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Items: 33


Menin Associates With the Mitotic Spindle and Is Important for Cell Division.

Sawicki MP, Gholkar AA, Torres JZ.

Endocrinology. 2019 Aug 1;160(8):1926-1936. doi: 10.1210/en.2019-00274.


Dissecting the mechanisms of cell division.

Ong JY, Torres JZ.

J Biol Chem. 2019 Jul 26;294(30):11382-11390. doi: 10.1074/jbc.AW119.008149. Epub 2019 Jun 7. Review.


Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1.

Xia X, Lo YC, Gholkar AA, Senese S, Ong JY, Velasquez EF, Damoiseaux R, Torres JZ.

ACS Chem Biol. 2019 May 17;14(5):994-1001. doi: 10.1021/acschembio.9b00173. Epub 2019 May 8.


Ensuring fidelity of chromosome segregation.

Ünal E, Torres JZ.

Mol Biol Cell. 2018 Mar 15;29(6):687. doi: 10.1091/mbc.E17-11-0673. No abstract available.


Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.

Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ.

Oncotarget. 2017 Oct 19;8(61):104007-104021. doi: 10.18632/oncotarget.21945. eCollection 2017 Nov 28.


A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.

Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI.

Neuro Oncol. 2018 May 18;20(6):764-775. doi: 10.1093/neuonc/nox215.


Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential.

Lo YC, Senese S, France B, Gholkar AA, Damoiseaux R, Torres JZ.

Sci Rep. 2017 Sep 12;7(1):11261. doi: 10.1038/s41598-017-11508-2.


Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM.

Free Radic Biol Med. 2017 Sep;110:176-187. doi: 10.1016/j.freeradbiomed.2017.06.006. Epub 2017 Jun 9.


NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.

Chan AH, Yi SW, Weiner EM, Amer BR, Sue CK, Wereszczynski J, Dillen CA, Senese S, Torres JZ, McCammon JA, Miller LS, Jung ME, Clubb RT.

Chem Biol Drug Des. 2017 Sep;90(3):327-344. doi: 10.1111/cbdd.12962. Epub 2017 Mar 6.


Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks.

Bradley M, Ramirez I, Cheung K, Gholkar AA, Torres JZ.

J Vis Exp. 2016 Dec 24;(118). doi: 10.3791/54870.


Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division.

Gholkar AA, Cheung K, Williams KJ, Lo YC, Hamideh SA, Nnebe C, Khuu C, Bensinger SJ, Torres JZ.

J Biol Chem. 2016 Aug 12;291(33):17001-8. doi: 10.1074/jbc.C116.737346. Epub 2016 Jul 4.


3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping.

Lo YC, Senese S, Damoiseaux R, Torres JZ.

ACS Chem Biol. 2016 Aug 19;11(8):2244-53. doi: 10.1021/acschembio.6b00253. Epub 2016 Jun 20.


Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB.

Soh H, Venkatesan N, Veena MS, Ravichandran S, Zinabadi A, Basak SK, Parvatiyar K, Srivastava M, Liang LJ, Gjertson DW, Torres JZ, Moatamed NA, Srivatsan ES.

Mol Cell Biol. 2016 May 31;36(12):1776-92. doi: 10.1128/MCB.00878-15. Print 2016 Jun 15.


Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.

Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ.

Mol Cell Proteomics. 2016 May;15(5):1658-69. doi: 10.1074/mcp.M115.056465. Epub 2016 Feb 29.


The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.

Gholkar AA, Senese S, Lo YC, Vides E, Contreras E, Hodara E, Capri J, Whitelegge JP, Torres JZ.

Cell Rep. 2016 Jan 12;14(2):180-8. doi: 10.1016/j.celrep.2015.12.035. Epub 2015 Dec 31.


Structures of potent anticancer compounds bound to tubulin.

McNamara DE, Senese S, Yeates TO, Torres JZ.

Protein Sci. 2015 Jul;24(7):1164-72. doi: 10.1002/pro.2704. Epub 2015 May 27.


A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.

Xia X, Gholkar A, Senese S, Torres JZ.

Cell Cycle. 2015;14(12):1938-47. doi: 10.1080/15384101.2015.1026487.


Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ.

Cell Cycle. 2015;14(7):1116-25. doi: 10.4161/15384101.2014.985066.


Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens.

Lo YC, Senese S, Li CM, Hu Q, Huang Y, Damoiseaux R, Torres JZ.

PLoS Comput Biol. 2015 Mar 31;11(3):e1004153. doi: 10.1371/journal.pcbi.1004153. eCollection 2015 Mar.


A unique insertion in STARD9's motor domain regulates its stability.

Senese S, Cheung K, Lo YC, Gholkar AA, Xia X, Wohlschlegel JA, Torres JZ.

Mol Biol Cell. 2015 Feb 1;26(3):440-52. doi: 10.1091/mbc.E14-03-0829. Epub 2014 Dec 10.


p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES.

J Biol Chem. 2014 Dec 12;289(50):34921-37. doi: 10.1074/jbc.M114.568543. Epub 2014 Oct 20.


Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.

Senese S, Lo YC, Huang D, Zangle TA, Gholkar AA, Robert L, Homet B, Ribas A, Summers MK, Teitell MA, Damoiseaux R, Torres JZ.

Cell Death Dis. 2014 Oct 16;5:e1462. doi: 10.1038/cddis.2014.420.


Dynamic and multi-pharmacophore modeling for designing polo-box domain inhibitors.

Sakkiah S, Senese S, Yang Q, Lee KW, Torres JZ.

PLoS One. 2014 Jul 18;9(7):e101405. doi: 10.1371/journal.pone.0101405. eCollection 2014.


An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ.

Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25.


STARD9/Kif16a is a novel mitotic kinesin and antimitotic target.

Torres JZ.

Bioarchitecture. 2012 Jan 1;2(1):19-22.


The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.


A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles.

Torres JZ, Ban KH, Jackson PK.

Mol Biol Cell. 2010 Mar 15;21(6):897-904. doi: 10.1091/mbc.E09-07-0598. Epub 2010 Jan 20.


High-throughput generation of tagged stable cell lines for proteomic analysis.

Torres JZ, Miller JJ, Jackson PK.

Proteomics. 2009 May;9(10):2888-91. doi: 10.1002/pmic.200800873.


The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.

Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK.

Dev Cell. 2007 Jul;13(1):29-42.


The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.

Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, Zakian VA.

Genes Dev. 2006 Nov 15;20(22):3104-16.


The Pif1p subfamily of helicases: region-specific DNA helicases?

Bessler JB, Torres JZ, Zakian VA.

Trends Cell Biol. 2001 Feb;11(2):60-5. Review.


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