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Items: 1 to 50 of 146

1.

Structural transitions during the scaffolding-driven assembly of a viral capsid.

Ignatiou A, Brasilès S, El Sadek Fadel M, Bürger J, Mielke T, Topf M, Tavares P, Orlova EV.

Nat Commun. 2019 Oct 24;10(1):4840. doi: 10.1038/s41467-019-12790-6.

2.

Critical assessment of methods of protein structure prediction (CASP)-Round XIII.

Kryshtafovych A, Schwede T, Topf M, Fidelis K, Moult J.

Proteins. 2019 Dec;87(12):1011-1020. doi: 10.1002/prot.25823. Epub 2019 Oct 23.

PMID:
31589781
3.

Cryo-electron microscopy targets in CASP13: Overview and evaluation of results.

Kryshtafovych A, Malhotra S, Monastyrskyy B, Cragnolini T, Joseph AP, Chiu W, Topf M.

Proteins. 2019 Dec;87(12):1128-1140. doi: 10.1002/prot.25817. Epub 2019 Oct 23.

PMID:
31576602
4.

Conserved Central Intraviral Protein Interactome of the Herpesviridae Family.

Hernández Durán A, Grünewald K, Topf M.

mSystems. 2019 Oct 1;4(5). pii: e00295-19. doi: 10.1128/mSystems.00295-19.

5.

Orbital outcomes after orbit-sparing surgery and free flap reconstruction.

Philips R, Topf MC, Graf A, Krein H, Heffelfinger R, Luginbuhl A, Curry J.

Oral Oncol. 2019 Nov;98:78-84. doi: 10.1016/j.oraloncology.2019.09.023. Epub 2019 Sep 25.

PMID:
31563040
6.

Does Insurance Status Impact Delivery of Care with Upper Airway Stimulation for OSA?

Patel J, Topf MC, Huntley C, Boon M.

Ann Otol Rhinol Laryngol. 2019 Sep 22:3489419878454. doi: 10.1177/0003489419878454. [Epub ahead of print]

PMID:
31544468
7.

Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans.

Demetriou C, Chanudet E; GOSgene, Joseph A, Topf M, Thomas AC, Bitner-Glindzicz M, Regan L, Stanier P, Moore GE.

Hum Mol Genet. 2019 Aug 22. pii: ddz203. doi: 10.1093/hmg/ddz203. [Epub ahead of print]

PMID:
31504499
8.

Risk factors for unplanned readmission in total laryngectomy patients.

Vimawala S, Topf MC, Savard C, Zhan T, Keane W, Luginbuhl A, Goldman R, Cognetti DM, Curry JM.

Laryngoscope. 2019 Aug 26. doi: 10.1002/lary.28255. [Epub ahead of print]

PMID:
31448822
9.

Target highlights in CASP13: Experimental target structures through the eyes of their authors.

Lepore R, Kryshtafovych A, Alahuhta M, Veraszto HA, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN Jr, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T.

Proteins. 2019 Dec;87(12):1037-1057. doi: 10.1002/prot.25805. Epub 2019 Sep 9.

PMID:
31442339
10.

Modelling structures in cryo-EM maps.

Malhotra S, Träger S, Dal Peraro M, Topf M.

Curr Opin Struct Biol. 2019 Oct;58:105-114. doi: 10.1016/j.sbi.2019.05.024. Epub 2019 Aug 5. Review.

PMID:
31394387
11.

Shift in the timing of microvascular free tissue transfer failures in head and neck reconstruction.

Sweeny L, Topf M, Wax MK, Rosenthal EL, Greene BJ, Heffelfinger R, Krein H, Luginbuhl A, Petrisor D, Troob SH, Hughley B, Hong S, Zhan T, Curry J.

Laryngoscope. 2019 Jul 9. doi: 10.1002/lary.28177. [Epub ahead of print]

PMID:
31287566
12.

Functional outcomes of temporomandibular joint reconstruction with vascularized tissue.

Hjelm N, Ortlip TE, Topf M, Luginbuhl A, Curry J, Krein H, Heffelfinger R.

Am J Otolaryngol. 2019 Sep - Oct;40(5):691-695. doi: 10.1016/j.amjoto.2019.06.004. Epub 2019 Jun 12.

PMID:
31227259
13.

Frequency and phenotypic spectrum of KMT2B dystonia in childhood: A single-center cohort study.

Carecchio M, Invernizzi F, Gonzàlez-Latapi P, Panteghini C, Zorzi G, Romito L, Leuzzi V, Galosi S, Reale C, Zibordi F, Joseph AP, Topf M, Piano C, Bentivoglio AR, Girotti F, Morana P, Morana B, Kurian MA, Garavaglia B, Mencacci NE, Lubbe SJ, Nardocci N.

Mov Disord. 2019 Jun 19. doi: 10.1002/mds.27771. [Epub ahead of print]

PMID:
31216378
14.

Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.

Hernández Durán A, Greco TM, Vollmer B, Cristea IM, Grünewald K, Topf M.

PLoS Biol. 2019 Jun 14;17(6):e3000316. doi: 10.1371/journal.pbio.3000316. eCollection 2019 Jun.

15.

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.

Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM.

Elife. 2019 Jun 4;8. pii: e41517. doi: 10.7554/eLife.41517.

16.

Pigmented Melanotic Schwannoma of the Neck: Report of 2 Cases and Review of the Literature.

Topf MC, Pham QH, D'Souza JN, Chaskes M, Tuluc M, Cognetti DM, Luginbuhl AJ.

Ear Nose Throat J. 2019 Feb;98(2):102-106. doi: 10.1177/0145561319826542. Epub 2019 Feb 13. Review.

PMID:
30884998
17.

In Reference to Should the Contralateral Tonsil Be Removed in Cases of HPV-Positive Squamous Cell Carcinoma of the Tonsil?

Cognetti D, Topf M, Roden D, Luginbuhl A, Curry J.

Laryngoscope. 2019 Jun;129(6):E194. doi: 10.1002/lary.27876. Epub 2019 Mar 5. No abstract available.

PMID:
30835832
18.

Loss of CD169+ Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Topf MC, Harshyne L, Tuluc M, Mardekian S, Vimawala S, Cognetti DM, Curry JM, Rodeck U, Luginbuhl A.

Otolaryngol Head Neck Surg. 2019 Jul;161(1):67-73. doi: 10.1177/0194599819829741. Epub 2019 Feb 12.

PMID:
30744470
19.

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.

Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D.

Nat Commun. 2018 Dec 14;9(1):5316. doi: 10.1038/s41467-018-07653-5.

20.

Mapping Aldehyde Dehydrogenase 1A1 Activity using an [18 F]Substrate-Based Approach.

Pereira R, Gendron T, Sanghera C, Greenwood HE, Newcombe J, McCormick PN, Sander K, Topf M, Årstad E, Witney TH.

Chemistry. 2019 Feb 11;25(9):2345-2351. doi: 10.1002/chem.201805473. Epub 2019 Jan 14.

21.

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.

Al-Olabi L, Polubothu S, Dowsett K, Andrews KA, Stadnik P, Joseph AP, Knox R, Pittman A, Clark G, Baird W, Bulstrode N, Glover M, Gordon K, Hargrave D, Huson SM, Jacques TS, James G, Kondolf H, Kangesu L, Keppler-Noreuil KM, Khan A, Lindhurst MJ, Lipson M, Mansour S, O'Hara J, Mahon C, Mosica A, Moss C, Murthy A, Ong J, Parker VE, Rivière JB, Sapp JC, Sebire NJ, Shah R, Sivakumar B, Thomas A, Virasami A, Waelchli R, Zeng Z, Biesecker LG, Barnacle A, Topf M, Semple RK, Patton EE, Kinsler VA.

J Clin Invest. 2018 Nov 1;128(11):5185. doi: 10.1172/JCI124649. Epub 2018 Nov 1. No abstract available.

22.

Comparing Upper Airway Stimulation to Transoral Robotic Base of Tongue Resection for Treatment of Obstructive Sleep Apnea.

Huntley C, Topf MC, Christopher V, Doghramji K, Curry J, Boon M.

Laryngoscope. 2019 Apr;129(4):1010-1013. doi: 10.1002/lary.27484. Epub 2018 Sep 12.

PMID:
30208214
23.

Association of Positive Initial Margins With Survival Among Patients With Squamous Cell Carcinoma Treated With Total Laryngectomy.

Tassone P, Savard C, Topf MC, Keane W, Luginbuhl A, Curry J, Cognetti D.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 1;144(11):1030-1036. doi: 10.1001/jamaoto.2018.1095.

24.

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor.

Smelt CLC, Sanders VR, Newcombe J, Burt RP, Sheppard TD, Topf M, Millar NS.

Neuropharmacology. 2018 Sep 1;139:194-204. doi: 10.1016/j.neuropharm.2018.07.009. Epub 2018 Jul 20.

25.

AJCC-8ed nodal staging does not predict outcomes in surgically managed HPV-associated oropharyngeal cancer.

Hobelmann KC, Topf MC, Bar-Ad V, Luginbuhl AJ, Keane WM, Curry JM, Cognetti DM.

Oral Oncol. 2018 Jul;82:138-143. doi: 10.1016/j.oraloncology.2018.05.016. Epub 2018 May 28.

PMID:
29909888
26.

Modeling Protein Complexes Using Restraints from Crosslinking Mass Spectrometry.

Bullock JMA, Sen N, Thalassinos K, Topf M.

Structure. 2018 Jul 3;26(7):1015-1024.e2. doi: 10.1016/j.str.2018.04.016. Epub 2018 May 24.

27.

Jwalk and MNXL web server: model validation using restraints from crosslinking mass spectrometry.

Bullock JMA, Thalassinos K, Topf M.

Bioinformatics. 2018 Oct 15;34(20):3584-3585. doi: 10.1093/bioinformatics/bty366.

28.

TERT, HRAS, and EIF1AX Mutations in a Patient with Follicular Adenoma.

Topf MC, Wang ZX, Tuluc M, Pribitkin EA.

Thyroid. 2018 Jun;28(6):815-817. doi: 10.1089/thy.2017.0504. Epub 2018 May 18.

PMID:
29669480
29.

Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.

Fedele L, Newcombe J, Topf M, Gibb A, Harvey RJ, Smart TG.

Nat Commun. 2018 Mar 6;9(1):957. doi: 10.1038/s41467-018-02927-4.

30.

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.

Al-Olabi L, Polubothu S, Dowsett K, Andrews KA, Stadnik P, Joseph AP, Knox R, Pittman A, Clark G, Baird W, Bulstrode N, Glover M, Gordon K, Hargrave D, Huson SM, Jacques TS, James G, Kondolf H, Kangesu L, Keppler-Noreuil KM, Khan A, Lindhurst MJ, Lipson M, Mansour S, O'Hara J, Mahon C, Mosica A, Moss C, Murthy A, Ong J, Parker VE, Rivière JB, Sapp JC, Sebire NJ, Shah R, Sivakumar B, Thomas A, Virasami A, Waelchli R, Zeng Z, Biesecker LG, Barnacle A, Topf M, Semple RK, Patton EE, Kinsler VA.

J Clin Invest. 2018 Apr 2;128(4):1496-1508. doi: 10.1172/JCI98589. Epub 2018 Mar 12. Erratum in: J Clin Invest. 2018 Nov 1;128(11):5185.

31.
32.

Unplanned readmission following transoral robotic surgery.

Topf MC, Vo A, Tassone P, Shumrick C, Luginbuhl A, Cognetti DM, Curry JM.

Oral Oncol. 2017 Dec;75:127-132. doi: 10.1016/j.oraloncology.2017.11.009. Epub 2017 Nov 11.

PMID:
29224809
33.

Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.

McTague A, Nair U, Malhotra S, Meyer E, Trump N, Gazina EV, Papandreou A, Ngoh A, Ackermann S, Ambegaonkar G, Appleton R, Desurkar A, Eltze C, Kneen R, Kumar AV, Lascelles K, Montgomery T, Ramesh V, Samanta R, Scott RH, Tan J, Whitehouse W, Poduri A, Scheffer IE, Chong WKK, Cross JH, Topf M, Petrou S, Kurian MA.

Neurology. 2018 Jan 2;90(1):e55-e66. doi: 10.1212/WNL.0000000000004762. Epub 2017 Dec 1.

34.

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.

Newcombe J, Chatzidaki A, Sheppard TD, Topf M, Millar NS.

Mol Pharmacol. 2018 Feb;93(2):128-140. doi: 10.1124/mol.117.110551. Epub 2017 Dec 1.

35.

First bite syndrome following transcervical arterial ligation after transoral robotic surgery.

Topf MC, Moritz E, Gleysteen J, Curry JM, Cognetti DM, Luginbuhl AJ.

Laryngoscope. 2018 Jul;128(7):1589-1593. doi: 10.1002/lary.27005. Epub 2017 Nov 20.

PMID:
29152739
36.

Structural basis of human kinesin-8 function and inhibition.

Locke J, Joseph AP, Peña A, Möckel MM, Mayer TU, Topf M, Moores CA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548. doi: 10.1073/pnas.1712169114. Epub 2017 Oct 23.

37.

A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.

Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A.

Nat Struct Mol Biol. 2017 Nov;24(11):931-943. doi: 10.1038/nsmb.3483. Epub 2017 Oct 9.

38.

EIF1AX Mutation in a Patient with Hürthle Cell Carcinoma.

Topf MC, Wang ZX, Furlong K, Miller JL, Tuluc M, Pribitkin EA.

Endocr Pathol. 2018 Mar;29(1):27-29. doi: 10.1007/s12022-017-9501-8.

PMID:
28965201
39.

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.

Wright ZVF, McCarthy S, Dickman R, Reyes FE, Sanchez-Martinez S, Cryar A, Kilford I, Hall A, Takle AK, Topf M, Gonen T, Thalassinos K, Tabor AB.

J Am Chem Soc. 2017 Sep 20;139(37):13063-13075. doi: 10.1021/jacs.7b06506. Epub 2017 Sep 7.

40.

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.

Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA.

Elife. 2017 Aug 11;6. pii: e27793. doi: 10.7554/eLife.27793.

41.

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Deville C, Carroni M, Franke KB, Topf M, Bukau B, Mogk A, Saibil HR.

Sci Adv. 2017 Aug 4;3(8):e1701726. doi: 10.1126/sciadv.1701726. eCollection 2017 Aug.

42.

Integrative modelling of cellular assemblies.

Joseph AP, Polles G, Alber F, Topf M.

Curr Opin Struct Biol. 2017 Oct;46:102-109. doi: 10.1016/j.sbi.2017.07.001. Epub 2017 Jul 20. Review.

43.

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease.

Schaefer N, Berger A, van Brederode J, Zheng F, Zhang Y, Leacock S, Littau L, Jablonka S, Malhotra S, Topf M, Winter F, Davydova D, Lynch JW, Paige CJ, Alzheimer C, Harvey RJ, Villmann C.

J Neurosci. 2017 Aug 16;37(33):7948-7961. doi: 10.1523/JNEUROSCI.0009-17.2017. Epub 2017 Jul 19.

44.

Macrophage type 2 differentiation in a patient with laryngeal squamous cell carcinoma and metastatic prostate adenocarcinoma to the cervical lymph nodes.

Topf MC, Tuluc M, Harshyne LA, Luginbuhl A.

J Immunother Cancer. 2017 Jul 18;5(1):60. doi: 10.1186/s40425-017-0264-z.

45.

Safety and efficacy of functional laryngectomy for end-stage dysphagia.

Topf MC, Magaña LC, Salmon K, Hamilton J, Keane WM, Luginbuhl A, Curry JM, Cognetti DM, Boon M, Spiegel JR.

Laryngoscope. 2018 Mar;128(3):597-602. doi: 10.1002/lary.26760. Epub 2017 Jul 17.

PMID:
28714539
46.

Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy.

Joseph AP, Lagerstedt I, Patwardhan A, Topf M, Winn M.

J Struct Biol. 2017 Jul;199(1):12-26. doi: 10.1016/j.jsb.2017.05.007. Epub 2017 May 25.

47.

Corrigendum: Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Meyer E, Carss KJ, Rankin J, Nichols JME, Grozeva D, Joseph AP, Mencacci NE, Papandreou A, Ng J, Barral S, Ngoh A, Ben-Pazi H, Willemsen MA, Arkadir D, Barnicoat A, Bergman H, Bhate S, Boys A, Darin N, Foulds N, Gutowski N, Hills A, Houlden H, Hurst JA, Israel Z, Kaminska M, Limousin P, Lumsden D, McKee S, Misra S, Mohammed SS, Nakou V, Nicolai J, Nilsson M, Pall H, Peall KJ, Peters GB, Prabhakar P, Reuter MS, Rump P, Segel R, Sinnema M, Smith M, Turnpenny P, White SM, Wieczorek D, Wiethoff S, Wilson BT, Winter G, Wragg C, Pope S, Heales SJH, Morrogh D; UK10K Consortium; Deciphering Developmental Disorders Study; NIHR BioResource Rare Diseases Consortium, Pittman A, Carr LJ, Perez-Dueñas B, Lin JP, Reis A, Gahl WA, Toro C, Bhatia KP, Wood NW, Kamsteeg EJ, Chong WK, Gissen P, Topf M, Dale RC, Chubb JR, Raymond FL, Kurian MA.

Nat Genet. 2017 May 26;49(6):969. doi: 10.1038/ng0617-969b. No abstract available.

PMID:
28546572
48.

In response to stomal maturation does not increase the rate of tracheocutaneous fistulas.

Levi JR, Topf MC, Mostovych NK, Yoo E, Barth P, Shah UK.

Laryngoscope. 2017 Sep;127(9):E331. doi: 10.1002/lary.26584. Epub 2017 Apr 20. No abstract available.

PMID:
28429497
49.

Geographic variation and within-individual correlations of physiological stress markers in a widespread reptile, the common garter snake (Thamnophis sirtalis).

Gangloff EJ, Sparkman AM, Holden KG, Corwin CJ, Topf M, Bronikowski AM.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Mar;205:68-76. doi: 10.1016/j.cbpa.2016.12.019. Epub 2016 Dec 21.

PMID:
28011409
50.

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Meyer E, Carss KJ, Rankin J, Nichols JM, Grozeva D, Joseph AP, Mencacci NE, Papandreou A, Ng J, Barral S, Ngoh A, Ben-Pazi H, Willemsen MA, Arkadir D, Barnicoat A, Bergman H, Bhate S, Boys A, Darin N, Foulds N, Gutowski N, Hills A, Houlden H, Hurst JA, Israel Z, Kaminska M, Limousin P, Lumsden D, McKee S, Misra S, Mohammed SS, Nakou V, Nicolai J, Nilsson M, Pall H, Peall KJ, Peters GB, Prabhakar P, Reuter MS, Rump P, Segel R, Sinnema M, Smith M, Turnpenny P, White SM, Wieczorek D, Wiethoff S, Wilson BT, Winter G, Wragg C, Pope S, Heales SJ, Morrogh D; UK10K Consortium; Deciphering Developmental Disorders Study; NIHR BioResource Rare Diseases Consortium, Pittman A, Carr LJ, Perez-Dueñas B, Lin JP, Reis A, Gahl WA, Toro C, Bhatia KP, Wood NW, Kamsteeg EJ, Chong WK, Gissen P, Topf M, Dale RC, Chubb JR, Raymond FL, Kurian MA.

Nat Genet. 2017 Feb;49(2):223-237. doi: 10.1038/ng.3740. Epub 2016 Dec 19. Erratum in: Nat Genet. 2017 May 26;49(6):969.

PMID:
27992417

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