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Items: 1 to 50 of 65

1.

Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission.

Lammertse HCA, van Berkel AA, Iacomino M, Toonen RF, Striano P, Gambardella A, Verhage M, Zara F.

Brain. 2019 Dec 19. pii: awz391. doi: 10.1093/brain/awz391. [Epub ahead of print]

PMID:
31855252
2.

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators.

Persoon CM, Hoogstraaten RI, Nassal JP, van Weering JRT, Kaeser PS, Toonen RF, Verhage M.

Neuron. 2019 Dec 18;104(6):1065-1080.e12. doi: 10.1016/j.neuron.2019.09.015. Epub 2019 Oct 31.

PMID:
31679900
3.

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.

Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M.

EMBO J. 2019 Sep 2;38(17):e101289. doi: 10.15252/embj.2018101289. Epub 2019 Aug 1.

4.

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M.

Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.

PMID:
31171447
5.

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.

King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF.

Sci Rep. 2019 Jun 3;9(1):8179. doi: 10.1038/s41598-019-44589-2.

6.

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.

Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, Peitz M, Toonen RF, Brüstle O, Verhage M.

Cell Rep. 2019 May 14;27(7):2199-2211.e6. doi: 10.1016/j.celrep.2019.04.058.

7.

Vti Proteins: Beyond Endolysosomal Trafficking.

Emperador-Melero J, Toonen RF, Verhage M.

Neuroscience. 2019 Nov 10;420:32-40. doi: 10.1016/j.neuroscience.2018.11.014. Epub 2018 Nov 22. Review.

8.

Pool size estimations for dense-core vesicles in mammalian CNS neurons.

Persoon CM, Moro A, Nassal JP, Farina M, Broeke JH, Arora S, Dominguez N, van Weering JR, Toonen RF, Verhage M.

EMBO J. 2018 Oct 15;37(20). pii: e99672. doi: 10.15252/embj.201899672. Epub 2018 Sep 5.

9.

Motor and non-motor determinants of health-related quality of life in young dystonia patients.

Eggink H, Coenen MA, de Jong R, Toonen RF, Eissens MH, Veenstra WS, Peall KJ, Sival DA, Elema A, Tijssen MA.

Parkinsonism Relat Disord. 2019 Jan;58:50-55. doi: 10.1016/j.parkreldis.2018.08.008. Epub 2018 Aug 29.

PMID:
30181088
10.

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.

Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M.

Nat Commun. 2018 Aug 24;9(1):3421. doi: 10.1038/s41467-018-05699-z.

11.

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.

Kovacevic J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse LN, Sullivan PF, Schoch S, Toonen RF, Stiedl O, Verhage M.

Brain. 2018 May 1;141(5):1350-1374. doi: 10.1093/brain/awy046.

12.

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1157. doi: 10.1083/JCB.20170320601192018c. Epub 2018 Jan 23. No abstract available.

13.

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1129-1142. doi: 10.1083/jcb.201703206. Epub 2018 Jan 16. Erratum in: J Cell Biol. 2018 Jan 23;:.

14.

Changes in the Content of Pediatric Physical Therapy for Infants: A Quantitative, Observational Study.

Hielkema T, Toonen RF, Hooijsma SJ, Dirks T, Reinders-Messelink HA, Maathuis CGB, Geertzen JHB, Hadders-Algra M.

Phys Occup Ther Pediatr. 2018;38(5):457-488. doi: 10.1080/01942638.2017.1405863. Epub 2017 Dec 21.

PMID:
29265913
15.

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.

Dominguez N, van Weering JRT, Borges R, Toonen RFG, Verhage M.

J Neurochem. 2018 Feb;144(3):241-254. doi: 10.1111/jnc.14263. Epub 2017 Dec 27.

16.

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.

Meijer M, Dörr B, Lammertse HC, Blithikioti C, van Weering JR, Toonen RF, Söllner TH, Verhage M.

EMBO J. 2018 Jan 17;37(2):300-320. doi: 10.15252/embj.201796484. Epub 2017 Nov 17.

17.

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.

van Keimpema L, Kooistra R, Toonen RF, Verhage M.

Sci Rep. 2017 Sep 7;7(1):10817. doi: 10.1038/s41598-017-10936-4.

18.

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.

He E, Wierda K, van Westen R, Broeke JH, Toonen RF, Cornelisse LN, Verhage M.

Nat Commun. 2017 Jun 21;8:15915. doi: 10.1038/ncomms15915.

19.

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells.

Nadadhur AG, Emperador Melero J, Meijer M, Schut D, Jacobs G, Li KW, Hjorth JJJ, Meredith RM, Toonen RF, Van Kesteren RE, Smit AB, Verhage M, Heine VM.

PLoS One. 2017 Jun 6;12(6):e0178533. doi: 10.1371/journal.pone.0178533. eCollection 2017.

20.

SNAP-25 gene family members differentially support secretory vesicle fusion.

Arora S, Saarloos I, Kooistra R, van de Bospoort R, Verhage M, Toonen RF.

J Cell Sci. 2017 Jun 1;130(11):1877-1889. doi: 10.1242/jcs.201889. Epub 2017 Apr 12.

21.

Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.

Santos TC, Wierda K, Broeke JH, Toonen RF, Verhage M.

J Neurosci. 2017 Apr 26;37(17):4525-4539. doi: 10.1523/JNEUROSCI.3352-16.2017. Epub 2017 Mar 27.

22.

Effect of early intervention on functional outcome at school age: Follow-up and process evaluation of a randomised controlled trial in infants at risk.

Hamer EG, Hielkema T, Bos AF, Dirks T, Hooijsma SJ, Reinders-Messelink HA, Toonen RF, Hadders-Algra M.

Early Hum Dev. 2017 Mar - Apr;106-107:67-74. doi: 10.1016/j.earlhumdev.2017.02.002. Epub 2017 Mar 2.

PMID:
28282530
23.

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.

Emperador Melero J, Nadadhur AG, Schut D, Weering JV, Heine VM, Toonen RF, Verhage M.

Stem Cell Reports. 2017 Mar 14;8(3):659-672. doi: 10.1016/j.stemcr.2017.01.019. Epub 2017 Feb 23.

24.

Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity.

de Jong AP, Meijer M, Saarloos I, Cornelisse LN, Toonen RF, Sørensen JB, Verhage M.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5095-100. doi: 10.1073/pnas.1522927113. Epub 2016 Apr 18.

25.

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

Schmitz SK, King C, Kortleven C, Huson V, Kroon T, Kevenaar JT, Schut D, Saarloos I, Hoetjes JP, de Wit H, Stiedl O, Spijker S, Li KW, Mansvelder HD, Smit AB, Cornelisse LN, Verhage M, Toonen RF.

EMBO J. 2016 Jun 1;35(11):1236-50. doi: 10.15252/embj.201592244. Epub 2016 Apr 7.

26.

Correction: CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.

Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF.

Elife. 2015 Nov 18;4:e12968. doi: 10.7554/eLife.12968. No abstract available.

27.

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons.

Meijer M, Cijsouw T, Toonen RF, Verhage M.

PLoS One. 2015 Sep 25;10(9):e0138950. doi: 10.1371/journal.pone.0138950. eCollection 2015.

28.

Detection of silent cells, synchronization and modulatory activity in developing cellular networks.

Hjorth JJ, Dawitz J, Kroon T, Pires J, Dassen VJ, Berkhout JA, Emperador Melero J, Nadadhur AG, Alevra M, Toonen RF, Heine VM, Mansvelder HD, Meredith RM.

Dev Neurobiol. 2016 Apr;76(4):357-74. doi: 10.1002/dneu.22319. Epub 2015 Jul 1.

29.

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences.

Giniatullina A, Maroteaux G, Geerts CJ, Koopmans B, Loos M, Klaassen R, Chen N, van der Schors RC, van Nierop P, Li KW, de Jong J, Altrock WD, Cornelisse LN, Toonen RF, van der Sluis S, Sullivan PF, Stiedl O, Posthuma D, Smit AB, Groffen AJ, Verhage M.

Neuroscience. 2015 Aug 6;300:518-38. doi: 10.1016/j.neuroscience.2015.05.047. Epub 2015 Jun 1.

PMID:
26045179
30.

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

Farzana F, Zalm R, Chen N, Li KW, Grant SG, Smit AB, Toonen RF, Verhage M.

Mol Neurobiol. 2016 May;53(4):2112-23. doi: 10.1007/s12035-015-9164-8. Epub 2015 May 2.

31.

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.

Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF.

Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05438. Erratum in: Elife. 2015;4:e12968.

32.

Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.

Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF.

J Cell Biol. 2014 Mar 3;204(5):759-75. doi: 10.1083/jcb.201308026.

33.

Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release.

Genc O, Kochubey O, Toonen RF, Verhage M, Schneggenburger R.

Elife. 2014 Feb 11;3:e01715. doi: 10.7554/eLife.01715.

34.

A closer look at FBXO41 as a Parkinson's disease risk factor.

King CR, van der Sluis S, Polderman TJ, Toonen RF.

Parkinsonism Relat Disord. 2013 Dec;19(12):1175-6. doi: 10.1016/j.parkreldis.2013.08.016. Epub 2013 Sep 6. No abstract available.

PMID:
24075121
35.

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.

Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC.

J Cell Biol. 2013 Jun 10;201(6):915-28. doi: 10.1083/jcb.201301011.

36.

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation.

Nijholt DA, Nölle A, van Haastert ES, Edelijn H, Toonen RF, Hoozemans JJ, Scheper W.

Neurobiol Aging. 2013 Jul;34(7):1759-71. doi: 10.1016/j.neurobiolaging.2013.01.008. Epub 2013 Feb 14.

37.

Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

van de Bospoort R, Farina M, Schmitz SK, de Jong A, de Wit H, Verhage M, Toonen RF.

J Cell Biol. 2012 Dec 10;199(6):883-91. doi: 10.1083/jcb.201208024.

38.

Dendritic position is a major determinant of presynaptic strength.

de Jong AP, Schmitz SK, Toonen RF, Verhage M.

J Cell Biol. 2012 Apr 16;197(2):327-37. doi: 10.1083/jcb.201112135. Epub 2012 Apr 9.

39.

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.

Meijer M, Burkhardt P, de Wit H, Toonen RF, Fasshauer D, Verhage M.

EMBO J. 2012 May 2;31(9):2156-68. doi: 10.1038/emboj.2012.72. Epub 2012 Mar 23.

40.

Crashpilot underachieves due to acetylation at the nerve terminal.

Toonen RF, Verhage M.

Neuron. 2011 Dec 8;72(5):679-81. doi: 10.1016/j.neuron.2011.11.008.

41.

Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality.

Dudok JJ, Groffen AJ, Toonen RF, Verhage M.

PLoS One. 2011;6(11):e28137. doi: 10.1371/journal.pone.0028137. Epub 2011 Nov 29.

42.

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

Lips ES, Cornelisse LN, Toonen RF, Min JL, Hultman CM; International Schizophrenia Consortium, Holmans PA, O'Donovan MC, Purcell SM, Smit AB, Verhage M, Sullivan PF, Visscher PM, Posthuma D.

Mol Psychiatry. 2012 Oct;17(10):996-1006. doi: 10.1038/mp.2011.117. Epub 2011 Sep 20.

43.

Automated analysis of neuronal morphology, synapse number and synaptic recruitment.

Schmitz SK, Hjorth JJ, Joemai RM, Wijntjes R, Eijgenraam S, de Bruijn P, Georgiou C, de Jong AP, van Ooyen A, Verhage M, Cornelisse LN, Toonen RF, Veldkamp WJ.

J Neurosci Methods. 2011 Feb 15;195(2):185-93. doi: 10.1016/j.jneumeth.2010.12.011. Epub 2010 Dec 15. Erratum in: J Neurosci Methods. 2011 Apr 15;197(1):190. Veldkamp, Wouter [corrected to Veldkamp, Wouter J H].

44.

Munc18 and Munc13 regulate early neurite outgrowth.

Broeke JH, Roelandse M, Luteijn MJ, Boiko T, Matus A, Toonen RF, Verhage M.

Biol Cell. 2010 Jun 30;102(8):479-88. doi: 10.1042/BC20100036.

45.

Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control.

Witte S, Baclayon M, Peterman EJ, Toonen RF, Mansvelder HD, Groot ML.

Opt Express. 2009 Jul 6;17(14):11335-49.

PMID:
19582048
46.

Automated quantification of cellular traffic in living cells.

Broeke JH, Ge H, Dijkstra IM, Cemgil AT, Riedl JA, Cornelisse LN, Toonen RF, Verhage M, Fitzgerald WJ.

J Neurosci Methods. 2009 Apr 15;178(2):378-84. doi: 10.1016/j.jneumeth.2008.12.018. Epub 2008 Dec 25.

PMID:
19146878
47.

Matrix-dependent local retention of secretory vesicle cargo in cortical neurons.

de Wit J, Toonen RF, Verhage M.

J Neurosci. 2009 Jan 7;29(1):23-37. doi: 10.1523/JNEUROSCI.3931-08.2009.

48.

Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

Toonen RF, Verhage M.

Trends Neurosci. 2007 Nov;30(11):564-72. Epub 2007 Oct 22. Review.

PMID:
17956762
49.
50.

Regulated exocytosis: merging ideas on fusing membranes.

Verhage M, Toonen RF.

Curr Opin Cell Biol. 2007 Aug;19(4):402-8. Epub 2007 Jul 16. Review.

PMID:
17629692

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