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Items: 27

1.

Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Stephenson S, Care MA, Fan I, Zougman A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2019 Feb 15;202(4):1287-1300. doi: 10.4049/jimmunol.1801407. Epub 2019 Jan 14.

2.

Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.

Al-Maskari M, Care MA, Robinson E, Cocco M, Tooze RM, Doody GM.

Sci Rep. 2018 Sep 25;8(1):14338. doi: 10.1038/s41598-018-32705-7.

3.

Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia.

Varghese AM, Rawstron A, Newton D, Tooze RM, Munir T, Dickson M, Doody GM, Hillmen P.

Br J Haematol. 2018 Sep;182(6):927-930. doi: 10.1111/bjh.14884. Epub 2017 Aug 2. No abstract available.

PMID:
28770560
4.

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.

Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V.

J Immunol. 2017 Aug 15;199(4):1250-1260. doi: 10.4049/jimmunol.1600941. Epub 2017 Jul 12.

5.

Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition.

Arumugakani G, Stephenson SJ, Newton DJ, Rawstron A, Emery P, Doody GM, McGonagle D, Tooze RM.

J Immunol. 2017 Jun 15;198(12):4618-4628. doi: 10.4049/jimmunol.1501761. Epub 2017 May 10.

6.

TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism.

New M, Sheikh S, Bekheet M, Olzscha H, Thezenas ML, Care MA, Fotheringham S, Tooze RM, Kessler B, La Thangue NB.

Cancer Res. 2016 Dec 1;76(23):6975-6987. Epub 2016 Oct 12.

7.

Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.

Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM.

J Immunol. 2016 Aug 15;197(4):1447-59. doi: 10.4049/jimmunol.1600624. Epub 2016 Jun 29.

8.

An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases.

Worrillow L, Baskaran P, Care MA, Varghese A, Munir T, Evans PA, O'Connor SJ, Rawstron A, Hazelwood L, Tooze RM, Hillmen P, Newton DJ.

Oncogene. 2016 Oct 6;35(40):5328-5336. doi: 10.1038/onc.2016.73. Epub 2016 Apr 4.

9.

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.

Kreuz S, Holmes KB, Tooze RM, Lefevre PF.

Mol Cancer. 2015 Dec 8;14:205. doi: 10.1186/s12943-015-0477-z.

10.
11.

Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas.

Sha C, Barrans S, Care MA, Cunningham D, Tooze RM, Jack A, Westhead DR.

Genome Med. 2015 Jul 1;7(1):64. doi: 10.1186/s13073-015-0187-6. eCollection 2015.

12.

Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans.

Vieira Braga FA, Hertoghs KM, Kragten NA, Doody GM, Barnes NA, Remmerswaal EB, Hsiao CC, Moerland PD, Wouters D, Derks IA, van Stijn A, Demkes M, Hamann J, Eldering E, Nolte MA, Tooze RM, ten Berge IJ, van Gisbergen KP, van Lier RA.

Eur J Immunol. 2015 Oct;45(10):2945-58. doi: 10.1002/eji.201545650. Epub 2015 Sep 7.

13.

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chan FC, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, Möller P, Wirth T, Ushmorov A.

Blood. 2014 Nov 13;124(20):3118-29. doi: 10.1182/blood-2014-07-590570. Epub 2014 Sep 17.

14.

SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Care MA, Cocco M, Laye JP, Barnes N, Huang Y, Wang M, Barrans S, Du M, Jack A, Westhead DR, Doody GM, Tooze RM.

Nucleic Acids Res. 2014 Jul;42(12):7591-610. doi: 10.1093/nar/gku451. Epub 2014 May 29.

15.

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes.

Savic S, Ouboussad L, Dickie LJ, Geiler J, Wong C, Doody GM, Churchman SM, Ponchel F, Emery P, Cook GP, Buch MH, Tooze RM, McDermott MF.

J Autoimmun. 2014 May;50:59-66. doi: 10.1016/j.jaut.2013.11.002. Epub 2013 Dec 31.

16.

A replicative self-renewal model for long-lived plasma cells: questioning irreversible cell cycle exit.

Tooze RM.

Front Immunol. 2013 Dec 18;4:460. doi: 10.3389/fimmu.2013.00460. Review.

17.

A microarray platform-independent classification tool for cell of origin class allows comparative analysis of gene expression in diffuse large B-cell lymphoma.

Care MA, Barrans S, Worrillow L, Jack A, Westhead DR, Tooze RM.

PLoS One. 2013;8(2):e55895. doi: 10.1371/journal.pone.0055895. Epub 2013 Feb 12.

18.

In vitro generation of long-lived human plasma cells.

Cocco M, Stephenson S, Care MA, Newton D, Barnes NA, Davison A, Rawstron A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2012 Dec 15;189(12):5773-85. doi: 10.4049/jimmunol.1103720. Epub 2012 Nov 16.

19.

BLIMP-1 and STAT3 counterregulate microRNA-21 during plasma cell differentiation.

Barnes NA, Stephenson S, Cocco M, Tooze RM, Doody GM.

J Immunol. 2012 Jul 1;189(1):253-60. doi: 10.4049/jimmunol.1101563. Epub 2012 May 25.

20.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C.

Leukemia. 2012 Aug;26(8):1829-41. doi: 10.1038/leu.2012.49. Epub 2012 Feb 20.

21.

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.

Mduff FK, Hook CE, Tooze RM, Huntly BJ, Pandolfi PP, Turner SD.

Lab Invest. 2011 Sep;91(9):1298-303. doi: 10.1038/labinvest.2011.96. Epub 2011 Jun 27.

22.

An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression.

Doody GM, Care MA, Burgoyne NJ, Bradford JR, Bota M, Bonifer C, Westhead DR, Tooze RM.

Nucleic Acids Res. 2010 Sep;38(16):5336-50. doi: 10.1093/nar/gkq268. Epub 2010 Apr 26.

23.

Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase.

Barnes NA, Stephenson SJ, Tooze RM, Doody GM.

J Immunol. 2009 Nov 1;183(9):5768-77. doi: 10.4049/jimmunol.0803480. Epub 2009 Oct 14.

24.

PRDM1/BLIMP-1 modulates IFN-gamma-dependent control of the MHC class I antigen-processing and peptide-loading pathway.

Doody GM, Stephenson S, McManamy C, Tooze RM.

J Immunol. 2007 Dec 1;179(11):7614-23.

25.
26.

BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response.

Doody GM, Stephenson S, Tooze RM.

Eur J Immunol. 2006 Jun;36(6):1572-82.

27.

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