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Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.

Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV.

Sci Rep. 2019 Dec 23;9(1):19634. doi: 10.1038/s41598-019-55907-z.


Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death.

Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM, Torti SV.

Cancer Res. 2019 Oct 15;79(20):5355-5366. doi: 10.1158/0008-5472.CAN-19-0369. Epub 2019 Jul 3.


A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification.

Moghieb A, Tesfay L, Nie S, Gritsenko M, Fillmore TL, Jacobs JM, Smith RD, Torti FM, Torti SV, Shi T, Ansong C.

Sci Rep. 2019 May 13;9(1):7264. doi: 10.1038/s41598-019-43756-9.


Winning the war with iron.

Torti SV, Torti FM.

Nat Nanotechnol. 2019 Jun;14(6):499-500. doi: 10.1038/s41565-019-0419-9. No abstract available.


Iron and Cancer.

Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM.

Annu Rev Nutr. 2018 Aug 21;38:97-125. doi: 10.1146/annurev-nutr-082117-051732. Review.


A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism.

Konstorum A, Lynch ML, Torti SV, Torti FM, Laubenbacher RC.

OMICS. 2018 Jul;22(7):502-513. doi: 10.1089/omi.2018.0060.


Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer.

Blanchette-Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, Claffey KP, Torti FM, Torti SV.

Oncogene. 2018 Jul;37(29):4013-4032. doi: 10.1038/s41388-018-0243-y. Epub 2018 Apr 26.


Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth.

Deng Z, Manz DH, Torti SV, Torti FM.

Oncotarget. 2017 Jul 17;8(47):82231-82243. doi: 10.18632/oncotarget.19288. eCollection 2017 Oct 10.


Effects of Ferroportin-Mediated Iron Depletion in Cells Representative of Different Histological Subtypes of Prostate Cancer.

Deng Z, Manz DH, Torti SV, Torti FM.

Antioxid Redox Signal. 2019 Mar 10;30(8):1043-1061. doi: 10.1089/ars.2017.7023. Epub 2017 Dec 11.


Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD.

Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review.


Iron addiction: a novel therapeutic target in ovarian cancer.

Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV.

Oncogene. 2017 Jul 20;36(29):4089-4099. doi: 10.1038/onc.2017.11. Epub 2017 Mar 20.


DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.

Lemler DJ, Lynch ML, Tesfay L, Deng Z, Paul BT, Wang X, Hegde P, Manz DH, Torti SV, Torti FM.

Breast Cancer Res. 2017 Mar 7;19(1):25. doi: 10.1186/s13058-017-0814-9.


Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts.

Torti SV, Lemler E, Mueller BK, Popp A, Torti FM.

Clin Exp Pharmacol. 2016 Nov;6(6). pii: 223. doi: 10.4172/2161-1459.1000223. Epub 2016 Nov 17.


Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.

Chifman J, Arat S, Deng Z, Lemler E, Pino JC, Harris LA, Kochen MA, Lopez CF, Akman SA, Torti FM, Torti SV, Laubenbacher R.

PLoS Comput Biol. 2017 Feb 6;13(2):e1005352. doi: 10.1371/journal.pcbi.1005352. eCollection 2017 Feb.


Mitochondria and Iron: current questions.

Paul BT, Manz DH, Torti FM, Torti SV.

Expert Rev Hematol. 2017 Jan;10(1):65-79. doi: 10.1080/17474086.2016.1268047. Epub 2016 Dec 12. Review. Erratum in: Expert Rev Hematol. 2017 Mar;10(3):275.


Iron and cancer: recent insights.

Manz DH, Blanchette NL, Paul BT, Torti FM, Torti SV.

Ann N Y Acad Sci. 2016 Mar;1368(1):149-61. doi: 10.1111/nyas.13008. Epub 2016 Feb 18. Review.


Sample Preparation of Arabidopsis thaliana Shoot Apices for Expression Studies of Photoperiod-Induced Genes.

Andrés F, Torti S, Vincent C, Coupland G.

Methods Mol Biol. 2016;1398:81-91. doi: 10.1007/978-1-4939-3356-3_8.


Modulation of hepcidin to treat iron deregulation: potential clinical applications.

Blanchette NL, Manz DH, Torti FM, Torti SV.

Expert Rev Hematol. 2016;9(2):169-86. doi: 10.1586/17474086.2016.1124757. Epub 2015 Dec 15. Review.


In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells.

Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X, Hong Y, Kern F, Wei TS, Zhang T, Nagarajan N, Basuli D, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, Xian W.

J Pathol. 2016 Mar;238(4):519-530. doi: 10.1002/path.4649. Epub 2016 Jan 9.


Cytoprotective Effect of Ferritin H in Renal Ischemia Reperfusion Injury.

Hatcher HC, Tesfay L, Torti SV, Torti FM.

PLoS One. 2015 Sep 17;10(9):e0138505. doi: 10.1371/journal.pone.0138505. eCollection 2015.


Targeting breast cancer with sugar-coated carbon nanotubes.

Fahrenholtz CD, Hadimani M, King SB, Torti SV, Singh R.

Nanomedicine (Lond). 2015;10(16):2481-97. doi: 10.2217/NNM.15.90. Epub 2015 Aug 21.


Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.

Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN.

Int J Nanomedicine. 2015 Jun 11;10:3937-53. doi: 10.2147/IJN.S80349. eCollection 2015.


SWP73 Subunits of Arabidopsis SWI/SNF Chromatin Remodeling Complexes Play Distinct Roles in Leaf and Flower Development.

Sacharowski SP, Gratkowska DM, Sarnowska EA, Kondrak P, Jancewicz I, Porri A, Bucior E, Rolicka AT, Franzen R, Kowalczyk J, Pawlikowska K, Huettel B, Torti S, Schmelzer E, Coupland G, Jerzmanowski A, Koncz C, Sarnowski TJ.

Plant Cell. 2015 Jul;27(7):1889-906. doi: 10.1105/tpc.15.00233. Epub 2015 Jun 23.


Hepcidin regulation in prostate and its disruption in prostate cancer.

Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV.

Cancer Res. 2015 Jun 1;75(11):2254-63. doi: 10.1158/0008-5472.CAN-14-2465. Epub 2015 Apr 9.


Yet another function of p53--the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy.

Chakradeo S, Sharma K, Alhaddad A, Bakhshwin D, Le N, Harada H, Nakajima W, Yeudall WA, Torti SV, Torti FM, Gewirtz DA.

Mol Pharmacol. 2015 May;87(5):803-14. doi: 10.1124/mol.114.095273. Epub 2015 Feb 9.


A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.

Sharma K, Goehe RW, Di X, Hicks MA 2nd, Torti SV, Torti FM, Harada H, Gewirtz DA.

Autophagy. 2014;10(12):2346-61. doi: 10.4161/15548627.2014.993283.


A systems biology approach to iron metabolism.

Chifman J, Laubenbacher R, Torti SV.

Adv Exp Med Biol. 2014;844:201-25. doi: 10.1007/978-1-4939-2095-2_10. Review.


SHORT VEGETATIVE PHASE reduces gibberellin biosynthesis at the Arabidopsis shoot apex to regulate the floral transition.

Andrés F, Porri A, Torti S, Mateos J, Romera-Branchat M, García-Martínez JL, Fornara F, Gregis V, Kater MM, Coupland G.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2760-9. doi: 10.1073/pnas.1409567111. Epub 2014 Jun 16.


Epidemiological associations between iron and cardiovascular disease and diabetes.

Basuli D, Stevens RG, Torti FM, Torti SV.

Front Pharmacol. 2014 May 20;5:117. doi: 10.3389/fphar.2014.00117. eCollection 2014. Review.


Histopathologic spectrum of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a diagnosis that needs clinico-pathological correlation.

Borroni G, Torti S, Pezzini C, Vassallo C, Rosso R, D'Ospina RM, Tomasini C, Brazzelli V.

G Ital Dermatol Venereol. 2014 Jun;149(3):291-300.


Drug-induced panniculitides.

Borroni G, Torti S, D'Ospina RM, Pezzini C.

G Ital Dermatol Venereol. 2014 Apr;149(2):263-70. Review.


The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated.

Huhn AJ, Parsonage D, Horita DA, Torti FM, Torti SV, Hollis T.

Protein Sci. 2014 Aug;23(8):1013-22. doi: 10.1002/pro.2486. Epub 2014 May 22.


IRP2 regulates breast tumor growth.

Wang W, Deng Z, Hatcher H, Miller LD, Di X, Tesfay L, Sui G, D'Agostino RB Jr, Torti FM, Torti SV.

Cancer Res. 2014 Jan 15;74(2):497-507. doi: 10.1158/0008-5472.CAN-13-1224. Epub 2013 Nov 27.


Fluorinated graphene oxide; a new multimodal material for biological applications.

Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM.

Adv Mater. 2013 Oct 18;25(39):5632-7. doi: 10.1002/adma201301804. Epub 2013 Aug 27.


Carbon nanotubes in hyperthermia therapy.

Singh R, Torti SV.

Adv Drug Deliv Rev. 2013 Dec;65(15):2045-60. doi: 10.1016/j.addr.2013.08.001. Epub 2013 Aug 8. Review.


Cellular iron metabolism in prognosis and therapy of breast cancer.

Torti SV, Torti FM.

Crit Rev Oncog. 2013;18(5):435-48. Review.


Application of circuit simulation method for differential modeling of TIM-2 iron uptake and metabolism in mouse kidney cells.

Xie Z, Harrison SH, Torti SV, Torti FM, Han J.

Front Physiol. 2013 Jun 7;4:136. doi: 10.3389/fphys.2013.00136. eCollection 2013.


Identification of pathways directly regulated by SHORT VEGETATIVE PHASE during vegetative and reproductive development in Arabidopsis.

Gregis V, Andrés F, Sessa A, Guerra RF, Simonini S, Mateos JL, Torti S, Zambelli F, Prazzoli GM, Bjerkan KN, Grini PE, Pavesi G, Colombo L, Coupland G, Kater MM.

Genome Biol. 2013 Jun 11;14(6):R56. doi: 10.1186/gb-2013-14-6-r56.


Ferritin H is a novel marker of early erythroid precursors and macrophages.

Wang W, Grier DD, Woo J, Ward M, Sui G, Torti SV, Torti FM, Beaty MW.

Histopathology. 2013 May;62(6):931-40. doi: 10.1111/his.12101.


Iron and cancer: more ore to be mined.

Torti SV, Torti FM.

Nat Rev Cancer. 2013 May;13(5):342-55. doi: 10.1038/nrc3495. Epub 2013 Apr 18. Review.


Heat localization for targeted tumor treatment with nanoscale near-infrared radiation absorbers.

Xie B, Singh R, Torti FM, Keblinski P, Torti S.

Phys Med Biol. 2012 Sep 21;57(18):5765-75. doi: 10.1088/0031-9155/57/18/5765. Epub 2012 Sep 5.


Longitudinal deep fissure and distal onycholysis of the right thumb. Amelanotic subungual melanoma.

Vassallo C, Derlino F, Torti S, Carugno A, Scotti-Foglieni A, Fiandrino G, Borroni G.

Arch Dermatol. 2012 Aug;148(8):947-52. doi: 10.1001/archdermatol.2012.1350. No abstract available.


AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition.

Torti S, Fornara F.

Plant Signal Behav. 2012 Oct 1;7(10):1251-4. doi: 10.4161/psb.21552. Epub 2012 Aug 20.


Spatial and temporal measurements of temperature and cell viability in response to nanoparticle-mediated photothermal therapy.

Whitney JR, Rodgers A, Harvie E, Carswell WF, Torti S, Puretzky AA, Rouleau CM, Geohegan DB, Rylander CG, Rylander MN.

Nanomedicine (Lond). 2012 Nov;7(11):1729-42. doi: 10.2217/nnm.12.66. Epub 2012 Jul 20.


Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells.

Tesfay L, Huhn AJ, Hatcher H, Torti FM, Torti SV.

PLoS One. 2012;7(7):e40030. doi: 10.1371/journal.pone.0040030. Epub 2012 Jul 2.


Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies.

Burke AR, Singh RN, Carroll DL, Torti FM, Torti SV.

J Mol Biomark Diagn. 2012 Jul 2;Suppl 8. doi: 10.4172/2155-9929.S8-003.


Spatially distinct regulatory roles for gibberellins in the promotion of flowering of Arabidopsis under long photoperiods.

Porri A, Torti S, Romera-Branchat M, Coupland G.

Development. 2012 Jun;139(12):2198-209. doi: 10.1242/dev.077164. Epub 2012 May 9.


Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging.

Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani SA, Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM.

Adv Mater. 2012 Jun 12;24(22):2992-8. doi: 10.1002/adma.201200706. Epub 2012 May 10. No abstract available.


Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.

Wan M, Huang W, Kute TE, Miller LD, Zhang Q, Hatcher H, Wang J, Stovall DB, Russell GB, Cao PD, Deng Z, Wang W, Zhang Q, Lei M, Torti SV, Akman SA, Sui G.

Am J Pathol. 2012 May;180(5):2120-33. doi: 10.1016/j.ajpath.2012.01.037. Epub 2012 Mar 20.


Analysis of the Arabidopsis shoot meristem transcriptome during floral transition identifies distinct regulatory patterns and a leucine-rich repeat protein that promotes flowering.

Torti S, Fornara F, Vincent C, Andrés F, Nordström K, Göbel U, Knoll D, Schoof H, Coupland G.

Plant Cell. 2012 Feb;24(2):444-62. doi: 10.1105/tpc.111.092791. Epub 2012 Feb 7.

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