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Items: 47

1.

The role of complement in IgA nephropathy.

Tortajada A, Gutierrez E, Pickering MC, Praga Terente M, Medjeral-Thomas N.

Mol Immunol. 2019 Oct;114:123-132. doi: 10.1016/j.molimm.2019.07.017. Epub 2019 Jul 24. Review.

PMID:
31351413
2.

Transition-Metal-Catalyzed Carboxylation Reactions with Carbon Dioxide.

Tortajada A, Juliá-Hernández F, Börjesson M, Moragas T, Martin R.

Angew Chem Int Ed Engl. 2018 Dec 3;57(49):15948-15982. doi: 10.1002/anie.201803186. Epub 2018 Oct 2. Review.

PMID:
29722461
3.

Ni-Catalyzed Site-Selective Dicarboxylation of 1,3-Dienes with CO2.

Tortajada A, Ninokata R, Martin R.

J Am Chem Soc. 2018 Feb 14;140(6):2050-2053. doi: 10.1021/jacs.7b13220. Epub 2018 Feb 1.

PMID:
29376353
4.

Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome.

Goicoechea de Jorge E, Tortajada A, García SP, Gastoldi S, Merinero HM, García-Fernández J, Arjona E, Cao M, Remuzzi G, Noris M, Rodríguez de Córdoba S.

J Am Soc Nephrol. 2018 Jan;29(1):240-249. doi: 10.1681/ASN.2017050518. Epub 2017 Oct 9.

5.

Complete functional characterization of disease-associated genetic variants in the complement factor H gene.

Merinero HM, García SP, García-Fernández J, Arjona E, Tortajada A, Rodríguez de Córdoba S.

Kidney Int. 2018 Feb;93(2):470-481. doi: 10.1016/j.kint.2017.07.015. Epub 2017 Sep 21.

PMID:
28941939
6.

How novel structures inform understanding of complement function.

de Jorge EG, Yebenes H, Serna M, Tortajada A, Llorca O, de Córdoba SR.

Semin Immunopathol. 2018 Jan;40(1):3-14. doi: 10.1007/s00281-017-0643-z. Epub 2017 Aug 14. Review.

PMID:
28808775
7.

Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.

Bettoni S, Galbusera M, Gastoldi S, Donadelli R, Tentori C, Spartà G, Bresin E, Mele C, Alberti M, Tortajada A, Yebenes H, Remuzzi G, Noris M.

J Immunol. 2017 Aug 1;199(3):1021-1040. doi: 10.4049/jimmunol.1601121. Epub 2017 Jun 26.

8.

Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.

Tortajada A, Gutiérrez E, Goicoechea de Jorge E, Anter J, Segarra A, Espinosa M, Blasco M, Roman E, Marco H, Quintana LF, Gutiérrez J, Pinto S, Lopez-Trascasa M, Praga M, Rodriguez de Córdoba S.

Kidney Int. 2017 Oct;92(4):953-963. doi: 10.1016/j.kint.2017.03.041. Epub 2017 Jun 19.

PMID:
28637589
9.

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

Csincsi ÁI, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti É, Tortajada A, Caesar JJE, Prohászka Z, Jokiranta TS, Lea SM, Rodríguez de Córdoba S, Józsi M.

J Immunol. 2017 Jul 1;199(1):292-303. doi: 10.4049/jimmunol.1600483. Epub 2017 May 22.

10.

Switchable Site-Selective Catalytic Carboxylation of Allylic Alcohols with CO2.

van Gemmeren M, Börjesson M, Tortajada A, Sun SZ, Okura K, Martin R.

Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6558-6562. doi: 10.1002/anie.201702857. Epub 2017 May 2.

PMID:
28464503
11.

Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii.

Moynié L, Luscher A, Rolo D, Pletzer D, Tortajada A, Weingart H, Braun Y, Page MG, Naismith JH, Köhler T.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02531-16. doi: 10.1128/AAC.02531-16. Print 2017 Apr.

12.

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

Subías Hidalgo M, Yébenes H, Rodríguez-Gallego C, Martín-Ambrosio A, Domínguez M, Tortajada A, Rodríguez de Córdoba S, Llorca O.

Eur J Immunol. 2017 Mar;47(3):504-515. doi: 10.1002/eji.201646758. Epub 2017 Feb 6.

13.

Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene.

Xiao X, Ghossein C, Tortajada A, Zhang Y, Meyer N, Jones M, Borsa NG, Nester CM, Thomas CP, de Córdoba SR, Smith RJ.

Mol Immunol. 2016 Sep;77:89-96. doi: 10.1016/j.molimm.2016.07.007. Epub 2016 Aug 1.

14.

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy.

Corvillo F, Bravo García-Morato M, Nozal P, Garrido S, Tortajada A, Rodríguez de Córdoba S, López-Trascasa M.

Clin Exp Immunol. 2016 Apr;184(1):118-25. doi: 10.1111/cei.12754. Epub 2016 Jan 22.

15.

Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.

Recalde S, Tortajada A, Subias M, Anter J, Blasco M, Maranta R, Coco R, Pinto S, Noris M, García-Layana A, Rodríguez de Córdoba S.

J Am Soc Nephrol. 2016 May;27(5):1305-11. doi: 10.1681/ASN.2015050580. Epub 2015 Sep 16.

16.

Factor H-related proteins determine complement-activating surfaces.

Józsi M, Tortajada A, Uzonyi B, Goicoechea de Jorge E, Rodríguez de Córdoba S.

Trends Immunol. 2015 Jun;36(6):374-84. doi: 10.1016/j.it.2015.04.008. Epub 2015 May 13. Review.

PMID:
25979655
17.

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

Martínez-Barricarte R, Heurich M, López-Perrote A, Tortajada A, Pinto S, López-Trascasa M, Sánchez-Corral P, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S.

Mol Immunol. 2015 Aug;66(2):263-73. doi: 10.1016/j.molimm.2015.03.248. Epub 2015 Apr 11.

18.

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

Subías M, Tortajada A, Gastoldi S, Galbusera M, López-Perrote A, Lopez Lde J, González-Fernández FA, Villegas-Martínez A, Dominguez M, Llorca O, Noris M, Morgan BP, Rodríguez de Córdoba S.

J Immunol. 2014 Dec 1;193(11):5567-75. doi: 10.4049/jimmunol.1402013. Epub 2014 Oct 29.

19.

A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation.

Valoti E, Alberti M, Tortajada A, Garcia-Fernandez J, Gastoldi S, Besso L, Bresin E, Remuzzi G, Rodriguez de Cordoba S, Noris M.

J Am Soc Nephrol. 2015 Jan;26(1):209-19. doi: 10.1681/ASN.2013121339. Epub 2014 Jun 5.

20.

Genetics of atypical hemolytic uremic syndrome (aHUS).

Rodríguez de Córdoba S, Hidalgo MS, Pinto S, Tortajada A.

Semin Thromb Hemost. 2014 Jun;40(4):422-30. doi: 10.1055/s-0034-1375296. Epub 2014 May 5. Review.

PMID:
24799305
21.

Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.

Francis DM, Koveal D, Tortajada A, Page R, Peti W.

PLoS One. 2014 Mar 17;9(3):e91934. doi: 10.1371/journal.pone.0091934. eCollection 2014.

22.

The differential regulation of p38α by the neuronal kinase interaction motif protein tyrosine phosphatases, a detailed molecular study.

Francis DM, Kumar GS, Koveal D, Tortajada A, Page R, Peti W.

Structure. 2013 Sep 3;21(9):1612-23. doi: 10.1016/j.str.2013.07.003. Epub 2013 Aug 8.

23.

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

Alcorlo M, Tortajada A, Rodríguez de Córdoba S, Llorca O.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13504-9. doi: 10.1073/pnas.1309618110. Epub 2013 Jul 30.

24.

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Tortajada A, Yébenes H, Abarrategui-Garrido C, Anter J, García-Fernández JM, Martínez-Barricarte R, Alba-Domínguez M, Malik TH, Bedoya R, Cabrera Pérez R, López Trascasa M, Pickering MC, Harris CL, Sánchez-Corral P, Llorca O, Rodríguez de Córdoba S.

J Clin Invest. 2013 Jun;123(6):2434-46.

25.

Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.

de Cordoba SR, Tortajada A, Harris CL, Morgan BP.

Immunobiology. 2012 Nov;217(11):1034-46. doi: 10.1016/j.imbio.2012.07.021. Review.

26.

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

Kopp A, Strobel S, Tortajada A, Rodríguez de Córdoba S, Sánchez-Corral P, Prohászka Z, López-Trascasa M, Józsi M.

J Immunol. 2012 Aug 15;189(4):1858-67. doi: 10.4049/jimmunol.1200357. Epub 2012 Jul 11.

27.

Resting and active states of the ERK2:HePTP complex.

Francis DM, Różycki B, Tortajada A, Hummer G, Peti W, Page R.

J Am Chem Soc. 2011 Nov 2;133(43):17138-41. doi: 10.1021/ja2075136. Epub 2011 Oct 10.

28.

Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance.

Tortajada A, Pinto S, Martínez-Ara J, López-Trascasa M, Sánchez-Corral P, de Córdoba SR.

Kidney Int. 2012 Jan;81(1):56-63. doi: 10.1038/ki.2011.291. Epub 2011 Aug 31.

29.

Effects of population outcrossing on rotifer fitness.

Tortajada AM, Carmona MJ, Serra M.

BMC Evol Biol. 2010 Oct 18;10:312. doi: 10.1186/1471-2148-10-312.

30.

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.

Martínez-Barricarte R, Heurich M, Valdes-Cañedo F, Vazquez-Martul E, Torreira E, Montes T, Tortajada A, Pinto S, Lopez-Trascasa M, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S.

J Clin Invest. 2010 Oct;120(10):3702-12. doi: 10.1172/JCI43343. Epub 2010 Sep 13.

31.

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome.

Hakobyan S, Tortajada A, Harris CL, de Córdoba SR, Morgan BP.

Kidney Int. 2010 Oct;78(8):782-8. doi: 10.1038/ki.2010.275. Epub 2010 Aug 11.

32.

Does haplodiploidy purge inbreeding depression in rotifer populations?

Tortajada AM, Carmona MJ, Serra M.

PLoS One. 2009 Dec 7;4(12):e8195. doi: 10.1371/journal.pone.0008195.

33.

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase.

Torreira E, Tortajada A, Montes T, Rodríguez de Córdoba S, Llorca O.

J Immunol. 2009 Dec 1;183(11):7347-51. doi: 10.4049/jimmunol.0902310. Epub 2009 Nov 4.

34.

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

Tortajada A, Montes T, Martínez-Barricarte R, Morgan BP, Harris CL, de Córdoba SR.

Hum Mol Genet. 2009 Sep 15;18(18):3452-61. doi: 10.1093/hmg/ddp289. Epub 2009 Jun 23.

35.

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B.

Montes T, Tortajada A, Morgan BP, Rodríguez de Córdoba S, Harris CL.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4366-71. doi: 10.1073/pnas.0812584106. Epub 2009 Mar 2.

36.

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.

Torreira E, Tortajada A, Montes T, Rodríguez de Córdoba S, Llorca O.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):882-7. doi: 10.1073/pnas.0810860106. Epub 2009 Jan 9.

37.

Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.

Critton DA, Tortajada A, Stetson G, Peti W, Page R.

Biochemistry. 2008 Dec 16;47(50):13336-45. doi: 10.1021/bi801724n.

38.

Induction of hypothermic conditions associated with increased micronuclei formation in sigma-1 receptor knockout mice after administration of the antipsychotic compound E-5842.

Guzmán A, Marín AP, García C, Fernández de Henestrosa AR, Ruiz MT, Tortajada A, Marcos R.

Environ Mol Mutagen. 2008 Dec;49(9):727-33. doi: 10.1002/em.20428.

PMID:
18800345
39.

Formation of micronucleated erythrocytes in mouse bone-marrow under conditions of hypothermia is not associated with stimulation of erythropoiesis.

Guzmán A, García C, Marín AP, Tortajada A, Ruiz MT, Fernández de Henestrosa AR, Marcos R.

Mutat Res. 2008 Oct 30;656(1-2):8-13. doi: 10.1016/j.mrgentox.2008.06.016. Epub 2008 Jul 30.

PMID:
18718553
40.

Evaluation of the genotoxic potential of three phenyltetrahydropyridinyl butylazole-derived sigma-receptor ligand drug candidates.

Guzmán A, García C, Marín AP, Proudlock RJ, Fernández de Henestrosa AR, Ruiz MT, Tortajada A, Lloyd M, Marcos R.

Mutat Res. 2008 May 31;653(1-2):91-8. doi: 10.1016/j.mrgentox.2008.03.011. Epub 2008 Apr 16.

PMID:
18502168
41.

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration.

Hakobyan S, Harris CL, Tortajada A, Goicochea de Jorge E, García-Layana A, Fernández-Robredo P, Rodríguez de Córdoba S, Morgan BP.

Invest Ophthalmol Vis Sci. 2008 May;49(5):1983-90. doi: 10.1167/iovs.07-1523.

PMID:
18436830
42.

Assessment of the genotoxic potential of the antipsychotic sigma receptor ligand E-5842.

Guzmán A, García C, Fernández de Henestrosa AR, Riley S, Ruiz MT, Marín AP, Tortajada A.

Mutat Res. 2006 Jun 16;605(1-2):63-77. Epub 2006 May 4.

PMID:
16677850
43.

Peptergents: peptide detergents that improve stability and functionality of a membrane protein, glycerol-3-phosphate dehydrogenase.

Yeh JI, Du S, Tortajada A, Paulo J, Zhang S.

Biochemistry. 2005 Dec 27;44(51):16912-9.

PMID:
16363804
44.

Induction of micronuclei in mouse bone-marrow erythrocytes in association with hypothermia after administration of the sigma receptor ligand E-5842.

Guzmán A, García C, Marín AP, Ruiz MT, Tortajada A, Fernández de Henestrosa AR.

Mutat Res. 2004 Dec 31;565(1):11-22.

PMID:
15576235
45.

Ocular tolerance of sertaconazole gel.

Romero A, Grau MT, Villamayor F, Zapatero J, Mayordomo L, Tortajada A, Sacristán A, Ortiz JA.

Mycoses. 1996 Jan-Feb;39(1-2):57-60.

PMID:
8786760
46.

Interlaboratory assessment of the bovine corneal opacity and permeability (BCOP) assay.

Gautheron P, Giroux J, Cottin M, Audegond L, Morilla A, Mayordomo-Blanco L, Tortajada A, Haynes G, Vericat JA, Pirovano R, Gillio Tos E, Hagemann C, Vanparys P, Deknudt G, Jacobs G, Prinsen M, Kalweit S, Spielmann H.

Toxicol In Vitro. 1994 Jun;8(3):381-92.

PMID:
20692929
47.

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