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Items: 35

1.

Miltefosine-Lopinavir Combination Therapy Against Leishmania infantum Infection: In vitro and in vivo Approaches.

Rebello KM, Andrade-Neto VV, Gomes CRB, de Souza MVN, Branquinha MH, Santos ALS, Torres-Santos EC, d'Avila-Levy CM.

Front Cell Infect Microbiol. 2019 Jun 28;9:229. doi: 10.3389/fcimb.2019.00229. eCollection 2019.

2.

Second-generation pterocarpanquinones: synthesis and antileishmanial activity.

Faiões VDS, da Frota LCRM, Cunha-Junior EF, Barcellos JCF, Da Silva T, Netto CD, Da-Silva SAG, da Silva AJM, Costa PRR, Torres-Santos EC.

J Venom Anim Toxins Incl Trop Dis. 2018 Nov 29;24:35. doi: 10.1186/s40409-018-0174-7. eCollection 2018.

3.

Leishmanicidal Activity of Withanolides from Aureliana Fasciculata var. Fasciculata.

Lima SCM, Pacheco JDS, Marques AM, Veltri ERP, Almeida-Lafetá RC, Figueiredo MR, Kaplan MAC, Torres-Santos EC.

Molecules. 2018 Nov 30;23(12). pii: E3160. doi: 10.3390/molecules23123160.

4.

Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines.

Oliveira VG, Dos Santos Faiões V, Gonçalves GBR, Lima MFO, Boechat FCS, Cunha AC, de Andrade-Neto VV, de C da Silva F, Torres-Santos EC, de Souza MCBV.

Curr Top Med Chem. 2018;18(17):1454-1464. doi: 10.2174/1568026618666181002110116.

PMID:
30277154
5.

Anti-Mycobacterium tuberculosis activity of essential oil and 6,7-dehydroroyleanone isolated from leaves of Tetradenia riparia (Hochst.) Codd (Lamiaceae).

Baldin VP, Scodro RBL, Lopes-Ortiz MA, de Almeida AL, Gazim ZC, Ferarrese L, Faiões VDS, Torres-Santos EC, Pires CTA, Caleffi-Ferracioli KR, Siqueira VLD, Cortez DAG, Cardoso RF.

Phytomedicine. 2018 Aug 1;47:34-39. doi: 10.1016/j.phymed.2018.04.043. Epub 2018 Apr 24.

PMID:
30166106
6.

Lopinavir, an HIV-1 peptidase inhibitor, induces alteration on the lipid metabolism of Leishmania amazonensis promastigotes.

Rebello KM, Andrade-Neto VV, Zuma AA, Motta MCM, Gomes CRB, de Souza MVN, Atella GC, Branquinha MH, Santos ALS, Torres-Santos EC, d'Avila-Levy CM.

Parasitology. 2018 Sep;145(10):1304-1310. doi: 10.1017/S0031182018000823. Epub 2018 May 28.

7.

Original antileishmanial hits: Variations around amidoximes.

Tabélé C, Faiões VDS, Grimaud F, Torres-Santos EC, Khoumeri O, Curti C, Vanelle P.

Eur J Med Chem. 2018 Mar 25;148:154-164. doi: 10.1016/j.ejmech.2018.02.029. Epub 2018 Feb 10.

PMID:
29459275
8.

In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.

Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb.

9.

Leishmaniasis treatment: update of possibilities for drug repurposing.

Andrade-Neto VV, Cunha-Junior EF, Dos Santos Faioes V, Pereira TM, Silva RL, Leon LL, Torres-Santos EC.

Front Biosci (Landmark Ed). 2018 Jan 1;23:967-996. Review.

PMID:
28930585
10.

Supercritical Fluid Extraction of Pyrrolidine Alkaloid from Leaves of Piper amalago L.

Carrara VS, Filho LC, Garcia VAS, Faiões VS, Cunha-Júnior EF, Torres-Santos EC, Cortez DAG.

Evid Based Complement Alternat Med. 2017;2017:7401748. doi: 10.1155/2017/7401748. Epub 2017 May 2.

11.

Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

Cunha-Júnior EF, Andrade-Neto VV, Lima ML, da Costa-Silva TA, Galisteo Junior AJ, Abengózar MA, Barbas C, Rivas L, Almeida-Amaral EE, Tempone AG, Torres-Santos EC.

PLoS Negl Trop Dis. 2017 Jan 3;11(1):e0005281. doi: 10.1371/journal.pntd.0005281. eCollection 2017 Jan.

12.

Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species.

Bernuci KZ, Iwanaga CC, Fernandez-Andrade CM, Lorenzetti FB, Torres-Santos EC, Faiões VD, Gonçalves JE, do Amaral W, Deschamps C, Scodro RB, Cardoso RF, Baldin VP, Cortez DA.

Molecules. 2016 Dec 12;21(12). pii: E1698. doi: 10.3390/molecules21121698.

13.

Evaluation of Chemical Composition and Antileishmanial and Antituberculosis Activities of Essential Oils of Piper Species.

Bernuci KZ, Iwanaga CC, Fernadez-Andrade CM, Lorenzetti FB, Torres-Santos EC, Faiões VD, Gonçalves JE, do Amaral W, Deschamps C, Scodro RB, Cardoso RF, Baldin VP, Cortez DA.

Molecules. 2016 Dec 12;21(12). pii: E1698.

14.

Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis.

Andrade-Neto VV, Cunha-Júnior EF, Canto-Cavalheiro MM, Atella GC, Fernandes TA, Costa PR, Torres-Santos EC.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6844-6852. doi: 10.1128/AAC.01545-16. Print 2016 Nov.

15.

Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis.

Cunha-Júnior EF, Martins TM, Canto-Cavalheiro MM, Marques PR, Portari EA, Coelho MG, Netto CD, Costa PR, Sabino KC, Torres-Santos EC.

Antimicrob Agents Chemother. 2016 May 23;60(6):3794-801. doi: 10.1128/AAC.01787-15. Print 2016 Jun.

16.

Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole.

Andrade-Neto VV, Pereira TM, Canto-Cavalheiro Md, Torres-Santos EC.

Parasit Vectors. 2016 Mar 31;9:183. doi: 10.1186/s13071-016-1467-8.

17.

Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis.

de Melos JL, Torres-Santos EC, Faiões Vdos S, Del Cistia Cde N, Sant'Anna CM, Rodrigues-Santos CE, Echevarria A.

Eur J Med Chem. 2015 Oct 20;103:409-17. doi: 10.1016/j.ejmech.2015.09.009. Epub 2015 Sep 8.

PMID:
26375353
18.

Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis.

Vasconcelos MF, Cunha-Júnior EF, Andrade-Neto VV, Siqueira LM, d'Avila-Levy CM, Moreth M, Cunico W, Souza MV, Gomes CR, Torres-Santos EC.

Int J Parasitol Drugs Drug Resist. 2014 Nov 8;4(3):210-3. doi: 10.1016/j.ijpddr.2014.10.005. eCollection 2014 Dec.

19.

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters.

Costa L, Pinheiro RO, Dutra PM, Santos RF, Cunha-Júnior EF, Torres-Santos EC, da Silva AJ, Costa PR, Da-Silva SA.

PLoS One. 2014 Oct 23;9(10):e109672. doi: 10.1371/journal.pone.0109672. eCollection 2014.

20.

The new pyrazolyltetrazole derivative MSN20 is effective via oral delivery against cutaneous leishmaniasis.

Faiões Vdos S, Dos Santos MS, Bernardino AM, Cunha-Júnior EF, Canto Cavalheiro MM, Torres-Santos EC.

Antimicrob Agents Chemother. 2014 Oct;58(10):6290-3. doi: 10.1128/AAC.02874-14. Epub 2014 Aug 4.

21.

Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of Leishmania amazonensis.

dos Santos Faiões V, Leon LL, Canto-Cavalheiro MM, Torres-Santos EC, Bernardino AM, Vegi PF, dos Santos MS.

Chem Biol Drug Des. 2014 Mar;83(3):272-7. doi: 10.1111/cbdd.12235. Epub 2013 Oct 30.

PMID:
24119090
22.

LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.

Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.

J Antimicrob Chemother. 2013 Apr;68(4):789-99. doi: 10.1093/jac/dks498. Epub 2013 Jan 3.

PMID:
23288404
23.

The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis.

Andrade-Neto VV, Matos-Guedes HL, Gomes DC, Canto-Cavalheiro MM, Rossi-Bergmann B, Torres-Santos EC.

Mem Inst Oswaldo Cruz. 2012 May;107(3):416-9.

24.

LDL uptake by Leishmania amazonensis: involvement of membrane lipid microdomains.

De Cicco NN, Pereira MG, Corrêa JR, Andrade-Neto VV, Saraiva FB, Chagas-Lima AC, Gondim KC, Torres-Santos EC, Folly E, Saraiva EM, Cunha-E-Silva NL, Soares MJ, Atella GC.

Exp Parasitol. 2012 Apr;130(4):330-40. doi: 10.1016/j.exppara.2012.02.014. Epub 2012 Feb 21.

25.

HPLC analysis of supercritical carbon dioxide and compressed propane extracts from Piper amalago L. with antileishmanial activity.

Carrara Vda S, Serra LZ, Cardozo-Filho L, Cunha EF Jr, Torres-Santos EC, Cortez DA.

Molecules. 2011 Dec 22;17(1):15-33. doi: 10.3390/molecules17010015.

26.

Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis.

Buarque CD, Militão GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR.

Bioorg Med Chem. 2011 Nov 15;19(22):6885-91. doi: 10.1016/j.bmc.2011.09.025. Epub 2011 Sep 21.

27.

The pharmacological inhibition of sterol biosynthesis in Leishmania is counteracted by enhancement of LDL endocytosis.

Andrade-Neto VV, Cicco NN, Cunha-Junior EF, Canto-Cavalheiro MM, Atella GC, Torres-Santos EC.

Acta Trop. 2011 Aug;119(2-3):194-8. doi: 10.1016/j.actatropica.2011.05.001. Epub 2011 May 13.

28.

Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.

da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC.

J Antimicrob Chemother. 2011 Jul;66(7):1555-9. doi: 10.1093/jac/dkr158. Epub 2011 Apr 29.

PMID:
21531758
29.

Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination.

Chaves SP, Torres-Santos EC, Marques C, Figliuolo VR, Persechini PM, Coutinho-Silva R, Rossi-Bergmann B.

Microbes Infect. 2009 Sep;11(10-11):842-9. doi: 10.1016/j.micinf.2009.05.001. Epub 2009 May 9.

PMID:
19439191
30.

Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.

Torres-Santos EC, Sampaio-Santos MI, Buckner FS, Yokoyama K, Gelb M, Urbina JA, Rossi-Bergmann B.

J Antimicrob Chemother. 2009 Mar;63(3):469-72. doi: 10.1093/jac/dkn546. Epub 2009 Jan 28.

31.

Synthesis of chalcone analogues with increased antileishmanial activity.

Boeck P, Bandeira Falcão CA, Leal PC, Yunes RA, Filho VC, Torres-Santos EC, Rossi-Bergmann B.

Bioorg Med Chem. 2006 Mar 1;14(5):1538-45. Epub 2005 Dec 28.

PMID:
16386424
32.

Antileishmanial activity of isolated triterpenoids from Pourouma guianensis.

Torres-Santos EC, Lopes D, Oliveira RR, Carauta JP, Falcao CA, Kaplan MA, Rossi-Bergmann B.

Phytomedicine. 2004 Feb;11(2-3):114-20.

PMID:
15070160
33.

Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous leishmaniasis.

Torres-Santos EC, Da Silva SA, Costa SS, Santos AP, Almeida AP, Rossi-Bergmann B.

Phytother Res. 2003 Aug;17(7):801-3.

PMID:
12916081
34.

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.

Torres-Santos EC, Rodrigues JM Jr, Moreira DL, Kaplan MA, Rossi-Bergmann B.

Antimicrob Agents Chemother. 1999 Jul;43(7):1776-8.

35.

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.

Torres-Santos EC, Moreira DL, Kaplan MA, Meirelles MN, Rossi-Bergmann B.

Antimicrob Agents Chemother. 1999 May;43(5):1234-41.

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