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Items: 1 to 50 of 468

1.

Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study.

Liu X, Vehik K, Huang Y, Larsson HE, Toppari J, Ziegler AG, She JX, Rewers M, Hagopian WA, Akolkar B, Krischer JP; TEDDY Study Group.

Diabetes Care. 2020 Jan 2. pii: dc191670. doi: 10.2337/dc19-1670. [Epub ahead of print]

PMID:
31896601
2.

Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy.

Ojwang V, Nwaru BI, Takkinen HM, Kaila M, Niemelä O, Haapala AM, Ilonen J, Toppari J, Hyöty H, Veijola R, Knip M, Virtanen SM.

Pediatr Allergy Immunol. 2019 Dec 12. doi: 10.1111/pai.13186. [Epub ahead of print]

PMID:
31829464
3.

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.

Valta M, Gazali AM, Viisanen T, Ihantola EL, Ekman I, Toppari J, Knip M, Veijola R, Ilonen J, Lempainen J, Kinnunen T.

Eur J Immunol. 2019 Dec 6. doi: 10.1002/eji.201948378. [Epub ahead of print]

PMID:
31808541
4.

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.

Vehik K, Lynch KF, Wong MC, Tian X, Ross MC, Gibbs RA, Ajami NJ, Petrosino JF, Rewers M, Toppari J, Ziegler AG, She JX, Lernmark A, Akolkar B, Hagopian WA, Schatz DA, Krischer JP, Hyöty H, Lloyd RE; TEDDY Study Group.

Nat Med. 2019 Dec;25(12):1865-1872. doi: 10.1038/s41591-019-0667-0. Epub 2019 Dec 2.

PMID:
31792456
5.

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study.

Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D; TEDDY Study Group.

Gut. 2019 Nov 19. pii: gutjnl-2019-319809. doi: 10.1136/gutjnl-2019-319809. [Epub ahead of print]

6.

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study.

Mattila M, Erlund I, Lee HS, Niinistö S, Uusitalo U, Andrén Aronsson C, Hummel S, Parikh H, Rich SS, Hagopian W, Toppari J, Lernmark Å, Ziegler AG, Rewers M, Krischer JP, Norris JM, Virtanen SM; TEDDY Study Group.

Diabetologia. 2020 Feb;63(2):278-286. doi: 10.1007/s00125-019-05028-z. Epub 2019 Nov 14.

PMID:
31728565
7.

Influence of Fano resonance on SERS enhancement in Fano-plasmonic oligomers.

Dutta A, Alam K, Nuutinen T, Hulkko E, Karvinen P, Kuittinen M, Toppari JJ, Vartiainen EM.

Opt Express. 2019 Oct 14;27(21):30031-30043. doi: 10.1364/OE.27.030031.

PMID:
31684257
8.

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes.

Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M.

Clin Exp Immunol. 2019 Oct 29. doi: 10.1111/cei.13391. [Epub ahead of print]

PMID:
31660582
9.

Metabolite-related dietary patterns and the development of islet autoimmunity.

Johnson RK, Vanderlinden L, DeFelice BC, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein A, Lernmark Å, Toppari J, Ziegler AG, She JX, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen SM, Norris JM; TEDDY Study Group.

Sci Rep. 2019 Oct 15;9(1):14819. doi: 10.1038/s41598-019-51251-4.

10.

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications.

Piskunen P, Shen B, Julin S, Ijäs H, Toppari JJ, Kostiainen MA, Linko V.

J Vis Exp. 2019 Sep 27;(151). doi: 10.3791/60313.

PMID:
31609310
11.

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies.

Koskinen MK, Mikk ML, Laine AP, Lempainen J, Löyttyniemi E, Vähäsalo P, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Veijola R, Ilonen J, Toppari J.

Diabetes. 2020 Jan;69(1):12-19. doi: 10.2337/db19-0329. Epub 2019 Oct 7.

PMID:
31591105
12.

Tracking Polariton Relaxation with Multiscale Molecular Dynamics Simulations.

Groenhof G, Climent C, Feist J, Morozov D, Toppari JJ.

J Phys Chem Lett. 2019 Sep 19;10(18):5476-5483. doi: 10.1021/acs.jpclett.9b02192. Epub 2019 Sep 4.

13.

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Diabetologia. 2019 Dec;62(12):2287-2297. doi: 10.1007/s00125-019-04980-0. Epub 2019 Aug 23.

14.

The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis.

Eggert A, Cisneros-Montalvo S, Anandan S, Musilli S, Stukenborg JB, Adamsson A, Nurmio M, Toppari J.

Reprod Toxicol. 2019 Dec;90:68-76. doi: 10.1016/j.reprotox.2019.08.005. Epub 2019 Aug 11.

15.

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk.

Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D; TEDDY Study Group.

JAMA. 2019 Aug 13;322(6):514-523. doi: 10.1001/jama.2019.10329.

PMID:
31408136
16.

Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes.

Hakola L, Miettinen ME, Syrjälä E, Åkerlund M, Takkinen HM, Korhonen TE, Ahonen S, Ilonen J, Toppari J, Veijola R, Nevalainen J, Knip M, Virtanen SM.

JAMA Pediatr. 2019 Aug 12. doi: 10.1001/jamapediatrics.2019.2564. [Epub ahead of print]

PMID:
31403683
17.

Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism.

Kuiri-Hänninen T, Koskenniemi J, Dunkel L, Toppari J, Sankilampi U.

Front Endocrinol (Lausanne). 2019 Jul 23;10:489. doi: 10.3389/fendo.2019.00489. eCollection 2019. Review.

18.

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.

Uusitalo U, Andren Aronsson C, Liu X, Kurppa K, Yang J, Liu E, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D; TEDDY Study Group.

Nutrients. 2019 Aug 2;11(8). pii: E1790. doi: 10.3390/nu11081790.

19.

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Ilonen J, Siljander H, Knip M.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5585-5594. doi: 10.1210/jc.2019-01069.

PMID:
31314077
20.

Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis.

Rotgers E, Cisneros-Montalvo S, Nurmio M, Toppari J.

J Cell Sci. 2019 Jul 15;132(14). pii: jcs229849. doi: 10.1242/jcs.229849.

21.

Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T.

Diabetologia. 2019 Sep;62(9):1681-1688. doi: 10.1007/s00125-019-4936-8. Epub 2019 Jul 3.

22.

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity.

Syrjälä E, Nevalainen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Sci Rep. 2019 May 23;9(1):7760. doi: 10.1038/s41598-019-44196-1.

23.

Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood.

Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A, Ilonen J.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4521-4530. doi: 10.1210/jc.2019-00421.

PMID:
31120497
24.

EAA clinical practice guidelines-gynecomastia evaluation and management.

Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N.

Andrology. 2019 Nov;7(6):778-793. doi: 10.1111/andr.12636. Epub 2019 May 16.

PMID:
31099174
25.

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease.

Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Clin Transl Gastroenterol. 2019 May 22;10(5):1-10. doi: 10.14309/ctg.0000000000000044.

26.

Identifying yeasts using surface enhanced Raman spectroscopy.

Lemma T, Wang J, Arstila K, Hytönen VP, Toppari JJ.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:299-307. doi: 10.1016/j.saa.2019.04.010. Epub 2019 Apr 13.

PMID:
31005737
27.

Populations, decreasing fertility, and reproductive health.

Skakkebaek NE, Jørgensen N, Andersson AM, Juul A, Main KM, Jensen TK, Toppari J.

Lancet. 2019 Apr 13;393(10180):1500-1501. doi: 10.1016/S0140-6736(19)30690-7. No abstract available.

PMID:
30983583
28.

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Krischer JP, Liu X, Vehik K, Akolkar B, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Lernmark Å; TEDDY Study Group.

Diabetes Care. 2019 Jun;42(6):1051-1060. doi: 10.2337/dc18-2282. Epub 2019 Apr 9.

PMID:
30967432
29.

Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice.

Faisal I, Cisneros-Montalvo S, Hamer G, Tuominen MM, Laurila PP, Tumiati M, Jauhiainen M, Kotaja N, Toppari J, Mäkelä JA, Kauppi L.

Endocrinology. 2019 May 1;160(5):1119-1136. doi: 10.1210/en.2018-01088.

PMID:
30759202
30.

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.

Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

31.

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Biomolecules. 2019 Jan 21;9(1). pii: E33. doi: 10.3390/biom9010033.

32.

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2277-2285. doi: 10.1210/jc.2018-02094.

33.

Plasmonic Nanosensor Array for Multiplexed DNA-based Pathogen Detection.

Zopf D, Pittner A, Dathe A, Grosse N, Csáki A, Arstila K, Toppari JJ, Schott W, Dontsov D, Uhlrich G, Fritzsche W, Stranik O.

ACS Sens. 2019 Feb 22;4(2):335-343. doi: 10.1021/acssensors.8b01073. Epub 2019 Feb 4.

PMID:
30657315
34.

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.

35.

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, Sosenko J, Hagopian WA, She JX, Steck AK, Rewers M, Simell O, Toppari J, Veijola R, Ziegler AG, Krischer JP, Akolkar B, Haller MJ; TEDDY Study Group.

Pediatr Diabetes. 2019 May;20(3):263-270. doi: 10.1111/pedi.12812. Epub 2019 Jan 29.

PMID:
30628751
36.

Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial.

Varimo T, Huopio H, Kariola L, Tenhola S, Voutilainen R, Toppari J, Toiviainen-Salo S, Hämäläinen E, Pulkkinen MA, Lääperi M, Tarkkanen A, Vaaralahti K, Miettinen PJ, Hero M, Raivio T.

Lancet Child Adolesc Health. 2019 Feb;3(2):109-120. doi: 10.1016/S2352-4642(18)30377-8. Epub 2019 Jan 4.

PMID:
30612946
37.

Testis Development.

Mäkelä JA, Koskenniemi JJ, Virtanen HE, Toppari J.

Endocr Rev. 2019 Aug 1;40(4):857-905. doi: 10.1210/er.2018-00140. Review.

PMID:
30590466
38.

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

Kohva E, Huopio H, Hero M, Miettinen PJ, Vaaralahti K, Sidoroff V, Toppari J, Raivio T.

J Endocr Soc. 2018 Oct 15;2(12):1345-1356. doi: 10.1210/js.2018-00225. eCollection 2018 Dec 1.

39.

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Sci Data. 2018 Nov 13;5:180250. doi: 10.1038/sdata.2018.250.

40.

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study.

Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler A, Akolkar B, Krischer J, Virtanen SM, Norris JM; TEDDY Study Group.

Pediatr Diabetes. 2019 Feb;20(1):86-92. doi: 10.1111/pedi.12794. Epub 2018 Dec 9.

PMID:
30411443
41.

GnRH antagonist treatment of malignant adrenocortical tumors.

Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA.

Endocr Relat Cancer. 2019 Jan 1;26(1):103-117. doi: 10.1530/ERC-17-0399.

42.

Surface Characteristics Control the Attachment and Functionality of (Chimeric) Avidin.

Shao D, Tapio K, Auer S, Toppari JJ, Hytönen VP, Ahlskog M.

Langmuir. 2018 Dec 18;34(50):15335-15342. doi: 10.1021/acs.langmuir.8b02855. Epub 2018 Nov 27.

PMID:
30398878
43.

Temporal development of the gut microbiome in early childhood from the TEDDY study.

Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF.

Nature. 2018 Oct;562(7728):583-588. doi: 10.1038/s41586-018-0617-x. Epub 2018 Oct 24.

44.

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.

Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Stewart CJ, Ajami NJ, Petrosino JF, Gevers D, Lähdesmäki H, Vlamakis H, Huttenhower C, Xavier RJ.

Nature. 2018 Oct;562(7728):589-594. doi: 10.1038/s41586-018-0620-2. Epub 2018 Oct 24.

45.

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Rewers M, Hyöty H, Lernmark Å, Hagopian W, She JX, Schatz D, Ziegler AG, Toppari J, Akolkar B, Krischer J; TEDDY Study Group.

Curr Diab Rep. 2018 Oct 23;18(12):136. doi: 10.1007/s11892-018-1113-2. Review.

46.

No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.

PMID:
30346370
47.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2019 Feb;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

PMID:
30338642
48.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

49.

Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children.

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P; TEDDY Study Group.

Diabetes. 2019 Jan;68(1):119-130. doi: 10.2337/db18-0594. Epub 2018 Oct 10.

50.

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group.

J Med Genet. 2019 Sep;56(9):602-605. doi: 10.1136/jmedgenet-2018-105532. Epub 2018 Oct 4.

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