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Description of 22 new alpha-1 antitrypsin genetic variants.

Renoux C, Odou MF, Tosato G, Teoli J, Abbou N, Lombard C, Zerimech F, Porchet N, Chapuis Cellier C, Balduyck M, Joly P.

Orphanet J Rare Dis. 2018 Sep 17;13(1):161. doi: 10.1186/s13023-018-0897-0.


Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression.

Sánchez-Martín D, Otsuka A, Kabashima K, Ha T, Wang D, Qian X, Lowy DR, Tosato G.

J Natl Cancer Inst. 2018 Apr 1;110(4):390-399. doi: 10.1093/jnci/djx219.


Ephrin ligands and Eph receptors contribution to hematopoiesis.

Tosato G.

Cell Mol Life Sci. 2017 Sep;74(18):3377-3394. doi: 10.1007/s00018-017-2566-1. Epub 2017 Jun 6. Review.


Evidence for a Mesothelial Origin of Body Cavity Effusion Lymphomas.

Sanchez-Martin D, Uldrick TS, Kwak H, Ohnuki H, Polizzotto MN, Annunziata CM, Raffeld M, Wyvill KM, Aleman K, Wang V, Marshall VA, Whitby D, Yarchoan R, Tosato G.

J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx016.


Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration.

Agerbaek MØ, Pereira MA, Clausen TM, Pehrson C, Oo HZ, Spliid C, Rich JR, Fung V, Nkrumah F, Neequaye J, Biggar RJ, Reynolds SJ, Tosato G, Pullarkat ST, Ayers LW, Theander TG, Daugaard M, Bhatia K, Nielsen MA, Mbulaiteye SM, Salanti A.

Int J Cancer. 2017 Apr 1;140(7):1597-1608. doi: 10.1002/ijc.30575. Epub 2017 Feb 6.


Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow.

Kwak H, Salvucci O, Weigert R, Martinez-Torrecuadrada JL, Henkemeyer M, Poulos MG, Butler JM, Tosato G.

J Clin Invest. 2016 Dec 1;126(12):4554-4568. doi: 10.1172/JCI87848. Epub 2016 Nov 7.


EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Chen II, Caprioli A, Ohnuki H, Kwak H, Porcher C, Tosato G.

Sci Rep. 2016 Jun 2;6:27195. doi: 10.1038/srep27195.


Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling.

Espígol-Frigolé G, Planas-Rigol E, Ohnuki H, Salvucci O, Kwak H, Ravichandran S, Luke B, Cid MC, Tosato G.

Sci Signal. 2016 Mar 15;9(419):ra28. doi: 10.1126/scisignal.aad2357.


Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).

Polizzotto MN, Uldrick TS, Wyvill KM, Aleman K, Marshall V, Wang V, Whitby D, Pittaluga S, Jaffe ES, Millo C, Tosato G, Little RF, Steinberg SM, Sereti I, Yarchoan R.

Clin Infect Dis. 2016 Mar 15;62(6):730-738. doi: 10.1093/cid/civ996. Epub 2015 Dec 12.


Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1.

Hu D, Wang V, Yang M, Abdullah S, Davis DA, Uldrick TS, Polizzotto MN, Veeranna RP, Pittaluga S, Tosato G, Yarchoan R.

J Virol. 2015 Oct 21;90(1):368-78. doi: 10.1128/JVI.01192-15. Print 2016 Jan 1.


EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.

Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon SO, Segarra M, Eberhart CG, Acker-Palmer A, Tosato G.

Nat Commun. 2015 Mar 26;6:6576. doi: 10.1038/ncomms7576.


Investigation of the interactions between the EphB2 receptor and SNEW peptide variants.

Ma B, Kolb S, Diprima M, Karna M, Tosato G, Yang Q, Huang Q, Nussinov R.

Growth Factors. 2014 Dec;32(6):236-46. doi: 10.3109/08977194.2014.985786. Epub 2014 Nov 20.


Contribution of viral mimics of cellular genes to KSHV infection and disease.

Sakakibara S, Tosato G.

Viruses. 2014 Sep 19;6(9):3472-86. doi: 10.3390/v6093472. Review.


Notch and TGFβ: Functional partners facilitating tumor progression.

Ohnuki H, Tosato G.

Oncoimmunology. 2014 May 23;3:e29029. eCollection 2014.


Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-β signaling to drive malignant progression.

Ohnuki H, Jiang K, Wang D, Salvucci O, Kwak H, Sánchez-Martín D, Maric D, Tosato G.

Cancer Res. 2014 Apr 1;74(7):2038-49. doi: 10.1158/0008-5472.CAN-13-3118. Epub 2014 Feb 11.


Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands.

Falivelli G, Lisabeth EM, Rubio de la Torre E, Perez-Tenorio G, Tosato G, Salvucci O, Pasquale EB.

PLoS One. 2013 Nov 29;8(11):e81445. doi: 10.1371/journal.pone.0081445. eCollection 2013.


Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.

Polizzotto MN, Uldrick TS, Wang V, Aleman K, Wyvill KM, Marshall V, Pittaluga S, O'Mahony D, Whitby D, Tosato G, Steinberg SM, Little RF, Yarchoan R.

Blood. 2013 Dec 19;122(26):4189-98. doi: 10.1182/blood-2013-08-519959. Epub 2013 Oct 30.


Human herpesvirus 8+ polyclonal IgMλ B-cell lymphocytosis mimicking plasmablastic leukemia/lymphoma in HIV-infected patients.

Oksenhendler E, Boutboul D, Beldjord K, Meignin V, de Labarthe A, Fieschi C, Dossier A, Agbalika F, Parravicini C, Tosato G, Gérard L, Galicier L.

Eur J Haematol. 2013 Dec;91(6):497-503. doi: 10.1111/ejh.12191. Epub 2013 Sep 18.


Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.

Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G.

Blood. 2012 Nov 8;120(19):4104-15. doi: 10.1182/blood-2012-02-410076. Epub 2012 Sep 24.


Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis.

Salvucci O, Tosato G.

Adv Cancer Res. 2012;114:21-57. doi: 10.1016/B978-0-12-386503-8.00002-8. Review.


A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.

Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick TS, Yarchoan R, Tosato G.

Oncogene. 2013 Mar 7;32(10):1223-32. doi: 10.1038/onc.2012.145. Epub 2012 Apr 23.


HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.

Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S.

Blood. 2012 May 31;119(22):5173-81. doi: 10.1182/blood-2011-09-377705. Epub 2012 Apr 9.


MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.

Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, Espigol-Frigole G, Wang S, Tosato G.

Haematologica. 2012 Jun;97(6):818-26. doi: 10.3324/haematol.2011.056945. Epub 2012 Jan 22.


Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling.

Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R, Tosato G.

Cancer Res. 2012 Mar 1;72(5):1157-69. doi: 10.1158/0008-5472.CAN-11-3067. Epub 2012 Jan 11.


PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity.

Noberini R, Mitra S, Salvucci O, Valencia F, Duggineni S, Prigozhina N, Wei K, Tosato G, Huang Z, Pasquale EB.

PLoS One. 2011;6(12):e28611. doi: 10.1371/journal.pone.0028611. Epub 2011 Dec 14.


Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.

Sakakibara S, Tosato G.

J Interferon Cytokine Res. 2011 Nov;31(11):791-801. doi: 10.1089/jir.2011.0043. Epub 2011 Jul 18. Review.


Adult human circulating CD34⁻Lin⁻CD45⁻CD133⁻ cells can differentiate into hematopoietic and endothelial cells.

Ciraci E, Della Bella S, Salvucci O, Rofani C, Segarra M, Bason C, Molinari A, Maric D, Tosato G, Berardi AC.

Blood. 2011 Aug 25;118(8):2105-15. doi: 10.1182/blood-2010-10-316596. Epub 2011 Jun 29.


High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy.

Uldrick TS, Polizzotto MN, Aleman K, O'Mahony D, Wyvill KM, Wang V, Marshall V, Pittaluga S, Steinberg SM, Tosato G, Whitby D, Little RF, Yarchoan R.

Blood. 2011 Jun 30;117(26):6977-86. doi: 10.1182/blood-2010-11-317610. Epub 2011 Apr 12.


NF-kappaB activation stimulates transcription and replication of retrovirus XMRV in human B-lineage and prostate carcinoma cells.

Sakakibara S, Sakakibara K, Tosato G.

J Virol. 2011 Apr;85(7):3179-86. doi: 10.1128/JVI.02333-10. Epub 2011 Jan 26.


Cytosolic phospholipase A2{alpha} and cancer: a role in tumor angiogenesis.

Tosato G, Segarra M, Salvucci O.

J Natl Cancer Inst. 2010 Sep 22;102(18):1377-9. doi: 10.1093/jnci/djq324. Epub 2010 Aug 20. No abstract available.


Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.

Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G.

Blood. 2010 Oct 21;116(16):3099-107. doi: 10.1182/blood-2010-01-265801. Epub 2010 Jul 6.


An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease.

Uldrick TS, Wang V, O'Mahony D, Aleman K, Wyvill KM, Marshall V, Steinberg SM, Pittaluga S, Maric I, Whitby D, Tosato G, Little RF, Yarchoan R.

Clin Infect Dis. 2010 Aug 1;51(3):350-8. doi: 10.1086/654798.


The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.

de la Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick PJ, Segarra M, Stone J, Maric D, Zhu J, Qian X, Lowy DR, Tosato G.

Blood. 2010 May 13;115(19):3970-9. doi: 10.1182/blood-2009-10-246967. Epub 2010 Mar 4.


Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.

McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G.

PLoS One. 2009 Dec 1;4(12):e8102. doi: 10.1371/journal.pone.0008102.


The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

Qian X, Li G, Vass WC, Papageorge A, Walker RC, Asnaghi L, Steinbach PJ, Tosato G, Hunter K, Lowy DR.

Cancer Cell. 2009 Sep 8;16(3):246-58. doi: 10.1016/j.ccr.2009.07.031.


Regulation of angiogenesis in malignancies associated with Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

Sakakibara S, Tosato G.

Future Microbiol. 2009 Sep;4(7):903-17. doi: 10.2217/fmb.09.49. Review.


Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma.

Gasperini P, Tosato G.

Leukemia. 2009 Oct;23(10):1867-74. doi: 10.1038/leu.2009.117. Epub 2009 Jun 25.


EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.

Salvucci O, Maric D, Economopoulou M, Sakakibara S, Merlin S, Follenzi A, Tosato G.

Blood. 2009 Aug 20;114(8):1707-16. doi: 10.1182/blood-2008-12-192294. Epub 2009 May 1.


Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells.

Sakakibara S, Pise-Masison CA, Brady JN, Tosato G.

J Virol. 2009 Mar;83(5):2140-53. doi: 10.1128/JVI.01871-08. Epub 2008 Dec 17.


Palmitoylation controls recycling in lysosomal sorting and trafficking.

McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G, Lefrancois S.

Traffic. 2008 Nov;9(11):1984-97. doi: 10.1111/j.1600-0854.2008.00814.x. Epub 2008 Aug 9.


Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth.

Segarra M, Williams CK, Sierra Mde L, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P, Tosato G.

Blood. 2008 Sep 1;112(5):1904-11. doi: 10.1182/blood-2007-11-126045. Epub 2008 Jun 24.


Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines.

Tosato G, Cohen JI.

Curr Protoc Immunol. 2007 Feb;Chapter 7:Unit 7.22. doi: 10.1002/0471142735.im0722s76.


Measurement of polyclonal immunoglobulin synthesis using the reverse plaque technique.

Tosato G, Pike SE, Blaese M.

Curr Protoc Immunol. 2001 May;Chapter 7:Unit 7.13. doi: 10.1002/0471142735.im0713s00.


Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.

Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL.

Cancer Res. 2008 Mar 15;68(6):1889-95. doi: 10.1158/0008-5472.CAN-07-2181.


Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis.

Gasperini P, Sakakibara S, Tosato G.

J Leukoc Biol. 2008 Oct;84(4):994-1000. doi: 10.1189/jlb.1107777. Review.


Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.

Narazaki M, Segarra M, Tosato G.

Blood. 2008 Apr 15;111(8):4126-36. doi: 10.1182/blood-2007-09-112474. Epub 2008 Feb 13.


Treatment of AIDS-related Kaposi's sarcoma with interleukin-12: rationale and preliminary evidence of clinical activity.

Yarchoan R, Pluda JM, Wyvill KM, Aleman K, Rodriguez-Chavez IR, Tosato G, Catanzaro AT, Steinberg SM, Little RF.

Crit Rev Immunol. 2007;27(5):401-14. Review.


Neuropilin-2: a new molecular target for antiangiogenic and antitumor strategies.

Narazaki M, Segarra M, Tosato G.

J Natl Cancer Inst. 2008 Jan 16;100(2):81-3. doi: 10.1093/jnci/djm305. Epub 2008 Jan 8. No abstract available.


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