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Items: 1 to 50 of 313

1.

Photolytic Labeling To Quantify Peptide-Water Interactions in Lyophilized Solids.

Chen Y, Topp EM.

Mol Pharm. 2019 Mar 4;16(3):1053-1064. doi: 10.1021/acs.molpharmaceut.8b01031. Epub 2019 Feb 14.

PMID:
30721080
2.

Do reductions in agricultural field drainage during the growing season impact bacterial densities and loads in small tile-fed watersheds?

Wilkes G, Sunohara MD, Topp E, Gottschall N, Craiovan E, Frey SK, Lapen DR.

Water Res. 2019 Mar 15;151:423-438. doi: 10.1016/j.watres.2018.11.074. Epub 2018 Nov 30.

PMID:
30639728
3.

Novel virulence, antibiotic resistance and toxin gene-specific PCR-based assays for rapid pathogenicity assessment of Arcobacter faecis and Arcobacter lanthieri.

Zambri M, Cloutier M, Adam Z, Lapen DR, Wilkes G, Sunohara M, Topp E, Talbot G, Khan IUH.

BMC Microbiol. 2019 Jan 11;19(1):11. doi: 10.1186/s12866-018-1357-7.

4.

Aquatic Bacterial Communities Associated With Land Use and Environmental Factors in Agricultural Landscapes Using a Metabarcoding Approach.

Chen W, Wilkes G, Khan IUH, Pintar KDM, Thomas JL, Lévesque CA, Chapados JT, Topp E, Lapen DR.

Front Microbiol. 2018 Oct 30;9:2301. doi: 10.3389/fmicb.2018.02301. eCollection 2018.

5.

Photolytic Labeling and Its Applications in Protein Drug Discovery and Development.

Chen Y, Topp EM.

J Pharm Sci. 2019 Feb;108(2):791-797. doi: 10.1016/j.xphs.2018.10.017. Epub 2018 Oct 16.

PMID:
30339867
6.

The impact of municipal sewage sludge stabilization processes on the abundance, field persistence, and transmission of antibiotic resistant bacteria and antibiotic resistance genes to vegetables at harvest.

Murray R, Tien YC, Scott A, Topp E.

Sci Total Environ. 2019 Feb 15;651(Pt 2):1680-1687. doi: 10.1016/j.scitotenv.2018.10.030. Epub 2018 Oct 6.

PMID:
30316087
7.

Quantitative real-time PCR-based assessment of tile drainage management influences on bacterial pathogens in tile drainage and groundwater.

Liu L, Cloutier M, Craiovan E, Edwards M, Frey SK, Gottschall N, Lapen DR, Sunohara M, Topp E, Khan IUH.

Sci Total Environ. 2018 May 15;624:1586-1597. doi: 10.1016/j.scitotenv.2017.10.200. Epub 2018 Jan 11.

PMID:
29929267
8.

Quantitative Analysis of Peptide-Matrix Interactions in Lyophilized Solids Using Photolytic Labeling.

Chen Y, Topp EM.

Mol Pharm. 2018 Jul 2;15(7):2797-2806. doi: 10.1021/acs.molpharmaceut.8b00283. Epub 2018 Jun 1.

PMID:
29792715
9.

Agriculture and Agri-Food Canada's research program on antimicrobial resistance.

Topp E.

Can Commun Dis Rep. 2017 Nov 2;43(11):224-227. eCollection 2017 Nov 2.

10.

Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance.

Larsson DGJ, Andremont A, Bengtsson-Palme J, Brandt KK, de Roda Husman AM, Fagerstedt P, Fick J, Flach CF, Gaze WH, Kuroda M, Kvint K, Laxminarayan R, Manaia CM, Nielsen KM, Plant L, Ploy MC, Segovia C, Simonet P, Smalla K, Snape J, Topp E, van Hengel AJ, Verner-Jeffreys DW, Virta MPJ, Wellington EM, Wernersson AS.

Environ Int. 2018 Aug;117:132-138. doi: 10.1016/j.envint.2018.04.041. Epub 2018 May 7.

11.

In-Situ Molecular Vapor Composition Measurements During Lyophilization.

Liechty ET, Strongrich AD, Moussa EM, Topp E, Alexeenko AA.

Pharm Res. 2018 Apr 11;35(6):115. doi: 10.1007/s11095-018-2395-4.

PMID:
29644443
12.

Explaining the accelerated degradation of ciprofloxacin, sulfamethazine, and erythromycin in different soil exposure scenarios by their aqueous extractability.

Goulas A, Sabourin L, Asghar F, Haudin CS, Benoit P, Topp E.

Environ Sci Pollut Res Int. 2018 Jun;25(16):16236-16245. doi: 10.1007/s11356-018-1834-4. Epub 2018 Mar 29.

PMID:
29594886
13.

Long-Term Exposure of Agricultural Soil to Veterinary Antibiotics Changes the Population Structure of Symbiotic Nitrogen-Fixing Rhizobacteria Occupying Nodules of Soybeans (Glycine max).

Revellin C, Hartmann A, Solanas S, Topp E.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e00109-18. doi: 10.1128/AEM.00109-18. Print 2018 May 1.

14.

Understanding the Proline-Centric Design of a Peptide-Mediated Macrolide Resistance Mechanism.

Lau CH, Topp E.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02618-17. doi: 10.1128/AAC.02618-17. Print 2018 Apr. No abstract available.

15.

Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen-Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).

Moussa EM, Singh SK, Kimmel M, Nema S, Topp EM.

Mol Pharm. 2018 Feb 5;15(2):356-368. doi: 10.1021/acs.molpharmaceut.7b00696. Epub 2018 Jan 22.

PMID:
29355022
16.

Enrichment of antibiotic resistance genes in soil receiving composts derived from swine manure, yard wastes, or food wastes, and evidence for multiyear persistence of swine Clostridium spp.

Scott A, Tien YC, Drury CF, Reynolds WD, Topp E.

Can J Microbiol. 2018 Mar;64(3):201-208. doi: 10.1139/cjm-2017-0642. Epub 2018 Jan 17.

PMID:
29342372
17.

Antimicrobial resistance and the environment: assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing.

Topp E, Larsson DGJ, Miller DN, Van den Eede C, Virta MPJ.

FEMS Microbiol Ecol. 2018 Mar 1;94(3). doi: 10.1093/femsec/fix185.

PMID:
29309580
18.

Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).

Moussa EM, Wilson NE, Zhou QT, Singh SK, Nema S, Topp EM.

Pharm Res. 2018 Jan 3;35(1):12. doi: 10.1007/s11095-017-2318-9.

PMID:
29299701
19.

Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations.

Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A.

Mol Pharm. 2018 Jan 2;15(1):1-11. doi: 10.1021/acs.molpharmaceut.7b00504. Epub 2017 Nov 28.

PMID:
29182876
20.

A Cooperative Folding Unit as the Structural Link for Energetic Coupling within a Protein.

Gardner NW, McGinness SM, Panchal J, Topp EM, Park C.

Biochemistry. 2017 Dec 19;56(50):6555-6564. doi: 10.1021/acs.biochem.7b00850. Epub 2017 Dec 6.

PMID:
29166011
21.

Genomic Analysis of Third Generation Cephalosporin Resistant Escherichia coli from Dairy Cow Manure.

Rehman MA, Yin X, Lepp D, Laing C, Ziebell K, Talbot G, Topp E, Diarra MS.

Vet Sci. 2017 Nov 17;4(4). pii: E57. doi: 10.3390/vetsci4040057.

22.

Enhanced Single-tube Multiplex PCR Assay for Detection and Identification of Six Arcobacter Species.

Khan IUH, Cloutier M, Libby M, Lapen DR, Wilkes G, Topp E.

J Appl Microbiol. 2017 Dec;123(6):1522-1532. doi: 10.1111/jam.13597. Epub 2017 Nov 7.

PMID:
28960631
23.

NOVEL ANTIBIOTIC RESISTANCE DETERMINANTS FROM AGRICULTURAL SOIL EXPOSED TO ANTIBIOTICS WIDELY USED IN HUMAN MEDICINE AND ANIMAL FARMING.

Lau CH, van Engelen K, Gordon S, Renaud J, Topp E.

Appl Environ Microbiol. 2017 Jun 16. pii: AEM.00989-17. doi: 10.1128/AEM.00989-17. [Epub ahead of print]

24.

Impact of pre-application treatment on municipal sludge composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest.

Lau CH, Li B, Zhang T, Tien YC, Scott A, Murray R, Sabourin L, Lapen DR, Duenk P, Topp E.

Sci Total Environ. 2017 Jun 1;587-588:214-222. doi: 10.1016/j.scitotenv.2017.02.123. Epub 2017 Feb 24.

PMID:
28242221
25.

Spectral Counting Approach to Measure Selectivity of High-Resolution LC-MS Methods for Environmental Analysis.

Renaud JB, Sabourin L, Topp E, Sumarah MW.

Anal Chem. 2017 Mar 7;89(5):2747-2754. doi: 10.1021/acs.analchem.6b03475. Epub 2017 Feb 16.

PMID:
28194977
26.

Impact of dairy manure pre-application treatment on manure composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest.

Tien YC, Li B, Zhang T, Scott A, Murray R, Sabourin L, Marti R, Topp E.

Sci Total Environ. 2017 Mar 1;581-582:32-39. doi: 10.1016/j.scitotenv.2016.12.138. Epub 2017 Jan 8.

PMID:
28076772
27.

Isolation and Characterization of Acinetobacter baumannii Recovered from Campylobacter Selective Medium.

Fernando DM, Khan IU, Patidar R, Lapen DR, Talbot G, Topp E, Kumar A.

Front Microbiol. 2016 Nov 18;7:1871. eCollection 2016.

28.

Comparison of commercial DNA extraction kits and quantitative PCR systems for better sensitivity in detecting the causative agent of paratuberculosis in dairy cow fecal samples.

Fock-Chow-Tho D, Topp E, Ibeagha-Awemu EA, Bissonnette N.

J Dairy Sci. 2017 Jan;100(1):572-581. doi: 10.3168/jds.2016-11384. Epub 2016 Nov 23.

29.

Waterborne Viruses and F-Specific Coliphages in Mixed-Use Watersheds: Microbial Associations, Host Specificities, and Affinities with Environmental/Land Use Factors.

Jones TH, Brassard J, Topp E, Wilkes G, Lapen DR.

Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02763-16. doi: 10.1128/AEM.02763-16. Print 2017 Feb 1.

30.

Monitoring Seven Potentially Pathogenic Escherichia coli Serogroups in a Closed Herd of Beef Cattle from Weaning to Finishing Phases.

Hallewell J, Reuter T, Stanford K, Topp E, Alexander TW.

Foodborne Pathog Dis. 2016 Dec;13(12):661-667. Epub 2016 Oct 25.

PMID:
27779903
31.

Towards a more accurate quantitative assessment of seasonal Cryptosporidium infection risks in surface waters using species and genotype information.

Lapen DR, Schmidt PJ, Thomas JL, Edge TA, Flemming C, Keithlin J, Neumann N, Pollari F, Ruecker N, Simhon A, Topp E, Wilkes G, Pintar KDM.

Water Res. 2016 Nov 15;105:625-637. doi: 10.1016/j.watres.2016.08.023. Epub 2016 Aug 13.

PMID:
27721171
32.

Brominated flame retardants and perfluoroalkyl acids in groundwater, tile drainage, soil, and crop grain following a high application of municipal biosolids to a field.

Gottschall N, Topp E, Edwards M, Payne M, Kleywegt S, Lapen DR.

Sci Total Environ. 2017 Jan 1;574:1345-1359. doi: 10.1016/j.scitotenv.2016.08.044. Epub 2016 Sep 16.

PMID:
27644852
33.

Editorial: Special section of FEMS Microbiology Ecology on the environmental dimension of antibiotic resistance.

Smalla K, Simonet P, Tiedje J, Topp E.

FEMS Microbiol Ecol. 2016 Nov;92(11). pii: fiw172. doi: 10.1093/femsec/fiw172. Epub 2016 Sep 7. No abstract available.

PMID:
27604258
34.

Fibpredictor: a computational method for rapid prediction of amyloid fibril structures.

Tabatabaei Ghomi H, Topp EM, Lill MA.

J Mol Model. 2016 Sep;22(9):206. doi: 10.1007/s00894-016-3066-1. Epub 2016 Aug 8.

PMID:
27502172
35.

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons.

Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EM, Gaze WH.

FEMS Microbiol Ecol. 2016 Oct;92(10). pii: fiw159. doi: 10.1093/femsec/fiw159. Epub 2016 Aug 5.

PMID:
27495240
36.

An evaluation of logic regression-based biomarker discovery across multiple intergenic regions for predicting host specificity in Escherichia coli.

Zhi S, Li Q, Yasui Y, Banting G, Edge TA, Topp E, McAllister TA, Neumann NF.

Mol Phylogenet Evol. 2016 Oct;103:133-142. doi: 10.1016/j.ympev.2016.07.016. Epub 2016 Jul 16.

PMID:
27431906
37.

Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.

Zhi S, Banting G, Li Q, Edge TA, Topp E, Sokurenko M, Scott C, Braithwaite S, Ruecker NJ, Yasui Y, McAllister T, Chui L, Neumann NF.

Appl Environ Microbiol. 2016 Aug 30;82(18):5505-18. doi: 10.1128/AEM.00143-16. Print 2016 Sep 15.

38.

Effect of Co-Composting Cattle Manure with Construction and Demolition Waste on the Archaeal, Bacterial, and Fungal Microbiota, and on Antimicrobial Resistance Determinants.

Holman DB, Hao X, Topp E, Yang HE, Alexander TW.

PLoS One. 2016 Jun 14;11(6):e0157539. doi: 10.1371/journal.pone.0157539. eCollection 2016.

39.

Antimicrobial Resistance of Escherichia fergusonii Isolated from Broiler Chickens.

Simmons K, Islam MR, Rempel H, Block G, Topp E, Diarra MS.

J Food Prot. 2016 Jun;79(6):929-38. doi: 10.4315/0362-028X.JFP-15-575.

PMID:
27296596
40.

Persistence of antibiotic resistance and plasmid-associated genes in soil following application of sewage sludge and abundance on vegetables at harvest.

Rahube TO, Marti R, Scott A, Tien YC, Murray R, Sabourin L, Duenk P, Lapen DR, Topp E.

Can J Microbiol. 2016 Jul;62(7):600-7. doi: 10.1139/cjm-2016-0034. Epub 2016 Mar 17.

PMID:
27277701
41.

Biosolids applied to agricultural land: Influence on structural and functional endpoints of soil fauna on a short- and long-term scale.

Coors A, Edwards M, Lorenz P, Römbke J, Schmelz RM, Topp E, Waszak K, Wilkes G, Lapen DR.

Sci Total Environ. 2016 Aug 15;562:312-326. doi: 10.1016/j.scitotenv.2016.03.226. Epub 2016 Apr 19.

PMID:
27100012
42.

Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field.

Topp E, Renaud J, Sumarah M, Sabourin L.

Sci Total Environ. 2016 Aug 15;562:136-144. doi: 10.1016/j.scitotenv.2016.03.210. Epub 2016 Apr 17.

PMID:
27096634
43.

Phenotypic and Genotypic Characteristics of Shiga Toxin-Producing Escherichia coli Isolated from Surface Waters and Sediments in a Canadian Urban-Agricultural Landscape.

Nadya S, Delaquis P, Chen J, Allen K, Johnson RP, Ziebell K, Laing C, Gannon V, Bach S, Topp E.

Front Cell Infect Microbiol. 2016 Apr 5;6:36. doi: 10.3389/fcimb.2016.00036. eCollection 2016.

44.

Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods.

Iyer LK, Sacha GA, Moorthy BS, Nail SL, Topp EM.

J Pharm Sci. 2016 May;105(5):1684-1692. doi: 10.1016/j.xphs.2016.02.033. Epub 2016 Apr 1.

45.

Physical Characterization and Innate Immunogenicity of Aggregated Intravenous Immunoglobulin (IGIV) in an In Vitro Cell-Based Model.

Moussa EM, Kotarek J, Blum JS, Marszal E, Topp EM.

Pharm Res. 2016 Jul;33(7):1736-51. doi: 10.1007/s11095-016-1914-4. Epub 2016 Apr 1.

PMID:
27037576
46.

Detection of virulence, antibiotic resistance and toxin (VAT) genes in Campylobacter species using newly developed multiplex PCR assays.

Laprade N, Cloutier M, Lapen DR, Topp E, Wilkes G, Villemur R, Khan IU.

J Microbiol Methods. 2016 May;124:41-7. doi: 10.1016/j.mimet.2016.03.009. Epub 2016 Mar 21.

PMID:
27012738
47.

Back to the Future of Soil Metagenomics.

Nesme J, Achouak W, Agathos SN, Bailey M, Baldrian P, Brunel D, Frostegård Å, Heulin T, Jansson JK, Jurkevitch E, Kruus KL, Kowalchuk GA, Lagares A, Lappin-Scott HM, Lemanceau P, Le Paslier D, Mandic-Mulec I, Murrell JC, Myrold DD, Nalin R, Nannipieri P, Neufeld JD, O'Gara F, Parnell JJ, Pühler A, Pylro V, Ramos JL, Roesch LF, Schloter M, Schleper C, Sczyrba A, Sessitsch A, Sjöling S, Sørensen J, Sørensen SJ, Tebbe CC, Topp E, Tsiamis G, van Elsas JD, van Keulen G, Widmer F, Wagner M, Zhang T, Zhang X, Zhao L, Zhu YG, Vogel TM, Simonet P.

Front Microbiol. 2016 Feb 10;7:73. doi: 10.3389/fmicb.2016.00073. eCollection 2016. No abstract available.

48.

Thiol-Disulfide Exchange in Human Growth Hormone.

Chandrasekhar S, Moorthy BS, Xie R, Topp EM.

Pharm Res. 2016 Jun;33(6):1370-82. doi: 10.1007/s11095-016-1879-3. Epub 2016 Feb 17.

49.

The case for plant-made veterinary immunotherapeutics.

Topp E, Irwin R, McAllister T, Lessard M, Joensuu JJ, Kolotilin I, Conrad U, Stöger E, Mor T, Warzecha H, Hall JC, McLean MD, Cox E, Devriendt B, Potter A, Depicker A, Virdi V, Holbrook L, Doshi K, Dussault M, Friendship R, Yarosh O, Yoo HS, MacDonald J, Menassa R.

Biotechnol Adv. 2016 Sep-Oct;34(5):597-604. doi: 10.1016/j.biotechadv.2016.02.007. Epub 2016 Feb 12. Review.

PMID:
26875776
50.

Immunogenicity of Therapeutic Protein Aggregates.

Moussa EM, Panchal JP, Moorthy BS, Blum JS, Joubert MK, Narhi LO, Topp EM.

J Pharm Sci. 2016 Feb;105(2):417-430. doi: 10.1016/j.xphs.2015.11.002. Review.

PMID:
26869409

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