, Gleiberman AS, Mett VL, Hutson AD, Singh AK, Gudkov AV, Burdelya LG.

Radiat Res. 2017 May;187(5):570-580. doi: 10.1667/RR14514.1. Epub 2017 Mar 21.

4.

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.

Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E.

PLoS One. 2015 Sep 14;10(9):e0135388. doi: 10.1371/journal.pone.0135388. eCollection 2015.

5.

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.

Burkhart C, Fleyshman D, Kohrn R, Commane M, Garrigan J, Kurbatov V, Toshkov I, Ramachandran R, Martello L, Gurova KV.

Oncotarget. 2014 Nov 30;5(22):11038-53.

6.

Daily rhythms are retained both in spontaneously developed sarcomas and in xenografts grown in immunocompromised SCID mice.

Comas M, Kuropatwinski KK, Wrobel M, Toshkov I, Antoch MP.

Chronobiol Int. 2014 Oct;31(8):901-10. doi: 10.3109/07420528.2014.925469. Epub 2014 Jun 16.

7.

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice.

Kojouharov BM, Brackett CM, Veith JM, Johnson CP, Gitlin II, Toshkov IA, Gleiberman AS, Gudkov AV, Burdelya LG.

Oncotarget. 2014 Feb 15;5(3):802-14.

8.

Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.

Antoch MP, Toshkov I, Kuropatwinski KK, Jackson M.

Cell Cycle. 2013 Dec 1;12(23):3673-80. doi: 10.4161/cc.26614. Epub 2013 Oct 2.

9.

Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma.

Ochoa-Callejero L, Toshkov I, Menne S, Martínez A.

J Med Virol. 2013 Jul;85(7):1127-38. doi: 10.1002/jmv.23571. Epub 2013 Apr 17.

PMID:
23595580
10.

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP.

Aging (Albany NY). 2012 Oct;4(10):715-22.

11.

Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.

Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV.

Cancer Prev Res (Phila). 2012 Aug;5(8):1025-35. doi: 10.1158/1940-6207.CAPR-11-0529. Epub 2012 Jun 11.

12.

Hepatitis delta virus infects the cells of hepadnavirus-induced hepatocellular carcinoma in woodchucks.

Freitas N, Salisse J, Cunha C, Toshkov I, Menne S, Gudima SO.

Hepatology. 2012 Jul;56(1):76-85. doi: 10.1002/hep.25663. Epub 2012 Apr 25.

13.

Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.

Burdelya LG, Gleiberman AS, Toshkov I, Aygun-Sunar S, Bapardekar M, Manderscheid-Kern P, Bellnier D, Krivokrysenko VI, Feinstein E, Gudkov AV.

Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):228-34. doi: 10.1016/j.ijrobp.2011.05.055. Epub 2011 Oct 14.

14.

Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.

Cheng L, Zhou Z, Flesken-Nikitin A, Toshkov IA, Wang W, Camps J, Ried T, Nikitin AY.

Oncogene. 2010 Oct 21;29(42):5700-11. doi: 10.1038/onc.2010.300. Epub 2010 Aug 2.

15.

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.

Leonova KI, Shneyder J, Antoch MP, Toshkov IA, Novototskaya LR, Komarov PG, Komarova EA, Gudkov AV.

Cell Cycle. 2010 Apr 1;9(7):1434-43. Epub 2010 Apr 1.

16.

Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR.

Schug TT, Berry DC, Toshkov IA, Cheng L, Nikitin AY, Noy N.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7546-51. doi: 10.1073/pnas.0709981105. Epub 2008 May 21.

17.

Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.

Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA, Lee C, Nikitin AY.

Cell Cycle. 2008 May 1;7(9):1197-204. Epub 2008 Mar 10.

18.

Toxicity and biomedical imaging of layered nanohybrids in the mouse.

Flesken-Nikitin A, Toshkov I, Naskar J, Tyner KM, Williams RM, Zipfel WR, Giannelis EP, Nikitin AY.

Toxicol Pathol. 2007 Oct;35(6):806-12.

PMID:
17943654
19.

Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection.

Menne S, Cote PJ, Butler SD, Toshkov IA, Gerin JL, Tennant BC.

Hepatology. 2007 Mar;45(3):614-22.

PMID:
17326155
20.

Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.

Casey J, Cote PJ, Toshkov IA, Chu CK, Gerin JL, Hornbuckle WE, Tennant BC, Korba BE.

Antimicrob Agents Chemother. 2005 Oct;49(10):4396-9.

21.

Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection.

Korba BE, Cote PJ, Menne S, Toshkov I, Baldwin BH, Wells FV, Tennant BC, Gerin JL.

Antivir Ther. 2004 Dec;9(6):937-52.

PMID:
15651753
22.

Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection.

Tennant BC, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL.

Gastroenterology. 2004 Nov;127(5 Suppl 1):S283-93. Review.

PMID:
15508096
23.

Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model.

Jacob JR, Korba BE, Cote PJ, Toshkov I, Delaney WE 4th, Gerin JL, Tennant BC.

Antiviral Res. 2004 Aug;63(2):115-21.

PMID:
15302140
25.

Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors.

Jacob JR, Sterczer A, Toshkov IA, Yeager AE, Korba BE, Cote PJ, Buendia MA, Gerin JL, Tennant BC.

Hepatology. 2004 Apr;39(4):1008-16.

PMID:
15057905
26.

Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax).

Peek SF, Cote PJ, Jacob JR, Toshkov IA, Hornbuckle WE, Baldwin BH, Wells FV, Chu CK, Gerin JL, Tennant BC, Korba BE.

Hepatology. 2001 Jan;33(1):254-66.

PMID:
11124844
27.

Temporal pathogenesis of experimental neonatal woodchuck hepatitis virus infection: increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection.

Cote PJ, Toshkov I, Bellezza C, Ascenzi M, Roneker C, Ann Graham L, Baldwin BH, Gaye K, Nakamura I, Korba BE, Tennant BC, Gerin JL.

Hepatology. 2000 Oct;32(4 Pt 1):807-17.

PMID:
11003627
28.

Establishment of tumor cell culture (ILA) derived from hamster pancreatic islets treated with BOP.

Toshkov I, Schmied B, Adrian TE, Murphy L, Haay W, Pour PM.

Int J Cancer. 1998 Nov 23;78(5):636-41.

29.

Hepatic expression of the woodchuck hepatitis virus X-antigen during acute and chronic infection and detection of a woodchuck hepatitis virus X-antigen antibody response.

Jacob JR, Ascenzi MA, Roneker CA, Toshkov IA, Cote PJ, Gerin JL, Tennant BC.

Hepatology. 1997 Dec;26(6):1607-15.

PMID:
9398005
30.

Experimental evidence for the origin of ductal-type adenocarcinoma from the islets of Langerhans.

Pour PM, Weide L, Liu G, Kazakoff K, Scheetz M, Toshkov I, Ikematsu Y, Fienhold MA, Sanger W.

Am J Pathol. 1997 Jun;150(6):2167-80.

31.

A novel adhesion factor produced by hamster pancreatic cancer cell line is effective on normal and carcinoma cell lines of different species.

Toshkov IA, Chaney WG, Colcher DM, Hollingsworth MA, Bratanova TK, Perini F, Pour PM.

Int J Pancreatol. 1995 Dec;18(3):249-55.

PMID:
8708397
32.

Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas.

Nair SC, Toshkov IA, Yaktine AL, Barnett TD, Chaney WG, Birt DF.

Mol Carcinog. 1995 Sep;14(1):10-5.

PMID:
7546218
33.

Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice with carbonic anhydrase II.

Nishimori I, Bratanova T, Toshkov I, Caffrey T, Mogaki M, Shibata Y, Hollingsworth MA.

J Immunol. 1995 May 1;154(9):4865-73.

PMID:
7722336
34.

Cellular and subcellular localization of transforming growth factor-alpha and epidermal growth factor receptor in normal and diseased human and hamster pancreas.

Tomioka T, Toshkov I, Kazakoff K, Andrén-Sandberg A, Takahashi T, Büchler M, Friess H, Vaughn R, Pour PM.

Teratog Carcinog Mutagen. 1995;15(5):231-50.

PMID:
8867879
35.

Hepatic preneoplasia in hepatitis B virus transgenic mice.

Toshkov I, Chisari FV, Bannasch P.

Hepatology. 1994 Nov;20(5):1162-72.

PMID:
7927248
36.

The patterns of coexpression of tumor-associated antigens CA 19-9, TAG-72, and DU-PAN-2 in human pancreatic cancer.

Toshkov I, Mogaki M, Kazakoff K, Pour PM.

Int J Pancreatol. 1994 Apr;15(2):97-103.

PMID:
8071575
37.

Persistence of the cholangiocellular and hepatocellular lesions observed in rats fed a choline-deficient/DL-ethionine-supplemented diet.

Hacker HJ, Steinberg P, Toshkov I, Oesch F, Bannasch P.

Carcinogenesis. 1992 Feb;13(2):271-6.

PMID:
1310907
38.

Virus-induced pancreatic cancer in guinea fowl. An electron-microscopical study.

Toshkov I, Kirev T, Bannasch P.

Int J Pancreatol. 1991 Sep;10(1):51-64.

PMID:
1661771
39.

Mucin histochemistry of virus-induced duodenal adenomas in guinea fowl.

Toshkov I, Kirev T.

J Cancer Res Clin Oncol. 1990;116(1):38-44.

PMID:
2312604
40.

Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus.

Toshkov I, Hacker HJ, Roggendorf M, Bannasch P.

J Cancer Res Clin Oncol. 1990;116(6):581-90.

PMID:
2152341
41.

Pathogenic effect of osteopetrosis virus strain MAV-2(0) on guinea fowl pancreas.

Kirev TT, Toshkov IA, Mladenov ZM.

Int J Pancreatol. 1989 Jul;5(1):29-34.

PMID:
2545796
42.

Virus-induced duodenal adenomas in guinea fowl.

Kirev TT, Toshkov IA, Mladenov ZM.

J Natl Cancer Inst. 1987 Nov;79(5):1117-21.

PMID:
3479637
43.

Virus-induced pancreatic cancer in guinea fowl: a morphologic study.

Kirev TT, Toshkov IA, Mladenov ZM.

J Natl Cancer Inst. 1986 Sep;77(3):713-20.

PMID:
3018343
44.

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