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Items: 13


ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G.

J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5.


Computational identification of natural peptides based on analysis of molecular evolution.

Toporik A, Borukhov I, Apatoff A, Gerber D, Kliger Y.

Bioinformatics. 2014 Aug 1;30(15):2137-41. doi: 10.1093/bioinformatics/btu195. Epub 2014 Apr 11.


The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.

Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63. doi: 10.1073/pnas.0903474106. Epub 2009 Oct 7.


Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept.

Kliger Y, Levy O, Oren A, Ashkenazy H, Tiran Z, Novik A, Rosenberg A, Amir A, Wool A, Toporik A, Schreiber E, Eshel D, Levine Z, Cohen Y, Nold-Petry C, Dinarello CA, Borukhov I.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13797-801. doi: 10.1073/pnas.0906514106. Epub 2009 Aug 5.


Activation of relaxin-related receptors by short, linear peptides derived from a collagen-containing precursor.

Shemesh R, Hermesh C, Toporik A, Levine Z, Novik A, Wool A, Kliger Y, Rosenberg A, Bathgate RA, Cohen Y.

Ann N Y Acad Sci. 2009 Apr;1160:78-86. doi: 10.1111/j.1749-6632.2009.03827.x.


A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.

Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J, Cohen Y.

J Pharmacol Exp Ther. 2009 Feb;328(2):426-34. doi: 10.1124/jpet.108.145821. Epub 2008 Nov 20.


Discovery and validation of novel peptide agonists for G-protein-coupled receptors.

Shemesh R, Toporik A, Levine Z, Hecht I, Rotman G, Wool A, Dahary D, Gofer E, Kliger Y, Soffer MA, Rosenberg A, Eshel D, Cohen Y.

J Biol Chem. 2008 Dec 12;283(50):34643-9. doi: 10.1074/jbc.M805181200. Epub 2008 Oct 9.


Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing.

Eshel D, Toporik A, Efrati T, Nakav S, Chen A, Douvdevani A.

Mol Immunol. 2008 Dec;46(2):250-7. doi: 10.1016/j.molimm.2008.08.280. Epub 2008 Oct 11.


Predicting proteolytic sites in extracellular proteins: only halfway there.

Kliger Y, Gofer E, Wool A, Toporik A, Apatoff A, Olshansky M.

Bioinformatics. 2008 Apr 15;24(8):1049-55. doi: 10.1093/bioinformatics/btn084. Epub 2008 Mar 4.


Transcription-mediated gene fusion in the human genome.

Akiva P, Toporik A, Edelheit S, Peretz Y, Diber A, Shemesh R, Novik A, Sorek R.

Genome Res. 2006 Jan;16(1):30-6. Epub 2005 Dec 12.


hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.

Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G.

Gene. 2004 Apr 28;331:17-31.


Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.

David A, Mabjeesh N, Azar I, Biton S, Engel S, Bernstein J, Romano J, Avidor Y, Waks T, Eshhar Z, Langer SZ, Lifschitz-Mercer B, Matzkin H, Rotman G, Toporik A, Savitsky K, Mintz L.

J Biol Chem. 2002 May 17;277(20):18084-90. Epub 2002 Feb 7.


Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase.

Toporik A, Gorzalczany Y, Hirshberg M, Pick E, Lotan O.

Biochemistry. 1998 May 19;37(20):7147-56.


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