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Items: 1 to 50 of 93

1.

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development.

García-León MJ, Fuentes P, de la Pompa JL, Toribio ML.

Development. 2018 Aug 13;145(16). pii: dev165597. doi: 10.1242/dev.165597.

PMID:
30042180
2.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

García-Peydró M, Fuentes P, Mosquera M, García-León MJ, Alcain J, Rodríguez A, García de Miguel P, Menéndez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Muñoz-Calleja C, Sánchez-Madrid F, Toribio ML.

J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21.

3.

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR.

Cancer Cell. 2017 Nov 13;32(5):608-623.e9. doi: 10.1016/j.ccell.2017.10.004.

4.

Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches.

Martín-Gayo E, González-García S, García-León MJ, Murcia-Ceballos A, Alcain J, García-Peydró M, Allende L, de Andrés B, Gaspar ML, Toribio ML.

J Exp Med. 2017 Nov 6;214(11):3361-3379. doi: 10.1084/jem.20161564. Epub 2017 Sep 25.

5.

Thymus-Derived Regulatory T Cell Development Is Regulated by C-Type Lectin-Mediated BIC/MicroRNA 155 Expression.

Sánchez-Díaz R, Blanco-Dominguez R, Lasarte S, Tsilingiri K, Martín-Gayo E, Linillos-Pradillo B, de la Fuente H, Sánchez-Madrid F, Nakagawa R, Toribio ML, Martín P.

Mol Cell Biol. 2017 Apr 14;37(9). pii: e00341-16. doi: 10.1128/MCB.00341-16. Print 2017 May 1.

6.

Modeling altered human T-cell development.

Toribio ML.

Blood. 2016 Aug 11;128(6):743-5. doi: 10.1182/blood-2016-06-723908. No abstract available.

7.

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.

Tremblay CS, Brown FC, Collett M, Saw J, Chiu SK, Sonderegger SE, Lucas SE, Alserihi R, Chau N, Toribio ML, McCormack MP, Chircop M, Robinson PJ, Jane SM, Curtis DJ.

Leukemia. 2016 Oct;30(10):1993-2001. doi: 10.1038/leu.2016.100. Epub 2016 Apr 27.

PMID:
27118408
8.

Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients.

Ogando J, Tardáguila M, Díaz-Alderete A, Usategui A, Miranda-Ramos V, Martínez-Herrera DJ, de la Fuente L, García-León MJ, Moreno MC, Escudero S, Cañete JD, Toribio ML, Cases I, Pascual-Montano A, Pablos JL, Mañes S.

Sci Rep. 2016 Feb 3;6:20223. doi: 10.1038/srep20223.

9.

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.

Ayllón V, Bueno C, Ramos-Mejía V, Navarro-Montero O, Prieto C, Real PJ, Romero T, García-León MJ, Toribio ML, Bigas A, Menendez P.

Leukemia. 2015 Aug;29(8):1741-53. doi: 10.1038/leu.2015.74. Epub 2015 Mar 17.

PMID:
25778099
10.

Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.

Rodríguez-Fraticelli AE, Bagwell J, Bosch-Fortea M, Boncompain G, Reglero-Real N, García-León MJ, Andrés G, Toribio ML, Alonso MA, Millán J, Perez F, Bagnat M, Martín-Belmonte F.

Nat Cell Biol. 2015 Mar;17(3):241-50. doi: 10.1038/ncb3106. Epub 2015 Feb 23.

11.

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies.

Garcillán B, Marin AV, Jiménez-Reinoso A, Briones AC, Muñoz-Ruiz M, García-León MJ, Gil J, Allende LM, Martínez-Naves E, Toribio ML, Regueiro JR.

Front Immunol. 2015 Jan 29;6:20. doi: 10.3389/fimmu.2015.00020. eCollection 2015. Review. No abstract available.

12.

Regulation of the transcriptional program by DNA methylation during human αβ T-cell development.

Rodriguez RM, Suarez-Alvarez B, Mosén-Ansorena D, García-Peydró M, Fuentes P, García-León MJ, Gonzalez-Lahera A, Macias-Camara N, Toribio ML, Aransay AM, Lopez-Larrea C.

Nucleic Acids Res. 2015 Jan;43(2):760-74. doi: 10.1093/nar/gku1340. Epub 2014 Dec 24.

13.

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.

Domínguez-Soto A, de las Casas-Engel M, Bragado R, Medina-Echeverz J, Aragoneses-Fenoll L, Martín-Gayo E, van Rooijen N, Berraondo P, Toribio ML, Moro MA, Cuartero I, Castrillo A, Sancho D, Sánchez-Torres C, Bruhns P, Sánchez-Ramón S, Corbí AL.

J Immunol. 2014 Nov 15;193(10):5181-9. doi: 10.4049/jimmunol.1303375. Epub 2014 Oct 17.

14.

Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression.

Cortés JR, Sánchez-Díaz R, Bovolenta ER, Barreiro O, Lasarte S, Matesanz-Marín A, Toribio ML, Sánchez-Madrid F, Martín P.

J Autoimmun. 2014 Dec;55:51-62. doi: 10.1016/j.jaut.2014.05.007. Epub 2014 Jun 14.

15.

Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells.

Galetto R, Lebuhotel C, Poirot L, Gouble A, Toribio ML, Smith J, Scharenberg A.

Mol Ther Methods Clin Dev. 2014 Jun 11;1:14021. doi: 10.1038/mtm.2014.21. eCollection 2014.

16.

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development.

Rubio R, Gutierrez-Aranda I, Sáez-Castillo AI, Labarga A, Rosu-Myles M, Gonzalez-Garcia S, Toribio ML, Menendez P, Rodriguez R.

Oncogene. 2013 Oct 10;32(41):4970-80. doi: 10.1038/onc.2012.507. Epub 2012 Dec 10.

PMID:
23222711
17.

Notch1 and IL-7 receptor signalling in early T-cell development and leukaemia.

González-García S, García-Peydró M, Alcain J, Toribio ML.

Curr Top Microbiol Immunol. 2012;360:47-73. doi: 10.1007/82_2012_231. Review.

PMID:
22695916
18.

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.

Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.

Nat Genet. 2011 Sep 4;43(10):932-9. doi: 10.1038/ng.924.

PMID:
21892159
19.

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.

Esteve P, Sandonìs A, Cardozo M, Malapeira J, Ibañez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P.

Nat Neurosci. 2011 May;14(5):562-9. doi: 10.1038/nn.2794. Epub 2011 Apr 10.

PMID:
21478884
20.

The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression.

Puig-Kröger A, Aguilera-Montilla N, Martínez-Nuñez R, Domínguez-Soto A, Sánchez-Cabo F, Martín-Gayo E, Zaballos A, Toribio ML, Groner Y, Ito Y, Dopazo A, Corcuera MT, Alonso Martín MJ, Vega MA, Corbí AL.

Immunobiology. 2010 Sep-Oct;215(9-10):812-20. doi: 10.1016/j.imbio.2010.05.018. Epub 2010 Jun 20.

PMID:
20615577
21.

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development.

Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML.

Blood. 2010 Jul 1;115(26):5366-75. doi: 10.1182/blood-2009-10-248260. Epub 2010 Mar 31.

22.

PHF6 mutations in T-cell acute lymphoblastic leukemia.

Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A.

Nat Genet. 2010 Apr;42(4):338-42. doi: 10.1038/ng.542. Epub 2010 Mar 14.

23.

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.

González-García S, García-Peydró M, Martín-Gayo E, Ballestar E, Esteller M, Bornstein R, de la Pompa JL, Ferrando AA, Toribio ML.

J Exp Med. 2009 Apr 13;206(4):779-91. doi: 10.1084/jem.20081922. Epub 2009 Apr 6. Erratum in: J Exp Med. 2009 Jul 6;206(7):1633.

24.

Identification of CMS as a cytosolic adaptor of the human pTalpha chain involved in pre-TCR function.

Navarro MN, Nusspaumer G, Fuentes P, González-García S, Alcain J, Toribio ML.

Blood. 2007 Dec 15;110(13):4331-40. Epub 2007 Sep 6.

25.

The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.

Dominguez-Soto A, Aragoneses-Fenoll L, Martin-Gayo E, Martinez-Prats L, Colmenares M, Naranjo-Gomez M, Borras FE, Munoz P, Zubiaur M, Toribio ML, Delgado R, Corbi AL.

Blood. 2007 Jun 15;109(12):5337-45. Epub 2007 Mar 5.

26.

Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates.

García-Peydró M, de Yébenes VG, Toribio ML.

J Immunol. 2006 Sep 15;177(6):3711-20.

27.

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

Soulier J, Clappier E, Cayuela JM, Regnault A, García-Peydró M, Dombret H, Baruchel A, Toribio ML, Sigaux F.

Blood. 2005 Jul 1;106(1):274-86. Epub 2005 Mar 17.

28.

Rapid and sensitive method for determining free amino acids in honey by gas chromatography with flame ionization or mass spectrometric detection.

Nozal MJ, Bernal JL, Toribio ML, Diego JC, Ruiz A.

J Chromatogr A. 2004 Aug 20;1047(1):137-46.

PMID:
15481469
29.

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.

Zapata DA, Schamel WW, Torres PS, Alarcón B, Rossi NE, Navarro MN, Toribio ML, Regueiro JR.

J Biol Chem. 2004 Jun 4;279(23):24485-92. Epub 2004 Apr 1.

30.
31.

T lymphoid differentiation in human bone marrow.

Klein F, Feldhahn N, Lee S, Wang H, Ciuffi F, von Elstermann M, Toribio ML, Sauer H, Wartenberg M, Barath VS, Krönke M, Wernet P, Rowley JD, Müschen M.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6747-52. Epub 2003 May 8.

32.
33.

Regulation of surface expression of the human pre-T cell receptor complex.

Carrasco YR, Navarro MN, de Yébenes VG, Ramiro AR, Toribio ML.

Semin Immunol. 2002 Oct;14(5):325-34. Review.

PMID:
12220933
35.

p73 is expressed in human thymic epithelial cells.

Ichimiya S, Kojima T, Momota H, Kondo N, Ozaki T, Nakagawara A, Toribio ML, Imamura M, Sato N.

J Histochem Cytochem. 2002 Apr;50(4):455-62.

PMID:
11897798
36.

Some hints concerning the shape of T-cell receptor structures.

Rubin B, Alibaud L, Huchenq-Champagne A, Arnaud J, Toribio ML, Constans J.

Scand J Immunol. 2002 Feb;55(2):111-8. Review.

37.

Differential developmental regulation and functional effects on pre-TCR surface expression of human pTalpha(a) and pTalpha(b) spliced isoforms.

Ramiro AR, Navarro MN, Carreira A, Carrasco YR, de Yébenes VG, Carrillo G, San Millán JL, Rubin B, Toribio ML.

J Immunol. 2001 Nov 1;167(9):5106-14.

38.
39.

Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.

Zapata DA, Pacheco-Castro A, Torres PS, Ramiro AR, San José E, Alarcón B, Alibaud L, Rubin B, Toribio ML, Regueiro JR.

J Biol Chem. 1999 Dec 3;274(49):35119-28.

40.
41.

Measles virus infection induces terminal differentiation of human thymic epithelial cells.

Valentin H, Azocar O, Horvat B, Williems R, Garrone R, Evlashev A, Toribio ML, Rabourdin-Combe C.

J Virol. 1999 Mar;73(3):2212-21.

42.

Identification of a late stage of small noncycling pTalpha- pre-T cells as immediate precursors of T cell receptor alpha/beta+ thymocytes.

Trigueros C, Ramiro AR, Carrasco YR, de Yebenes VG, Albar JP, Toribio ML.

J Exp Med. 1998 Oct 19;188(8):1401-12.

43.

Enhanced green fluorescent protein as an efficient reporter gene for retroviral transduction of human multipotent lymphoid precursors.

Ramiro AR, De Yébenes VG, Trigueros C, Carrasco YR, Toribio ML.

Hum Gene Ther. 1998 May 1;9(7):1103-9.

PMID:
9607421
44.

Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.

Márquez C, Trigueros C, Franco JM, Ramiro AR, Carrasco YR, López-Botet M, Toribio ML.

Blood. 1998 Apr 15;91(8):2760-71.

45.

TCR-gamma gene rearrangement with interstitial deletion within the TRGV2 gene segment is not detected in normal T-lymphocytes.

Castellanos A, Martin-Seisdedos C, Toribio ML, San Miguel JF, González Sarmiento R.

Leukemia. 1998 Feb;12(2):251-3. No abstract available.

PMID:
9519793
46.

CD10 is expressed on human thymic epithelial cell lines and modulates thymopentin-induced cell proliferation.

Guérin S, Mari B, Fernandez E, Belhacene N, Toribio ML, Auberger P.

FASEB J. 1997 Oct;11(12):1003-11.

PMID:
9337153
47.

Herpesvirus saimiri immortalization of alpha beta and gamma delta human T-lineage cells derived from CD34+ intrathymic precursors in vitro.

Pacheco-Castro A, Márquez C, Toribio ML, Ramiro AR, Trigueros C, Regueiro JR.

Int Immunol. 1996 Nov;8(11):1797-805.

PMID:
8943575
48.

Expression of functionally active alpha 4 beta 1 integrin by thymic epithelial cells.

Nieto M, Gómez M, Sánchez-Mateos P, Fernández E, Marazuela M, Sacedón R, Varas A, González-Amaro R, Zapata AG, Toribio ML, Sánchez-Madrid F.

Clin Exp Immunol. 1996 Oct;106(1):170-8.

49.

Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.

Ramiro AR, Trigueros C, Márquez C, San Millán JL, Toribio ML.

J Exp Med. 1996 Aug 1;184(2):519-30.

50.

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