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Items: 1 to 50 of 233

1.

Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.

Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I.

J Alzheimers Dis. 2019;72(1):229-246. doi: 10.3233/JAD-181171.

PMID:
31594216
2.

Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin.

Walker DG, Lue LF, Beach TG, Tooyama I.

Cells. 2019 Jul 23;8(7). pii: E766. doi: 10.3390/cells8070766.

3.

Transcriptome analysis revealed bisphenol A and nonylphenol affect reproduction.

Tanaka T, Ono Y, Hikihara N, Yoshida A, Yamada H, Higaki S, Nishie T, Tooyama I, Iida K, Hirasawa A, Takada T.

Reprod Toxicol. 2019 Sep;88:39-47. doi: 10.1016/j.reprotox.2019.06.006. Epub 2019 Jul 6.

PMID:
31288075
4.

Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated with Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study.

Fujiyoshi A, Miura K, Ohkubo T, Miyagawa N, Saito Y, Miyazawa I, Shiino A, Kadota A, Kadowaki S, Hisamatsu T, Torii S, Takashima N, Tooyama I, Ueshima H.

J Epidemiol. 2019 May 25. doi: 10.2188/jea.JE20180258. [Epub ahead of print]

5.

Elevated fasting blood glucose levels are associated with lower cognitive function, with a threshold in non-diabetic individuals: a population-based study.

Liu Z, Zaid M, Hisamatsu T, Tanaka S, Fujiyoshi A, Miyagawa N, Ito T, Kadota A, Tooyama I, Miura K, Ueshima H.

J Epidemiol. 2019 May 25. doi: 10.2188/jea.JE20180193. [Epub ahead of print]

6.

Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men.

Liu Y, Fujiyoshi A, Arima H, Kadota A, Kadowaki S, Hisamatsu T, Miyazawa I, Kondo K, Tooyama I, Miura K, Ueshima H; SESSA Research Group.

J Atheroscler Thromb. 2019 May 15. doi: 10.5551/jat.47977. [Epub ahead of print]

7.

A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon.

Bellier JP, Yuan PQ, Mukaisho K, Tooyama I, Taché Y, Kimura H.

Front Neuroanat. 2019 Apr 16;13:37. doi: 10.3389/fnana.2019.00037. eCollection 2019.

8.

The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence.

Tano A, Kadota Y, Morimune T, Jam FA, Yukiue H, Bellier JP, Sokoda T, Maruo Y, Tooyama I, Mori M.

J Cell Sci. 2019 Apr 16;132(8). pii: jcs227801. doi: 10.1242/jcs.227801.

9.

Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases.

Mendsaikhan A, Tooyama I, Walker DG.

Cells. 2019 Mar 11;8(3). pii: E230. doi: 10.3390/cells8030230. Review.

10.

Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin.

Mendsaikhan A, Takeuchi S, Walker DG, Tooyama I.

Front Mol Neurosci. 2019 Jan 8;11:470. doi: 10.3389/fnmol.2018.00470. eCollection 2018.

11.

Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5.

Yanagisawa D, Hamezah HS, Durani LW, Taguchi H, Tooyama I.

PLoS One. 2018 Dec 6;13(12):e0208440. doi: 10.1371/journal.pone.0208440. eCollection 2018.

12.

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model.

Wan Nasri WN, Makpol S, Mazlan M, Tooyama I, Wan Ngah WZ, Damanhuri HA.

J Alzheimers Dis. 2019;70(s1):S239-S254. doi: 10.3233/JAD-180496.

13.
14.

Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat.

Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Bellier JP, Makpol S, Ngah WZW, Damanhuri HA, Tooyama I.

Exp Gerontol. 2018 Oct 1;111:53-64. doi: 10.1016/j.exger.2018.07.002. Epub 2018 Jul 5.

15.

Establishment of a cell model of X-linked sideroblastic anemia using genome editing.

Kaneko K, Kubota Y, Nomura K, Hayashimoto H, Chida T, Yoshino N, Wayama M, Ogasawara K, Nakamura Y, Tooyama I, Furuyama K.

Exp Hematol. 2018 Sep;65:57-68.e2. doi: 10.1016/j.exphem.2018.06.002. Epub 2018 Jun 13.

PMID:
29908199
16.

Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice.

Durani LW, Hamezah HS, Ibrahim NF, Yanagisawa D, Nasaruddin ML, Mori M, Azizan KA, Damanhuri HA, Makpol S, Wan Ngah WZ, Tooyama I.

J Alzheimers Dis. 2018;64(1):249-267. doi: 10.3233/JAD-170880.

17.

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.

Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M.

Sci Rep. 2018 Apr 16;8(1):6030. doi: 10.1038/s41598-018-24463-3.

18.

Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau.

Liu Z, Kameshima N, Nanjo T, Shiino A, Kato T, Shimizu S, Shimizu T, Tanaka S, Miura K, Tooyama I.

J Alzheimers Dis. 2018;62(2):737-744. doi: 10.3233/JAD-170962.

19.

Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes.

Jam FA, Kadota Y, Mendsaikhan A, Tooyama I, Mori M.

Sci Rep. 2018 Feb 15;8(1):3132. doi: 10.1038/s41598-018-21445-3.

20.

Cryopreservation of male and female gonial cells by vitrification in the critically endangered cyprinid honmoroko Gnathopogon caerulescens.

Higaki S, Todo T, Teshima R, Tooyama I, Fujioka Y, Sakai N, Takada T.

Fish Physiol Biochem. 2018 Apr;44(2):503-513. doi: 10.1007/s10695-017-0449-x. Epub 2017 Nov 30.

PMID:
29192358
21.

Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice.

Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Sogabe T, Tooyama I.

J Neurosci Res. 2018 May;96(5):841-851. doi: 10.1002/jnr.24188. Epub 2017 Oct 24.

PMID:
29063641
22.

Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum.

Durani LW, Hamezah HS, Ibrahim NF, Yanagisawa D, Makpol S, Damanhuri HA, Tooyama I.

Biochem Biophys Res Commun. 2017 Nov 25;493(3):1356-1363. doi: 10.1016/j.bbrc.2017.09.164. Epub 2017 Sep 29.

23.

Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions.

Hamezah HS, Durani LW, Ibrahim NF, Yanagisawa D, Kato T, Shiino A, Tanaka S, Damanhuri HA, Ngah WZW, Tooyama I.

Exp Gerontol. 2017 Dec 1;99:69-79. doi: 10.1016/j.exger.2017.09.008. Epub 2017 Sep 14.

24.

Successful vitrification of whole juvenile testis in the critically endangered cyprinid honmoroko (Gnathopogon caerulescens).

Higaki S, Kuwata N, Tanaka K, Tooyama I, Fujioka Y, Sakai N, Takada T.

Zygote. 2017 Oct;25(5):652-661. doi: 10.1017/S0967199417000430. Epub 2017 Aug 24.

PMID:
28835302
25.

Characterization of a Novel Monoclonal Antibody against Human Mitochondrial Ferritin and Its Immunohistochemical Application in Human and Monkey Substantia Nigra.

Yang M, Yang H, Guan H, Kato T, Mukaisho K, Sugihara H, Ogasawara K, Terada T, Tooyama I.

Acta Histochem Cytochem. 2017 Feb 28;50(1):49-55. doi: 10.1267/ahc.16034. Epub 2017 Feb 23.

26.

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.

Bellier JP, Xie Y, Farouk SM, Sakaue Y, Tooyama I, Kimura H.

Brain Struct Funct. 2017 Sep;222(7):3043-3061. doi: 10.1007/s00429-017-1385-3. Epub 2017 Feb 28.

PMID:
28247020
27.

In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens).

Higaki S, Shimada M, Kawamoto K, Todo T, Kawasaki T, Tooyama I, Fujioka Y, Sakai N, Takada T.

Sci Rep. 2017 Feb 17;7:42852. doi: 10.1038/srep42852.

28.

Proton magnetic resonance spectroscopy assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls.

Ito T, Tanaka-Mizuno S, Iwashita N, Tooyama I, Shiino A, Miura K, Fukui S.

J Pain Res. 2017 Jan 31;10:287-293. doi: 10.2147/JPR.S123403. eCollection 2017.

29.

Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression.

Guan H, Yang H, Yang M, Yanagisawa D, Bellier JP, Mori M, Takahata S, Nonaka T, Zhao S, Tooyama I.

Exp Neurol. 2017 May;291:51-61. doi: 10.1016/j.expneurol.2017.02.001. Epub 2017 Feb 3.

30.

Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.

Shiino A, Chen YW, Tanigaki K, Yamada A, Vigers P, Watanabe T, Tooyama I, Akiguchi I.

Sci Rep. 2017 Jan 3;7:39818. doi: 10.1038/srep39818.

31.

Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord.

Abdelalim EM, Bellier JP, Tooyama I.

Front Neuroanat. 2016 Dec 2;10:116. eCollection 2016.

32.

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice.

Ibrahim NF, Yanagisawa D, Durani LW, Hamezah HS, Damanhuri HA, Wan Ngah WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I.

J Alzheimers Dis. 2017;55(2):597-612.

33.

Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease.

Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I.

J Neurosci Res. 2017 Jul;95(7):1485-1494. doi: 10.1002/jnr.23983. Epub 2016 Oct 28.

34.

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.

Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I.

Neurobiol Aging. 2016 Nov;47:168-179. doi: 10.1016/j.neurobiolaging.2016.07.025. Epub 2016 Aug 12.

35.

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S, Ariga H.

J Alzheimers Dis. 2017;55(1):67-72.

PMID:
27662308
36.

Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.

Ogawa T, Irikawa N, Yanagisawa D, Shiino A, Tooyama I, Shimizu T.

Auris Nasus Larynx. 2017 Apr;44(2):168-173. doi: 10.1016/j.anl.2016.06.010. Epub 2016 Jul 12.

PMID:
27427537
37.

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.

Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I.

Neuroscience. 2016 Jul 22;328:92-106. doi: 10.1016/j.neuroscience.2016.04.035. Epub 2016 Apr 28.

38.

Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body.

Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M.

Sci Rep. 2016 Apr 25;6:24868. doi: 10.1038/srep24868.

39.

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior.

Inden M, Takata K, Yanagisawa D, Ashihara E, Tooyama I, Shimohama S, Kitamura Y.

Neurochem Int. 2016 Mar;94:74-81. doi: 10.1016/j.neuint.2016.02.008. Epub 2016 Feb 18.

PMID:
26911419
40.

Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).

Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S.

Ageing Res Rev. 2016 Sep;30:85-94. doi: 10.1016/j.arr.2015.12.008. Epub 2016 Jan 6. Review.

PMID:
26772439
41.

S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.

Sonoda Y, Tooyama I, Mukai H, Maeda K, Akiyama H, Kawamata T.

Neuropathology. 2016 Aug;36(4):325-32. doi: 10.1111/neup.12275. Epub 2015 Nov 18.

PMID:
26582459
42.

Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.

Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I.

Biochem Biophys Rep. 2015 Oct 26;4:357-368. doi: 10.1016/j.bbrep.2015.10.009. eCollection 2015 Dec.

43.

CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions.

Wada Y, Iwasaki Y, Abe T, Wada K, Tooyama I, Ikemura T.

Genes Genet Syst. 2015;90(1):43-53. doi: 10.1266/ggs.90.43.

44.

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.

Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I.

Neurosci Lett. 2015 Mar 30;591:19-24. doi: 10.1016/j.neulet.2015.02.013. Epub 2015 Feb 9.

45.

Upregulation of mitochondrial ferritin by proinflammatory cytokines: implications for a role in Alzheimer's disease.

Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I.

J Alzheimers Dis. 2015;45(3):797-811. doi: 10.3233/JAD-142595.

PMID:
25624418
46.

Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.

McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev E, Tooyama I, Gore JC, Pham W.

J Alzheimers Dis. 2015;44(1):283-95. doi: 10.3233/JAD-140798.

47.

Immunohistochemical Localization of an Isoform of TRK-Fused Gene-Like Protein in the Rat Retina.

Masuda C, Takeuchi S, J Bisem N, R Vincent S, Tooyama I.

Acta Histochem Cytochem. 2014 May 1;47(2):75-83. doi: 10.1267/ahc.14018. Epub 2014 Apr 25.

48.

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice.

Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I.

Neurobiol Aging. 2015 Jan;36(1):201-10. doi: 10.1016/j.neurobiolaging.2014.07.041. Epub 2014 Aug 2.

PMID:
25179227
49.

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.

Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.

Am J Hum Genet. 2014 Sep 4;95(3):294-300. doi: 10.1016/j.ajhg.2014.07.013. Epub 2014 Aug 21.

50.

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.

Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M.

Nat Commun. 2014 Jun 4;5:3917. doi: 10.1038/ncomms4917.

PMID:
24894631

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