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Items: 35


Miltefosine-Lopinavir Combination Therapy Against Leishmania infantum Infection: In vitro and in vivo Approaches.

Rebello KM, Andrade-Neto VV, Gomes CRB, de Souza MVN, Branquinha MH, Santos ALS, Torres-Santos EC, d'Avila-Levy CM.

Front Cell Infect Microbiol. 2019 Jun 28;9:229. doi: 10.3389/fcimb.2019.00229. eCollection 2019.


Second-generation pterocarpanquinones: synthesis and antileishmanial activity.

Faiões VDS, da Frota LCRM, Cunha-Junior EF, Barcellos JCF, Da Silva T, Netto CD, Da-Silva SAG, da Silva AJM, Costa PRR, Torres-Santos EC.

J Venom Anim Toxins Incl Trop Dis. 2018 Nov 29;24:35. doi: 10.1186/s40409-018-0174-7. eCollection 2018.


Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata.

Lima SCM, Pacheco JDS, Marques AM, Veltri ERP, Almeida-Lafetá RC, Figueiredo MR, Kaplan MAC, Torres-Santos EC.

Molecules. 2018 Nov 30;23(12). pii: E3160. doi: 10.3390/molecules23123160.


Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines.

Oliveira VG, Dos Santos Faiões V, Gonçalves GBR, Lima MFO, Boechat FCS, Cunha AC, de Andrade-Neto VV, de C da Silva F, Torres-Santos EC, de Souza MCBV.

Curr Top Med Chem. 2018;18(17):1454-1464. doi: 10.2174/1568026618666181002110116.


Anti-Mycobacterium tuberculosis activity of essential oil and 6,7-dehydroroyleanone isolated from leaves of Tetradenia riparia (Hochst.) Codd (Lamiaceae).

Baldin VP, Scodro RBL, Lopes-Ortiz MA, de Almeida AL, Gazim ZC, Ferarrese L, Faiões VDS, Torres-Santos EC, Pires CTA, Caleffi-Ferracioli KR, Siqueira VLD, Cortez DAG, Cardoso RF.

Phytomedicine. 2018 Aug 1;47:34-39. doi: 10.1016/j.phymed.2018.04.043. Epub 2018 Apr 24.


Lopinavir, an HIV-1 peptidase inhibitor, induces alteration on the lipid metabolism of Leishmania amazonensis promastigotes.

Rebello KM, Andrade-Neto VV, Zuma AA, Motta MCM, Gomes CRB, de Souza MVN, Atella GC, Branquinha MH, Santos ALS, Torres-Santos EC, d'Avila-Levy CM.

Parasitology. 2018 Sep;145(10):1304-1310. doi: 10.1017/S0031182018000823. Epub 2018 May 28.


Original antileishmanial hits: Variations around amidoximes.

Tabélé C, Faiões VDS, Grimaud F, Torres-Santos EC, Khoumeri O, Curti C, Vanelle P.

Eur J Med Chem. 2018 Mar 25;148:154-164. doi: 10.1016/j.ejmech.2018.02.029. Epub 2018 Feb 10.


In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.

Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb.


Leishmaniasis treatment: update of possibilities for drug repurposing.

Andrade-Neto VV, Cunha-Junior EF, Dos Santos Faioes V, Pereira TM, Silva RL, Leon LL, Torres-Santos EC.

Front Biosci (Landmark Ed). 2018 Jan 1;23:967-996. Review.


Supercritical Fluid Extraction of Pyrrolidine Alkaloid from Leaves of Piper amalago L.

Carrara VS, Filho LC, Garcia VAS, Faiões VS, Cunha-Júnior EF, Torres-Santos EC, Cortez DAG.

Evid Based Complement Alternat Med. 2017;2017:7401748. doi: 10.1155/2017/7401748. Epub 2017 May 2.


Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

Cunha-Júnior EF, Andrade-Neto VV, Lima ML, da Costa-Silva TA, Galisteo Junior AJ, Abengózar MA, Barbas C, Rivas L, Almeida-Amaral EE, Tempone AG, Torres-Santos EC.

PLoS Negl Trop Dis. 2017 Jan 3;11(1):e0005281. doi: 10.1371/journal.pntd.0005281. eCollection 2017 Jan.


Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species.

Bernuci KZ, Iwanaga CC, Fernandez-Andrade CM, Lorenzetti FB, Torres-Santos EC, Faiões VD, Gonçalves JE, do Amaral W, Deschamps C, Scodro RB, Cardoso RF, Baldin VP, Cortez DA.

Molecules. 2016 Dec 12;21(12). pii: E1698. doi: 10.3390/molecules21121698.


Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species.

Bernuci KZ, Iwanaga CC, Fernadez-Andrade CM, Lorenzetti FB, Torres-Santos EC, Faiões VD, Gonçalves JE, do Amaral W, Deschamps C, Scodro RB, Cardoso RF, Baldin VP, Cortez DA.

Molecules. 2016 Dec 12;21(12). pii: E1698.


Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis.

Andrade-Neto VV, Cunha-Júnior EF, Canto-Cavalheiro MM, Atella GC, Fernandes TA, Costa PR, Torres-Santos EC.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6844-6852. doi: 10.1128/AAC.01545-16. Print 2016 Nov.


Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis.

Cunha-Júnior EF, Martins TM, Canto-Cavalheiro MM, Marques PR, Portari EA, Coelho MG, Netto CD, Costa PR, Sabino KC, Torres-Santos EC.

Antimicrob Agents Chemother. 2016 May 23;60(6):3794-801. doi: 10.1128/AAC.01787-15. Print 2016 Jun.


Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole.

Andrade-Neto VV, Pereira TM, Canto-Cavalheiro Md, Torres-Santos EC.

Parasit Vectors. 2016 Mar 31;9:183. doi: 10.1186/s13071-016-1467-8.


Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis.

de Melos JL, Torres-Santos EC, Faiões Vdos S, Del Cistia Cde N, Sant'Anna CM, Rodrigues-Santos CE, Echevarria A.

Eur J Med Chem. 2015 Oct 20;103:409-17. doi: 10.1016/j.ejmech.2015.09.009. Epub 2015 Sep 8.


Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis.

Vasconcelos MF, Cunha-Júnior EF, Andrade-Neto VV, Siqueira LM, d'Avila-Levy CM, Moreth M, Cunico W, Souza MV, Gomes CR, Torres-Santos EC.

Int J Parasitol Drugs Drug Resist. 2014 Nov 8;4(3):210-3. doi: 10.1016/j.ijpddr.2014.10.005. eCollection 2014 Dec.


Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters.

Costa L, Pinheiro RO, Dutra PM, Santos RF, Cunha-Júnior EF, Torres-Santos EC, da Silva AJ, Costa PR, Da-Silva SA.

PLoS One. 2014 Oct 23;9(10):e109672. doi: 10.1371/journal.pone.0109672. eCollection 2014.


The new pyrazolyltetrazole derivative MSN20 is effective via oral delivery against cutaneous leishmaniasis.

Faiões Vdos S, Dos Santos MS, Bernardino AM, Cunha-Júnior EF, Canto Cavalheiro MM, Torres-Santos EC.

Antimicrob Agents Chemother. 2014 Oct;58(10):6290-3. doi: 10.1128/AAC.02874-14. Epub 2014 Aug 4.


Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of Leishmania amazonensis.

dos Santos Faiões V, Leon LL, Canto-Cavalheiro MM, Torres-Santos EC, Bernardino AM, Vegi PF, dos Santos MS.

Chem Biol Drug Des. 2014 Mar;83(3):272-7. doi: 10.1111/cbdd.12235. Epub 2013 Oct 30.


LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.

Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.

J Antimicrob Chemother. 2013 Apr;68(4):789-99. doi: 10.1093/jac/dks498. Epub 2013 Jan 3.


The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis.

Andrade-Neto VV, Matos-Guedes HL, Gomes DC, Canto-Cavalheiro MM, Rossi-Bergmann B, Torres-Santos EC.

Mem Inst Oswaldo Cruz. 2012 May;107(3):416-9.


LDL uptake by Leishmania amazonensis: involvement of membrane lipid microdomains.

De Cicco NN, Pereira MG, Corrêa JR, Andrade-Neto VV, Saraiva FB, Chagas-Lima AC, Gondim KC, Torres-Santos EC, Folly E, Saraiva EM, Cunha-E-Silva NL, Soares MJ, Atella GC.

Exp Parasitol. 2012 Apr;130(4):330-40. doi: 10.1016/j.exppara.2012.02.014. Epub 2012 Feb 21.


HPLC analysis of supercritical carbon dioxide and compressed propane extracts from Piper amalago L. with antileishmanial activity.

Carrara Vda S, Serra LZ, Cardozo-Filho L, Cunha EF Jr, Torres-Santos EC, Cortez DA.

Molecules. 2011 Dec 22;17(1):15-33. doi: 10.3390/molecules17010015.


Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.

Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR.

Bioorg Med Chem. 2011 Nov 15;19(22):6885-91. doi: 10.1016/j.bmc.2011.09.025. Epub 2011 Sep 21.


The pharmacological inhibition of sterol biosynthesis in Leishmania is counteracted by enhancement of LDL endocytosis.

Andrade-Neto VV, Cicco NN, Cunha-Junior EF, Canto-Cavalheiro MM, Atella GC, Torres-Santos EC.

Acta Trop. 2011 Aug;119(2-3):194-8. doi: 10.1016/j.actatropica.2011.05.001. Epub 2011 May 13.


Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.

da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC.

J Antimicrob Chemother. 2011 Jul;66(7):1555-9. doi: 10.1093/jac/dkr158. Epub 2011 Apr 29.


Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination.

Chaves SP, Torres-Santos EC, Marques C, Figliuolo VR, Persechini PM, Coutinho-Silva R, Rossi-Bergmann B.

Microbes Infect. 2009 Sep;11(10-11):842-9. doi: 10.1016/j.micinf.2009.05.001. Epub 2009 May 9.


Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.

Torres-Santos EC, Sampaio-Santos MI, Buckner FS, Yokoyama K, Gelb M, Urbina JA, Rossi-Bergmann B.

J Antimicrob Chemother. 2009 Mar;63(3):469-72. doi: 10.1093/jac/dkn546. Epub 2009 Jan 28.


Synthesis of chalcone analogues with increased antileishmanial activity.

Boeck P, Bandeira Falcão CA, Leal PC, Yunes RA, Filho VC, Torres-Santos EC, Rossi-Bergmann B.

Bioorg Med Chem. 2006 Mar 1;14(5):1538-45. Epub 2005 Dec 28.


Antileishmanial activity of isolated triterpenoids from Pourouma guianensis.

Torres-Santos EC, Lopes D, Oliveira RR, Carauta JP, Falcao CA, Kaplan MA, Rossi-Bergmann B.

Phytomedicine. 2004 Feb;11(2-3):114-20.


Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous leishmaniasis.

Torres-Santos EC, Da Silva SA, Costa SS, Santos AP, Almeida AP, Rossi-Bergmann B.

Phytother Res. 2003 Aug;17(7):801-3.


Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.

Torres-Santos EC, Rodrigues JM Jr, Moreira DL, Kaplan MA, Rossi-Bergmann B.

Antimicrob Agents Chemother. 1999 Jul;43(7):1776-8.


Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.

Torres-Santos EC, Moreira DL, Kaplan MA, Meirelles MN, Rossi-Bergmann B.

Antimicrob Agents Chemother. 1999 May;43(5):1234-41.

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