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Items: 1 to 50 of 136

1.

Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.

Force J, Howie LJ, Abbott SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK.

Clin Breast Cancer. 2018 Oct;18(5):410-417. doi: 10.1016/j.clbc.2018.02.010. Epub 2018 Feb 24.

PMID:
29615305
2.

Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 Oct 18;18(11):1271. doi: 10.1038/ni1117-1271c.

PMID:
29044240
3.

Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed a Western Diet.

Wang K, Jin X, You M, Tian W, Le Leu RK, Topping DL, Conlon MA, Wu L, Hu F.

Nutrients. 2017 Aug 14;9(8). pii: E875. doi: 10.3390/nu9080875.

4.

Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951c. No abstract available.

PMID:
28722715
5.

HR+, HER2- Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles.

Sammons SL, Topping DL, Blackwell KL.

Curr Cancer Drug Targets. 2017;17(7):637-649. doi: 10.2174/1568009617666170330120452. Review.

6.

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 May;18(5):552-562. doi: 10.1038/ni.3713. Epub 2017 Mar 27. Erratum in: Nat Immunol. 2017 Oct 18;18(11):1271. Nat Immunol. 2017 Jul 19;18(8):951.

PMID:
28346408
7.

Targeted delivery of short-chain fatty acids to the human large bowel.

Topping DL.

Am J Clin Nutr. 2016 Jul;104(1):1-2. doi: 10.3945/ajcn.116.137711. Epub 2016 Jun 22. No abstract available.

PMID:
27334235
8.

High wholegrain barley β-glucan lowers food intake but does not alter small intestinal macronutrient digestibility in ileorectostomised rats.

Belobrajdic DP, Hino S, Kondo T, Jobling SA, Morell MK, Topping DL, Morita T, Bird AR.

Int J Food Sci Nutr. 2016 Sep;67(6):678-85. doi: 10.1080/09637486.2016.1194811. Epub 2016 Jun 9.

PMID:
27282074
9.

Polyphenol-Rich Propolis Extracts Strengthen Intestinal Barrier Function by Activating AMPK and ERK Signaling.

Wang K, Jin X, Chen Y, Song Z, Jiang X, Hu F, Conlon MA, Topping DL.

Nutrients. 2016 May 7;8(5). pii: E272. doi: 10.3390/nu8050272.

10.

Dietary polysaccharides and polyphenols can promote health by influencing gut microbiota populations.

Conlon MA, Topping DL.

Food Funct. 2016 Apr;7(4):1730. doi: 10.1039/c6fo90009g. No abstract available.

PMID:
27068450
11.

Soluble arabinoxylan alters digesta flow and protein digestion of red meat-containing diets in pigs.

Zhang D, Williams BA, Mikkelsen D, Li X, Keates HL, Lisle AT, Collins HM, Fincher GB, Bird AR, Topping DL, Gidley MJ, Bryden WL.

Nutrition. 2015 Sep;31(9):1141-7. doi: 10.1016/j.nut.2015.03.006. Epub 2015 Apr 7.

PMID:
26233873
12.

Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial.

Le Leu RK, Winter JM, Christophersen CT, Young GP, Humphreys KJ, Hu Y, Gratz SW, Miller RB, Topping DL, Bird AR, Conlon MA.

Br J Nutr. 2015 Jul;114(2):220-30. doi: 10.1017/S0007114515001750. Epub 2015 Jun 17.

13.

Lowering of large bowel butyrate levels in healthy populations is unlikely to be beneficial.

Conlon MA, Bird AR, Clarke JM, Le Leu RK, Christophersen CT, Lockett TJ, Topping DL.

J Nutr. 2015 May;145(5):1030-1. doi: 10.3945/jn.114.209460. No abstract available.

PMID:
25934666
14.

Resistant starch alters colonic contractility and expression of related genes in rats fed a Western diet.

Patten GS, Kerr CA, Dunne RA, Shaw JM, Bird AR, Regina A, Morell MK, Lockett TJ, Molloy PL, Abeywardena MY, Topping DL, Conlon MA.

Dig Dis Sci. 2015 Jun;60(6):1624-32. doi: 10.1007/s10620-015-3537-8. Epub 2015 Jan 24.

PMID:
25616610
15.

Butyrylated starch affects colorectal cancer markers beneficially and dose-dependently in genotoxin-treated rats.

Toden S, Lockett TJ, Topping DL, Scherer BL, Watson EJ, Southwood JG, Clarke JM.

Cancer Biol Ther. 2014;15(11):1515-23. doi: 10.4161/15384047.2014.955764.

16.

Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial.

Humphreys KJ, Conlon MA, Young GP, Topping DL, Hu Y, Winter JM, Bird AR, Cobiac L, Kennedy NA, Michael MZ, Le Leu RK.

Cancer Prev Res (Phila). 2014 Aug;7(8):786-95. doi: 10.1158/1940-6207.CAPR-14-0053.

17.

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H.

Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13. Erratum in: Nature. 2014 Feb 13;506(7487):254.

PMID:
24226770
18.

Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals.

West NP, Christophersen CT, Pyne DB, Cripps AW, Conlon MA, Topping DL, Kang S, McSweeney CS, Fricker PA, Aguirre D, Clarke JM.

Exerc Immunol Rev. 2013;19:102-19.

19.

Colorectal carcinogenesis: a cellular response to sustained risk environment.

Fung KY, Ooi CC, Zucker MH, Lockett T, Williams DB, Cosgrove LJ, Topping DL.

Int J Mol Sci. 2013 Jun 27;14(7):13525-41. doi: 10.3390/ijms140713525. Review.

20.

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate.

Fung KY, Cosgrove L, Lockett T, Head R, Topping DL.

Br J Nutr. 2012 Sep;108(5):820-31. doi: 10.1017/S0007114512001948. Epub 2012 Jun 7. Review.

PMID:
22676885
21.

Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet.

Conlon MA, Kerr CA, McSweeney CS, Dunne RA, Shaw JM, Kang S, Bird AR, Morell MK, Lockett TJ, Molloy PL, Regina A, Toden S, Clarke JM, Topping DL.

J Nutr. 2012 May;142(5):832-40. doi: 10.3945/jn.111.147660. Epub 2012 Mar 28.

22.

An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs.

Belobrajdic DP, Bird AR, Conlon MA, Williams BA, Kang S, McSweeney CS, Zhang D, Bryden WL, Gidley MJ, Topping DL.

Br J Nutr. 2012 May;107(9):1274-82. doi: 10.1017/S0007114511004338. Epub 2011 Nov 24.

PMID:
22115395
23.

Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats.

Clarke JM, Young GP, Topping DL, Bird AR, Cobiac L, Scherer BL, Winkler JG, Lockett TJ.

Carcinogenesis. 2012 Jan;33(1):197-202. doi: 10.1093/carcin/bgr254. Epub 2011 Nov 10.

24.

Colonocyte telomere shortening is greater with dietary red meat than white meat and is attenuated by resistant starch.

O'Callaghan NJ, Toden S, Bird AR, Topping DL, Fenech M, Conlon MA.

Clin Nutr. 2012 Feb;31(1):60-4. doi: 10.1016/j.clnu.2011.09.003. Epub 2011 Oct 1.

PMID:
21963168
25.

Butyrate esterified to starch is released in the human gastrointestinal tract.

Clarke JM, Topping DL, Christophersen CT, Bird AR, Lange K, Saunders I, Cobiac L.

Am J Clin Nutr. 2011 Nov;94(5):1276-83. doi: 10.3945/ajcn.111.017228. Epub 2011 Sep 21.

PMID:
21940597
26.

Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.

Winter J, Nyskohus L, Young GP, Hu Y, Conlon MA, Bird AR, Topping DL, Le Leu RK.

Cancer Prev Res (Phila). 2011 Nov;4(11):1920-8. doi: 10.1158/1940-6207.CAPR-11-0176. Epub 2011 Sep 1.

27.

Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics.

Bird AR, Conlon MA, Christophersen CT, Topping DL.

Benef Microbes. 2010 Nov;1(4):423-31. doi: 10.3920/BM2010.0041. Review.

PMID:
21831780
28.

Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum.

Ito H, Takemura N, Sonoyama K, Kawagishi H, Topping DL, Conlon MA, Morita T.

J Agric Food Chem. 2011 May 25;59(10):5771-8. doi: 10.1021/jf200859z. Epub 2011 Apr 29.

PMID:
21506616
29.

Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch.

McOrist AL, Miller RB, Bird AR, Keogh JB, Noakes M, Topping DL, Conlon MA.

J Nutr. 2011 May;141(5):883-9. doi: 10.3945/jn.110.128504. Epub 2011 Mar 23.

PMID:
21430242
30.

Bifidobacteria can protect from enteropathogenic infection through production of acetate.

Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H.

Nature. 2011 Jan 27;469(7331):543-7. doi: 10.1038/nature09646.

PMID:
21270894
31.

Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats.

Bajka BH, Clarke JM, Topping DL, Cobiac L, Abeywardena MY, Patten GS.

Nutr Res. 2010 Jun;30(6):427-34. doi: 10.1016/j.nutres.2010.06.003.

PMID:
20650351
32.

Over-expression of specific HvCslF cellulose synthase-like genes in transgenic barley increases the levels of cell wall (1,3;1,4)-β-d-glucans and alters their fine structure.

Burton RA, Collins HM, Kibble NA, Smith JA, Shirley NJ, Jobling SA, Henderson M, Singh RR, Pettolino F, Wilson SM, Bird AR, Topping DL, Bacic A, Fincher GB.

Plant Biotechnol J. 2011 Feb;9(2):117-35. doi: 10.1111/j.1467-7652.2010.00532.x.

33.

Effects of dietary beef and chicken with and without high amylose maize starch on blood malondialdehyde, interleukins, IGF-I, insulin, leptin, MMP-2, and TIMP-2 concentrations in rats.

Toden S, Belobrajdic DP, Bird AR, Topping DL, Conlon MA.

Nutr Cancer. 2010;62(4):454-65. doi: 10.1080/01635580903532382.

PMID:
20432166
34.

Changes in starch physical characteristics following digestion of foods in the human small intestine.

Zhou Z, Topping DL, Morell MK, Bird AR.

Br J Nutr. 2010 Aug;104(4):573-81. doi: 10.1017/S0007114510000875. Epub 2010 Apr 23.

PMID:
20412607
35.

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome.

Topping DL, Bird AR, Young GP.

N Engl J Med. 2009 Apr 2;360(14):1462; author reply 1462-3. No abstract available.

PMID:
19348022
36.

Comparative effects of a high-amylose starch and a fructooligosaccharide on fecal bifidobacteria numbers and short-chain fatty acids in pigs fed Bifidobacterium animalis.

Bird AR, Vuaran M, Crittenden R, Hayakawa T, Playne MJ, Brown IL, Topping DL.

Dig Dis Sci. 2009 May;54(5):947-54. doi: 10.1007/s10620-008-0451-3. Epub 2008 Dec 17.

PMID:
19089616
37.

Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats.

Clarke JM, Topping DL, Bird AR, Young GP, Cobiac L.

Carcinogenesis. 2008 Nov;29(11):2190-4. doi: 10.1093/carcin/bgn192. Epub 2008 Aug 13.

38.

Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats.

Bajka BH, Clarke JM, Cobiac L, Topping DL.

Carcinogenesis. 2008 Nov;29(11):2169-74. doi: 10.1093/carcin/bgn173. Epub 2008 Aug 5.

PMID:
18684730
39.

Processing of novel elevated amylose wheats: functional properties and starch digestibility of extruded products.

Chanvrier H, Appelqvist IA, Bird AR, Gilbert E, Htoon A, Li Z, Lillford PJ, Lopez-Rubio A, Morell MK, Topping DL.

J Agric Food Chem. 2007 Dec 12;55(25):10248-57. Epub 2007 Nov 15.

PMID:
18001033
40.

Excretion of starch and esterified short-chain fatty acids by ileostomy subjects after the ingestion of acylated starches.

Clarke JM, Bird AR, Topping DL, Cobiac L.

Am J Clin Nutr. 2007 Oct;86(4):1146-51.

PMID:
17921395
41.

Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects.

Bird AR, Vuaran MS, King RA, Noakes M, Keogh J, Morell MK, Topping DL.

Br J Nutr. 2008 May;99(5):1032-40. Epub 2007 Oct 8.

PMID:
17919346
42.

High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch.

Toden S, Bird AR, Topping DL, Conlon MA.

Carcinogenesis. 2007 Nov;28(11):2355-62. Epub 2007 Oct 4.

PMID:
17916911
43.

Potato pulps lowered the serum cholesterol and triglyceride levels in rats.

Hashimoto N, Ito Y, Han KH, Shimada K, Sekikawa M, Topping DL, Bird AR, Noda T, Chiji H, Fukushima M.

J Nutr Sci Vitaminol (Tokyo). 2006 Dec;52(6):445-50.

44.
45.
47.
48.

Hepatoprotective effects of purple potato extract against D-galactosamine-induced liver injury in rats.

Han KH, Hashimoto N, Shimada K, Sekikawa M, Noda T, Yamauchi H, Hashimoto M, Chiji H, Topping DL, Fukushima M.

Biosci Biotechnol Biochem. 2006 Jun;70(6):1432-7.

49.

Interactive effects of dietary resistant starch and fish oil on short-chain fatty acid production and agonist-induced contractility in ileum of young rats.

Patten GS, Conlon MA, Bird AR, Adams MJ, Topping DL, Abeywardena MY.

Dig Dis Sci. 2006 Feb;51(2):254-61.

PMID:
16534666
50.

Resistant starch prevents colonic DNA damage induced by high dietary cooked red meat or casein in rats.

Toden S, Bird AR, Topping DL, Conlon MA.

Cancer Biol Ther. 2006 Mar;5(3):267-72. Epub 2006 Mar 5.

PMID:
16410726

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