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Items: 28


How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours.

Toscano MG, de Haan P.

Front Immunol. 2018 May 28;9:1160. doi: 10.3389/fimmu.2018.01160. eCollection 2018. Review.


LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.


Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies.

Toscano MG, van der Velden J, van der Werf S, Odijk M, Roque A, Camacho-Garcia RJ, Herrera-Gomez IG, Mancini I, de Haan P.

Mol Ther Methods Clin Dev. 2017 Jul 5;6:124-134. doi: 10.1016/j.omtm.2017.06.007. eCollection 2017 Sep 15.


Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells.

Benabdellah K, Muñoz P, Cobo M, Gutierrez-Guerrero A, Sánchez-Hernández S, Garcia-Perez A, Anderson P, Carrillo-Gálvez AB, Toscano MG, Martin F.

Sci Rep. 2016 Nov 17;6:37289. doi: 10.1038/srep37289.


The 'Omics' of Amyotrophic Lateral Sclerosis.

Caballero-Hernandez D, Toscano MG, Cejudo-Guillen M, Garcia-Martin ML, Lopez S, Franco JM, Quintana FJ, Roodveldt C, Pozo D.

Trends Mol Med. 2016 Jan;22(1):53-67. doi: 10.1016/j.molmed.2015.11.001. Epub 2015 Dec 13. Review.


Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model.

Toscano MG, Muñoz P, Sánchez-Gilabert A, Cobo M, Benabdellah K, Anderson P, Ramos-Mejía V, Real PJ, Neth O, Molinos-Quintana A, Gregory PD, Holmes MC, Martin F.

Mol Ther. 2016 Feb;24(2):342-353. doi: 10.1038/mt.2015.196. Epub 2015 Oct 27.


SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.

Toscano MG, Navarro-Montero O, Ayllon V, Ramos-Mejia V, Guerrero-Carreno X, Bueno C, Romero T, Lamolda M, Cobo M, Martin F, Menendez P, Real PJ.

Mol Ther. 2015 Jan;23(1):158-70. doi: 10.1038/mt.2014.196. Epub 2014 Oct 8.


Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity.

Carrillo-Galvez AB, Cobo M, Cuevas-Ocaña S, Gutiérrez-Guerrero A, Sánchez-Gilabert A, Bongarzone P, García-Pérez A, Muñoz P, Benabdellah K, Toscano MG, Martín F, Anderson P.

Stem Cells. 2015 Jan;33(1):183-95. doi: 10.1002/stem.1821.


Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome.

Toscano MG, Anderson P, Muñoz P, Lucena G, Cobo M, Benabdellah K, Gregory PD, Holmes MC, Martin F.

Dis Model Mech. 2013 Mar;6(2):544-54. doi: 10.1242/dmm.010652. Epub 2013 Jan 11.


Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis.

Cobo M, Anderson P, Benabdellah K, Toscano MG, Muñoz P, García-Pérez A, Gutierrez I, Delgado M, Martin F.

Cell Transplant. 2013;22(5):839-54.


Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells.

Kocieda VP, Adhikary S, Emig F, Yen JH, Toscano MG, Ganea D.

J Biol Chem. 2012 Oct 26;287(44):36922-35. doi: 10.1074/jbc.M112.402958. Epub 2012 Sep 12.


Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors.

Muñoz P, Toscano MG, Real PJ, Benabdellah K, Cobo M, Bueno C, Ramos-Mejía V, Menendez P, Anderson P, Martín F.

PLoS One. 2012;7(6):e39091. doi: 10.1371/journal.pone.0039091. Epub 2012 Jun 14.


Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines.

Benabdellah K, Cobo M, Muñoz P, Toscano MG, Martin F.

PLoS One. 2011;6(8):e23734. doi: 10.1371/journal.pone.0023734. Epub 2011 Aug 18.


Cecal ligation puncture procedure.

Toscano MG, Ganea D, Gamero AM.

J Vis Exp. 2011 May 7;(51). pii: 2860. doi: 10.3791/2860.


Physiological and tissue-specific vectors for treatment of inherited diseases.

Toscano MG, Romero Z, Muñoz P, Cobo M, Benabdellah K, Martin F.

Gene Ther. 2011 Feb;18(2):117-27. doi: 10.1038/gt.2010.138. Epub 2010 Oct 21. Review.


Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.

Kong W, Yen JH, Vassiliou E, Adhikary S, Toscano MG, Ganea D.

Lipids Health Dis. 2010 Feb 1;9:12. doi: 10.1186/1476-511X-9-12.


Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs.

Toscano MG, Delgado M, Kong W, Martin F, Skarica M, Ganea D.

Mol Ther. 2010 May;18(5):1035-45. doi: 10.1038/mt.2009.293. Epub 2010 Jan 12.


Was cDNA sequences modulate transgene expression of was promoter-driven lentiviral vectors.

Toscano MG, Benabdellah K, Muñoz P, Frecha C, Cobo M, Martín F.

Hum Gene Ther. 2009 Nov;20(11):1279-90. doi: 10.1089/hum.2009.118.


Safer vectors for gene therapy of primary immunodeficiencies.

Romero Z, Toscano MG, Unciti JD, Molina I, Martín F.

Curr Gene Ther. 2009 Aug;9(4):291-305. Review.


In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis.

Delgado M, Toscano MG, Benabdellah K, Cobo M, O'Valle F, Gonzalez-Rey E, Martín F.

Arthritis Rheum. 2008 Apr;58(4):1026-37. doi: 10.1002/art.23283.


Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis.

Frecha C, Toscano MG, Costa C, Saez-Lara MJ, Cosset FL, Verhoeyen E, Martin F.

Gene Ther. 2008 Jun;15(12):930-41. doi: 10.1038/gt.2008.20. Epub 2008 Mar 6.


Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein.

Toscano MG, Frecha C, Benabdellah K, Cobo M, Blundell M, Thrasher AJ, García-Olivares E, Molina IJ, Martin F.

Hum Gene Ther. 2008 Feb;19(2):179-97. doi: 10.1089/hum.2007.098.


Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences.

Martín F, Toscano MG, Blundell M, Frecha C, Srivastava GK, Santamaría M, Thrasher AJ, Molina IJ.

Gene Ther. 2005 Apr;12(8):715-23.


Efficient lentiviral transduction of Herpesvirus saimiri immortalized T cells as a model for gene therapy in primary immunodeficiencies.

Toscano MG, Frecha C, Ortega C, Santamaría M, Martín F, Molina IJ.

Gene Ther. 2004 Jun;11(12):956-61.


Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma.

Stronati L, Gensabella G, Lamberti C, Barattini P, Frasca D, Tanzarella C, Giacobini S, Toscano MG, Santacroce C, Danesi DT.

Cancer. 2001 Nov 1;92(9):2484-92.


Flow cytometric DNA ploidy, p53, PCNA, and c-erbB-2 protein expressions as predictors of survival in surgically resected gastric cancer patients.

Danesi DT, Spanò M, Fabiano A, Altavista P, Pasqualetti P, Toscano MG, Antonini F, Catalano P, Mecozzi A, Picconi A, Daffinà A, Cucchiara G.

Cytometry. 2000 Feb 15;42(1):27-34.


Flow cytometric and immunohistochemical correlations in high incidence human solid tumors.

Danesi DT, Spanò M, Antonini F, Altavista P, Catalano P, Cordelli E, Pasqualetti P, Santacroce C, Toscano MG, Mecozzi A, Fabiano A.

Tumori. 1997 May-Jun;83(3):689-97.


Retrospective analysis of the prognostic significance of DNA ploidy patterns in gastric cancer.

Tirindelli Danesi D, Cucchiara G, Picconi A, Daffinà M, Fabiano A, Antonini F, Toscano MG, Pasqualetti P, Altavista P, Cordelli E, Spanò M.

Eur J Histochem. 1997;41 Suppl 2:147-8. No abstract available.


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