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Items: 1 to 50 of 459

1.

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications.

Piskunen P, Shen B, Julin S, Ijäs H, Toppari JJ, Kostiainen MA, Linko V.

J Vis Exp. 2019 Sep 27;(151). doi: 10.3791/60313.

PMID:
31609310
2.

Longitudinal Pattern of First-Phase Insulin Response Is Associated with Genetic Variants Outside the Class II HLA Region in Children with Multiple Autoantibodies.

Koskinen MK, Mikk ML, Laine AP, Lempainen J, Löyttyniemi E, Vähäsalo P, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Veijola R, Ilonen J, Toppari J.

Diabetes. 2019 Oct 7. pii: db190329. doi: 10.2337/db19-0329. [Epub ahead of print]

PMID:
31591105
3.

Tracking Polariton Relaxation with Multiscale Molecular Dynamics Simulations.

Groenhof G, Climent C, Feist J, Morozov D, Toppari JJ.

J Phys Chem Lett. 2019 Sep 19;10(18):5476-5483. doi: 10.1021/acs.jpclett.9b02192. Epub 2019 Sep 4.

PMID:
31453696
4.

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Diabetologia. 2019 Aug 23. doi: 10.1007/s00125-019-04980-0. [Epub ahead of print]

PMID:
31444528
5.

The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis.

Eggert A, Cisneros-Montalvo S, Anandan S, Musilli S, Stukenborg JB, Adamsson A, Nurmio M, Toppari J.

Reprod Toxicol. 2019 Aug 11;90:68-76. doi: 10.1016/j.reprotox.2019.08.005. [Epub ahead of print]

6.

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk.

Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D; TEDDY Study Group.

JAMA. 2019 Aug 13;322(6):514-523. doi: 10.1001/jama.2019.10329.

PMID:
31408136
7.

Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes.

Hakola L, Miettinen ME, Syrjälä E, Åkerlund M, Takkinen HM, Korhonen TE, Ahonen S, Ilonen J, Toppari J, Veijola R, Nevalainen J, Knip M, Virtanen SM.

JAMA Pediatr. 2019 Aug 12. doi: 10.1001/jamapediatrics.2019.2564. [Epub ahead of print]

PMID:
31403683
8.

Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism.

Kuiri-Hänninen T, Koskenniemi J, Dunkel L, Toppari J, Sankilampi U.

Front Endocrinol (Lausanne). 2019 Jul 23;10:489. doi: 10.3389/fendo.2019.00489. eCollection 2019. Review.

9.

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.

Uusitalo U, Andren Aronsson C, Liu X, Kurppa K, Yang J, Liu E, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D; TEDDY Study Group.

Nutrients. 2019 Aug 2;11(8). pii: E1790. doi: 10.3390/nu11081790.

10.

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Ilonen J, Siljander H, Knip M.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5585-5594. doi: 10.1210/jc.2019-01069.

PMID:
31314077
11.

Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis.

Rotgers E, Cisneros-Montalvo S, Nurmio M, Toppari J.

J Cell Sci. 2019 Jul 15;132(14). pii: jcs229849. doi: 10.1242/jcs.229849.

12.

Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T.

Diabetologia. 2019 Sep;62(9):1681-1688. doi: 10.1007/s00125-019-4936-8. Epub 2019 Jul 3.

13.

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity.

Syrjälä E, Nevalainen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Sci Rep. 2019 May 23;9(1):7760. doi: 10.1038/s41598-019-44196-1.

14.

Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood.

Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A, Ilonen J.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4521-4530. doi: 10.1210/jc.2019-00421.

PMID:
31120497
15.

EAA clinical practice guidelines-gynecomastia evaluation and management.

Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N.

Andrology. 2019 Nov;7(6):778-793. doi: 10.1111/andr.12636. Epub 2019 May 16.

PMID:
31099174
16.

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease.

Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Clin Transl Gastroenterol. 2019 May 22;10(5):1-10. doi: 10.14309/ctg.0000000000000044.

17.

Identifying yeasts using surface enhanced Raman spectroscopy.

Lemma T, Wang J, Arstila K, Hytönen VP, Toppari JJ.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:299-307. doi: 10.1016/j.saa.2019.04.010. Epub 2019 Apr 13.

PMID:
31005737
18.

Populations, decreasing fertility, and reproductive health.

Skakkebaek NE, Jørgensen N, Andersson AM, Juul A, Main KM, Jensen TK, Toppari J.

Lancet. 2019 Apr 13;393(10180):1500-1501. doi: 10.1016/S0140-6736(19)30690-7. No abstract available.

PMID:
30983583
19.

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Lernmark Å; TEDDY Study Group.

Diabetes Care. 2019 Jun;42(6):1051-1060. doi: 10.2337/dc18-2282. Epub 2019 Apr 9.

PMID:
30967432
20.

Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice.

Faisal I, Cisneros-Montalvo S, Hamer G, Tuominen MM, Laurila PP, Tumiati M, Jauhiainen M, Kotaja N, Toppari J, Mäkelä JA, Kauppi L.

Endocrinology. 2019 May 1;160(5):1119-1136. doi: 10.1210/en.2018-01088.

PMID:
30759202
21.

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.

Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

22.

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Biomolecules. 2019 Jan 21;9(1). pii: E33. doi: 10.3390/biom9010033.

23.

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2277-2285. doi: 10.1210/jc.2018-02094.

24.

Plasmonic Nanosensor Array for Multiplexed DNA-based Pathogen Detection.

Zopf D, Pittner A, Dathe A, Grosse N, Csáki A, Arstila K, Toppari JJ, Schott W, Dontsov D, Uhlrich G, Fritzsche W, Stranik O.

ACS Sens. 2019 Feb 22;4(2):335-343. doi: 10.1021/acssensors.8b01073. Epub 2019 Feb 4.

PMID:
30657315
25.

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.

26.

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, Sosenko J, Hagopian WA, She JX, Steck AK, Rewers M, Simell O, Toppari J, Veijola R, Ziegler AG, Krischer JP, Akolkar B, Haller MJ; TEDDY Study Group.

Pediatr Diabetes. 2019 May;20(3):263-270. doi: 10.1111/pedi.12812. Epub 2019 Jan 29.

PMID:
30628751
27.

Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial.

Varimo T, Huopio H, Kariola L, Tenhola S, Voutilainen R, Toppari J, Toiviainen-Salo S, Hämäläinen E, Pulkkinen MA, Lääperi M, Tarkkanen A, Vaaralahti K, Miettinen PJ, Hero M, Raivio T.

Lancet Child Adolesc Health. 2019 Feb;3(2):109-120. doi: 10.1016/S2352-4642(18)30377-8. Epub 2019 Jan 4.

PMID:
30612946
28.

Testis Development.

Mäkelä JA, Koskenniemi JJ, Virtanen HE, Toppari J.

Endocr Rev. 2019 Aug 1;40(4):857-905. doi: 10.1210/er.2018-00140.

PMID:
30590466
29.

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

Kohva E, Huopio H, Hero M, Miettinen PJ, Vaaralahti K, Sidoroff V, Toppari J, Raivio T.

J Endocr Soc. 2018 Oct 15;2(12):1345-1356. doi: 10.1210/js.2018-00225. eCollection 2018 Dec 1.

30.

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Sci Data. 2018 Nov 13;5:180250. doi: 10.1038/sdata.2018.250.

31.

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study.

Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler A, Akolkar B, Krischer J, Virtanen SM, Norris JM; TEDDY Study Group.

Pediatr Diabetes. 2019 Feb;20(1):86-92. doi: 10.1111/pedi.12794. Epub 2018 Dec 9.

PMID:
30411443
32.

GnRH antagonist treatment of malignant adrenocortical tumors.

Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA.

Endocr Relat Cancer. 2019 Jan 1;26(1):103-117. doi: 10.1530/ERC-17-0399.

33.

Surface Characteristics Control the Attachment and Functionality of (Chimeric) Avidin.

Shao D, Tapio K, Auer S, Toppari JJ, Hytönen VP, Ahlskog M.

Langmuir. 2018 Dec 18;34(50):15335-15342. doi: 10.1021/acs.langmuir.8b02855. Epub 2018 Nov 27.

PMID:
30398878
34.

Temporal development of the gut microbiome in early childhood from the TEDDY study.

Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF.

Nature. 2018 Oct;562(7728):583-588. doi: 10.1038/s41586-018-0617-x. Epub 2018 Oct 24.

35.

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.

Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Stewart CJ, Ajami NJ, Petrosino JF, Gevers D, Lähdesmäki H, Vlamakis H, Huttenhower C, Xavier RJ.

Nature. 2018 Oct;562(7728):589-594. doi: 10.1038/s41586-018-0620-2. Epub 2018 Oct 24.

36.

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Rewers M, Hyöty H, Lernmark Å, Hagopian W, She JX, Schatz D, Ziegler AG, Toppari J, Akolkar B, Krischer J; TEDDY Study Group.

Curr Diab Rep. 2018 Oct 23;18(12):136. doi: 10.1007/s11892-018-1113-2. Review.

PMID:
30353256
37.

No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.

PMID:
30346370
38.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2019 Feb;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

PMID:
30338642
39.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

40.

Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children.

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P; TEDDY Study Group.

Diabetes. 2019 Jan;68(1):119-130. doi: 10.2337/db18-0594. Epub 2018 Oct 10.

41.

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group.

J Med Genet. 2019 Sep;56(9):602-605. doi: 10.1136/jmedgenet-2018-105532. Epub 2018 Oct 4.

42.

An update on semen quality among young Finnish men and comparison with Danish data.

Rodprasert W, Virtanen HE, Sadov S, Perheentupa A, Skakkebaek NE, Jørgensen N, Toppari J.

Andrology. 2019 Jan;7(1):15-23. doi: 10.1111/andr.12550. Epub 2018 Sep 24.

43.

A DNA-nanoparticle actuator enabling optical monitoring of nanoscale movements induced by an electric field.

Tapio K, Shao D, Auer S, Tuppurainen J, Ahlskog M, Hytönen VP, Toppari JJ.

Nanoscale. 2018 Nov 7;10(41):19297-19309. doi: 10.1039/c8nr05535a. Epub 2018 Sep 13.

PMID:
30209452
44.

Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice.

Jaeschke H, Undeutsch H, Patyra K, Löf C, Eszlinger M, Khalil M, Jännäri M, Makkonen K, Toppari J, Zhang FP, Poutanen M, Paschke R, Kero J.

Thyroid. 2018 Oct;28(10):1372-1386. doi: 10.1089/thy.2018.0041.

PMID:
30132406
45.

Coherent Light Harvesting through Strong Coupling to Confined Light.

Groenhof G, Toppari JJ.

J Phys Chem Lett. 2018 Sep 6;9(17):4848-4851. doi: 10.1021/acs.jpclett.8b02032. Epub 2018 Aug 13.

46.

Association of In Utero Persistent Organic Pollutant Exposure With Placental Thyroid Hormones.

Li ZM, Hernandez-Moreno D, Main KM, Skakkebæk NE, Kiviranta H, Toppari J, Feldt-Rasmussen U, Shen H, Schramm KW, De Angelis M.

Endocrinology. 2018 Oct 1;159(10):3473-3481. doi: 10.1210/en.2018-00542.

PMID:
30059991
47.

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Sci Rep. 2018 Jul 13;8(1):10635. doi: 10.1038/s41598-018-28907-8.

48.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

49.

Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents.

Sadov S, Virtanen HE, Main KM, Andersson AM, Juul A, Jula A, Raitakari OT, Pahkala K, Niinikoski H, Toppari J.

Acta Paediatr. 2019 Feb;108(2):321-327. doi: 10.1111/apa.14480. Epub 2018 Jul 20.

50.

DNA-Assisted Molecular Lithography.

Shen B, Linko V, Toppari JJ.

Methods Mol Biol. 2018;1811:299-314. doi: 10.1007/978-1-4939-8582-1_20.

PMID:
29926461

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