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Trends in clinical trial investigator workforce and turnover: An analysis of the U.S. FDA 1572 BMIS database.

Fordyce CB, Roe MT, Pierre C, Hinkley T, Hamre G, Tenaerts P, McCall J, Topping JD.

Contemp Clin Trials Commun. 2019 May 21;15:100380. doi: 10.1016/j.conctc.2019.100380. eCollection 2019 Sep.


Elevated CO2 effects on nitrogen assimilation and growth of C3 vascular plants are similar regardless of N-form assimilated.

Andrews M, Condron LM, Kemp PD, Topping JF, Lindsey K, Hodge S, Raven JA.

J Exp Bot. 2019 Jan 7;70(2):683-690. doi: 10.1093/jxb/ery371.


Evaluating Foundational Data Quality in the National Patient-Centered Clinical Research Network (PCORnet®).

Qualls LG, Phillips TA, Hammill BG, Topping J, Louzao DM, Brown JS, Curtis LH, Marsolo K.

EGEMS (Wash DC). 2018 Apr 13;6(1):3. doi: 10.5334/egems.199.


Federal, provincial and territorial public health response plan for biological events.

McNeill R, Topping J; FPT Response Plan Task Group.

Can Commun Dis Rep. 2018 Jan 4;44(1):1-5. eCollection 2018 Jan 4.


Epidermal expression of a sterol biosynthesis gene regulates root growth by a non-cell-autonomous mechanism in Arabidopsis.

Short E, Leighton M, Imriz G, Liu D, Cope-Selby N, Hetherington F, Smertenko A, Hussey PJ, Topping JF, Lindsey K.

Development. 2018 May 15;145(10). pii: dev160572. doi: 10.1242/dev.160572.


Bayesian uncertainty analysis for complex systems biology models: emulation, global parameter searches and evaluation of gene functions.

Vernon I, Liu J, Goldstein M, Rowe J, Topping J, Lindsey K.

BMC Syst Biol. 2018 Jan 2;12(1):1. doi: 10.1186/s12918-017-0484-3.


Defects in the Cell Signaling Mediator β-Catenin Cause the Retinal Vascular Condition FEVR.

Panagiotou ES, Sanjurjo Soriano C, Poulter JA, Lord EC, Dzulova D, Kondo H, Hiyoshi A, Chung BH, Chu YW, Lai CHY, Tafoya ME, Karjosukarso D, Collin RWJ, Topping J, Downey LM, Ali M, Inglehearn CF, Toomes C.

Am J Hum Genet. 2017 Jun 1;100(6):960-968. doi: 10.1016/j.ajhg.2017.05.001.


Screening methods for obstructive sleep apnoea in severely obese pregnant women.

Longworth H, McCallin K, Narayanan RP, Turner MA, Quenby S, Rycroft D, Charnley M, Abayomi J, Topping J, Weeks AD, Wilding JPH.

Clin Obes. 2017 Aug;7(4):239-244. doi: 10.1111/cob.12196. Epub 2017 May 29.


A Risk Score for Predicting Multiple Sclerosis.

Dobson R, Ramagopalan S, Topping J, Smith P, Solanky B, Schmierer K, Chard D, Giovannoni G.

PLoS One. 2016 Nov 1;11(11):e0164992. doi: 10.1371/journal.pone.0164992. eCollection 2016.


Resolution of a disputed albendazole result in the UK Official Control System - time for more guidance?

Walker M, Gray K, Hopley C, Mussell C, Clifford L, Meinerikandathevan J, Firpo L, Topping J, Santacruz D.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Apr;34(4):489-493. doi: 10.1080/19440049.2016.1243807. Epub 2016 Oct 19.


A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases.

Montfort A, Pearce O, Maniati E, Vincent BG, Bixby L, Böhm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M, Balkwill FR.

Clin Cancer Res. 2017 Jan 1;23(1):250-262. doi: 10.1158/1078-0432.CCR-16-0081. Epub 2016 Jun 27.


Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma.

Böhm S, Montfort A, Pearce OM, Topping J, Chakravarty P, Everitt GL, Clear A, McDermott JR, Ennis D, Dowe T, Fitzpatrick A, Brockbank EC, Lawrence AC, Jeyarajah A, Faruqi AZ, McNeish IA, Singh N, Lockley M, Balkwill FR.

Clin Cancer Res. 2016 Jun 15;22(12):3025-36. doi: 10.1158/1078-0432.CCR-15-2657.


The effects of intrathecal rituximab on biomarkers in multiple sclerosis.

Topping J, Dobson R, Lapin S, Maslyanskiy A, Kropshofer H, Leppert D, Giovannoni G, Evdoshenko E.

Mult Scler Relat Disord. 2016 Mar;6:49-53. doi: 10.1016/j.msard.2016.01.001. Epub 2016 Jan 19.


Abscisic acid regulates root growth under osmotic stress conditions via an interacting hormonal network with cytokinin, ethylene and auxin.

Rowe JH, Topping JF, Liu J, Lindsey K.

New Phytol. 2016 Jul;211(1):225-39. doi: 10.1111/nph.13882. Epub 2016 Feb 18.


Fit for Birth - the effect of weight changes in obese pregnant women on maternal and neonatal outcomes: a pilot prospective cohort study.

Narayanan RP, Weeks AD, Quenby S, Rycroft D, Hart A, Longworth H, Charnley M, Abayomi J, Topping J, Turner MA, Wilding JP.

Clin Obes. 2016 Feb;6(1):79-88. doi: 10.1111/cob.12129. Epub 2016 Jan 6.


Spatiotemporal modelling of hormonal crosstalk explains the level and patterning of hormones and gene expression in Arabidopsis thaliana wild-type and mutant roots.

Moore S, Zhang X, Mudge A, Rowe JH, Topping JF, Liu J, Lindsey K.

New Phytol. 2015 Sep;207(4):1110-22. doi: 10.1111/nph.13421. Epub 2015 Apr 23.


Compliance with results reporting at

Anderson ML, Chiswell K, Peterson ED, Tasneem A, Topping J, Califf RM.

N Engl J Med. 2015 Mar 12;372(11):1031-9. doi: 10.1056/NEJMsa1409364.


Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick JP, Meier UC, Marta M, Dalla Costa G, Runia T, Evdoshenko E, Lazareva N, Thouvenot E, Iaffaldano P, Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killestein J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC, Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, Martínez AD, Carra A, Salvetti M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J, Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D, Derfuss T, Lindberg R, Yaldizli Ö, Vécsei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A, Tumani H, Havrdová E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Teunissen C, Montalban X, Tintoré M, Olsson T, Trojano M, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Kappos L, Furlan R, Martinelli V, Comi G, Ramagopalan SV, Giovannoni G.

Mult Scler. 2015 Jul;21(8):1013-24. doi: 10.1177/1352458514568827. Epub 2015 Feb 13.


Programmed cell death during development of cowpea (Vigna unguiculata (L.) Walp.) seed coat.

Lima NB, Trindade FG, da Cunha M, Oliveira AE, Topping J, Lindsey K, Fernandes KV.

Plant Cell Environ. 2015 Apr;38(4):718-28. doi: 10.1111/pce.12432. Epub 2014 Oct 1.


Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.

Lu CH, Petzold A, Topping J, Allen K, Macdonald-Wallis C, Clarke J, Pearce N, Kuhle J, Giovannoni G, Fratta P, Sidle K, Fish M, Orrell R, Howard R, Greensmith L, Malaspina A.

J Neurol Neurosurg Psychiatry. 2015 May;86(5):565-73. doi: 10.1136/jnnp-2014-307672. Epub 2014 Jul 9.


Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis.

Puentes F, Topping J, Kuhle J, van der Star BJ, Douiri A, Giovannoni G, Baker D, Amor S, Malaspina A.

J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):274-8. doi: 10.1136/jnnp-2013-305494. Epub 2013 Sep 27.


Increased neurofilament light chain blood levels in neurodegenerative neurological diseases.

Gaiottino J, Norgren N, Dobson R, Topping J, Nissim A, Malaspina A, Bestwick JP, Monsch AU, Regeniter A, Lindberg RL, Kappos L, Leppert D, Petzold A, Giovannoni G, Kuhle J.

PLoS One. 2013 Sep 20;8(9):e75091. doi: 10.1371/journal.pone.0075091. eCollection 2013.


Transcriptional analysis through RNA sequencing of giant cells induced by Meloidogyne graminicola in rice roots.

Ji H, Gheysen G, Denil S, Lindsey K, Topping JF, Nahar K, Haegeman A, De Vos WH, Trooskens G, Van Criekinge W, De Meyer T, Kyndt T.

J Exp Bot. 2013 Sep;64(12):3885-98. doi: 10.1093/jxb/ert219. Epub 2013 Jul 23.


Interaction of PLS and PIN and hormonal crosstalk in Arabidopsis root development.

Liu J, Mehdi S, Topping J, Friml J, Lindsey K.

Front Plant Sci. 2013 Apr 5;4:75. doi: 10.3389/fpls.2013.00075. eCollection 2013.


Cerebrospinal fluid and urinary biomarkers in multiple sclerosis.

Dobson R, Topping J, Davis A, Thompson E, Giovannoni G.

Acta Neurol Scand. 2013 Nov;128(5):321-7. doi: 10.1111/ane.12119. Epub 2013 Mar 7.


Distinct and conserved transcriptomic changes during nematode-induced giant cell development in tomato compared with Arabidopsis: a functional role for gene repression.

Portillo M, Cabrera J, Lindsey K, Topping J, Andrés MF, Emiliozzi M, Oliveros JC, García-Casado G, Solano R, Koltai H, Resnick N, Fenoll C, Escobar C.

New Phytol. 2013 Mar;197(4):1276-90. doi: 10.1111/nph.12121.


Comparison of two commercial ELISA systems for evaluating anti-EBNA1 IgG titers.

Dobson R, Topping J, Giovannoni G.

J Med Virol. 2013 Jan;85(1):128-31. doi: 10.1002/jmv.23446.


Assay selection affects John Cunningham virus serostatus classification in multiple sclerosis.

Raffel JB, Hunt D, Topping J, Bremner J, Brown KE, Giovannoni G.

Ann Neurol. 2012 Aug;72(2):295-6; author reply 296-7. doi: 10.1002/ana.23629. No abstract available.


Safety effects of drawstring requirements for children's upper outerwear garments.

Rodgers GB, Topping JC.

Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):651-5. doi: 10.1001/archpediatrics.2011.1269.


Virolysis of feline calicivirus and human GII.4 norovirus following chlorine exposure under standardized light soil disinfection conditions.

Nowak P, Topping JR, Bellamy K, Fotheringham V, Gray JJ, Golding JP, Wiseman G, Knight AI.

J Food Prot. 2011 Dec;74(12):2113-8. doi: 10.4315/0362-028X.JFP-11-087.


Coeliac disease and granulomatous ileocolitis: an association or chance occurrence?

Johns CE, Topping JH, Bloxham C, Dhar A.

J R Coll Physicians Edinb. 2011 Dec;41(4):319-22. doi: 10.4997/JRCPE.2011.407.


The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study.

Bhala N, Angulo P, van der Poorten D, Lee E, Hui JM, Saracco G, Adams LA, Charatcharoenwitthaya P, Topping JH, Bugianesi E, Day CP, George J.

Hepatology. 2011 Oct;54(4):1208-16. doi: 10.1002/hep.24491. Epub 2011 Aug 9.


Components of complex lipid biosynthetic pathways in developing castor (Ricinus communis) seeds identified by MudPIT analysis of enriched endoplasmic reticulum.

Brown AP, Kroon JT, Topping JF, Robson JL, Simon WJ, Slabas AR.

J Proteome Res. 2011 Aug 5;10(8):3565-77. doi: 10.1021/pr2002066. Epub 2011 Jun 29.


Measurement of the virolysis of human GII.4 norovirus in response to disinfectants and sanitisers.

Nowak P, Topping JR, Fotheringham V, Gallimore CI, Gray JJ, Iturriza-Gómara M, Knight AI.

J Virol Methods. 2011 Jun;174(1-2):7-11. doi: 10.1016/j.jviromet.2011.03.004. Epub 2011 Mar 23.


Analysis of vascular development in the hydra sterol biosynthetic mutants of Arabidopsis.

Pullen M, Clark N, Zarinkamar F, Topping J, Lindsey K.

PLoS One. 2010 Aug 17;5(8):e12227. doi: 10.1371/journal.pone.0012227.


Metaproteomic and metagenomic analyses of defined oceanic microbial populations using microwave cell fixation and flow cytometric sorting.

Mary I, Oliver A, Skipp P, Holland R, Topping J, Tarran G, Scanlan DJ, O'Connor CD, Whiteley AS, Burkill PH, Zubkov MV.

FEMS Microbiol Ecol. 2010 Oct;74(1):10-8. doi: 10.1111/j.1574-6941.2010.00927.x. Epub 2010 Jul 5.


Modelling and experimental analysis of hormonal crosstalk in Arabidopsis.

Liu J, Mehdi S, Topping J, Tarkowski P, Lindsey K.

Mol Syst Biol. 2010 Jun 8;6:373. doi: 10.1038/msb.2010.26.


Effects of exercise training amount on physical activity energy expenditure.

Hollowell RP, Willis LH, Slentz CA, Topping JD, Bhakpar M, Kraus WE.

Med Sci Sports Exerc. 2009 Aug;41(8):1640-4. doi: 10.1249/MSS.0b013e31819c71a4.


Identification of 'hot spots' of obesity and being underweight in early pregnancy in Liverpool.

Abayomi JC, Watkinson H, Boothby J, Topping J, Hackett AF.

J Hum Nutr Diet. 2009 Jun;22(3):246-54. doi: 10.1111/j.1365-277X.2009.00956.x.


Staff wellbeing. Fitter, happier.

Topping J.

Health Serv J. 2009 Jan 22;119(6140):26-7. No abstract available.


A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction.

Delpisheh A, Brabin L, Topping J, Reyad M, Tang AW, Brabin BJ.

Eur J Obstet Gynecol Reprod Biol. 2009 Mar;143(1):38-42. doi: 10.1016/j.ejogrb.2008.11.006. Epub 2009 Jan 14.


Temperature inactivation of Feline calicivirus vaccine strain FCV F-9 in comparison with human noroviruses using an RNA exposure assay and reverse transcribed quantitative real-time polymerase chain reaction-A novel method for predicting virus infectivity.

Topping JR, Schnerr H, Haines J, Scott M, Carter MJ, Willcocks MM, Bellamy K, Brown DW, Gray JJ, Gallimore CI, Knight AI.

J Virol Methods. 2009 Mar;156(1-2):89-95. doi: 10.1016/j.jviromet.2008.10.024. Epub 2008 Dec 18.


MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis.

Casson SA, Topping JF, Lindsey K.

Plant J. 2009 Mar;57(5):857-69. doi: 10.1111/j.1365-313X.2008.03738.x. Epub 2008 Nov 4.


Prenatal alcohol exposure, CYP17 gene polymorphisms and fetal growth restriction.

Delpisheh A, Topping J, Reyad M, Tang A, Brabin BJ.

Eur J Obstet Gynecol Reprod Biol. 2008 May;138(1):49-53. Epub 2007 Sep 17.


Views of breastfeeding difficulties among drop-in-clinic attendees.

Berridge K, McFadden K, Abayomi J, Topping J.

Matern Child Nutr. 2005 Oct;1(4):250-62.


Transabdominal cerclage: the significance of dual pathology and increased preterm delivery.

Farquharson RG, Topping J, Quenby SM.

BJOG. 2005 Oct;112(10):1424-6.


Recurrent miscarriage and long-term thrombosis risk: a case-control study.

Quenby S, Farquharson RG, Dawood F, Hughes AM, Topping J.

Hum Reprod. 2005 Jun;20(6):1729-32. Epub 2005 Mar 17.


Prospective observational study of bone mineral density during pregnancy: low molecular weight heparin versus control.

Carlin AJ, Farquharson RG, Quenby SM, Topping J, Fraser WD.

Hum Reprod. 2004 May;19(5):1211-4. Epub 2004 Apr 7.


Importance of plant sterols in pattern formation and hormone signalling.

Lindsey K, Pullen ML, Topping JF.

Trends Plant Sci. 2003 Nov;8(11):521-5.


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