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Items: 20

1.

Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy.

Torres Hernandez AX, Weeramange CJ, Desman P, Fatino A, Haney O, Rafferty RJ.

Medchemcomm. 2018 Dec 20;10(1):169-179. doi: 10.1039/c8md00463c. eCollection 2019 Jan 1.

2.

Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis.

Torres-Hernandez A, Wang W, Nikiforov Y, Tejada K, Torres L, Kalabin A, Wu Y, Haq MIU, Khan MY, Zhao Z, Su W, Camargo J, Hundeyin M, Diskin B, Adam S, Rossi JAK, Kurz E, Aykut B, Shadaloey SAA, Leinwand J, Miller G.

Oncogene. 2019 Feb 11. doi: 10.1038/s41388-019-0734-5. [Epub ahead of print]

PMID:
30742098
3.

Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?

Grunhut J, Wang W, Aykut B, Gakhal I, Torres-Hernandez A, Miller G.

Eur Med J Hepatol. 2018;6(1):100-109. Epub 2018 May 31.

4.

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, Werba G, Zhang K, Guo Y, Li Q, Akkad N, Lall S, Wadowski B, Gutierrez J, Kochen Rossi JA, Herzog JW, Diskin B, Torres-Hernandez A, Leinwand J, Wang W, Taunk PS, Savadkar S, Janal M, Saxena A, Li X, Cohen D, Sartor RB, Saxena D, Miller G.

Cancer Discov. 2018 Apr;8(4):403-416. doi: 10.1158/2159-8290.CD-17-1134. Epub 2018 Mar 22.

PMID:
29567829
5.

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.

Daley D, Mani VR, Mohan N, Akkad N, Pandian GSDB, Savadkar S, Lee KB, Torres-Hernandez A, Aykut B, Diskin B, Wang W, Farooq MS, Mahmud AI, Werba G, Morales EJ, Lall S, Wadowski BJ, Rubin AG, Berman ME, Narayanan R, Hundeyin M, Miller G.

J Exp Med. 2017 Jun 5;214(6):1711-1724. doi: 10.1084/jem.20161707. Epub 2017 Apr 25.

6.

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

Daley D, Mani VR, Mohan N, Akkad N, Ochi A, Heindel DW, Lee KB, Zambirinis CP, Pandian GSB, Savadkar S, Torres-Hernandez A, Nayak S, Wang D, Hundeyin M, Diskin B, Aykut B, Werba G, Barilla RM, Rodriguez R, Chang S, Gardner L, Mahal LK, Ueberheide B, Miller G.

Nat Med. 2017 May;23(5):556-567. doi: 10.1038/nm.4314. Epub 2017 Apr 10.

7.

TIMPing Fate: Why Pancreatic Cancer Cells Sojourn in the Liver.

Torres-Hernandez A, Miller G.

Gastroenterology. 2016 Nov;151(5):807-808. doi: 10.1053/j.gastro.2016.09.035. Epub 2016 Oct 1. No abstract available.

PMID:
27702557
8.

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation.

Daley D, Zambirinis CP, Seifert L, Akkad N, Mohan N, Werba G, Barilla R, Torres-Hernandez A, Hundeyin M, Mani VRK, Avanzi A, Tippens D, Narayanan R, Jang JE, Newman E, Pillarisetty VG, Dustin ML, Bar-Sagi D, Hajdu C, Miller G.

Cell. 2016 Sep 8;166(6):1485-1499.e15. doi: 10.1016/j.cell.2016.07.046. Epub 2016 Aug 25.

9.

Mincle Signaling Promotes Con A Hepatitis.

Greco SH, Torres-Hernandez A, Kalabin A, Whiteman C, Rokosh R, Ravirala S, Ochi A, Gutierrez J, Salyana MA, Mani VR, Nagaraj SV, Deutsch M, Seifert L, Daley D, Barilla R, Hundeyin M, Nikifrov Y, Tejada K, Gelb BE, Katz SC, Miller G.

J Immunol. 2016 Oct 1;197(7):2816-27. doi: 10.4049/jimmunol.1600598. Epub 2016 Aug 24.

10.

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.

Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G.

Nature. 2016 Apr 14;532(7598):245-9. doi: 10.1038/nature17403. Epub 2016 Apr 6.

11.

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice.

Seifert L, Werba G, Tiwari S, Giao Ly NN, Nguy S, Alothman S, Alqunaibit D, Avanzi A, Daley D, Barilla R, Tippens D, Torres-Hernandez A, Hundeyin M, Mani VR, Hajdu C, Pellicciotta I, Oh P, Du K, Miller G.

Gastroenterology. 2016 Jun;150(7):1659-1672.e5. doi: 10.1053/j.gastro.2016.02.070. Epub 2016 Mar 3.

12.

Mincle suppresses Toll-like receptor 4 activation.

Greco SH, Mahmood SK, Vahle AK, Ochi A, Batel J, Deutsch M, Barilla R, Seifert L, Pachter HL, Daley D, Torres-Hernandez A, Hundeyin M, Mani VR, Miller G.

J Leukoc Biol. 2016 Jul;100(1):185-94. doi: 10.1189/jlb.3A0515-185R. Epub 2016 Jan 8.

PMID:
26747838
13.

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.

Seifert L, Deutsch M, Alothman S, Alqunaibit D, Werba G, Pansari M, Pergamo M, Ochi A, Torres-Hernandez A, Levie E, Tippens D, Greco SH, Tiwari S, Ly NNG, Eisenthal A, van Heerden E, Avanzi A, Barilla R, Zambirinis CP, Rendon M, Daley D, Pachter HL, Hajdu C, Miller G.

Cell Rep. 2015 Dec 1;13(9):1909-1921. doi: 10.1016/j.celrep.2015.10.058. Epub 2015 Nov 19.

14.

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis.

Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, Seifert L, Daley D, Greco SH, Deutsch M, Jonnadula S, Torres-Hernandez A, Tippens D, Pushalkar S, Eisenthal A, Saxena D, Ahn J, Hajdu C, Engle DD, Tuveson D, Miller G.

J Exp Med. 2015 Nov 16;212(12):2077-94. doi: 10.1084/jem.20142162. Epub 2015 Oct 19.

15.

TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.

Greco SH, Tomkötter L, Vahle AK, Rokosh R, Avanzi A, Mahmood SK, Deutsch M, Alothman S, Alqunaibit D, Ochi A, Zambirinis C, Mohaimin T, Rendon M, Levie E, Pansari M, Torres-Hernandez A, Daley D, Barilla R, Pachter HL, Tippens D, Malik H, Boutajangout A, Wisniewski T, Miller G.

PLoS One. 2015 Jul 14;10(7):e0132786. doi: 10.1371/journal.pone.0132786. eCollection 2015.

16.

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.

Deutsch M, Graffeo CS, Rokosh R, Pansari M, Ochi A, Levie EM, Van Heerden E, Tippens DM, Greco S, Barilla R, Tomkötter L, Zambirinis CP, Avanzi N, Gulati R, Pachter HL, Torres-Hernandez A, Eisenthal A, Daley D, Miller G.

Cell Death Dis. 2015 May 7;6:e1759. doi: 10.1038/cddis.2015.126.

17.

[Multidrug resistant Acinetobacter baumanii:clinical update and new highlights].

Torres HA, Vázquez EG, Yagüe G, Gómez JG.

Rev Esp Quimioter. 2010 Mar;23(1):12-9. Review. Spanish.

18.

CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.

Vasilatos SN, Broadwater G, Barry WT, Baker JC Jr, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL.

Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):901-14. doi: 10.1158/1055-9965.EPI-08-0875. Epub 2009 Mar 3.

19.

ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months tamoxifen chemoprevention.

Baker JC Jr, Ostrander JH, Lem S, Broadwater G, Bean GR, D'Amato NC, Goldenberg VK, Rowell C, Ibarra-Drendall C, Grant T, Pilie PG, Vasilatos SN, Troch MM, Scott V, Wilke LG, Paisie C, Rabiner SM, Torres-Hernandez A, Zalles CM, Seewaldt VL.

Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1884-90. doi: 10.1158/1055-9965.EPI-07-2696.

20.

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