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Items: 1 to 50 of 79

1.

Peering through zebrafish to understand inherited bone marrow failure syndromes.

Oyarbide U, Topczewski J, Corey SJ.

Haematologica. 2019 Jan;104(1):13-24. doi: 10.3324/haematol.2018.196105. Epub 2018 Dec 20. Review.

2.

"It's a (Kinetic) Trap!" - Selectively Differentiating Allylic Azide Isomers.

Topczewski JJ, Porter MR.

Synlett. 2018 Jul;29(12):1537-1542. doi: 10.1055/s-0037-1609479.

PMID:
30505072
3.

Catalytic Racemization of Activated Organic Azides.

Ott AA, Topczewski JJ.

Org Lett. 2018 Nov 16;20(22):7253-7256. doi: 10.1021/acs.orglett.8b03168. Epub 2018 Nov 5.

PMID:
30394752
4.

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.

Divakaran A, Talluri SK, Ayoub AM, Mishra NK, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schonbrunn EK, Harki DA, Pomerantz WCK.

J Med Chem. 2018 Oct 25;61(20):9316-9334. doi: 10.1021/acs.jmedchem.8b01248. Epub 2018 Oct 16.

5.

Palladium-catalyzed salt-free double decarboxylative aryl allylation.

Daley RA, Topczewski JJ.

Org Biomol Chem. 2018 Aug 23. doi: 10.1039/c8ob01806e. [Epub ahead of print]

PMID:
30137100
6.

Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition.

Hu B, Gao Y, Davies L, Woo S, Topczewski J, Jessen JR, Lin F.

Development. 2018 Aug 28;145(17). pii: dev163303. doi: 10.1242/dev.163303.

PMID:
30082271
7.

Evidence for a Sigmatropic and an Ionic Pathway in the Winstein Rearrangement.

Ott AA, Packard MH, Ortuño MA, Johnson A, Suding VP, Cramer CJ, Topczewski JJ.

J Org Chem. 2018 Aug 3;83(15):8214-8224. doi: 10.1021/acs.joc.8b00961. Epub 2018 Jun 14.

PMID:
29870252
8.

Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development.

Pogoda HM, Riedl-Quinkertz I, Löhr H, Waxman JS, Dale RM, Topczewski J, Schulte-Merker S, Hammerschmidt M.

Development. 2018 May 8;145(9). pii: dev159418. doi: 10.1242/dev.159418.

9.

Regiocontrolled Wacker Oxidation of Cinnamyl Azides.

Carlson AS, Calcanas C, Brunner RM, Topczewski JJ.

Org Lett. 2018 Mar 16;20(6):1604-1607. doi: 10.1021/acs.orglett.8b00344. Epub 2018 Mar 2.

PMID:
29498865
10.

Stereoselective Dynamic Cyclization of Allylic Azides: Synthesis of Tetralins, Chromanes, and Tetrahydroquinolines.

Porter MR, Shaker RM, Calcanas C, Topczewski JJ.

J Am Chem Soc. 2018 Jan 31;140(4):1211-1214. doi: 10.1021/jacs.7b11299. Epub 2018 Jan 10.

PMID:
29303567
11.

Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).

Kell MJ, Riccio RE, Baumgartner EA, Compton ZJ, Pecorin PJ, Mitchell TA, Topczewski J, LeClair EE.

PLoS One. 2018 Jan 2;13(1):e0190353. doi: 10.1371/journal.pone.0190353. eCollection 2018.

12.

Why is Aged Acetylcholinesterase So Difficult to Reactivate?

Quinn DM, Topczewski J, Yasapala N, Lodge A.

Molecules. 2017 Sep 4;22(9). pii: E1464. doi: 10.3390/molecules22091464. Review.

13.

Dynamic Kinetic Resolution of Allylic Azides via Asymmetric Dihydroxylation.

Ott AA, Goshey CS, Topczewski JJ.

J Am Chem Soc. 2017 Jun 14;139(23):7737-7740. doi: 10.1021/jacs.7b04203. Epub 2017 Jun 5.

PMID:
28574252
14.

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.

Sredni ST, Suzuki M, Yang JP, Topczewski J, Bailey AW, Gokirmak T, Gross JN, de Andrade A, Kondo A, Piper DR, Tomita T.

Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26551. Epub 2017 Apr 11.

PMID:
28398638
15.

Multi-Shell Nano-CarboScavengers for Petroleum Spill Remediation.

Daza EA, Misra SK, Scott J, Tripathi I, Promisel C, Sharma BK, Topczewski J, Chaudhuri S, Pan D.

Sci Rep. 2017 Feb 3;7:41880. doi: 10.1038/srep41880.

16.

Palladium-catalysed transannular C-H functionalization of alicyclic amines.

Topczewski JJ, Cabrera PJ, Saper NI, Sanford MS.

Nature. 2016 Mar 10;531(7593):220-224. doi: 10.1038/nature16957. Epub 2016 Feb 17.

17.

A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.

Sisson BE, Dale RM, Mui SR, Topczewska JM, Topczewski J.

Mech Dev. 2015 Nov;138 Pt 3:279-90. doi: 10.1016/j.mod.2015.10.001. Epub 2015 Oct 14.

18.

Development of quantitative structure activity relationships for the binding affinity of methoxypyridinium cations for human acetylcholinesterase.

Morrill JA, Topczewski JJ, Lodge AM, Yasapala N, Quinn DM.

J Mol Graph Model. 2015 Nov;62:181-189. doi: 10.1016/j.jmgm.2015.09.016. Epub 2015 Sep 30.

PMID:
26454505
19.

Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.

Cvjetkovic N, Maili L, Weymouth KS, Hashmi SS, Mulliken JB, Topczewski J, Letra A, Yuan Q, Blanton SH, Swindell EC, Hecht JT.

Mol Genet Genomic Med. 2015 Sep;3(5):440-51. doi: 10.1002/mgg3.155. Epub 2015 May 7.

20.

Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates.

Zhang Q, Stockdale DP, Mixdorf JC, Topczewski JJ, Nguyen HM.

J Am Chem Soc. 2015 Sep 23;137(37):11912-5. doi: 10.1021/jacs.5b07492. Epub 2015 Sep 10.

PMID:
26348569
21.

Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.

Miller N, Feng Z, Edens BM, Yang B, Shi H, Sze CC, Hong BT, Su SC, Cantu JA, Topczewski J, Crawford TO, Ko CP, Sumner CJ, Ma L, Ma YC.

J Neurosci. 2015 Apr 15;35(15):6038-50. doi: 10.1523/JNEUROSCI.3716-14.2015.

22.

Comparison of different numerical treatments for x-ray phase tomography of soft tissue from differential phase projections.

Pelliccia D, Vaz R, Svalbe I, Morgan KS, Marathe S, Xiao X, Assoufid L, Anderson RA, Topczewski J, Bryson-Richardson RJ.

Phys Med Biol. 2015 Apr 21;60(8):3065-80. doi: 10.1088/0031-9155/60/8/3065. Epub 2015 Mar 24.

PMID:
25802946
23.
24.

Late-stage [18F]Fluorination: New Solutions to Old Problems.

Brooks AF, Topczewski JJ, Ichiishi N, Sanford MS, Scott PJ.

Chem Sci. 2014 Dec 1;5(12):4545-4553.

25.

Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts.

Ichiishi N, Brooks AF, Topczewski JJ, Rodnick ME, Sanford MS, Scott PJ.

Org Lett. 2014 Jun 20;16(12):3224-7. doi: 10.1021/ol501243g. Epub 2014 Jun 3.

26.

Electrophilic aromatic prenylation via cascade cyclization.

Kodet JG, Topczewski JJ, Gardner KD, Wiemer DF.

Tetrahedron. 2013 Oct 4;69(44):9212-9218.

27.

Abstract 76: Modeling Craniosynostosis in Zebrafish using the Genome Editing Technique CRISPR.

Favelevic T, Anderson R, Topczewski J, Gosain AK, Topczewska JM.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):87. doi: 10.1097/01.prs.0000445109.46997.1e. No abstract available.

PMID:
25942187
28.

Abstract 74: characterization of the koliber mutant: a new model for craniosynostosis research.

Gee YY, Shoela RA, Anderson R, Topczewski J, Gosain A, Topczewska JM.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):85-6. doi: 10.1097/01.prs.0000445107.08879.69. No abstract available.

PMID:
25942185
29.

Abstract 52: mutating fibroblast growth factor receptor 1 (fgfr1) in zebrafish to create a new model of craniosynostosis.

Tomaszewski JP, Gart MS, Shoela RA, Topczewski J, Topczewska JM, Gosain AK.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):63-4. doi: 10.1097/01.prs.0000445085.30857.ca. No abstract available.

PMID:
25942163
30.

Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.

Gray RS, Wilm TP, Smith J, Bagnat M, Dale RM, Topczewski J, Johnson SL, Solnica-Krezel L.

Dev Biol. 2014 Feb 1;386(1):72-85. doi: 10.1016/j.ydbio.2013.11.028. Epub 2013 Dec 11.

31.

Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.

Topczewski JJ, Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5786-9. doi: 10.1016/j.bmcl.2013.09.008. Epub 2013 Sep 8.

PMID:
24076173
32.

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene.

Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT.

Development. 2013 Nov;140(21):4362-74. doi: 10.1242/dev.098061. Epub 2013 Sep 25.

33.

Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents.

Topczewski JJ, Quinn DM.

Org Lett. 2013 Mar 1;15(5):1084-7. doi: 10.1021/ol400054m. Epub 2013 Feb 14.

34.

Notum homolog plays a novel role in primary motor innervation.

Cantu JA, Flowers GP, Topczewski J.

J Neurosci. 2013 Jan 30;33(5):2177-87. doi: 10.1523/JNEUROSCI.3694-12.2013.

35.

Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration.

Duszynski RJ, Topczewski J, LeClair EE.

Dev Growth Differ. 2013 Feb;55(2):282-300. doi: 10.1111/dgd.12035. Epub 2013 Jan 28.

36.

A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway.

Flowers GP, Topczewska JM, Topczewski J.

Development. 2012 Jul;139(13):2416-25. doi: 10.1242/dev.063206.

37.

Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration.

Moore AC, Mark TE, Hogan AK, Topczewski J, LeClair EE.

J Comp Neurol. 2012 Dec 15;520(18):4184-203. doi: 10.1002/cne.23147.

38.

miR-27b controls venous specification and tip cell fate.

Biyashev D, Veliceasa D, Topczewski J, Topczewska JM, Mizgirev I, Vinokour E, Reddi AL, Licht JD, Revskoy SY, Volpert OV.

Blood. 2012 Mar 15;119(11):2679-87. doi: 10.1182/blood-2011-07-370635. Epub 2011 Dec 29.

39.

Planar cell polarity signaling in craniofacial development.

Topczewski J, Dale RM, Sisson BE.

Organogenesis. 2011 Oct-Dec;7(4):255-9. doi: 10.4161/org.7.4.18797. Epub 2011 Oct 1. Review.

40.

Iridium-catalyzed allylic fluorination of trichloroacetimidates.

Topczewski JJ, Tewson TJ, Nguyen HM.

J Am Chem Soc. 2011 Dec 7;133(48):19318-21. doi: 10.1021/ja2087213. Epub 2011 Nov 11.

PMID:
22059470
41.

Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

Topczewski JJ, Callahan MP, Kodet JG, Inbarasu JD, Mente NR, Beutler JA, Wiemer DF.

Bioorg Med Chem. 2011 Dec 15;19(24):7570-81. doi: 10.1016/j.bmc.2011.10.034. Epub 2011 Oct 19.

42.

First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.

Topczewski JJ, Wiemer DF.

Tetrahedron Lett. 2011 Apr 6;52(14):1628-1630.

43.

Simple, economical heat-shock devices for zebrafish housing racks.

Duszynski RJ, Topczewski J, LeClair EE.

Zebrafish. 2011 Dec;8(4):211-9. doi: 10.1089/zeb.2011.0693. Epub 2011 Sep 13.

44.

Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene.

Dale RM, Topczewski J.

Dev Biol. 2011 Sep 15;357(2):518-31. doi: 10.1016/j.ydbio.2011.06.020. Epub 2011 Jun 25.

45.

Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.

Topczewski JJ, Kodet JG, Wiemer DF.

J Org Chem. 2011 Feb 4;76(3):909-19. doi: 10.1021/jo1022102. Epub 2011 Jan 12.

46.

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity.

Topczewski JJ, Kuder CH, Neighbors JD, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Sep 15;18(18):6734-41. doi: 10.1016/j.bmc.2010.07.056. Epub 2010 Jul 29.

47.

Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis.

Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW.

PLoS One. 2010 Apr 28;5(4):e10367. doi: 10.1371/journal.pone.0010367.

48.

Development and regeneration of the zebrafish maxillary barbel: a novel study system for vertebrate tissue growth and repair.

LeClair EE, Topczewski J.

PLoS One. 2010 Jan 15;5(1):e8737. doi: 10.1371/journal.pone.0008737.

49.

Methods for the study of the zebrafish maxillary barbel.

LeClair EE, Topczewski J.

J Vis Exp. 2009 Nov 23;(33). pii: 1558. doi: 10.3791/1558.

50.

Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.

Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon HG.

Dev Biol. 2010 Jan 15;337(2):233-45. doi: 10.1016/j.ydbio.2009.10.039. Epub 2009 Nov 3.

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