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Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.

Toomey S, Carr A, Mezynski MJ, Elamin Y, Rafee S, Cremona M, Morgan C, Madden S, Abdul-Jalil KI, Gately K, Farrelly A, Kay EW, Kennedy S, O'Byrne K, Grogan L, Breathnach O, Morris PG, Eustace AJ, Fay J, Cummins R, O'Grady A, Kalachand R, O'Donovan N, Kelleher F, O'Reilly A, Doherty M, Crown J, Hennessy BT.

J Transl Med. 2020 Feb 22;18(1):99. doi: 10.1186/s12967-020-02273-4.


Preclinical drug testing and clinical trial planning of palbociclib (CDK4/6 inhibitor) drug combination with a PI3K or MAPK inhibitor for colorectal cancer (CRC).

Lee CL, Toomey S, Farrelly A, Hennessy B.

Ann Oncol. 2019 Feb;30 Suppl 1:i7. doi: 10.1093/annonc/mdz029.012. Epub 2020 Jan 8. No abstract available.


Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer.

Kennedy SP, O'Neill M, Cunningham D, Morris PG, Toomey S, Blanco-Aparicio C, Martinez S, Pastor J, Eustace AJ, Hennessy BT.

Oncogene. 2020 Feb 10. doi: 10.1038/s41388-020-1202-y. [Epub ahead of print]


Suitability of elderly adult hospital readmission rates for profiling readmissions in younger adult and pediatric populations.

Bucholz EM, Toomey SL, Butala NM, Chien AT, Yeh RW, Schuster MA.

Health Serv Res. 2020 Apr;55(2):277-287. doi: 10.1111/1475-6773.13269. Epub 2020 Feb 9.


Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients.

Roche S, O'Neill F, Murphy J, Swan N, Meiller J, Conlon NT, Geoghegan J, Conlon K, McDermott R, Rahman R, Toomey S, Straubinger NL, Straubinger RM, O'Connor R, McVey G, Moriarty M, Clynes M.

Int J Mol Sci. 2020 Jan 31;21(3). pii: E962. doi: 10.3390/ijms21030962.


Factors Associated With Family Experience in Pediatric Inpatient Care.

Feng JY, Toomey SL, Elliott MN, Zaslavsky AM, Onorato SE, Schuster MA.

Pediatrics. 2020 Mar;145(3). pii: e20191264. doi: 10.1542/peds.2019-1264. Epub 2020 Feb 3.


Laparoscopic Guided Regional Analgesia (Lagra) Reduces Post-Operative Pain After Laparoscopic Cholecystectomy

Joyce D, Craig R, Mansoor S, Toomey S.

Ir Med J. 2019 Jun 17;112(6):957. No abstract available.


Genomic profiling of a dedifferentiated mucosal melanoma following exposure to immunotherapy.

Prior L, Toomey S, Greally M, Keane F, Lim M, Harrold E, O'Keane C, Bulger K, Hennessy BT, Furney SJ, McCaffrey J.

Melanoma Res. 2020 Apr;30(2):213-218. doi: 10.1097/CMR.0000000000000636.


Altered Steroid Milieu in AI-Resistant Breast Cancer Facilitates AR Mediated Gene-Expression Associated with Poor Response to Therapy.

Creevey L, Bleach R, Madden SF, Toomey S, Bane FT, Varešlija D, Hill AD, Young LS, McIlroy M.

Mol Cancer Ther. 2019 Oct;18(10):1731-1743. doi: 10.1158/1535-7163.MCT-18-0791. Epub 2019 Jul 9.


Trends in Pediatric Hospitalizations and Readmissions: 2010-2016.

Bucholz EM, Toomey SL, Schuster MA.

Pediatrics. 2019 Feb;143(2). pii: e20181958. doi: 10.1542/peds.2018-1958.


Racial, Ethnic, and Socioeconomic Disparities in Patient Safety Events for Hospitalized Children.

Stockwell DC, Landrigan CP, Toomey SL, Westfall MY, Liu S, Parry G, Coopersmith AS, Schuster MA; GAPPS Study Group.

Hosp Pediatr. 2019 Jan;9(1):1-5. doi: 10.1542/hpeds.2018-0131. Epub 2018 Dec 3.


Potential Impact of Initial Clinical Data on Adjustment of Pediatric Readmission Rates.

Nakamura MM, Toomey SL, Zaslavsky AM, Petty CR, Lin C, Savova GK, Rose S, Brittan MS, Lin JL, Bryant MC, Ashrafzadeh S, Schuster MA.

Acad Pediatr. 2019 Jul;19(5):589-598. doi: 10.1016/j.acap.2018.09.006. Epub 2018 Nov 20.


Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer.

Smith YE, Toomey S, Napoletano S, Kirwan G, Schadow C, Chubb AJ, Mikkelsen JH, Oxvig C, Harmey JH.

BMC Cancer. 2018 Oct 22;18(1):1016. doi: 10.1186/s12885-018-4950-0.


Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents.

Jean J, Farrell DS, Farrelly AM, Toomey S, Barlow JW.

Heliyon. 2018 Sep 4;4(9):e00767. doi: 10.1016/j.heliyon.2018.e00767. eCollection 2018 Sep.


Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH).

Coté D, Eustace A, Toomey S, Cremona M, Milewska M, Furney S, Carr A, Fay J, Kay E, Kennedy S, Crown J, Hennessy B, Madden S.

PLoS One. 2018 Aug 2;13(8):e0200996. doi: 10.1371/journal.pone.0200996. eCollection 2018.


Improving Response Rates and Representation of Hard-to-Reach Groups in Family Experience Surveys.

Toomey SL, Elliott MN, Zaslavsky AM, Quinn J, Klein DJ, Wagner S, Thomson C, Wu M, Onorato S, Schuster MA.

Acad Pediatr. 2019 May - Jun;19(4):446-453. doi: 10.1016/j.acap.2018.07.007. Epub 2018 Jul 26.


Frequency, impact and a preclinical study of novel ERBB gene family mutations in HER2-positive breast cancer.

Elster N, Toomey S, Fan Y, Cremona M, Morgan C, Weiner Gorzel K, Bhreathnach U, Milewska M, Murphy M, Madden S, Naidoo J, Fay J, Kay E, Carr A, Kennedy S, Furney S, Mezynski J, Breathhnach O, Morris P, Grogan L, Hill A, Kennedy S, Crown J, Gallagher W, Hennessy B, Eustace A.

Ther Adv Med Oncol. 2018 Jul 13;10:1758835918778297. doi: 10.1177/1758835918778297. eCollection 2018.


Associations of Eczema Severity and Parent Knowledge With Child Quality of Life in a Pediatric Primary Care Population.

Rea CJ, Tran KD, Jorina M, Wenren LM, Hawryluk EB, Toomey SL.

Clin Pediatr (Phila). 2018 Nov;57(13):1506-1514. doi: 10.1177/0009922818787295. Epub 2018 Jul 16.


An insight into the molecular genetics of a uveal melanoma patient cohort.

Kennedy S, Rice M, Toomey S, Horgan N, Hennessey BT, Larkin A.

J Cancer Res Clin Oncol. 2018 Oct;144(10):1861-1868. doi: 10.1007/s00432-018-2705-6. Epub 2018 Jul 14.


Adverse Events in Hospitalized Pediatric Patients.

Stockwell DC, Landrigan CP, Toomey SL, Loren SS, Jang J, Quinn JA, Ashrafzadeh S, Wang MJ, Wu M, Sharek PJ, Classen DC, Srivastava R, Parry G, Schuster MA; GAPPS Study Group.

Pediatrics. 2018 Aug;142(2). pii: e20173360. doi: 10.1542/peds.2017-3360. Epub 2018 Jul 13.


Care Quality and Spending Among Commercially Insured Children With Disabilities.

Chien AT, Toomey SL, Kuo DZ, Van Cleave J, Houtrow AJ, Okumura MJ, Westfall MY, Petty CR, Quinn JA, Kuhlthau KA, Schuster MA.

Acad Pediatr. 2019 Apr;19(3):291-299. doi: 10.1016/j.acap.2018.06.004. Epub 2018 Jun 19.


Ensuring Timely Connection to Early Intervention for Young Children With Developmental Delays.

Conroy K, Rea C, Kovacikova GI, Sprecher E, Reisinger E, Durant H, Starmer A, Cox J, Toomey SL.

Pediatrics. 2018 Jul;142(1). pii: e20174017. doi: 10.1542/peds.2017-4017. Epub 2018 Jun 6.


Brief Report on the Detection of the EGFR T790M Mutation in Exhaled Breath Condensate from Lung Cancer Patients.

Smyth RJ, Toomey SM, Sartori A, O'Hanrahan E, Cuffe SD, Breathnach OS, Morgan RK, Hennessy BT.

J Thorac Oncol. 2018 Aug;13(8):1213-1216. doi: 10.1016/j.jtho.2018.04.033. Epub 2018 May 8.


Shared Care: Using an Electronic Consult Form to Facilitate Primary Care Provider-Specialty Care Coordination.

Rea CJ, Wenren LM, Tran KD, Zwemer E, Mallon D, Bernson-Leung M, Samuels RC, Toomey SL.

Acad Pediatr. 2018 Sep - Oct;18(7):797-804. doi: 10.1016/j.acap.2018.03.010. Epub 2018 Apr 3.


A Randomized Controlled Trial of an Eczema Care Plan.

Rea CJ, Tran KD, Jorina M, Wenren LM, Hawryluk EB, Toomey SL.

Acad Pediatr. 2018 Sep - Oct;18(7):789-796. doi: 10.1016/j.acap.2018.02.015. Epub 2018 Mar 2.


Children and young people's versus parents' responses in an English national inpatient survey.

Hargreaves DS, Sizmur S, Pitchforth J, Tallett A, Toomey SL, Hopwood B, Schuster MA, Viner RM.

Arch Dis Child. 2018 May;103(5):486-491. doi: 10.1136/archdischild-2017-313801. Epub 2018 Feb 6.


Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

Milewska M, Cremona M, Morgan C, O'Shea J, Carr A, Vellanki SH, Hopkins AM, Toomey S, Madden SF, Hennessy BT, Eustace AJ.

Ther Adv Med Oncol. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040. eCollection 2018.


A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib.

O'Shea J, Cremona M, Morgan C, Milewska M, Holmes F, Espina V, Liotta L, O'Shaughnessy J, Toomey S, Madden SF, Carr A, Elster N, Hennessy BT, Eustace AJ.

Oncotarget. 2017 Jul 22;8(49):85120-85135. doi: 10.18632/oncotarget.19461. eCollection 2017 Oct 17.


Readmission After Pediatric Mental Health Admissions.

Feng JY, Toomey SL, Zaslavsky AM, Nakamura MM, Schuster MA.

Pediatrics. 2017 Dec;140(6). pii: e20171571. doi: 10.1542/peds.2017-1571. Epub 2017 Nov 3. Erratum in: Pediatrics. 2019 Jan;143(1):.


Education on the Brain: A Partnership Between a Pediatric Primary Care Center and Neurology Residency.

Zwemer E, Bernson-Leung M, Rea C, Patel AA, Guerriero R, Urion DK, Toomey SL.

Clin Pediatr (Phila). 2018 Jan;57(1):46-51. doi: 10.1177/0009922817691819. Epub 2017 Feb 13.


Pediatric Readmissions After Hospitalizations for Lower Respiratory Infections.

Nakamura MM, Zaslavsky AM, Toomey SL, Petty CR, Bryant MC, Geanacopoulos AT, Jha AK, Schuster MA.

Pediatrics. 2017 Aug;140(2). pii: e20160938. doi: 10.1542/peds.2016-0938.


Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

Toomey S, Eustace AJ, Fay J, Sheehan KM, Carr A, Milewska M, Madden SF, Teiserskiene A, Kay EW, O'Donovan N, Gallagher W, Grogan L, Breathnach O, Walshe J, Kelly C, Moulton B, Kennedy MJ, Gullo G, Hill AD, Power C, Duke D, Hambly N, Crown J, Hennessy BT.

Breast Cancer Res. 2017 Jul 27;19(1):87. doi: 10.1186/s13058-017-0883-9.


Preparation for Transition to Adult Care Among Medicaid-Insured Adolescents.

Sawicki GS, Garvey KC, Toomey SL, Williams KA, Hargraves JL, James T, Raphael JL, Giardino AP, Schuster MA, Finkelstein JA.

Pediatrics. 2017 Jul;140(1). pii: e20162768. doi: 10.1542/peds.2016-2768.


Comparative Incidence of Patellofemoral Complications Between 2 Total Knee Arthroplasty Systems in a Multicenter, Prospective Clinical Study.

Toomey SD, Daccach JA, Shah JC, Himden SE, Lesko JP, Hamilton WG.

J Arthroplasty. 2017 Sep;32(9S):S187-S192. doi: 10.1016/j.arth.2017.04.014. Epub 2017 Apr 20.


Validation of New Quality Measures for Transitions Between Sites of Care.

Parast L, Burkhart Q, Desai AD, Simon TD, Allshouse C, Britto MT, Leyenaar JK, Gidengil CA, Toomey SL, Elliott MN, Schneider EC, Mangione-Smith R.

Pediatrics. 2017 May;139(5). pii: e20164178. doi: 10.1542/peds.2016-4178. Epub 2017 Apr 14.


Impact of an Individual Mandate and Other Health Reforms on Dependent Coverage for Adolescents and Young Adults.

Wisk LE, Finkelstein JA, Toomey SL, Sawicki GS, Schuster MA, Galbraith AA.

Health Serv Res. 2018 Jun;53(3):1581-1599. doi: 10.1111/1475-6773.12723. Epub 2017 May 30.


Variation in Family Experience of Pediatric Inpatient Care As Measured by Child HCAHPS.

Toomey SL, Elliott MN, Zaslavsky AM, Klein DJ, Ndon S, Hardy S, Wu M, Schuster MA.

Pediatrics. 2017 Apr;139(4). pii: e20163372. doi: 10.1542/peds.2016-3372. Epub 2017 Mar 22.


Quality of Primary Care for Children With Disabilities Enrolled in Medicaid.

Chien AT, Kuhlthau KA, Toomey SL, Quinn JA, Okumura MJ, Kuo DZ, Houtrow AJ, Van Cleave J, Landrum MB, Jang J, Janmey I, Furdyna MJ, Schuster MA.

Acad Pediatr. 2017 May - Jun;17(4):443-449. doi: 10.1016/j.acap.2016.10.015. Epub 2017 Mar 9.


Chronic Physical Health Conditions and Emotional Problems From Early Adolescence Through Midadolescence.

Jones LC, Mrug S, Elliott MN, Toomey SL, Tortolero S, Schuster MA.

Acad Pediatr. 2017 Aug;17(6):649-655. doi: 10.1016/j.acap.2017.02.002. Epub 2017 Feb 12.


The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer.

Toomey S, Madden SF, Furney SJ, Fan Y, McCormack M, Stapleton C, Cremona M, Cavalleri GL, Milewska M, Elster N, Carr A, Fay J, Kay EW, Kennedy S, Crown J, Gallagher WM, Hennessy BT, Eustace AJ.

Oncotarget. 2016 Nov 15;7(46):75518-75525. doi: 10.18632/oncotarget.12782.


Development and Pilot Testing of Caregiver-Reported Pediatric Quality Measures for Transitions Between Sites of Care.

Desai AD, Burkhart Q, Parast L, Simon TD, Allshouse C, Britto MT, Leyenaar JK, Gidengil CA, Toomey SL, Elliott MN, Schneider EC, Mangione-Smith R.

Acad Pediatr. 2016 Nov - Dec;16(8):760-769. doi: 10.1016/j.acap.2016.07.008. Epub 2016 Aug 2.


Firearm Ownership and Acquisition Among Parents With Risk Factors for Self-Harm or Other Violence.

Ladapo JA, Elliott MN, Kanouse DE, Schwebel DC, Toomey SL, Mrug S, Cuccaro PM, Tortolero SR, Schuster MA.

Acad Pediatr. 2016 Nov - Dec;16(8):742-749. doi: 10.1016/j.acap.2016.05.145. Epub 2016 Jun 24.


Relationship Between Adolescent Report of Patient-Centered Care and of Quality of Primary Care.

Toomey SL, Elliott MN, Schwebel DC, Tortolero SR, Cuccaro PM, Davies SL, Kampalath V, Schuster MA.

Acad Pediatr. 2016 Nov - Dec;16(8):770-776. doi: 10.1016/j.acap.2016.01.006. Epub 2016 Jan 20.


BCL-2 system analysis identifies high-risk colorectal cancer patients.

Lindner AU, Salvucci M, Morgan C, Monsefi N, Resler AJ, Cremona M, Curry S, Toomey S, O'Byrne R, Bacon O, Stühler M, Flanagan L, Wilson R, Johnston PG, Salto-Tellez M, Camilleri-Broët S, McNamara DA, Kay EW, Hennessy BT, Laurent-Puig P, Van Schaeybroeck S, Prehn JHM.

Gut. 2017 Dec;66(12):2141-2148. doi: 10.1136/gutjnl-2016-312287. Epub 2016 Sep 23.


A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer.

Salvucci M, Würstle ML, Morgan C, Curry S, Cremona M, Lindner AU, Bacon O, Resler AJ, Murphy ÁC, O'Byrne R, Flanagan L, Dasgupta S, Rice N, Pilati C, Zink E, Schöller LM, Toomey S, Lawler M, Johnston PG, Wilson R, Camilleri-Broët S, Salto-Tellez M, McNamara DA, Kay EW, Laurent-Puig P, Van Schaeybroeck S, Hennessy BT, Longley DB, Rehm M, Prehn JH.

Clin Cancer Res. 2017 Mar 1;23(5):1200-1212. doi: 10.1158/1078-0432.CCR-16-1084. Epub 2016 Sep 20.


Racial and Ethnic Disparities in ADHD Diagnosis and Treatment.

Coker TR, Elliott MN, Toomey SL, Schwebel DC, Cuccaro P, Tortolero Emery S, Davies SL, Visser SN, Schuster MA.

Pediatrics. 2016 Sep;138(3). pii: e20160407. doi: 10.1542/peds.2016-0407. Epub 2016 Aug 23.


Potentially Preventable 30-Day Hospital Readmissions at a Children's Hospital.

Toomey SL, Peltz A, Loren S, Tracy M, Williams K, Pengeroth L, Ste Marie A, Onorato S, Schuster MA.

Pediatrics. 2016 Aug;138(2). pii: e20154182. doi: 10.1542/peds.2015-4182.


RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Toomey S, Eustace AJ, Pritzker LB, Pritzker KP, Fay J, O'Grady A, Cummins R, Grogan L, Kennedy J, O'Connor D, Young L, Kay EW, O'Donovan N, Gallagher WM, Kalachand R, Crown J, Hennessy BT.

J Natl Cancer Inst. 2016 Jul 4;108(8). pii: djw111. doi: 10.1093/jnci/djw111. Print 2016 Aug. No abstract available.


Performance of the Global Assessment of Pediatric Patient Safety (GAPPS) Tool.

Landrigan CP, Stockwell D, Toomey SL, Loren S, Tracy M, Jang J, Quinn JA, Ashrafzadeh S, Wang M, Sharek PJ, Parry G, Schuster MA.

Pediatrics. 2016 Jun;137(6). pii: e20154076. doi: 10.1542/peds.2015-4076.


Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation.

Wang X, Xi W, Toomey S, Chiang YC, Hasek J, Laue TM, Denis CL.

PLoS One. 2016 Mar 8;11(3):e0150616. doi: 10.1371/journal.pone.0150616. eCollection 2016.

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