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Items: 1 to 50 of 323

1.

Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS).

Kumar L, Chandrababu KB, Balakrishnan SM, Allmendinger A, Walters B, Zarraga IE, Chang DP, Nayak P, Topp EM.

Mol Pharm. 2019 Nov 4;16(11):4485-4495. doi: 10.1021/acs.molpharmaceut.9b00614. Epub 2019 Oct 17.

PMID:
31568722
2.

Does Dietary Consumption of Antibiotics by Humans Promote Antibiotic Resistance in the Gut Microbiome?

Subirats J, Domingues A, Topp E.

J Food Prot. 2019 Oct;82(10):1636-1642. doi: 10.4315/0362-028X.JFP-19-158.

PMID:
31512932
3.

Effects of ionic interactions on protein stability prediction using solid-state hydrogen deuterium exchange with mass spectrometry (ssHDX-MS).

AbouGhaly MHH, Du J, Patel SM, Topp EM.

Int J Pharm. 2019 Sep 10;568:118512. doi: 10.1016/j.ijpharm.2019.118512. Epub 2019 Jul 10.

PMID:
31301464
4.

Effects of drying method and excipient on structure and stability of protein solids using solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS).

Wilson NE, Topp EM, Zhou QT.

Int J Pharm. 2019 Aug 15;567:118470. doi: 10.1016/j.ijpharm.2019.118470. Epub 2019 Jun 25.

PMID:
31252148
5.

Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine.

Kammari R, Topp EM.

Mol Pharm. 2019 Jul 1;16(7):2935-2946. doi: 10.1021/acs.molpharmaceut.9b00162. Epub 2019 Jun 18.

PMID:
31244225
6.

Impact of seasonal temperature transition, alkalinity and other abiotic factors on the persistence of viruses in swine and dairy manures.

Auffret MD, Brassard J, Jones TH, Gagnon N, Gagné MJ, Muehlhauser V, Masse L, Topp E, Talbot G.

Sci Total Environ. 2019 Apr 1;659:640-648. doi: 10.1016/j.scitotenv.2018.12.306. Epub 2018 Dec 28.

PMID:
31096393
7.

Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum.

Martin-Laurent F, Topp E, Billet L, Batisson I, Malandain C, Besse-Hoggan P, Morin S, Artigas J, Bonnineau C, Kergoat L, Devers-Lamrani M, Pesce S.

Environ Sci Pollut Res Int. 2019 Jun;26(18):18930-18937. doi: 10.1007/s11356-019-05122-0. Epub 2019 May 4.

PMID:
31055743
8.

A Novel Photoreactive Excipient to Probe Peptide-Matrix Interactions in Lyophilized Solids.

Chen Y, Topp EM.

J Pharm Sci. 2019 Apr 26. pii: S0022-3549(19)30292-8. doi: 10.1016/j.xphs.2019.04.024. [Epub ahead of print]

PMID:
31034909
9.

Plant-Produced Chimeric VHH-sIgA Against Enterohemorrhagic E. coli Intimin Shows Cross-Serotype Inhibition of Bacterial Adhesion to Epithelial Cells.

Saberianfar R, Chin-Fatt A, Scott A, Henry KA, Topp E, Menassa R.

Front Plant Sci. 2019 Mar 12;10:270. doi: 10.3389/fpls.2019.00270. eCollection 2019.

10.

From farm management to bacteriophage therapy: strategies to reduce antibiotic use in animal agriculture.

Kahn LH, Bergeron G, Bourassa MW, De Vegt B, Gill J, Gomes F, Malouin F, Opengart K, Ritter GD, Singer RS, Storrs C, Topp E.

Ann N Y Acad Sci. 2019 Apr;1441(1):31-39. doi: 10.1111/nyas.14034. Review.

PMID:
30924542
11.

Photolytic Labeling To Quantify Peptide-Water Interactions in Lyophilized Solids.

Chen Y, Topp EM.

Mol Pharm. 2019 Mar 4;16(3):1053-1064. doi: 10.1021/acs.molpharmaceut.8b01031. Epub 2019 Feb 14.

PMID:
30721080
12.

Do reductions in agricultural field drainage during the growing season impact bacterial densities and loads in small tile-fed watersheds?

Wilkes G, Sunohara MD, Topp E, Gottschall N, Craiovan E, Frey SK, Lapen DR.

Water Res. 2019 Mar 15;151:423-438. doi: 10.1016/j.watres.2018.11.074. Epub 2018 Nov 30.

PMID:
30639728
13.

Novel virulence, antibiotic resistance and toxin gene-specific PCR-based assays for rapid pathogenicity assessment of Arcobacter faecis and Arcobacter lanthieri.

Zambri M, Cloutier M, Adam Z, Lapen DR, Wilkes G, Sunohara M, Topp E, Talbot G, Khan IUH.

BMC Microbiol. 2019 Jan 11;19(1):11. doi: 10.1186/s12866-018-1357-7.

14.

Aquatic Bacterial Communities Associated With Land Use and Environmental Factors in Agricultural Landscapes Using a Metabarcoding Approach.

Chen W, Wilkes G, Khan IUH, Pintar KDM, Thomas JL, Lévesque CA, Chapados JT, Topp E, Lapen DR.

Front Microbiol. 2018 Oct 30;9:2301. doi: 10.3389/fmicb.2018.02301. eCollection 2018.

15.

Photolytic Labeling and Its Applications in Protein Drug Discovery and Development.

Chen Y, Topp EM.

J Pharm Sci. 2019 Feb;108(2):791-797. doi: 10.1016/j.xphs.2018.10.017. Epub 2018 Oct 16.

PMID:
30339867
16.

The impact of municipal sewage sludge stabilization processes on the abundance, field persistence, and transmission of antibiotic resistant bacteria and antibiotic resistance genes to vegetables at harvest.

Murray R, Tien YC, Scott A, Topp E.

Sci Total Environ. 2019 Feb 15;651(Pt 2):1680-1687. doi: 10.1016/j.scitotenv.2018.10.030. Epub 2018 Oct 6.

PMID:
30316087
17.

Quantitative real-time PCR-based assessment of tile drainage management influences on bacterial pathogens in tile drainage and groundwater.

Liu L, Cloutier M, Craiovan E, Edwards M, Frey SK, Gottschall N, Lapen DR, Sunohara M, Topp E, Khan IUH.

Sci Total Environ. 2018 May 15;624:1586-1597. doi: 10.1016/j.scitotenv.2017.10.200. Epub 2018 Jan 11.

PMID:
29929267
18.

Quantitative Analysis of Peptide-Matrix Interactions in Lyophilized Solids Using Photolytic Labeling.

Chen Y, Topp EM.

Mol Pharm. 2018 Jul 2;15(7):2797-2806. doi: 10.1021/acs.molpharmaceut.8b00283. Epub 2018 Jun 1.

PMID:
29792715
19.

Agriculture and Agri-Food Canada's research program on antimicrobial resistance.

Topp E.

Can Commun Dis Rep. 2017 Nov 2;43(11):224-227. eCollection 2017 Nov 2.

20.

Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance.

Larsson DGJ, Andremont A, Bengtsson-Palme J, Brandt KK, de Roda Husman AM, Fagerstedt P, Fick J, Flach CF, Gaze WH, Kuroda M, Kvint K, Laxminarayan R, Manaia CM, Nielsen KM, Plant L, Ploy MC, Segovia C, Simonet P, Smalla K, Snape J, Topp E, van Hengel AJ, Verner-Jeffreys DW, Virta MPJ, Wellington EM, Wernersson AS.

Environ Int. 2018 Aug;117:132-138. doi: 10.1016/j.envint.2018.04.041. Epub 2018 May 7.

21.

In-Situ Molecular Vapor Composition Measurements During Lyophilization.

Liechty ET, Strongrich AD, Moussa EM, Topp E, Alexeenko AA.

Pharm Res. 2018 Apr 11;35(6):115. doi: 10.1007/s11095-018-2395-4.

PMID:
29644443
22.

Explaining the accelerated degradation of ciprofloxacin, sulfamethazine, and erythromycin in different soil exposure scenarios by their aqueous extractability.

Goulas A, Sabourin L, Asghar F, Haudin CS, Benoit P, Topp E.

Environ Sci Pollut Res Int. 2018 Jun;25(16):16236-16245. doi: 10.1007/s11356-018-1834-4. Epub 2018 Mar 29.

PMID:
29594886
23.

Long-Term Exposure of Agricultural Soil to Veterinary Antibiotics Changes the Population Structure of Symbiotic Nitrogen-Fixing Rhizobacteria Occupying Nodules of Soybeans (Glycine max).

Revellin C, Hartmann A, Solanas S, Topp E.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e00109-18. doi: 10.1128/AEM.00109-18. Print 2018 May 1.

24.

Understanding the Proline-Centric Design of a Peptide-Mediated Macrolide Resistance Mechanism.

Lau CH, Topp E.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02618-17. doi: 10.1128/AAC.02618-17. Print 2018 Apr. No abstract available.

25.

Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen-Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).

Moussa EM, Singh SK, Kimmel M, Nema S, Topp EM.

Mol Pharm. 2018 Feb 5;15(2):356-368. doi: 10.1021/acs.molpharmaceut.7b00696. Epub 2018 Jan 22.

PMID:
29355022
26.

Enrichment of antibiotic resistance genes in soil receiving composts derived from swine manure, yard wastes, or food wastes, and evidence for multiyear persistence of swine Clostridium spp.

Scott A, Tien YC, Drury CF, Reynolds WD, Topp E.

Can J Microbiol. 2018 Mar;64(3):201-208. doi: 10.1139/cjm-2017-0642. Epub 2018 Jan 17.

PMID:
29342372
27.

Antimicrobial resistance and the environment: assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing.

Topp E, Larsson DGJ, Miller DN, Van den Eede C, Virta MPJ.

FEMS Microbiol Ecol. 2018 Mar 1;94(3). doi: 10.1093/femsec/fix185.

PMID:
29309580
28.

Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).

Moussa EM, Wilson NE, Zhou QT, Singh SK, Nema S, Topp EM.

Pharm Res. 2018 Jan 3;35(1):12. doi: 10.1007/s11095-017-2318-9.

PMID:
29299701
29.

Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations.

Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A.

Mol Pharm. 2018 Jan 2;15(1):1-11. doi: 10.1021/acs.molpharmaceut.7b00504. Epub 2017 Nov 28.

PMID:
29182876
30.

A Cooperative Folding Unit as the Structural Link for Energetic Coupling within a Protein.

Gardner NW, McGinness SM, Panchal J, Topp EM, Park C.

Biochemistry. 2017 Dec 19;56(50):6555-6564. doi: 10.1021/acs.biochem.7b00850. Epub 2017 Dec 6.

PMID:
29166011
31.

Genomic Analysis of Third Generation Cephalosporin Resistant Escherichia coli from Dairy Cow Manure.

Rehman MA, Yin X, Lepp D, Laing C, Ziebell K, Talbot G, Topp E, Diarra MS.

Vet Sci. 2017 Nov 17;4(4). pii: E57. doi: 10.3390/vetsci4040057.

32.

Enhanced Single-tube Multiplex PCR Assay for Detection and Identification of Six Arcobacter Species.

Khan IUH, Cloutier M, Libby M, Lapen DR, Wilkes G, Topp E.

J Appl Microbiol. 2017 Dec;123(6):1522-1532. doi: 10.1111/jam.13597. Epub 2017 Nov 7.

PMID:
28960631
33.

Novel Antibiotic Resistance Determinants from Agricultural Soil Exposed to Antibiotics Widely Used in Human Medicine and Animal Farming.

Lau CH, van Engelen K, Gordon S, Renaud J, Topp E.

Appl Environ Microbiol. 2017 Aug 1;83(16). pii: e00989-17. doi: 10.1128/AEM.00989-17. Print 2017 Aug 15.

34.

Impact of pre-application treatment on municipal sludge composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest.

Lau CH, Li B, Zhang T, Tien YC, Scott A, Murray R, Sabourin L, Lapen DR, Duenk P, Topp E.

Sci Total Environ. 2017 Jun 1;587-588:214-222. doi: 10.1016/j.scitotenv.2017.02.123. Epub 2017 Feb 24.

PMID:
28242221
35.

Spectral Counting Approach to Measure Selectivity of High-Resolution LC-MS Methods for Environmental Analysis.

Renaud JB, Sabourin L, Topp E, Sumarah MW.

Anal Chem. 2017 Mar 7;89(5):2747-2754. doi: 10.1021/acs.analchem.6b03475. Epub 2017 Feb 16.

PMID:
28194977
36.

Impact of dairy manure pre-application treatment on manure composition, soil dynamics of antibiotic resistance genes, and abundance of antibiotic-resistance genes on vegetables at harvest.

Tien YC, Li B, Zhang T, Scott A, Murray R, Sabourin L, Marti R, Topp E.

Sci Total Environ. 2017 Mar 1;581-582:32-39. doi: 10.1016/j.scitotenv.2016.12.138. Epub 2017 Jan 8.

PMID:
28076772
37.

Isolation and Characterization of Acinetobacter baumannii Recovered from Campylobacter Selective Medium.

Fernando DM, Khan IU, Patidar R, Lapen DR, Talbot G, Topp E, Kumar A.

Front Microbiol. 2016 Nov 18;7:1871. eCollection 2016.

38.

Comparison of commercial DNA extraction kits and quantitative PCR systems for better sensitivity in detecting the causative agent of paratuberculosis in dairy cow fecal samples.

Fock-Chow-Tho D, Topp E, Ibeagha-Awemu EA, Bissonnette N.

J Dairy Sci. 2017 Jan;100(1):572-581. doi: 10.3168/jds.2016-11384. Epub 2016 Nov 23.

39.

Waterborne Viruses and F-Specific Coliphages in Mixed-Use Watersheds: Microbial Associations, Host Specificities, and Affinities with Environmental/Land Use Factors.

Jones TH, Brassard J, Topp E, Wilkes G, Lapen DR.

Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02763-16. doi: 10.1128/AEM.02763-16. Print 2017 Feb 1.

40.

Monitoring Seven Potentially Pathogenic Escherichia coli Serogroups in a Closed Herd of Beef Cattle from Weaning to Finishing Phases.

Hallewell J, Reuter T, Stanford K, Topp E, Alexander TW.

Foodborne Pathog Dis. 2016 Dec;13(12):661-667. Epub 2016 Oct 25.

PMID:
27779903
41.

Towards a more accurate quantitative assessment of seasonal Cryptosporidium infection risks in surface waters using species and genotype information.

Lapen DR, Schmidt PJ, Thomas JL, Edge TA, Flemming C, Keithlin J, Neumann N, Pollari F, Ruecker N, Simhon A, Topp E, Wilkes G, Pintar KDM.

Water Res. 2016 Nov 15;105:625-637. doi: 10.1016/j.watres.2016.08.023. Epub 2016 Aug 13.

PMID:
27721171
42.

Brominated flame retardants and perfluoroalkyl acids in groundwater, tile drainage, soil, and crop grain following a high application of municipal biosolids to a field.

Gottschall N, Topp E, Edwards M, Payne M, Kleywegt S, Lapen DR.

Sci Total Environ. 2017 Jan 1;574:1345-1359. doi: 10.1016/j.scitotenv.2016.08.044. Epub 2016 Sep 16.

PMID:
27644852
43.

Editorial: Special section of FEMS Microbiology Ecology on the environmental dimension of antibiotic resistance.

Smalla K, Simonet P, Tiedje J, Topp E.

FEMS Microbiol Ecol. 2016 Nov;92(11). pii: fiw172. doi: 10.1093/femsec/fiw172. Epub 2016 Sep 7. No abstract available.

PMID:
27604258
44.

Fibpredictor: a computational method for rapid prediction of amyloid fibril structures.

Tabatabaei Ghomi H, Topp EM, Lill MA.

J Mol Model. 2016 Sep;22(9):206. doi: 10.1007/s00894-016-3066-1. Epub 2016 Aug 8.

PMID:
27502172
45.

Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons.

Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EM, Gaze WH.

FEMS Microbiol Ecol. 2016 Oct;92(10). pii: fiw159. doi: 10.1093/femsec/fiw159. Epub 2016 Aug 5.

PMID:
27495240
46.

An evaluation of logic regression-based biomarker discovery across multiple intergenic regions for predicting host specificity in Escherichia coli.

Zhi S, Li Q, Yasui Y, Banting G, Edge TA, Topp E, McAllister TA, Neumann NF.

Mol Phylogenet Evol. 2016 Oct;103:133-142. doi: 10.1016/j.ympev.2016.07.016. Epub 2016 Jul 16.

PMID:
27431906
47.

Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.

Zhi S, Banting G, Li Q, Edge TA, Topp E, Sokurenko M, Scott C, Braithwaite S, Ruecker NJ, Yasui Y, McAllister T, Chui L, Neumann NF.

Appl Environ Microbiol. 2016 Aug 30;82(18):5505-18. doi: 10.1128/AEM.00143-16. Print 2016 Sep 15.

48.

Effect of Co-Composting Cattle Manure with Construction and Demolition Waste on the Archaeal, Bacterial, and Fungal Microbiota, and on Antimicrobial Resistance Determinants.

Holman DB, Hao X, Topp E, Yang HE, Alexander TW.

PLoS One. 2016 Jun 14;11(6):e0157539. doi: 10.1371/journal.pone.0157539. eCollection 2016.

49.

Antimicrobial Resistance of Escherichia fergusonii Isolated from Broiler Chickens.

Simmons K, Islam MR, Rempel H, Block G, Topp E, Diarra MS.

J Food Prot. 2016 Jun;79(6):929-38. doi: 10.4315/0362-028X.JFP-15-575.

PMID:
27296596
50.

Persistence of antibiotic resistance and plasmid-associated genes in soil following application of sewage sludge and abundance on vegetables at harvest.

Rahube TO, Marti R, Scott A, Tien YC, Murray R, Sabourin L, Duenk P, Lapen DR, Topp E.

Can J Microbiol. 2016 Jul;62(7):600-7. doi: 10.1139/cjm-2016-0034. Epub 2016 Mar 17.

PMID:
27277701

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