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Items: 1 to 50 of 198

1.

Serum-based phospho-neurofilament-heavy protein as theranostic biomarker in three models of traumatic brain injury: an Operation Brain Trauma Therapy (OBTT) study.

Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf J, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock J, Tortella FC, Kochanek PM, Wang KKW.

J Neurotrauma. 2018 Jul 10. doi: 10.1089/neu.2017.5586. [Epub ahead of print]

PMID:
29987972
2.

Operation Brain Trauma Therapy: 2016 Update.

Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.

Mil Med. 2018 Mar 1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184.

PMID:
29635589
3.

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions.

Cernak I, Stein DG, Elder GA, Ahlers S, Curley K, DePalma RG, Duda J, Ikonomovic M, Iverson GL, Kobeissy F, Koliatsos VE, Leggieri MJ Jr, Pacifico AM, Smith DH, Swanson R, Thompson FJ, Tortella FC.

Brain Inj. 2017;31(9):1168-1176. doi: 10.1080/02699052.2016.1274779. Review.

PMID:
28981339
4.

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury.

Johnson D, Cartagena CM, Tortella FC, Dave JR, Schmid KE, Boutté AM.

J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S145-S149. doi: 10.1097/TA.0000000000001475.

PMID:
28452880
5.

Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury.

Lu XM, Cao Y, Mountney A, Liao Z, Shear DA, Tortella FC.

J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S25-S34. doi: 10.1097/TA.0000000000001470.

PMID:
28452872
6.

Functional and Molecular Correlates after Single and Repeated Rat Closed-Head Concussion: Indices of Vulnerability after Brain Injury.

Mountney A, Boutté AM, Cartagena CM, Flerlage WF, Johnson WD, Rho C, Lu XC, Yarnell A, Marcsisin S, Sousa J, Vuong C, Zottig V, Leung LY, Deng-Bryant Y, Gilsdorf J, Tortella FC, Shear DA.

J Neurotrauma. 2017 Oct 1;34(19):2768-2789. doi: 10.1089/neu.2016.4679. Epub 2017 May 24.

PMID:
28326890
7.

Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells.

Spurlock MS, Ahmed AI, Rivera KN, Yokobori S, Lee SW, Sam PN, Shear DA, Hefferan MP, Hazel TG, Johe KK, Gajavelli S, Tortella FC, Bullock RM.

J Neurotrauma. 2017 Jun 1;34(11):1981-1995. doi: 10.1089/neu.2016.4602. Epub 2017 Mar 23.

PMID:
28249550
8.

Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice.

Tortella FC.

Methods Mol Biol. 2016;1462:735-40. doi: 10.1007/978-1-4939-3816-2_40.

PMID:
27604748
9.

Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma.

Pandya JD, Sullivan PG, Leung LY, Tortella FC, Shear DA, Deng-Bryant Y.

Methods Mol Biol. 2016;1462:597-610. doi: 10.1007/978-1-4939-3816-2_32.

PMID:
27604740
10.

Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury.

Cartagena CM, Mountney A, Hwang H, Swiercz A, Rammelkamp Z, Boutte AM, Shear DA, Tortella FC, Schmid KE.

PLoS One. 2016 Jul 18;11(7):e0158576. doi: 10.1371/journal.pone.0158576. eCollection 2016.

11.

Neuroprotection and anti-seizure effects of levetiracetam in a rat model of penetrating ballistic-like brain injury.

Caudle KL, Lu XC, Mountney A, Shear DA, Tortella FC.

Restor Neurol Neurosci. 2016;34(2):257-70. doi: 10.3233/RNN-150580.

PMID:
26890099
12.

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury.

Lu XC, Shear DA, Deng-Bryant Y, Leung LY, Wei G, Chen Z, Tortella FC.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):30-9. doi: 10.1089/ther.2015.0017. Epub 2015 Dec 18.

13.

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.

Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri SP, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):595-605. doi: 10.1089/neu.2015.4132.

PMID:
26671651
14.

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KK, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):581-94. doi: 10.1089/neu.2015.4131.

PMID:
26671550
15.

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey PE, Povlishock JT, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):606-14. doi: 10.1089/neu.2015.4133. Review.

PMID:
26671284
16.

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey PE, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):553-66. doi: 10.1089/neu.2015.4122.

PMID:
26671075
17.

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Shear DA, Dixon CE, Bramlett HM, Mondello S, Dietrich WD, Deng-Bryant Y, Schmid KE, Wang KK, Hayes RL, Povlishock JT, Kochanek PM, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):523-37. doi: 10.1089/neu.2015.4115.

PMID:
26670792
18.

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):538-52. doi: 10.1089/neu.2015.4116.

PMID:
26670694
19.

Intravenous Administration of Simvastatin Improves Cognitive Outcome following Severe Traumatic Brain Injury in Rats.

Mountney A, Boutté AM, Gilsdorf J, Lu XC, Tortella FC, Shear DA.

J Neurotrauma. 2016 Aug 15;33(16):1492-500. doi: 10.1089/neu.2015.4139. Epub 2016 Apr 19.

PMID:
26542887
20.

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD, Wang KK, Caudle K, Empey PE, Poloyac SM, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Shear DA.

J Neurotrauma. 2016 Mar 15;33(6):567-80. doi: 10.1089/neu.2015.4130. Epub 2016 Jan 20.

PMID:
26541177
21.

Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.

Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, Saville B, Tyndall JA, Nash M, Buki A, Barzo P, Hack D, Tortella FC, Schmid K, Hayes RL, Vossough A, Sweriduk ST, Bazarian JJ.

J Neurotrauma. 2016 Jan 15;33(2):203-14. doi: 10.1089/neu.2015.4149. Epub 2015 Dec 18.

22.

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):513-22. doi: 10.1089/neu.2015.4113. Epub 2015 Dec 10. Review.

PMID:
26439468
23.

Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories.

Smith DH, Hicks RR, Johnson VE, Bergstrom DA, Cummings DM, Noble LJ, Hovda D, Whalen M, Ahlers ST, LaPlaca M, Tortella FC, Duhaime AC, Dixon CE.

J Neurotrauma. 2015 Nov 15;32(22):1725-35. doi: 10.1089/neu.2014.3861. Epub 2015 Aug 27.

24.

Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury.

Bhattacharyya S, Zhang X, Feferman L, Johnson D, Tortella FC, Guizzetti M, Tobacman JK.

J Neurochem. 2015 Aug;134(4):728-39. doi: 10.1111/jnc.13156. Epub 2015 Jun 28.

25.

Traumatic Brain Injury and Polytrauma in Theaters of Combat: The Case for Neurotrauma Resuscitation?

Tortella FC, Leung LY.

Shock. 2015 Aug;44 Suppl 1:17-26. doi: 10.1097/SHK.0000000000000380. Review.

PMID:
25895144
26.

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.

Lu XC, Shear DA, Graham PB, Bridson GW, Uttamsingh V, Chen Z, Leung LY, Tortella FC.

J Neurotrauma. 2015 Oct 15;32(20):1621-32. doi: 10.1089/neu.2014.3766. Epub 2015 Jun 11.

27.

Serum Glial Fibrillary Acidic Protein Predicts Tissue Glial Fibrillary Acidic Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain Injury.

Boutté AM, Deng-Bryant Y, Johnson D, Tortella FC, Dave JR, Shear DA, Schmid KE.

J Neurotrauma. 2016 Jan 1;33(1):147-56. doi: 10.1089/neu.2014.3672. Epub 2015 Jun 8.

PMID:
25789543
28.

Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.

Deng-Bryant Y, Readnower RD, Leung LY, Cunningham TL, Shear DA, Tortella FC.

Restor Neurol Neurosci. 2015;33(2):189-203. doi: 10.3233/RNN-140455.

PMID:
25588460
29.

Minor and repetitive head injury.

Buki A, Kovacs N, Czeiter E, Schmid K, Berger RP, Kobeissy F, Italiano D, Hayes RL, Tortella FC, Mezosi E, Schwarcz A, Toth A, Nemes O, Mondello S.

Adv Tech Stand Neurosurg. 2015;42:147-92. doi: 10.1007/978-3-319-09066-5_8. Review.

PMID:
25411149
30.

Brain Injury Markers: Where are We?

Mondello S, Tortella FC.

Front Neurol. 2014 Aug 4;5:145. doi: 10.3389/fneur.2014.00145. eCollection 2014. No abstract available.

31.

Temporal alterations in aquaporin and transcription factor HIF1α expression following penetrating ballistic-like brain injury (PBBI).

Cartagena CM, Phillips KL, Tortella FC, Dave JR, Schmid KE.

Mol Cell Neurosci. 2014 May;60:81-7. doi: 10.1016/j.mcn.2014.04.005. Epub 2014 Apr 24.

PMID:
24769105
32.

Correlations between blood-brain barrier disruption and neuroinflammation in an experimental model of penetrating ballistic-like brain injury.

Cunningham TL, Cartagena CM, Lu XC, Konopko M, Dave JR, Tortella FC, Shear DA.

J Neurotrauma. 2014 Mar 1;31(5):505-14. doi: 10.1089/neu.2013.2965.

33.

Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.

Mountney A, Shear DA, Potter B, Marcsisin SR, Sousa J, Melendez V, Tortella FC, Lu XC.

J Neurotrauma. 2013 Dec 1;30(23):1973-82. doi: 10.1089/neu.2013.3001. Epub 2013 Oct 18.

34.

The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage.

Mondello S, Schmid K, Berger RP, Kobeissy F, Italiano D, Jeromin A, Hayes RL, Tortella FC, Buki A.

Med Res Rev. 2014 May;34(3):503-31. doi: 10.1002/med.21295. Epub 2013 Jun 28. Review.

PMID:
23813922
35.

A military-centered approach to neuroprotection for traumatic brain injury.

Shear DA, Tortella FC.

Front Neurol. 2013 Jun 12;4:73. doi: 10.3389/fneur.2013.00073. eCollection 2013.

36.

Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3.

Cartagena CM, Phillips KL, Williams GL, Konopko M, Tortella FC, Dave JR, Schmid KE.

Neuromolecular Med. 2013 Sep;15(3):504-14. doi: 10.1007/s12017-013-8236-z. Epub 2013 Jun 14.

PMID:
23765588
37.

Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study.

Tate CM, Wang KK, Eonta S, Zhang Y, Carr W, Tortella FC, Hayes RL, Kamimori GH.

J Neurotrauma. 2013 Oct 1;30(19):1620-30. doi: 10.1089/neu.2012.2683. Epub 2013 Aug 29.

PMID:
23687938
38.

Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate.

Lu XC, Dave JR, Chen Z, Cao Y, Liao Z, Tortella FC.

Life Sci. 2013 Jun 13;92(22):1055-63. doi: 10.1016/j.lfs.2013.04.004. Epub 2013 Apr 18.

PMID:
23603142
39.

The acute effects of hemorrhagic shock on cerebral blood flow, brain tissue oxygen tension, and spreading depolarization following penetrating ballistic-like brain injury.

Leung LY, Wei G, Shear DA, Tortella FC.

J Neurotrauma. 2013 Jul 15;30(14):1288-98. doi: 10.1089/neu.2012.2715. Epub 2013 Jul 11.

PMID:
23461630
40.

Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury.

Zoltewicz JS, Mondello S, Yang B, Newsom KJ, Kobeissy F, Yao C, Lu XC, Dave JR, Shear DA, Schmid K, Rivera V, Cram T, Seaney J, Zhang Z, Wang KK, Hayes RL, Tortella FC.

J Neurotrauma. 2013 Jul 1;30(13):1161-9. doi: 10.1089/neu.2012.2762.

PMID:
23409698
41.

Similarities and differences of acute nonconvulsive seizures and other epileptic activities following penetrating and ischemic brain injuries in rats.

Lu XC, Mountney A, Chen Z, Wei G, Cao Y, Leung LY, Khatri V, Cunningham T, Tortella FC.

J Neurotrauma. 2013 Apr 1;30(7):580-90. doi: 10.1089/neu.2012.2641. Epub 2013 Apr 15.

PMID:
23234254
42.

Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.

Boutté AM, Yao C, Kobeissy F, May Lu XC, Zhang Z, Wang KK, Schmid K, Tortella FC, Dave JR.

Electrophoresis. 2012 Dec;33(24):3693-704. doi: 10.1002/elps.201200196.

PMID:
23161467
43.

Long-term administration of amnion-derived cellular cytokine suspension promotes functional recovery in a model of penetrating ballistic-like brain injury.

Deng-Bryant Y, Chen Z, van der Merwe C, Liao Z, Dave JR, Rupp R, Shear DA, Tortella FC.

J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S156-64. doi: 10.1097/TA.0b013e3182625f5f.

PMID:
22847087
44.

The diagnosis of traumatic brain injury on the battlefield.

Schmid KE, Tortella FC.

Front Neurol. 2012 Jun 12;3:90. doi: 10.3389/fneur.2012.00090. eCollection 2012.

45.

Changes in apoptotic mechanisms following penetrating ballistic-like brain injury.

Cartagena CM, Schmid KE, Phillips KL, Tortella FC, Dave JR.

J Mol Neurosci. 2013 Feb;49(2):301-11. doi: 10.1007/s12031-012-9828-z. Epub 2012 Jun 11.

PMID:
22684621
46.

Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.

Papa L, Lewis LM, Silvestri S, Falk JL, Giordano P, Brophy GM, Demery JA, Liu MC, Mo J, Akinyi L, Mondello S, Schmid K, Robertson CS, Tortella FC, Hayes RL, Wang KK.

J Trauma Acute Care Surg. 2012 May;72(5):1335-44. doi: 10.1097/TA.0b013e3182491e3d.

47.

Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention.

Papa L, Lewis LM, Falk JL, Zhang Z, Silvestri S, Giordano P, Brophy GM, Demery JA, Dixit NK, Ferguson I, Liu MC, Mo J, Akinyi L, Schmid K, Mondello S, Robertson CS, Tortella FC, Hayes RL, Wang KK.

Ann Emerg Med. 2012 Jun;59(6):471-83. doi: 10.1016/j.annemergmed.2011.08.021. Epub 2011 Nov 8.

48.

A novel animal model of closed-head concussive-induced mild traumatic brain injury: development, implementation, and characterization.

Chen Z, Leung LY, Mountney A, Liao Z, Yang W, Lu XC, Dave J, Deng-Bryant Y, Wei G, Schmid K, Shear DA, Tortella FC.

J Neurotrauma. 2012 Jan 20;29(2):268-80. doi: 10.1089/neu.2011.2057. Epub 2011 Dec 19.

PMID:
21988140
49.

Brain oxygen tension monitoring following penetrating ballistic-like brain injury in rats.

Murakami Y, Wei G, Yang X, Lu XC, Leung LY, Shear DA, Tortella FC.

J Neurosci Methods. 2012 Jan 15;203(1):115-21. doi: 10.1016/j.jneumeth.2011.09.025. Epub 2011 Sep 29.

PMID:
21983109
50.

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy.

Kochanek PM, Bramlett H, Dietrich WD, Dixon CE, Hayes RL, Povlishock J, Tortella FC, Wang KK.

J Trauma. 2011 Jul;71(1 Suppl):S15-24. doi: 10.1097/TA.0b013e31822117fe. Review. No abstract available.

PMID:
21795873

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