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Items: 1 to 50 of 205

1.

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.

Stockstill K, Wahlman C, Braden K, Chen Z, Yosten GL, Tosh DK, Jacobson KA, Doyle TM, Samson WK, Salvemini D.

Pain. 2019 Sep 3. doi: 10.1097/j.pain.0000000000001697. [Epub ahead of print]

PMID:
31490328
2.

Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells.

Al-Adsani A, Burke ZD, Eberhard D, Lawrence KL, Shen CN, Rustgi AK, Sakaue H, Mark Farrant J, Tosh D.

PLoS One. 2019 Jul 2;14(7):e0219419. doi: 10.1371/journal.pone.0219419. eCollection 2019.

3.

Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1).

Abel B, Tosh DK, Durell SR, Murakami M, Vahedi S, Jacobson KA, Ambudkar SV.

Mol Pharmacol. 2019 Aug;96(2):180-192. doi: 10.1124/mol.118.115295. Epub 2019 May 24.

4.

Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.

Coppi E, Cherchi F, Fusco I, Failli P, Vona A, Dettori I, Gaviano L, Lucarini E, Jacobson KA, Tosh DK, Salvemini D, Ghelardini C, Pedata F, Di Cesare Mannelli L, Pugliese AM.

Pain. 2019 May;160(5):1103-1118. doi: 10.1097/j.pain.0000000000001488.

PMID:
31008816
5.

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development.

Jacobson KA, Tosh DK, Jain S, Gao ZG.

Front Cell Neurosci. 2019 Mar 28;13:124. doi: 10.3389/fncel.2019.00124. eCollection 2019. Review.

6.

Design and in Vivo Characterization of A1 Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh DK, Rao H, Bitant A, Salmaso V, Mannes P, Lieberman DI, Vaughan KL, Mattison JA, Rothwell AC, Auchampach JA, Ciancetta A, Liu N, Cui Z, Gao ZG, Reitman ML, Gavrilova O, Jacobson KA.

J Med Chem. 2019 Feb 14;62(3):1502-1522. doi: 10.1021/acs.jmedchem.8b01662. Epub 2019 Jan 3.

PMID:
30605331
7.

Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens.

Hall CE, Hagan LM, Bergmann-Leitner E, Tosh DM, Bennett JW, Regules JA, Chuang I, Angov E, Dutta S, Chattopadhyay D, Yadava A.

Infect Immun. 2019 Feb 21;87(3). pii: e00541-18. doi: 10.1128/IAI.00541-18. Print 2019 Mar.

8.

Seasonal and predator-prey effects on circadian activity of free-ranging mammals revealed by camera traps.

Caravaggi A, Gatta M, Vallely MC, Hogg K, Freeman M, Fadaei E, Dick JTA, Montgomery WI, Reid N, Tosh DG.

PeerJ. 2018 Nov 21;6:e5827. doi: 10.7717/peerj.5827. eCollection 2018.

9.

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists.

Tosh DK, Ciancetta A, Mannes P, Warnick E, Janowsky A, Eshleman AJ, Gizewski E, Brust TF, Bohn LM, Auchampach JA, Gao ZG, Jacobson KA.

ACS Omega. 2018 Oct 31;3(10):12658-12678. doi: 10.1021/acsomega.8b01237. Epub 2018 Oct 4.

10.

Next generation in vitro liver model design: Combining a permeable polystyrene membrane with a transdifferentiated cell line.

Luetchford KA, Wung N, Argyle IS, Storm MP, Weston SD, Tosh D, Ellis MJ.

J Memb Sci. 2018 Nov 1;565:425-438. doi: 10.1016/j.memsci.2018.07.063.

11.

Probing structure-activity relationship in β-arrestin2 recruitment of diversely substituted adenosine derivatives.

Storme J, Tosh DK, Gao ZG, Jacobson KA, Stove CP.

Biochem Pharmacol. 2018 Dec;158:103-113. doi: 10.1016/j.bcp.2018.10.003. Epub 2018 Oct 4.

PMID:
30292756
12.

HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.

Fairhall EA, Leitch AC, Lakey AF, Abdelghany TM, Ibrahim I, Tosh D, Kass GEN, Wilson C, Wright MC.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1633-1640. doi: 10.1016/j.bbrc.2018.07.092. Epub 2018 Jul 26.

PMID:
30057318
13.

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation.

Navratna V, Tosh DK, Jacobson KA, Gouaux E.

PLoS One. 2018 Jul 2;13(7):e0200085. doi: 10.1371/journal.pone.0200085. eCollection 2018.

14.

Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins.

Gratte FD, Pasic S, Olynyk JK, Yeoh GCT, Tosh D, Coombe DR, Tirnitz-Parker JEE.

Sci Rep. 2018 Mar 12;8(1):4385. doi: 10.1038/s41598-018-22596-z.

15.

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Burke ZD, Reed KR, Yeh SW, Meniel V, Sansom OJ, Clarke AR, Tosh D.

Sci Rep. 2018 Feb 9;8(1):2735. doi: 10.1038/s41598-018-20888-y.

16.

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms.

Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D.

Pain. 2018 Jun;159(6):1025-1034. doi: 10.1097/j.pain.0000000000001177.

17.

A binding kinetics study of human adenosine A3 receptor agonists.

Xia L, Kyrizaki A, Tosh DK, van Duijl TT, Roorda JC, Jacobson KA, IJzerman AP, Heitman LH.

Biochem Pharmacol. 2018 Jul;153:248-259. doi: 10.1016/j.bcp.2017.12.026. Epub 2018 Jan 3.

18.

Polypharmacology of conformationally locked methanocarba nucleosides.

Jacobson KA, Tosh DK, Toti KS, Ciancetta A.

Drug Discov Today. 2017 Dec;22(12):1782-1791. doi: 10.1016/j.drudis.2017.07.013. Epub 2017 Aug 3. Review.

19.

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.

Jacobson KA, Merighi S, Varani K, Borea PA, Baraldi S, Aghazadeh Tabrizi M, Romagnoli R, Baraldi PG, Ciancetta A, Tosh DK, Gao ZG, Gessi S.

Med Res Rev. 2018 Jul;38(4):1031-1072. doi: 10.1002/med.21456. Epub 2017 Jul 6. Review.

20.

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.

Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA.

J Med Chem. 2017 Apr 13;60(7):3109-3123. doi: 10.1021/acs.jmedchem.7b00141. Epub 2017 Mar 20.

21.

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

Epstein JE, Paolino KM, Richie TL, Sedegah M, Singer A, Ruben AJ, Chakravarty S, Stafford A, Ruck RC, Eappen AG, Li T, Billingsley PF, Manoj A, Silva JC, Moser K, Nielsen R, Tosh D, Cicatelli S, Ganeshan H, Case J, Padilla D, Davidson S, Garver L, Saverino E, Murshedkar T, Gunasekera A, Twomey PS, Reyes S, Moon JE, James ER, Kc N, Li M, Abot E, Belmonte A, Hauns K, Belmonte M, Huang J, Vasquez C, Remich S, Carrington M, Abebe Y, Tillman A, Hickey B, Regules J, Villasante E, Sim BKL, Hoffman SL.

JCI Insight. 2017 Jan 12;2(1):e89154. doi: 10.1172/jci.insight.89154.

22.

Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.

Nathubhai A, Haikarainen T, Koivunen J, Murthy S, Koumanov F, Lloyd MD, Holman GD, Pihlajaniemi T, Tosh D, Lehtiö L, Threadgill MD.

J Med Chem. 2017 Jan 26;60(2):814-820. doi: 10.1021/acs.jmedchem.6b01574. Epub 2017 Jan 9.

PMID:
27983846
23.

Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.

Tosh DK, Ciancetta A, Warnick E, Crane S, Gao ZG, Jacobson KA.

J Med Chem. 2016 Dec 22;59(24):11006-11026. doi: 10.1021/acs.jmedchem.6b01183. Epub 2016 Dec 9.

24.

Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.

Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML.

Neuropharmacology. 2017 Mar 1;114:101-113. doi: 10.1016/j.neuropharm.2016.11.026. Epub 2016 Nov 30.

25.

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

Colleypriest BJ, Burke ZD, Griffiths LP, Chen Y, Yu WY, Jover R, Bock M, Biddlestone L, Quinlan JM, Ward SG, Mark Farrant J, Slack JM, Tosh D.

Differentiation. 2017 Jan - Feb;93:39-49. doi: 10.1016/j.diff.2016.11.001. Epub 2016 Nov 19.

26.

Maternal vitamin A deficiency during pregnancy affects vascularized islet development.

Chien CY, Lee HS, Cho CH, Lin KI, Tosh D, Wu RR, Mao WY, Shen CN.

J Nutr Biochem. 2016 Oct;36:51-59. doi: 10.1016/j.jnutbio.2016.07.010. Epub 2016 Aug 4.

PMID:
27573099
27.

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.

Baltos JA, Paoletta S, Nguyen AT, Gregory KJ, Tosh DK, Christopoulos A, Jacobson KA, May LT.

Mol Pharmacol. 2016 Jul;90(1):12-22. doi: 10.1124/mol.116.103283. Epub 2016 May 2.

28.

Pure species in a continuum of genetic and morphological variation: sympatric oaks at the edge of their range.

Beatty GE, Montgomery WI, Spaans F, Tosh DG, Provan J.

Ann Bot. 2016 Apr;117(4):541-9. doi: 10.1093/aob/mcw002. Epub 2016 Feb 29.

29.

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy.

Bennett JW, Yadava A, Tosh D, Sattabongkot J, Komisar J, Ware LA, McCarthy WF, Cowden JJ, Regules J, Spring MD, Paolino K, Hartzell JD, Cummings JF, Richie TL, Lumsden J, Kamau E, Murphy J, Lee C, Parekh F, Birkett A, Cohen J, Ballou WR, Polhemus ME, Vanloubbeeck YF, Vekemans J, Ockenhouse CF.

PLoS Negl Trop Dis. 2016 Feb 26;10(2):e0004423. doi: 10.1371/journal.pntd.0004423. eCollection 2016 Feb.

30.

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.

Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA.

J Med Chem. 2016 Apr 14;59(7):3249-63. doi: 10.1021/acs.jmedchem.5b01998. Epub 2016 Feb 18.

31.

Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.

Janowsky A, Tosh DK, Eshleman AJ, Jacobson KA.

J Pharmacol Exp Ther. 2016 Apr;357(1):24-35. doi: 10.1124/jpet.115.229666. Epub 2016 Jan 26.

32.

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

Carlin JL, Tosh DK, Xiao C, Piñol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML.

J Pharmacol Exp Ther. 2016 Feb;356(2):474-82. doi: 10.1124/jpet.115.229872. Epub 2015 Nov 25.

33.

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.

Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D.

Neuron. 2015 Aug 5;87(3):549-62. doi: 10.1016/j.neuron.2015.07.010.

34.

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.

Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA.

Medchemcomm. 2015;6:555-563.

35.

Metabolic mapping of A3 adenosine receptor agonist MRS5980.

Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz KW, O'Connor R, Jacobson KA, Gonzalez FJ.

Biochem Pharmacol. 2015 Sep 15;97(2):215-23. doi: 10.1016/j.bcp.2015.07.007. Epub 2015 Jul 23.

36.

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.

Tosh DK, Crane S, Chen Z, Paoletta S, Gao ZG, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA.

ACS Med Chem Lett. 2015 May 20;6(7):804-8. doi: 10.1021/acsmedchemlett.5b00150. eCollection 2015 Jul 9.

37.

Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults.

Ockenhouse CF, Regules J, Tosh D, Cowden J, Kathcart A, Cummings J, Paolino K, Moon J, Komisar J, Kamau E, Oliver T, Chhoeu A, Murphy J, Lyke K, Laurens M, Birkett A, Lee C, Weltzin R, Wille-Reece U, Sedegah M, Hendriks J, Versteege I, Pau MG, Sadoff J, Vanloubbeeck Y, Lievens M, Heerwegh D, Moris P, Guerra Mendoza Y, Jongert E, Cohen J, Voss G, Ballou WR, Vekemans J.

PLoS One. 2015 Jul 6;10(7):e0131571. doi: 10.1371/journal.pone.0131571. eCollection 2015.

38.

Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain.

Tosh DK, Padia J, Salvemini D, Jacobson KA.

Purinergic Signal. 2015 Sep;11(3):371-87. doi: 10.1007/s11302-015-9459-2. Epub 2015 Jun 27.

39.

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors.

Jacobson KA, Gao ZG, Paoletta S, Kiselev E, Chakraborty S, Jayasekara PS, Balasubramanian R, Tosh DK.

Comput Struct Biotechnol J. 2014 Oct 16;13:286-98. doi: 10.1016/j.csbj.2014.10.004. eCollection 2015. Review.

40.

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.

Ford A, Castonguay A, Cottet M, Little JW, Chen Z, Symons-Liguori AM, Doyle T, Egan TM, Vanderah TW, De Koninck Y, Tosh DK, Jacobson KA, Salvemini D.

J Neurosci. 2015 Apr 15;35(15):6057-67. doi: 10.1523/JNEUROSCI.4495-14.2015. Erratum in: J Neurosci. 2015 Jun 10;35(23):8971.

41.

Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.

Wang KC, Brooks DA, Summers-Pearce B, Bobrovskaya L, Tosh DN, Duffield JA, Botting KJ, Zhang S, Caroline McMillen I, Morrison JL.

Physiol Rep. 2015 Feb 3;3(2). pii: e12270. doi: 10.14814/phy2.12270. Print 2015 Feb 1.

42.

IGF-2R-Gαq signaling and cardiac hypertrophy in the low-birth-weight lamb.

Wang KC, Tosh DN, Zhang S, McMillen IC, Duffield JA, Brooks DA, Morrison JL.

Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R627-35. doi: 10.1152/ajpregu.00346.2014. Epub 2015 Jan 28.

43.

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

Kia R, Kelly L, Sison-Young RL, Zhang F, Pridgeon CS, Heslop JA, Metcalfe P, Kitteringham NR, Baxter M, Harrison S, Hanley NA, Burke ZD, Storm MP, Welham MJ, Tosh D, Küppers-Munther B, Edsbagge J, Starkey Lewis PJ, Bonner F, Harpur E, Sidaway J, Bowes J, Fenwick SW, Malik H, Goldring CE, Park BK.

Toxicol Sci. 2015 Mar;144(1):173-85. doi: 10.1093/toxsci/kfu269. Epub 2014 Dec 18.

44.

Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7.

Carter E, Miron-Buchacra G, Goldoni S, Danahay H, Westwick J, Watson ML, Tosh D, Ward SG.

PLoS One. 2014 Dec 2;9(12):e113555. doi: 10.1371/journal.pone.0113555. eCollection 2014.

45.

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.

Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA.

J Med Chem. 2014 Dec 11;57(23):9901-14. doi: 10.1021/jm501021n. Epub 2014 Nov 25.

46.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, Salvemini D.

Brain. 2015 Jan;138(Pt 1):28-35. doi: 10.1093/brain/awu330. Epub 2014 Nov 19.

47.

Mutational analysis of the FIGLA gene in women with idiopathic premature ovarian failure.

Tosh D, Rani HS, Murty US, Deenadayal A, Grover P.

Menopause. 2015 May;22(5):520-6. doi: 10.1097/GME.0000000000000340.

PMID:
25314148
48.

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.

Janes K, Esposito E, Doyle T, Cuzzocrea S, Tosh DK, Jacobson KA, Salvemini D.

Pain. 2014 Dec;155(12):2560-7. doi: 10.1016/j.pain.2014.09.016. Epub 2014 Sep 19.

49.

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

Sangan CB, Jover R, Heimberg H, Tosh D.

Mol Cell Endocrinol. 2015 Jan 5;399:50-9. doi: 10.1016/j.mce.2014.09.009. Epub 2014 Sep 16.

PMID:
25224487
50.

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy.

Janes K, Wahlman C, Little JW, Doyle T, Tosh DK, Jacobson KA, Salvemini D.

Brain Behav Immun. 2015 Feb;44:91-9. doi: 10.1016/j.bbi.2014.08.010. Epub 2014 Sep 8.

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