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Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Aug 15. pii: blood.2019000040. doi: 10.1182/blood.2019000040. [Epub ahead of print]


CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells.

Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE.

Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14.


mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.

Shi G, Ozog S, Torbett BE, Compton AA.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10069-E10078. doi: 10.1073/pnas.1811892115. Epub 2018 Oct 9.


Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy.

Jin J, Britschgi A, Schläfli AM, Humbert M, Shan-Krauer D, Batliner J, Federzoni EA, Ernst M, Torbett BE, Yousefi S, Simon HU, Tschan MP.

Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.


Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.

Iwasaki M, Minder P, Caì Y, Kuhn JH, Yates JR 3rd, Torbett BE, de la Torre JC.

PLoS Pathog. 2018 Feb 20;14(2):e1006892. doi: 10.1371/journal.ppat.1006892. eCollection 2018 Feb.


Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells.

Heffner GC, Bonner M, Christiansen L, Pierciey FJ, Campbell D, Smurnyy Y, Zhang W, Hamel A, Shaw S, Lewis G, Goss KA, Garijo O, Torbett BE, Horton H, Finer MH, Gregory PD, Veres G.

Mol Ther. 2018 Jan 3;26(1):320-328. doi: 10.1016/j.ymthe.2017.09.025. Epub 2017 Oct 5.


Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.

Flynn WF, Haldane A, Torbett BE, Levy RM.

Mol Biol Evol. 2017 Jun 1;34(6):1291-1306. doi: 10.1093/molbev/msx095.


PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

Haimovici A, Humbert M, Federzoni EA, Shan-Krauer D, Brunner T, Frese S, Kaufmann T, Torbett BE, Tschan MP.

Cell Death Differ. 2017 May;24(5):866-877. doi: 10.1038/cdd.2017.40. Epub 2017 Mar 31.


Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo.

Baird A, Deng C, Eliceiri MH, Haghi F, Dang X, Coimbra R, Costantini TW, Torbett BE, Eliceiri BP.

Wound Repair Regen. 2016 Nov;24(6):1004-1014. doi: 10.1111/wrr.12471. Epub 2016 Oct 4.


Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.

Weber MR, Zuka M, Lorger M, Tschan M, Torbett BE, Zijlstra A, Quigley JP, Staflin K, Eliceiri BP, Krueger JS, Marchese P, Ruggeri ZM, Felding BH.

Thromb Res. 2016 Apr;140 Suppl 1:S27-36. doi: 10.1016/S0049-3848(16)30095-0.


The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.

Wampfler J, Federzoni EA, Torbett BE, Fey MF, Tschan MP.

Leuk Res. 2016 Feb;41:96-102. doi: 10.1016/j.leukres.2015.12.006. Epub 2015 Dec 19.


CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus.

Kang H, Minder P, Park MA, Mesquitta WT, Torbett BE, Slukvin II.

Mol Ther Nucleic Acids. 2015 Dec 15;4:e268. doi: 10.1038/mtna.2015.42.


CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data.

Routh A, Chang MW, Okulicz JF, Johnson JE, Torbett BE.

Methods. 2015 Dec;91:40-47. doi: 10.1016/j.ymeth.2015.09.021. Epub 2015 Sep 25.


Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly.

Khamaikawin W, Saoin S, Nangola S, Chupradit K, Sakkhachornphop S, Hadpech S, Onlamoon N, Ansari AA, Byrareddy SN, Boulanger P, Hong SS, Torbett BE, Tayapiwatana C.

Mol Ther Nucleic Acids. 2015 Aug 25;4:e249. doi: 10.1038/mtna.2015.22.


ASGCT and JSGT Joint Position Statement on Human Genomic Editing.

Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M.

Mol Ther. 2015 Aug;23(8):1282. doi: 10.1038/mt.2015.118. No abstract available.


Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.

Tschan MP, Federzoni EA, Haimovici A, Britschgi C, Moser BA, Jin J, Reddy VA, Sheeter DA, Fischer KM, Sun P, Torbett BE.

Biochim Biophys Acta. 2015 Sep;1849(9):1198-208. doi: 10.1016/j.bbagrm.2015.07.009. Epub 2015 Jul 15.



Torbett BE, Goodsell DS, Richman DD.

Curr Top Microbiol Immunol. 2015;389:v-vii. No abstract available.


Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.

Wang CX, Torbett BE.

Curr Opin Hematol. 2015 Jul;22(4):302-8. doi: 10.1097/MOH.0000000000000150. Review.


Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells.

Wampfler J, Federzoni EA, Torbett BE, Fey MF, Tschan MP.

J Leukoc Biol. 2015 Sep;98(3):357-63. doi: 10.1189/jlb.1AB0514-258R. Epub 2015 May 19.


Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.

Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP.

Leuk Res Rep. 2015 Apr 23;4(1):32-5. doi: 10.1016/j.lrr.2015.04.002. eCollection 2015.


Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease.

Flynn WF, Chang MW, Tan Z, Oliveira G, Yuan J, Okulicz JF, Torbett BE, Levy RM.

PLoS Comput Biol. 2015 Apr 20;11(4):e1004249. doi: 10.1371/journal.pcbi.1004249. eCollection 2015 Apr.


Understanding the rules of the road: proteomic approaches to interrogate the blood brain barrier.

Torbett BE, Baird A, Eliceiri BP.

Front Neurosci. 2015 Mar 4;9:70. doi: 10.3389/fnins.2015.00070. eCollection 2015. Review.


Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

Mori M, Kovalenko L, Lyonnais S, Antaki D, Torbett BE, Botta M, Mirambeau G, Mély Y.

Curr Top Microbiol Immunol. 2015;389:53-92. doi: 10.1007/82_2015_433. Review.


The Response to Burn Injury in Mice With Human Hematolymphoid Systems.

Costantini TW, Meads M, Dang X, Coimbra R, Torbett BE, Baird A, Eliceiri BP.

Ann Surg. 2016 Jan;263(1):199-204. doi: 10.1097/SLA.0000000000001123.


Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells.

Barclay SL, Yang Y, Zhang S, Fong R, Barraza A, Nolta JA, Torbett BE, Abedi M, Bauer G, Anderson JS.

Stem Cells. 2015 Mar;33(3):870-9. doi: 10.1002/stem.1919.


Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.

Haimovici A, Brigger D, Torbett BE, Fey MF, Tschan MP.

Leuk Res. 2014 Sep;38(9):1041-7. doi: 10.1016/j.leukres.2014.06.010. Epub 2014 Jul 1.


Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.

Garg D, Torbett BE.

Virus Res. 2014 Nov 26;193:135-43. doi: 10.1016/j.virusres.2014.07.004. Epub 2014 Jul 12. Review.


Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE.

Blood. 2014 Aug 7;124(6):913-23. doi: 10.1182/blood-2013-12-546218. Epub 2014 Jun 9.


CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation.

Federzoni EA, Humbert M, Torbett BE, Behre G, Fey MF, Tschan MP.

Sci Rep. 2014 Mar 3;4:4261. doi: 10.1038/srep04261.


Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor.

Amirache F, Lévy C, Costa C, Mangeot PE, Torbett BE, Wang CX, Nègre D, Cosset FL, Verhoeyen E.

Blood. 2014 Feb 27;123(9):1422-4. doi: 10.1182/blood-2013-11-540641. No abstract available. Erratum in: Blood. 2014 Jun 5;123(23):3682.


A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction.

Breuer S, Espinola S, Morelli X, Torbett BE, Arold ST, Engels IH.

Curr Chem Genom Transl Med. 2013 Jul 26;7:16-20. doi: 10.2174/2213988501307010016. eCollection 2013.


The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

Humbert M, Federzoni EA, Britschgi A, Schläfli AM, Valk PJ, Kaufmann T, Haferlach T, Behre G, Simon HU, Torbett BE, Fey MF, Tschan MP.

J Leukoc Biol. 2014 Jan;95(1):83-93. doi: 10.1189/jlb.1112608. Epub 2013 Sep 13.


Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation.

Brigger D, Torbett BE, Chen J, Fey MF, Tschan MP.

Biochem Biophys Res Commun. 2013 Aug 23;438(2):283-8. doi: 10.1016/j.bbrc.2013.07.056. Epub 2013 Jul 24.


Small molecule regulation of protein conformation by binding in the Flap of HIV protease.

Tiefenbrunn T, Forli S, Baksh MM, Chang MW, Happer M, Lin YC, Perryman AL, Rhee JK, Torbett BE, Olson AJ, Elder JH, Finn MG, Stout CD.

ACS Chem Biol. 2013;8(6):1223-31. doi: 10.1021/cb300611p. Epub 2013 Mar 29.


Rapid deep sequencing of patient-derived HIV with ion semiconductor technology.

Chang MW, Oliveira G, Yuan J, Okulicz JF, Levy S, Torbett BE.

J Virol Methods. 2013 Apr;189(1):232-4. doi: 10.1016/j.jviromet.2013.01.019. Epub 2013 Feb 4.


The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients.

Federzoni EA, Humbert M, Valk PJ, Behre G, Leibundgut EO, Torbett BE, Fey MF, Tschan MP.

Br J Haematol. 2013 Mar;160(6):855-9. doi: 10.1111/bjh.12170. Epub 2012 Dec 17. No abstract available.


BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation.

Schläfli AM, Torbett BE, Fey MF, Tschan MP.

Exp Hematol Oncol. 2012 Sep 4;1(1):25. doi: 10.1186/2162-3619-1-25.


Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores.

Joshi P, Sloan B, Torbett BE, Stoddart CA.

Virology. 2013 Feb 5;436(1):162-72. doi: 10.1016/j.virol.2012.11.005. Epub 2012 Nov 30.


Identification of HIV-1 inhibitors targeting the nucleocapsid protein.

Breuer S, Chang MW, Yuan J, Torbett BE.

J Med Chem. 2012 Jun 14;55(11):4968-77. doi: 10.1021/jm201442t. Epub 2012 May 24.


PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.

Federzoni EA, Valk PJ, Torbett BE, Haferlach T, Löwenberg B, Fey MF, Tschan MP.

Blood. 2012 May 24;119(21):4963-70. doi: 10.1182/blood-2011-09-378117. Epub 2012 Apr 12.


The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24.


Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment.

Yuan J, Wang J, Crain K, Fearns C, Kim KA, Hua KL, Gregory PD, Holmes MC, Torbett BE.

Mol Ther. 2012 Apr;20(4):849-59. doi: 10.1038/mt.2011.310. Epub 2012 Jan 24.


Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells.

Batliner J, Buehrer E, Federzoni EA, Jenal M, Tobler A, Torbett BE, Fey MF, Tschan MP.

Br J Haematol. 2012 Apr;157(2):270-4. doi: 10.1111/j.1365-2141.2011.08964.x. Epub 2011 Dec 7. No abstract available.


A specific protein disorder catalyzer of HIV-1 Nef.

Lugari A, Breuer S, Coursindel T, Opi S, Restouin A, Shi X, Nazabal A, Torbett BE, Martinez J, Collette Y, Parrot I, Arold ST, Morelli X.

Bioorg Med Chem. 2011 Dec 15;19(24):7401-6. doi: 10.1016/j.bmc.2011.10.051. Epub 2011 Oct 20.


The proteome of mouse brain microvessel membranes and basal lamina.

Chun HB, Scott M, Niessen S, Hoover H, Baird A, Yates J 3rd, Torbett BE, Eliceiri BP.

J Cereb Blood Flow Metab. 2011 Dec;31(12):2267-81. doi: 10.1038/jcbfm.2011.104. Epub 2011 Jul 27.


Accessory mutations maintain stability in drug-resistant HIV-1 protease.

Chang MW, Torbett BE.

J Mol Biol. 2011 Jul 22;410(4):756-60. doi: 10.1016/j.jmb.2011.03.038.


Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.

Lin YC, Perryman AL, Olson AJ, Torbett BE, Elder JH, Stout CD.

Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):540-8. doi: 10.1107/S0907444911011681. Epub 2011 May 12.


A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease.

Breuer S, Sepulveda H, Chen Y, Trotter J, Torbett BE.

Biochemistry. 2011 May 24;50(20):4371-81. doi: 10.1021/bi200031m. Epub 2011 Apr 27.


CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.

Batliner J, Mancarelli MM, Jenal M, Reddy VA, Fey MF, Torbett BE, Tschan MP.

Mol Immunol. 2011 Jan;48(4):714-9. doi: 10.1016/j.molimm.2010.10.016. Epub 2010 Nov 20.


Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina.

Chang MW, Ayeni C, Breuer S, Torbett BE.

PLoS One. 2010 Aug 4;5(8):e11955. doi: 10.1371/journal.pone.0011955.

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